NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|61656190|ref|NP_001013400|]
View 

leucine-rich repeat-containing protein 52 precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18784505)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-184 2.70e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 2.70e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656190  43 HLTEYPADIPLNT--RRLYLNNNKITSLPAlQLGFLSDLVYLDCQNNRIREVmDYTFIGIFRLIYLDLSSNNLTSIsPFS 120
Cdd:COG4886 124 QLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEP 200

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61656190 121 FSVLTNLVRLNISHNpHLLYLDKyVFANTTSLRYLDLRNTGLHIIDhnGFHHLVVLQTLYLSGN 184
Cdd:COG4886 201 LGNLTNLEELDLSGN-QLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN 260
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
184-222 5.40e-03

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 34.33  E-value: 5.40e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 61656190    184 NPWICNCSFLDFTIHLLVSHMdHPDAQNATCTEPAELKG 222
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH-LQDPVDLRCASPSSLRG 38
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-184 2.70e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 2.70e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656190  43 HLTEYPADIPLNT--RRLYLNNNKITSLPAlQLGFLSDLVYLDCQNNRIREVmDYTFIGIFRLIYLDLSSNNLTSIsPFS 120
Cdd:COG4886 124 QLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEP 200

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61656190 121 FSVLTNLVRLNISHNpHLLYLDKyVFANTTSLRYLDLRNTGLHIIDhnGFHHLVVLQTLYLSGN 184
Cdd:COG4886 201 LGNLTNLEELDLSGN-QLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
79-136 1.91e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 1.91e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 61656190    79 LVYLDCQNNRIREVMDYTFIGIFRLIYLDLSSNNLTSISPFSFSVLTNLVRLNISHNP 136
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 56-159 2.37e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 2.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656190  56 RRLYLNNNKITSLPALQ-LGFLSDLvYLDCQNNRIREVM---DYTFIGIFR-LIYLDLSSNNLTSISPfsFSVLTNLVRL 130
Cdd:cd21340  71 KKLYLGGNRISVVEGLEnLTNLEEL-HIENQRLPPGEKLtfdPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQL 147

                        90       100       110
                ....*....|....*....|....*....|.
gi 61656190 131 NISHNpHLLYLD--KYVFANTTSLRYLDLRN 159
Cdd:cd21340 148 DASNN-QISDLEelLDLLSSWPSLRELDLTG 177
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 54-135 6.77e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 6.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656190   54 NTRRLYLNNNKITSLPALQLGFLSDLVYLDCQNNRIREVMDYTFIGIFRLIYLDLSSNNLTSISPFSFSVLTNLVRLNIS 133
Cdd:PLN00113 476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555


                 ..
gi 61656190  134 HN 135
Cdd:PLN00113 556 QN 557
LRRCT smart00082
Leucine rich repeat C-terminal domain;
184-222 5.40e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 34.33  E-value: 5.40e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 61656190    184 NPWICNCSFLDFTIHLLVSHMdHPDAQNATCTEPAELKG 222
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH-LQDPVDLRCASPSSLRG 38
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-184 2.70e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 2.70e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656190  43 HLTEYPADIPLNT--RRLYLNNNKITSLPAlQLGFLSDLVYLDCQNNRIREVmDYTFIGIFRLIYLDLSSNNLTSIsPFS 120
Cdd:COG4886 124 QLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEP 200

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61656190 121 FSVLTNLVRLNISHNpHLLYLDKyVFANTTSLRYLDLRNTGLHIIDhnGFHHLVVLQTLYLSGN 184
Cdd:COG4886 201 LGNLTNLEELDLSGN-QLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-193 6.77e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 6.77e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656190  54 NTRRLYLNNNKITSLPAlQLGFLSDLVYLDCQNNRIREVMDyTFIGIFRLIYLDLSSNNLTSIsPFSFSVLTNLVRLNIS 133
Cdd:COG4886 114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLS 190

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61656190 134 HNPhLLYLDKyVFANTTSLRYLDLRNTGLHIIDhNGFHHLVVLQTLYLSGN-----PWICNCSFL 193
Cdd:COG4886 191 NNQ-ITDLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNqltdlPELGNLTNL 252
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-197 2.03e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 2.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656190  54 NTRRLYLNNNKITSLPAlQLGFLSDLVYLDCQNNRIREVMDyTFIGIFRLIYLDLSSNNLTSISpfSFSVLTNLVRLNIS 133
Cdd:COG4886 183 NLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLS 258

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61656190 134 HNpHLLYLDKyvFANTTSLRYLDLRNTGLHIIDHNGFHHLVVLQTLYLSGNPWICNCSFLDFTI 197
Cdd:COG4886 259 NN-QLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-184 3.66e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 3.66e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656190  54 NTRRLYLNNNKitslpalQLGFLSDLVYLDCQNNRIREvMDYTFIGIFRLIYLDLSSNNLTSIsPFSFSVLTNLVRLNIS 133
Cdd:COG4886  97 NLTELDLSGNE-------ELSNLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLS 167

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 61656190 134 HNPhLLYLDKyVFANTTSLRYLDLRNTGLHIIdHNGFHHLVVLQTLYLSGN 184
Cdd:COG4886 168 NNQ-LTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215
LRR_8 pfam13855
Leucine rich repeat;
79-136 1.91e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 1.91e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 61656190    79 LVYLDCQNNRIREVMDYTFIGIFRLIYLDLSSNNLTSISPFSFSVLTNLVRLNISHNP 136
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 56-159 2.37e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 2.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656190  56 RRLYLNNNKITSLPALQ-LGFLSDLvYLDCQNNRIREVM---DYTFIGIFR-LIYLDLSSNNLTSISPfsFSVLTNLVRL 130
Cdd:cd21340  71 KKLYLGGNRISVVEGLEnLTNLEEL-HIENQRLPPGEKLtfdPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQL 147

                        90       100       110
                ....*....|....*....|....*....|.
gi 61656190 131 NISHNpHLLYLD--KYVFANTTSLRYLDLRN 159
Cdd:cd21340 148 DASNN-QISDLEelLDLLSSWPSLRELDLTG 177
LRR_8 pfam13855
Leucine rich repeat;
102-162 3.10e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 3.10e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61656190   102 RLIYLDLSSNNLTSISPFSFSVLTNLVRLNISHNpHLLYLDKYVFANTTSLRYLDLRNTGL 162
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
125-185 5.43e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 5.43e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61656190   125 TNLVRLNISHNpHLLYLDKYVFANTTSLRYLDLRNTGLHIIDHNGFHHLVVLQTLYLSGNP 185
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-227 2.66e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 2.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656190  43 HLTEYPADIPLNT--RRLYLNNNKITSLPalQLGFLSDLVYLDCQNNRIREVMDYTFIGifRLIYLDLSSNNLTSISPFS 120
Cdd:COG4886 216 QLTDLPEPLANLTnlETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLANLT--NLKTLDLSNNQLTDLKLKE 291

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656190 121 FSVLTNLVRLNISHNPHLLYLDKYVFANTTSLRYLDLRNTGLHIIDHNGFHHLVVLQTLYLSGNPWICNCSFLDFTIHLL 200
Cdd:COG4886 292 LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371

                       170       180
                ....*....|....*....|....*..
gi 61656190 201 VSHMDHPDAQNATCTEPAELKGWPITK 227
Cdd:COG4886 372 LGLLEATLLTLALLLLTLLLLLLTTTA 398
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 54-135 6.77e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 6.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656190   54 NTRRLYLNNNKITSLPALQLGFLSDLVYLDCQNNRIREVMDYTFIGIFRLIYLDLSSNNLTSISPFSFSVLTNLVRLNIS 133
Cdd:PLN00113 476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555


                 ..
gi 61656190  134 HN 135
Cdd:PLN00113 556 QN 557
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 102-142 2.62e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 2.62e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 61656190   102 RLIYLDLSSNNLTSISPfsFSVLTNLVRLNISHNPHLLYLD 142
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDLS 40
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 86-160 2.41e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.52  E-value: 2.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61656190    86 NNRIREVMDYTFIGIfRLIYLDLSSNnLTSISPFSFSVLTNLVRLNISHNphLLYLDKYVFANtTSLRYLDLRNT 160
Cdd:pfam13306  42 PSSLTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSN--LTSIGSYAFSN-CSLKSITIPSS 111
LRRCT smart00082
Leucine rich repeat C-terminal domain;
184-222 5.40e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 34.33  E-value: 5.40e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 61656190    184 NPWICNCSFLDFTIHLLVSHMdHPDAQNATCTEPAELKG 222
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH-LQDPVDLRCASPSSLRG 38
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 150-194 7.18e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.76  E-value: 7.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 61656190   150 TSLRYLDLRNTGLHIIDhnGFHHLVVLQTLYLSGNPWICNCSFLD 194
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITDLSDLA 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH