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Conserved domains on  [gi|10835141|ref|NP_000563|]
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interleukin-10 isoform 1 precursor [Homo sapiens]

Protein Classification

IL10 domain-containing protein( domain architecture ID 10465045)

IL10 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IL10 pfam00726
Interleukin 10;
5-174 1.06e-101

Interleukin 10;


:

Pssm-ID: 334228  Cd Length: 170  Bit Score: 289.58  E-value: 1.06e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835141     5 ALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALS 84
Cdd:pfam00726   1 VTLQCLVLLAGVGPSRGQYTAPECGCTHQPDSFPHMLRELRDAFSRVKTFFQTKDQLDNLLLTESLLEDFKGYLGCQALS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835141    85 EMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIF 164
Cdd:pfam00726  81 EMIQFYLEEVMPQAENHGPEIKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVEKVKNAFNKLQEKGVYKAMSEFDIF 160
                         170
                  ....*....|
gi 10835141   165 INYIEAYMTM 174
Cdd:pfam00726 161 INYIETYMTI 170
 
Name Accession Description Interval E-value
IL10 pfam00726
Interleukin 10;
5-174 1.06e-101

Interleukin 10;


Pssm-ID: 334228  Cd Length: 170  Bit Score: 289.58  E-value: 1.06e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835141     5 ALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALS 84
Cdd:pfam00726   1 VTLQCLVLLAGVGPSRGQYTAPECGCTHQPDSFPHMLRELRDAFSRVKTFFQTKDQLDNLLLTESLLEDFKGYLGCQALS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835141    85 EMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIF 164
Cdd:pfam00726  81 EMIQFYLEEVMPQAENHGPEIKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVEKVKNAFNKLQEKGVYKAMSEFDIF 160
                         170
                  ....*....|
gi 10835141   165 INYIEAYMTM 174
Cdd:pfam00726 161 INYIETYMTI 170
IL10 smart00188
Interleukin-10 family; Interleukin-10 inhibits the synthesis of a number of cytokines, ...
37-173 3.42e-84

Interleukin-10 family; Interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells.


Pssm-ID: 128485  Cd Length: 137  Bit Score: 244.39  E-value: 3.42e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835141     37 LPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENL 116
Cdd:smart00188   1 LPHMLRELRAAFSRVKTFFQMKDQLDNILLTESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENHGPDIKEHVNSLGEKL 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 10835141    117 KTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMT 173
Cdd:smart00188  81 KTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGVYKAMSEFDIFINYIEAYMT 137
 
Name Accession Description Interval E-value
IL10 pfam00726
Interleukin 10;
5-174 1.06e-101

Interleukin 10;


Pssm-ID: 334228  Cd Length: 170  Bit Score: 289.58  E-value: 1.06e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835141     5 ALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALS 84
Cdd:pfam00726   1 VTLQCLVLLAGVGPSRGQYTAPECGCTHQPDSFPHMLRELRDAFSRVKTFFQTKDQLDNLLLTESLLEDFKGYLGCQALS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835141    85 EMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIF 164
Cdd:pfam00726  81 EMIQFYLEEVMPQAENHGPEIKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVEKVKNAFNKLQEKGVYKAMSEFDIF 160
                         170
                  ....*....|
gi 10835141   165 INYIEAYMTM 174
Cdd:pfam00726 161 INYIETYMTI 170
IL10 smart00188
Interleukin-10 family; Interleukin-10 inhibits the synthesis of a number of cytokines, ...
37-173 3.42e-84

Interleukin-10 family; Interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells.


Pssm-ID: 128485  Cd Length: 137  Bit Score: 244.39  E-value: 3.42e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10835141     37 LPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENL 116
Cdd:smart00188   1 LPHMLRELRAAFSRVKTFFQMKDQLDNILLTESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENHGPDIKEHVNSLGEKL 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 10835141    117 KTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMT 173
Cdd:smart00188  81 KTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGVYKAMSEFDIFINYIEAYMT 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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