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Conserved domains on  [gi|985099449|gb|KWX95756|]
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sugar ABC transporter permease [Enterococcus faecium]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 11417684)

carbohydrate ABC transporter permease, part of a periplasmic binding protein (PBP)-dependent ABC transporter may be involved in transport of one or more of a variety of mono-, di-, or polysaccharides, such as trehalose/maltose (MalG) and alginate (AlgM); responsible for translocation of the substrate across the membrane

Gene Ontology:  GO:0055085|GO:0008643
PubMed:  19234479|27273632
TCDB:  3.A.1.1.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 14-294 1.05e-82

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 250.40  E-value: 1.05e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  14 WLNRVIVTFLVVITIVPLIYVLVASFMDPATLINKGISFNPKDWTIQGYQRVFADDSILRGFVNSLFYSFSFSLLTVFIT 93
Cdd:COG0395   15 ILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  94 MITAYPLSRPNLAGKKIIMTFFVITMFVGG--GLIPTYLLVKNLGMLDSVWAIIVPGAI--NVWNIILARTYFSALPKEL 169
Cdd:COG0395   95 SLAAYALARFRFRGRKLLFLLILATLMIPGqvLLIPLYLLFRQLGLLNTYWGLILPYLAfgLPFGIFLLRQFFRSIPREL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449 170 SEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAFVGQWNSYFDAMIYIKDPDLQPLQLVLRNILIQNQPSQDMVganta 249
Cdd:COG0395  175 EEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYGTDWGLL----- 249

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 985099449 250 maemkqiaelikYATIVISSLPLIIMYPFFQKYFDKGVLVGSVKG 294
Cdd:COG0395  250 ------------MAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 14-294 1.05e-82

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 250.40  E-value: 1.05e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  14 WLNRVIVTFLVVITIVPLIYVLVASFMDPATLINKGISFNPKDWTIQGYQRVFADDSILRGFVNSLFYSFSFSLLTVFIT 93
Cdd:COG0395   15 ILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  94 MITAYPLSRPNLAGKKIIMTFFVITMFVGG--GLIPTYLLVKNLGMLDSVWAIIVPGAI--NVWNIILARTYFSALPKEL 169
Cdd:COG0395   95 SLAAYALARFRFRGRKLLFLLILATLMIPGqvLLIPLYLLFRQLGLLNTYWGLILPYLAfgLPFGIFLLRQFFRSIPREL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449 170 SEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAFVGQWNSYFDAMIYIKDPDLQPLQLVLRNILIQNQPSQDMVganta 249
Cdd:COG0395  175 EEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYGTDWGLL----- 249

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 985099449 250 maemkqiaelikYATIVISSLPLIIMYPFFQKYFDKGVLVGSVKG 294
Cdd:COG0395  250 ------------MAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
malG PRK10998
maltose ABC transporter permease MalG;
1-294 1.35e-13

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 69.74  E-value: 1.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449   1 MNSALSKIDRQILWLNRVIVTFLVVITIVPLIYVLVASF----MDPATLINKGISFnpKDWTIQ-GYQRVFADDSI---- 71
Cdd:PRK10998   1 MAMVQPKSQKLRLFATHLLLLGFIALIMFPLLMVIAISLregnFATGSLIPEQISW--EHWKLAlGFSVEHADGRVtppp 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  72 ---LRGFVNSLFYSFSFSLLTVFITMITAYPLSRPNLAGKKIIMTFFVI-TMFVGG-GLIPTYLLVKNLGM------LDS 140
Cdd:PRK10998  79 fpvLLWLWNSVKVAGITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIfQMFPAVlSLVALYALFDRLGQyipfigLNT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449 141 VWAIIVPG----AINVWNIilaRTYFSALPKELSEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAFVGQWNSYFDAMI 216
Cdd:PRK10998 159 HGGVIFAYlggiALHVWTI---KGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASL 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 985099449 217 YIKDPDLQPLQLVLRNILiqnQPSQDMVGANTAMAemkqiaelikyatiVISSLPLIIMYPFFQKYFDKGVLVGSVKG 294
Cdd:PRK10998 236 LLRDVNSYTLAVGMQQYL---NPQNYLWGDFAAAA--------------VLSAIPITVVFLLAQRWLVGGLTAGGVKG 296
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 75-211 2.44e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 55.75  E-value: 2.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  75 FVNSLFYSFSFSLLTVFITMITAYPLSRPNLAGKKIIMTFF--------VITMFVGGGLIPTYLLVKNLGMLDSVWAIIV 146
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIdlllslpsLVLGLLLVLLFGVLLGWGILPGLGLPALILA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985099449 147 PGAINVWNIILARTYFSALPKELSEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAFVGQWNSY 211
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEF 145
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 102-209 8.27e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 42.29  E-value: 8.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  102 RPNLAGKKIIMTFFVITMFvggglIPTYLLVKNLGML-------DSVWAIIVPGAIN--VWNIILARTYFSALPKELSEA 172
Cdd:pfam00528  11 RRGRRLDRLLRPLIDLLQA-----LPSFVLAILLVVIailsilgHGILPAIILALLGwaGYARLIRRAALRSLPSDLVEA 85

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 985099449  173 ATIDGANDLQILFKVMLPLAKPIMFVLFLYAFVGQWN 209
Cdd:pfam00528  86 ARALGASRWQIFRKIILPNALPPILTGLALAFGGALG 122
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 14-294 1.05e-82

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 250.40  E-value: 1.05e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  14 WLNRVIVTFLVVITIVPLIYVLVASFMDPATLINKGISFNPKDWTIQGYQRVFADDSILRGFVNSLFYSFSFSLLTVFIT 93
Cdd:COG0395   15 ILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  94 MITAYPLSRPNLAGKKIIMTFFVITMFVGG--GLIPTYLLVKNLGMLDSVWAIIVPGAI--NVWNIILARTYFSALPKEL 169
Cdd:COG0395   95 SLAAYALARFRFRGRKLLFLLILATLMIPGqvLLIPLYLLFRQLGLLNTYWGLILPYLAfgLPFGIFLLRQFFRSIPREL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449 170 SEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAFVGQWNSYFDAMIYIKDPDLQPLQLVLRNILIQNQPSQDMVganta 249
Cdd:COG0395  175 EEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYGTDWGLL----- 249

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 985099449 250 maemkqiaelikYATIVISSLPLIIMYPFFQKYFDKGVLVGSVKG 294
Cdd:COG0395  250 ------------MAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 6-294 5.17e-52

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 171.87  E-value: 5.17e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449   6 SKIDRQILWLNRVIVTFLVVITIVPLIYVLVASFMDPATLInkGISFNPKDWTIQGYQRVFADDSILRGFVNSLFYSFSF 85
Cdd:COG3833    8 KRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLY--SSSLIPENFTLENYKKLFTETPFLRWFLNSLIVAVVT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  86 SLLTVFITMITAYPLSRPNLAGKKIIMTFFVITMFVGG--GLIPTYLLVKNLGMLDSVWAIIV---PGAINVwNIILART 160
Cdd:COG3833   86 AIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAflALVALYLLLSALGLLNTLLGLILvylGGAIPF-NTWLMKG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449 161 YFSALPKELSEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAFVGQWNSYFDAMIYIKDPDLQPLQLVLRNILIQNQPS 240
Cdd:COG3833  165 YFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSDQRNT 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 985099449 241 QDMVGAntamaemkqiaelikyATIVISSLPLIIMYPFFQKYFDKGVLVGSVKG 294
Cdd:COG3833  245 NWGVFA----------------AGAVLVAIPIVILFLFLQRYLVSGLTAGGVKG 282
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 14-205 1.09e-20

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 89.02  E-value: 1.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  14 WLNRVIVTFLVVITIVPLIYVLVASFMDpatliNKGISFNPKDWTIQGYQRVFADDSILRGFVNSLFYSFSFSLLTVFIT 93
Cdd:COG1177    7 LLLRLFLALVLLFLYLPILVLVLYSFND-----SWFLTFPPEGFTLRWYAELFSDPRLLDALLNSLLIALLSTLLATVLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  94 MITAYPLSRPNLAGKKIIMTFFVITMFVGG---GlIPTYLLVKNLGMLDSVWAII----VPGAINVWNIILARtyFSALP 166
Cdd:COG1177   82 TPAALALARYRFRGRRLLLALLLLPLVVPGivlG-VALLLLFSALGLSGGLWGLIlahvVFTLPFVVLVVLAR--LQGFD 158

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 985099449 167 KELSEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAFV 205
Cdd:COG1177  159 PSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFT 197
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
20-211 7.09e-17

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 79.02  E-value: 7.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  20 VTFLVVITIVPLIYVLVASFMDpATLINKGISFNpkdwTIQGYQRVFADDSILRGFVNSLFYSFSFSLLTVFITMITAYP 99
Cdd:COG1175   28 LLLLLVFVLYPLLYTLYLSFTD-WNLLGPPPEFV----GLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVLGLLLALL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449 100 LSRPnLAGKKIIMTFF---VITMFVGGGLIPTYLLVKNLGML----------------DSVWAIIVPGAINVW-----NI 155
Cdd:COG1175  103 LNRK-LRGRGFFRTLFflpWVISPVVVALIWKWLFNPDYGLLnallgalglepinwlgDPSLALPAVIIVTVWkgtgfNM 181

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 985099449 156 ILARTYFSALPKELSEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAFVGQWNSY 211
Cdd:COG1175  182 LIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVF 237
malG PRK10998
maltose ABC transporter permease MalG;
1-294 1.35e-13

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 69.74  E-value: 1.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449   1 MNSALSKIDRQILWLNRVIVTFLVVITIVPLIYVLVASF----MDPATLINKGISFnpKDWTIQ-GYQRVFADDSI---- 71
Cdd:PRK10998   1 MAMVQPKSQKLRLFATHLLLLGFIALIMFPLLMVIAISLregnFATGSLIPEQISW--EHWKLAlGFSVEHADGRVtppp 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  72 ---LRGFVNSLFYSFSFSLLTVFITMITAYPLSRPNLAGKKIIMTFFVI-TMFVGG-GLIPTYLLVKNLGM------LDS 140
Cdd:PRK10998  79 fpvLLWLWNSVKVAGITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIfQMFPAVlSLVALYALFDRLGQyipfigLNT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449 141 VWAIIVPG----AINVWNIilaRTYFSALPKELSEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAFVGQWNSYFDAMI 216
Cdd:PRK10998 159 HGGVIFAYlggiALHVWTI---KGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASL 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 985099449 217 YIKDPDLQPLQLVLRNILiqnQPSQDMVGANTAMAemkqiaelikyatiVISSLPLIIMYPFFQKYFDKGVLVGSVKG 294
Cdd:PRK10998 236 LLRDVNSYTLAVGMQQYL---NPQNYLWGDFAAAA--------------VLSAIPITVVFLLAQRWLVGGLTAGGVKG 296
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
76-223 8.93e-13

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 67.07  E-value: 8.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  76 VNSLFYSFSFSLLTVFITMITAYPLS--RPNLAGKKIIMTFFVITMFVGGGLIPTYLLVKNLGMLDSVWAIIVPGAINVW 153
Cdd:PRK10973  78 LNSFVMAFSITVGKITVSMLSAFAIVwfRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASAT 157

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449 154 NIILARTYFSALPKELSEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAFVGQWNSYFDAMIYIKDPDL 223
Cdd:PRK10973 158 ATFLFRQFFMTLPDELVEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSL 227
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
18-205 1.27e-12

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 67.88  E-value: 1.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  18 VIVTFLVVITIVPLIYVLVASFMdpatlinkgiSFNPKDWTIQGYQRVFADDSILRGFVNSLFYSFSFSLLTVFITMITA 97
Cdd:COG1178  293 LCLLLVLLGLLLPLLALLLWSLT----------KALDDNLTLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLA 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  98 YPLSRPNLAGKKIIMTFFVITM-----FVGGGLIPTYLLVKNLGMLDSVWAIIVPgainvwNIILA-----RTYFSAL-- 165
Cdd:COG1178  363 YLVRRRRGRLARLLDRLAMLPYavpgiVLGLGLLLLFNRPLPLLLYGTLAILVLA------YVVRFlpfalRSLEAALaq 436

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 985099449 166 -PKELSEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAFV 205
Cdd:COG1178  437 iDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFV 477
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 1-194 4.69e-12

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 64.78  E-value: 4.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449   1 MNSALSKIDRQILWLNrVIVTFLVVITIVPLIYVLVASFMDPATlinkgISFNPKDWTIQGYQRVFADDSILRGFVNSLF 80
Cdd:COG1176    1 MSAALRRRLRPLLLLL-PALLWLLLFFVLPLLLLLVYSFTTRDP-----YGGVVPGFTLENYARLFTDPLYLKVLLRTLW 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  81 YSFSFSLLTVFITMITAYPLSRPNLAGKKIIMTFFVITMFVGGgLIPTY--------------------LLVKNLGMLDS 140
Cdd:COG1176   75 IALLTTLICLLLGYPIAYFLARAPPRWRNLLLLLVILPFWTSF-LVRTYawivllgrngllnslllalgLIDEPLRLLYT 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 985099449 141 VWAIIVpGAINVW---NIILARTYFSALPKELSEAATIDGANDLQILFKVMLPLAKP 194
Cdd:COG1176  154 EFAVVI-GLVYVYlpfMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLP 209
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
1-205 5.54e-12

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 65.95  E-value: 5.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449   1 MNSALSKIDRQILWLnrvIVTFLVVITIVPLIYVLVASFMDPatlinkgisfnpkdwtIQGYQRVFADDSILRGFVNSLF 80
Cdd:COG1178    1 MSTRPRRRPRLLLLL---LALLLALLVLLPLLALLLRAFTDG----------------LANFWALLSDPYLWRALGNTLL 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  81 YSFSFSLLTVFITMITAYPLSRPNLAGKKIIMTFFVITM----FVGG----------GLIpTYLLVKNLGM----LDSVW 142
Cdd:COG1178   62 LALLVTLLSLLLGVPLAWLLARTDFPGRRLLRWLLLLPLalppYVVAlawialfgpnGLL-NTLLRALFGLeppdIYGLG 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985099449 143 AIIVpgAINVWNI----ILARTYFSALPKELSEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAFV 205
Cdd:COG1178  141 GIIL--VLVLFNYpyvyLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFL 205
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 75-211 2.44e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 55.75  E-value: 2.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  75 FVNSLFYSFSFSLLTVFITMITAYPLSRPNLAGKKIIMTFF--------VITMFVGGGLIPTYLLVKNLGMLDSVWAIIV 146
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIdlllslpsLVLGLLLVLLFGVLLGWGILPGLGLPALILA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985099449 147 PGAINVWNIILARTYFSALPKELSEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAFVGQWNSY 211
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEF 145
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 14-194 2.41e-08

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 53.99  E-value: 2.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  14 WLNRVIVTFLVVITIVPLI-YVLVASFMDPATLInkgisfnpkdwtiqgyqRVFADDSILRGFVNSLFYSFSFSLLTVFI 92
Cdd:COG0555   11 LTLGLTLLYLSLIVLLPLAaLVLKAAGLGWAEFW-----------------AVLTSPRVLAALKLSLGTALIAALINLVF 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  93 TMITAYPLSRPNLAGKKIIMTF----FVI----------TMFVGGGLIPTYLLVKNLGMLDSVWAIIV-------PGAIN 151
Cdd:COG0555   74 GLPLAWVLVRYRFPGKRLVDALvdlpFALptavagiallLLFGPNGWLGQLLAPLGIKVAFTPLGIVLaqtfvslPFVVR 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 985099449 152 VwniilARTYFSALPKELSEAATIDGANDLQILFKVMLPLAKP 194
Cdd:COG0555  154 T-----VQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLP 191
malF PRK10999
maltose ABC transporter permease MalF;
60-196 6.55e-06

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 47.26  E-value: 6.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  60 QGYQRVFADDSILRGFVNSLFYSFSFSLLTVFIT----MITAYPLSRPNLAGKKI----------IMTFFVITMFVGggl 125
Cdd:PRK10999 268 KNFTRVFTDEGIQKPFIAIFIWTVVFSLLTVVLTvavgMVLACLVQWEALKGKAVyrvllilpyaVPSFISILIFKG--- 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449 126 iptyLLVKNLG----MLDSVWAI----------------IVpgaiNVW-----NIILARTYFSALPKELSEAATIDGAND 180
Cdd:PRK10999 345 ----LFNQSFGeinmMLSALFGIkpawfsdptlaktmilIV----NTWlgypyMMILCMGLLKAIPDDLYEASAMDGAGP 416

                        170
                 ....*....|....*..
gi 985099449 181 LQILFKVMLPL-AKPIM 196
Cdd:PRK10999 417 FQNFFKITLPLlIKPLT 433
potC PRK09500
spermidine/putrescine ABC transporter membrane protein; Reviewed
 14-204 2.01e-05

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 236542 [Multi-domain]  Cd Length: 256  Bit Score: 44.98  E-value: 2.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  14 WLNRVIVTFLVVITIVPLIYVLVASFMDPAtlinkgISFNPKDWTIQGYQRVFADDSILRGFVNSLFYSFSFSLLTVFIT 93
Cdd:PRK09500   4 LLRGGFMTLVYAYLYIPIIILIVNSFNSSR------FGINWKGFTTKWYELLFNNDSLLQAAQHSLTMAVFSATFATLIG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  94 MITAYPLSRPNLAGKKIIMT-FFVITM----FVGGGLIPTYLLVK-NLGMLDSVWAIIVPGAINVWNIILARtyFSALPK 167
Cdd:PRK09500  78 SLTAVALYRYRFRGKKFVSGmLFVVMMspdiVMAISLLVLFMLLGiQLGFWSLLFAHITFCLPFVVVTVYSR--LKGFDV 155

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 985099449 168 ELSEAATIDGANDLQILFKVMLPLAKPIMFVLFLYAF 204
Cdd:PRK09500 156 RMLEAAKDLGASEFTILRKIILPLALPAVAAGWLLSF 192
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 102-209 8.27e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 42.29  E-value: 8.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  102 RPNLAGKKIIMTFFVITMFvggglIPTYLLVKNLGML-------DSVWAIIVPGAIN--VWNIILARTYFSALPKELSEA 172
Cdd:pfam00528  11 RRGRRLDRLLRPLIDLLQA-----LPSFVLAILLVVIailsilgHGILPAIILALLGwaGYARLIRRAALRSLPSDLVEA 85

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 985099449  173 ATIDGANDLQILFKVMLPLAKPIMFVLFLYAFVGQWN 209
Cdd:pfam00528  86 ARALGASRWQIFRKIILPNALPPILTGLALAFGGALG 122
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 62-201 1.36e-04

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 42.77  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449  62 YQRVFADDSILRGFVNSLFYSFSFSLLTVFITMITAYPLSR-PNLAGKK--------------IIMTFFVITMF-VGGGL 125
Cdd:COG4209   75 FKFLFSSPDFWRVLRNTLLISLLKLVFGFPLPIILALLLNElRSKRFKKtvqtisylphflswVVVAGIVYQFLsPDTGL 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985099449 126 IPTylLVKNLGMlDSV---------WAIIVpgAINVW-----NIILartYFSAL---PKELSEAATIDGANDLQILFKVM 188
Cdd:COG4209  155 VNQ--LLRALGG-EPInfltepkyfRPIYV--FSGIWkeagwGSII---YLAAItgiDPELYEAAAIDGAGRWQQIWHIT 226

                        170
                 ....*....|...
gi 985099449 189 LPLAKPIMFVLFL 201
Cdd:COG4209  227 LPGIRPTIVILLI 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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