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Conserved domains on  [gi|56119156|ref|NP_001007576|]
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zinc finger protein 58 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-61 1.05e-27

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.98  E-value: 1.05e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156      2 LSFWDVAIDFSPEERECLEPDQWDLYRDVMLENYSHLDFLGLALSKPFLVTFLEQRQGPW 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-489 6.77e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 6.77e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 106 FKCEECGKAFNNRSNLSEHKRIHTGEKPYKC--EECGKAFRIRSKLSTHQRVHTGEKPYKCE-ECGKAFNSHSNLSEHKR 182
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 183 IHTGEKPYKCEECGKAFSTR---------STYYRHQKNHTGKKPYKCEECA-------------KEFSYPSLLKVHQRIH 240
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSRdpqlpdllsISNLRNNPLPGNNSSSVNTPQSnslhpplpanslsKDPSSNLSLLISSNVS 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 241 SAEKSYKCEECGKPFYCPLLLKKHQIIHSAEKPYKCAECGKAFHYPSLLKRHQRIHAGKKPCKCKDCDRAFYSSAFLKRH 320
Cdd:COG5048 194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 321 QRIHSEE-------NSYKCGECGKRFCSFPHLQYHQR--FHSGE--KPYKC--EQCGKTFSTLSYLPWHKLRHSGEKSYK 387
Cdd:COG5048 274 SPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 388 C--EKCGKMFYSTLDLKKHQKIHEYKcGECHYgfPNYAALTAHQRVHTGEKPHVCEqcgkdfSRIDSLNQhqlvhtGEKP 465
Cdd:COG5048 354 EklLNSSSKFSPLLNNEPPQSLQQYK-DLKND--KKSETLSNSCIRNFKRDSNLSL------HIITHLSF------RPYN 418

                       410       420
                ....*....|....*....|....
gi 56119156 466 YKCEKCGKCFYRSSSLKRHQGIHS 489
Cdd:COG5048 419 CKNPPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-61 1.05e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.98  E-value: 1.05e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156      2 LSFWDVAIDFSPEERECLEPDQWDLYRDVMLENYSHLDFLGLALSKPFLVTFLEQRQGPW 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 1-42 1.94e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.28  E-value: 1.94e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 56119156     1 MLSFWDVAIDFSPEERECLEPDQWDLYRDVMLENYSHLDFLG 42
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-489 6.77e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 6.77e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 106 FKCEECGKAFNNRSNLSEHKRIHTGEKPYKC--EECGKAFRIRSKLSTHQRVHTGEKPYKCE-ECGKAFNSHSNLSEHKR 182
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 183 IHTGEKPYKCEECGKAFSTR---------STYYRHQKNHTGKKPYKCEECA-------------KEFSYPSLLKVHQRIH 240
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSRdpqlpdllsISNLRNNPLPGNNSSSVNTPQSnslhpplpanslsKDPSSNLSLLISSNVS 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 241 SAEKSYKCEECGKPFYCPLLLKKHQIIHSAEKPYKCAECGKAFHYPSLLKRHQRIHAGKKPCKCKDCDRAFYSSAFLKRH 320
Cdd:COG5048 194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 321 QRIHSEE-------NSYKCGECGKRFCSFPHLQYHQR--FHSGE--KPYKC--EQCGKTFSTLSYLPWHKLRHSGEKSYK 387
Cdd:COG5048 274 SPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 388 C--EKCGKMFYSTLDLKKHQKIHEYKcGECHYgfPNYAALTAHQRVHTGEKPHVCEqcgkdfSRIDSLNQhqlvhtGEKP 465
Cdd:COG5048 354 EklLNSSSKFSPLLNNEPPQSLQQYK-DLKND--KKSETLSNSCIRNFKRDSNLSL------HIITHLSF------RPYN 418

                       410       420
                ....*....|....*....|....
gi 56119156 466 YKCEKCGKCFYRSSSLKRHQGIHS 489
Cdd:COG5048 419 CKNPPCSKSFNRHYNLIPHKKIHT 442
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-41 1.41e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 64.49  E-value: 1.41e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 56119156   2 LSFWDVAIDFSPEERECLEPDQWDLYRDVMLENYSHLDFL 41
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
zf-H2C2_2 pfam13465
Zinc-finger double domain;
176-201 2.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.03e-04
                          10        20
                  ....*....|....*....|....*.
gi 56119156   176 NLSEHKRIHTGEKPYKCEECGKAFST 201
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-61 1.05e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.98  E-value: 1.05e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156      2 LSFWDVAIDFSPEERECLEPDQWDLYRDVMLENYSHLDFLGLALSKPFLVTFLEQRQGPW 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 1-42 1.94e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.28  E-value: 1.94e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 56119156     1 MLSFWDVAIDFSPEERECLEPDQWDLYRDVMLENYSHLDFLG 42
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-489 6.77e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 6.77e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 106 FKCEECGKAFNNRSNLSEHKRIHTGEKPYKC--EECGKAFRIRSKLSTHQRVHTGEKPYKCE-ECGKAFNSHSNLSEHKR 182
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 183 IHTGEKPYKCEECGKAFSTR---------STYYRHQKNHTGKKPYKCEECA-------------KEFSYPSLLKVHQRIH 240
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSRdpqlpdllsISNLRNNPLPGNNSSSVNTPQSnslhpplpanslsKDPSSNLSLLISSNVS 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 241 SAEKSYKCEECGKPFYCPLLLKKHQIIHSAEKPYKCAECGKAFHYPSLLKRHQRIHAGKKPCKCKDCDRAFYSSAFLKRH 320
Cdd:COG5048 194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 321 QRIHSEE-------NSYKCGECGKRFCSFPHLQYHQR--FHSGE--KPYKC--EQCGKTFSTLSYLPWHKLRHSGEKSYK 387
Cdd:COG5048 274 SPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 388 C--EKCGKMFYSTLDLKKHQKIHEYKcGECHYgfPNYAALTAHQRVHTGEKPHVCEqcgkdfSRIDSLNQhqlvhtGEKP 465
Cdd:COG5048 354 EklLNSSSKFSPLLNNEPPQSLQQYK-DLKND--KKSETLSNSCIRNFKRDSNLSL------HIITHLSF------RPYN 418

                       410       420
                ....*....|....*....|....
gi 56119156 466 YKCEKCGKCFYRSSSLKRHQGIHS 489
Cdd:COG5048 419 CKNPPCSKSFNRHYNLIPHKKIHT 442
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-41 1.41e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 64.49  E-value: 1.41e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 56119156   2 LSFWDVAIDFSPEERECLEPDQWDLYRDVMLENYSHLDFL 41
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-468 2.02e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 2.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 160 KPYKCEECGKAFNSHSNLSEHKRIHTGEKPYKC--EECGKAFSTRSTYYRHQKNHTGKKPYkcEECAKEFSYPSLLKVHQ 237
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 238 RIHSAEKSYkceecgKPFYCPLLLKKHQIIHS-AEKPYKCAECGKAFHYPSLLKRHQRIHAGKK----PCKCKDCDRAFY 312
Cdd:COG5048 110 LSSSSSNSN------DNNLLSSHSLPPSSRDPqLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplPANSLSKDPSSN 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 313 SSAFLkrHQRIHSEENSYKCGECGKRFCSFPHLQYHQRFHSGEKPYKCEQCGKTFSTLSYLPWHKLRHSGEKSYKCEKCG 392
Cdd:COG5048 184 LSLLI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 393 KMFYST----------LDLKKHQ-KIHEYKCGECHYGFPNYAALTAHQR--VHTGE--KPHVC--EQCGKDFSRIDSLNQ 455
Cdd:COG5048 262 RSSLPTassqssspneSDSSSEKgFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                       330
                ....*....|...
gi 56119156 456 HQLVHTGEKPYKC 468
Cdd:COG5048 342 HILLHTSISPAKE 354
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 298-381 3.45e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.33  E-value: 3.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 298 GKKPCKCK--DCDRAFYSSAFLKRHqRIHseensykcGECGKRFCSFPHLQYHQRFHSGEKPYKCEQCGKTFSTLSYLPW 375
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 56119156 376 HKlRHS 381
Cdd:COG5189 417 HR-KHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
176-201 2.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.03e-04
                          10        20
                  ....*....|....*....|....*.
gi 56119156   176 NLSEHKRIHTGEKPYKCEECGKAFST 201
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
269-329 3.61e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 3.61e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56119156 269 SAEKPYKCAECGKAFHYPSLLKRHQRIHAGKKPCKCKD--CDRAFYSSAFLKRHQRIHSEENS 329
Cdd:COG5048  29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
120-143 4.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.40e-04
                          10        20
                  ....*....|....*....|....
gi 56119156   120 NLSEHKRIHTGEKPYKCEECGKAF 143
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 158-241 8.13e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 8.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 158 GEKPYKCE--ECGKAFNSHSNLSEHKrihtgekpyKCEECGKAFSTRSTYYRHQKNHTGKKPYKCEECAKEFSYPSLLKV 235
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 56119156 236 HqRIHS 241
Cdd:COG5189 417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
344-369 9.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 56119156   344 HLQYHQRFHSGEKPYKCEQCGKTFST 369
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
149-173 1.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.86e-03
                          10        20
                  ....*....|....*....|....*
gi 56119156   149 LSTHQRVHTGEKPYKCEECGKAFNS 173
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 214-292 2.03e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 214 GKKPYKCE--ECAKEFSYPSLLKVHqRIHsAEKSYKCEECGKPfycplllKKHQIIHSAEKPYKCAECGKAFHYPSLLKR 291
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH-GHQNQKLHENPSP-------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                .
gi 56119156 292 H 292
Cdd:COG5189 417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 102-181 3.74e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56119156 102 GEKAFKCE--ECGKAFNNRSNLSEHkRIHTGEKPYKCEECGKafrirsklSTHQRVHTGEKPYKCEECGKAFNSHSNLSE 179
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ..
gi 56119156 180 HK 181
Cdd:COG5189 417 HR 418
AccD COG0777
Acetyl-CoA carboxylase beta subunit [Lipid transport and metabolism]; Acetyl-CoA carboxylase ...
 386-432 3.84e-03

Acetyl-CoA carboxylase beta subunit [Lipid transport and metabolism]; Acetyl-CoA carboxylase beta subunit is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440540 [Multi-domain]  Cd Length: 280  Bit Score: 39.27  E-value: 3.84e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 56119156 386 YKCEKCGKMFYSTlDLKKHQKIheykCGECHYGFPnyaaLTAHQRVH 432
Cdd:COG0777  26 TKCPSCGEILYRK-ELEENLYV----CPKCGHHFR----ISARERLE 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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