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Conserved domains on  [gi|62122857|ref|NP_001014357|]
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protein RUFY3 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RUN super family cl45896
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 68-223 1.91e-101

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


The actual alignment was detected with superfamily member cd17695:

Pssm-ID: 459241  Cd Length: 156  Bit Score: 299.97  E-value: 1.91e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  68 ERLNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKSKKTFLGQNKSFWGPLELVEKLTPEAGEIT 147
Cdd:cd17695   1 ERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLCPEAEEIA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62122857 148 ASVKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMMEEEGAVIAGLLVGLNVIDANLC 223
Cdd:cd17695  81 ASVRDLPGLKTPLGRARAWLRLALMQKKLADYLRCLIIRRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLC 156
EnvC super family cl34844
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 257-464 2.76e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG4942:

Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.30  E-value: 2.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 257 QITAILDQKNYVEELNRHLSASVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEELERVKEEGSYFVESSRKASRADG 336
Cdd:COG4942  42 ELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPP 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 337 TA---NGQVLGETRKQLKEETQLRLDVEKELELQIGMKQEMELSMKMLEKDICEKHDALVELRQQLDDVRTLNHELSVKS 413
Cdd:COG4942 122 LAlllSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLL 201

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 62122857 414 QSSESSAKQKSDIIGRLEEKTNQMGSIIKQLESSEKDMAKQARTLNTAAGK 464
Cdd:COG4942 202 ARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALK 252
 
Name Accession Description Interval E-value
RUN_RUFY2 cd17695
RUN domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; ...
 68-223 1.91e-101

RUN domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; RUFY2, also called Rab4-interacting protein related, is a novel embryonic factor that contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between. It is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. This model represents the RUN domain of RUFY2.


Pssm-ID: 439057  Cd Length: 156  Bit Score: 299.97  E-value: 1.91e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  68 ERLNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKSKKTFLGQNKSFWGPLELVEKLTPEAGEIT 147
Cdd:cd17695   1 ERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLCPEAEEIA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62122857 148 ASVKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMMEEEGAVIAGLLVGLNVIDANLC 223
Cdd:cd17695  81 ASVRDLPGLKTPLGRARAWLRLALMQKKLADYLRCLIIRRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLC 156
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 103-226 1.24e-43

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 150.12  E-value: 1.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857   103 QFFVVMEHCLKHGLKS------KKTFLGQNKSFWGPLELVEKLTPEAGEITASVKDLPGLKT---PLGRGRAWLRLALMQ 173
Cdd:pfam02759   1 QLCAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQIHTpysPDGRGRAWIRLALNE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 62122857   174 KKLSDYMKTIINRKDLLGEFYEPNALMMEEEGA-VIAGLLVGLNVIDANLCMKG 226
Cdd:pfam02759  81 KLLDQWLKLLLSNKELLSEYYEPWALLADPEFGeILLGLLVGLSALDFNLCLKL 134
RUN smart00593
domain involved in Ras-like GTPase signaling;
163-225 8.04e-17

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 74.57  E-value: 8.04e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62122857    163 GRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMM-EEEGAVIAGLLVGLNVIDANLCMK 225
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEELLSKYYEPWAFLRdPEEGEQLLGLLVGLSALDFNLPVD 64
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 257-464 2.76e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.30  E-value: 2.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 257 QITAILDQKNYVEELNRHLSASVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEELERVKEEGSYFVESSRKASRADG 336
Cdd:COG4942  42 ELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPP 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 337 TA---NGQVLGETRKQLKEETQLRLDVEKELELQIGMKQEMELSMKMLEKDICEKHDALVELRQQLDDVRTLNHELSVKS 413
Cdd:COG4942 122 LAlllSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLL 201

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 62122857 414 QSSESSAKQKSDIIGRLEEKTNQMGSIIKQLESSEKDMAKQARTLNTAAGK 464
Cdd:COG4942 202 ARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALK 252
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 255-470 1.02e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.05  E-value: 1.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    255 DGQITAILDQKNYVEELNRH---LSASVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEELERVKEEGSYFVESSRKA 331
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKieeLEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    332 SrADGTANGQVLGETRKQLKEETQLRLDVEKELELQIGMKQEMELSMKMLEKDICEKHDALVELRQQLDDVRTLNHELSV 411
Cdd:TIGR02168  746 E-ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRE 824

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 62122857    412 KSQSSESSAKQKSDIIGRLEEKTNQMGSIIKQLESSEKDMAKQARTLNTAAGKLLQRQQ 470
Cdd:TIGR02168  825 RLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERA 883
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 264-465 3.04e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 40.10  E-value: 3.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    264 QKNYVEELNRHLSASVNNLQAKVDALEKSNTKLTEelavANNRIITLQEELERVKEEGSYF--VESSRKASRADGTANGQ 341
Cdd:pfam15921  487 KKMTLESSERTVSDLTASLQEKERAIEATNAEITK----LRSRVDLKLQELQHLKNEGDHLrnVQTECEALKLQMAEKDK 562

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    342 VLGETRKQLKEETQL---------RLDVEK-ELELQIGmKQEMELSMKMLEKDiceKHDALV-ELRQQLDDVRTLNHELS 410
Cdd:pfam15921  563 VIEILRQQIENMTQLvgqhgrtagAMQVEKaQLEKEIN-DRRLELQEFKILKD---KKDAKIrELEARVSDLELEKVKLV 638

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 62122857    411 VKSQSSESSAK----QKSDIIGRLEEKTNQMGSIIKQLESSEKDMAKQARTLNTAAGKL 465
Cdd:pfam15921  639 NAGSERLRAVKdikqERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKL 697
 
Name Accession Description Interval E-value
RUN_RUFY2 cd17695
RUN domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; ...
 68-223 1.91e-101

RUN domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; RUFY2, also called Rab4-interacting protein related, is a novel embryonic factor that contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between. It is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. This model represents the RUN domain of RUFY2.


Pssm-ID: 439057  Cd Length: 156  Bit Score: 299.97  E-value: 1.91e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  68 ERLNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKSKKTFLGQNKSFWGPLELVEKLTPEAGEIT 147
Cdd:cd17695   1 ERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLCPEAEEIA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62122857 148 ASVKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMMEEEGAVIAGLLVGLNVIDANLC 223
Cdd:cd17695  81 ASVRDLPGLKTPLGRARAWLRLALMQKKLADYLRCLIIRRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLC 156
RUN_RUFY3 cd17696
RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; ...
 68-223 2.65e-100

RUN domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; RUFY3, also called Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. This model represents the RUN domain of RUFY3.


Pssm-ID: 439058  Cd Length: 156  Bit Score: 297.29  E-value: 2.65e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  68 ERLNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKSKKTFLGQNKSFWGPLELVEKLTPEAGEIT 147
Cdd:cd17696   1 ERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEIT 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62122857 148 ASVKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMMEEEGAVIAGLLVGLNVIDANLC 223
Cdd:cd17696  81 ASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINRKDLLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFC 156
RUN_RUFY1_like cd17681
RUN domain found in RUN and FYVE domain-containing proteins, RUFY1, RUFY2, RUFY3 and similar ...
 68-222 1.82e-95

RUN domain found in RUN and FYVE domain-containing proteins, RUFY1, RUFY2, RUFY3 and similar proteins; This family includes RUN and FYVE domain-containing protein RUFY1, RUFY2, and RUFY3. RUFY1, also called FYVE-finger protein EIP1, or La-binding protein 1, or Rab4-interacting protein (Rabip4), or Zinc finger FYVE domain-containing protein 12 (ZFY12), a human homolog of mouse Rabip4, an effector of Rab4 GTPase that regulates recycling of endocytosed cargo. RUFY1 is an endosomal protein that functions as a dual effector of Rab4 and Rab14 and is involved in efficient recycling of transferrin (Tfn). It is a downstream effector of Etk, a downstream tyrosine kinase of PI3-kinase that is involved in regulation of vesicle trafficking. RUFY2, also called Rab4-interacting protein related, is a novel embryonic factor that is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. RUFY3, also called Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. RUFY1, RUFY2, and RUFY3 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439043  Cd Length: 155  Bit Score: 284.85  E-value: 1.82e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  68 ERLNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKSKKTFLGQNKSFWGPLELVEKLTPEAGEIT 147
Cdd:cd17681   1 ERRNLLNLAKLSIKELIESALSFGRTLDSDHVPLQQFFVILEHVLRHGLKVKKSFLGPNKSFWPVLEHVEKLVPEANEIT 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62122857 148 ASVKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMMEEEGAVIAGLLVGLNVIDANL 222
Cdd:cd17681  81 ASVRDLPGIKTPLGRARAWLRLALMQKKLADYFRALIENKDLLSEFYEPGALMMSEEAVVIAGLLVGLNVIDCNL 155
RUN_RUFY1 cd17694
RUN domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins; ...
 68-223 1.87e-93

RUN domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins; RUFY1, also called FYVE-finger protein EIP1, or La-binding protein 1, or Rab4-interacting protein (Rabip4), or Zinc finger FYVE domain-containing protein 12 (ZFY12), a human homolog of mouse Rabip4, an effector of Rab4 GTPase that regulates recycling of endocytosed cargo. RUFY1 is an endosomal protein that functions as a dual effector of Rab4 and Rab14 and is involved in efficient recycling of transferrin (Tfn). It is a downstream effector of Etk, a downstream tyrosine kinase of PI3-kinase that is involved in regulation of vesicle trafficking. RUFY1 contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439056  Cd Length: 156  Bit Score: 279.48  E-value: 1.87e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  68 ERLNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKSKKTFLGQNKSFWGPLELVEKLTPEAGEIT 147
Cdd:cd17694   1 ERANLMNMMKLSIKVLIQSALSLGRTLDSDYPPLQQFFVVLEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDIA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62122857 148 ASVKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMMEEEGAVIAGLLVGLNVIDANLC 223
Cdd:cd17694  81 TSARNLPELKTAVGRGRAWLHLALMQKKLADYLKVLIDRKDLLSEFYEPGALMMEEEGAVIVGLLVGLNVIDANLC 156
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 103-226 1.24e-43

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 150.12  E-value: 1.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857   103 QFFVVMEHCLKHGLKS------KKTFLGQNKSFWGPLELVEKLTPEAGEITASVKDLPGLKT---PLGRGRAWLRLALMQ 173
Cdd:pfam02759   1 QLCAALEALLSHGLKRssllilRAAGLLPERSFWALLERVGKLVPPAEELLSSVQELEQIHTpysPDGRGRAWIRLALNE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 62122857   174 KKLSDYMKTIINRKDLLGEFYEPNALMMEEEGA-VIAGLLVGLNVIDANLCMKG 226
Cdd:pfam02759  81 KLLDQWLKLLLSNKELLSEYYEPWALLADPEFGeILLGLLVGLSALDFNLCLKL 134
RUN_RUNDC3 cd17684
RUN domain found in RUN domain-containing protein 3 (RUNDC3) and similar proteins; RUNDC3 ...
 71-222 5.94e-35

RUN domain found in RUN domain-containing protein 3 (RUNDC3) and similar proteins; RUNDC3 contains two isoforms, RUNDC3A and RUNDC3B. RUNDC3A, also called Rap2-interacting protein 8 (RPIP8), may act as an effector of Rap2A GTPase in neuronal cells. RUNDC3B, also called Rap2-binding protein 9, or Rap2-interacting protein 9 (RPIP-9), contains a RUN domain in its N-terminal region that mediates interaction with Rap2, an important component of the Mitogen-Activated Protein Kinase (MAPK) cascade, which regulates cellular proliferation and differentiation. It also contains characteristic binding sites for MAPK intermediates. Both RUNDC3A and RUNDC3B contain a RUN domain.


Pssm-ID: 439046  Cd Length: 150  Bit Score: 127.51  E-value: 5.94e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  71 NLMNMAKLSIKGLIESALNlgRTLDSDYAPLQQFFVVMEHCLKHGLKSKKTFLG--QNKSFWGPLELVEKLTPeaGEITA 148
Cdd:cd17684   1 NLVTVCRLSVKSLIDKACL--ETIDDSSEELINFAAILEQILSHRLKPVKPWYGseEPRTFWDYIRVACKKVP--QNCIA 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62122857 149 SVKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMMEEEGAVIAGLLVGLNVIDANL 222
Cdd:cd17684  77 SIEQMENIKSPKAKGRAWIRVALMEKRLSEYLSTALKQTRLTRNFYQDGAIMLSEDATVLCGMLIGLNAIDFSF 150
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 79-222 8.59e-32

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 119.07  E-value: 8.59e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  79 SIKGLIESALNLGR-------TLDSDYAPLQQFFVVMEHCLKHGLKSKKtFLGQNKSFWGPLELVEKLTPEAGEITA--S 149
Cdd:cd17671   2 AVKELLESFADNGEaddsaalTLTDDDPVVGRLCAALEAILSHGLKPKR-FGGGKVSFWDFLEALEKLLPAPSLKQAirD 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62122857 150 VKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMM-EEEGAVIAGLLVGLNVIDANL 222
Cdd:cd17671  81 INSLSNVKTDDGRGRAWIRLALNEKSLESYLAALLSDQSLLRKYYEPWALLRdPEEAELFLSLLVGLSSLDFNL 154
RUN_RUNDC3B cd17700
RUN domain found in RUN domain-containing protein 3B (RUNDC3B) and similar proteins; RUN ...
 71-223 5.66e-24

RUN domain found in RUN domain-containing protein 3B (RUNDC3B) and similar proteins; RUN domain-containing protein 3B (RUNDC3B), also called Rap2-binding protein 9, or Rap2-interacting protein 9 (RPIP-9), contains a RUN domain in its N-terminal region that mediates interaction with Rap2, an important component of the Mitogen-Activated Protein Kinase (MAPK) cascade, which regulates cellular proliferation and differentiation. It also contains characteristic binding sites for MAPK intermediates. RUNDC3B contains a RUN domain.


Pssm-ID: 439062  Cd Length: 151  Bit Score: 97.73  E-value: 5.66e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  71 NLMNMAKLSIKGLIESALNlgRTLDSDYAPLQQFFVVMEHCLKHGLKSKKTFLGQN--KSFWGPLELVEKLTPEAgeITA 148
Cdd:cd17700   1 NLITVCRFSVKTLIDRSCF--ETIDDSSPEFVNFAAILEQILSHRLKGQVTWFGYEspRSFWDYIRVACSKVPHN--CIC 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62122857 149 SVKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMMEEEGAVIAGLLVGLNVIDANLC 223
Cdd:cd17700  77 SIENMENVSSSRAKGRAWIRVALMEKRLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFC 151
RUN_RUNDC3A cd17699
RUN domain found in RUN domain-containing protein 3A (RUNDC3A) and similar proteins; RUN ...
 71-223 4.50e-22

RUN domain found in RUN domain-containing protein 3A (RUNDC3A) and similar proteins; RUN domain-containing protein 3A (RUNDC3A), also called Rap2-interacting protein 8 (RPIP8), may act as an effector of Rap2A GTPase in neuronal cells. It contains a RUN domain.


Pssm-ID: 439061  Cd Length: 151  Bit Score: 92.40  E-value: 4.50e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  71 NLMNMAKLSIKGLIESALnlGRTLDSDYAPLQQFFVVMEHCLKHGLK---SKKTFLGQnKSFWGPLELVEKLTPEagEIT 147
Cdd:cd17699   1 NLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKgpvSWFSSDGQ-RGFWDYIRLACSKVPN--NCI 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62122857 148 ASVKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMMEEEGAVIAGLLVGLNVIDANLC 223
Cdd:cd17699  76 SSIENMENISTSRAKGRAWIRVALMEKRLSEYIATALRDTRTTRRFYDDGAIMLREESTVLTGMLIGLSAIDFSFC 151
RUN smart00593
domain involved in Ras-like GTPase signaling;
163-225 8.04e-17

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 74.57  E-value: 8.04e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62122857    163 GRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMM-EEEGAVIAGLLVGLNVIDANLCMK 225
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEELLSKYYEPWAFLRdPEEGEQLLGLLVGLSALDFNLPVD 64
RUN_RUFY4_like cd17682
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil ...
 80-208 1.77e-16

RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil domain-containing protein 1 (FYCO1), and similar proteins; The family includes RUFY4 and FYCO1. RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. FYCO1, also called zinc finger FYVE domain-containing protein 7 (ZFYVE7), is a multidomain autophagy adaptor protein that interacts with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7, and phosphatidylinositol 3-phosphate (PI3P), to mediate microtubule plus-end-directed autophagosome transport. Both RUFY4 and FYCO1 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439044  Cd Length: 150  Bit Score: 76.50  E-value: 1.77e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  80 IKGLIESALNLGRTLDSDYAP-LQQFFVVMEHCLKHGLKSKKTFLGQNKSFWGPLE-LVEKLTPEAG---EITASVKDLP 154
Cdd:cd17682   2 LKGCVLDLKSEFGEITDPDNPyLRPFCETLEKILRKGLKEKVSLGGRRKDYWDWLEeLLKKLNKIPKslsDAVKFVKSCK 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 62122857 155 GLKTPLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMMEEEGAVI 208
Cdd:cd17682  82 KVKTNQGRGRLFIRYALNKKCLHDPVQQLVKNPKLLSDYYSPDSILGNEILSEI 135
RUN_PLEKHM1 cd17679
RUN domain found in pleckstrin homology domain-containing family M member 1 (PLEKHM1) and ...
 114-222 8.85e-13

RUN domain found in pleckstrin homology domain-containing family M member 1 (PLEKHM1) and similar proteins; PLEKHM1, also called PH domain-containing family M member 1, or 162 kDa adapter protein (AP162), may act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. This model represents the RUN domain of PLEKHM1.


Pssm-ID: 439041 [Multi-domain]  Cd Length: 171  Bit Score: 66.46  E-value: 8.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 114 HGLKSK-----KTFLGQN------KSFWgplELVEKLTPEagEITASVKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKT 182
Cdd:cd17679  46 HGLKDKfiskvSSVFSGDvdklpePNFW---PLLLKFSHR--DVIDQIEHLSQITTDVGRCRAWIRLALNDGLLESYLEA 120

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 62122857 183 IINRKDLLGEFYEPNALMM-EEEGAVIAGLLVGLNVIDANL 222
Cdd:cd17679 121 ILKDKSALKSYYNPSAFLRdPEQLDILKSLLQGLESFQFEL 161
RUN_SNX29 cd17689
RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN ...
 112-218 4.91e-12

RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN domain-containing protein 2A (RUNDC2A), belongs to the sorting nexin family. Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain, a phospholipid-binding motif, or through protein-protein interactions with membrane-associated protein complexes. Some sorting nexin family members have been shown to facilitate protein sorting. This model contains the RUN domain of SNX29.


Pssm-ID: 439051  Cd Length: 166  Bit Score: 64.17  E-value: 4.91e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 112 LKHGLKSKKTFLGQNKSFWGPLELVEKLTPEAGEIT--ASVKD------------LPGLKTPLGRGRAWLRLALMQKKLS 177
Cdd:cd17689  38 LQHGLKTSRSPNLVSSAVTQVSGLAGSLGSAETEPTfwPFVKEhltkhelerfelLKNIWTDIGRGRAWLRSALNEHSLE 117

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 62122857 178 DYMKTIINRKDLLGEFYEPNALMM-EEEGAVIAGLLVGLNVI 218
Cdd:cd17689 118 RYLHILLSNENLLRQYYEDWAFLRdEERSSMLPNMAAGLGSI 159
RUN_RUFY4 cd17697
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4) and similar proteins; ...
 108-222 6.49e-12

RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4) and similar proteins; RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. RUFY4 belongs to the FUFY protein family which is characterized by the presence of an N-terminal RUN domain and a C-terminal FYVE domain; this model represents the RUN domain of RUFY4.


Pssm-ID: 439059  Cd Length: 150  Bit Score: 63.28  E-value: 6.49e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 108 MEHCLKHGLKSKKTFLGQNKSFWGPLELVEKLTPEAGEITASVKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIINRK 187
Cdd:cd17697  35 LEYLLQFDQKEKKSFFGSRKDYWDFLCLCLNRHRGGTEGIHFVNSTDKLKTPLGKGRAFIRYCLVQQQLAESLQLCLLNP 114

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 62122857 188 DLLGEFYEPNA-LMMEEEGAVIAGLLVGLNVIDANL 222
Cdd:cd17697 115 ELTGEWYYARSpFLSPELRSDILDSLYELNGVNFDL 150
RUN_FYCO1 cd17698
RUN domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar ...
 74-222 2.14e-11

RUN domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins; FYCO1, also called zinc finger FYVE domain-containing protein 7 (ZFYVE7), is a multidomain autophagy adaptor protein that interacts with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7, and Phosphatidylinositol 3-phosphate (PI3P), to mediate microtubule plus-end-directed autophagosome transport. This model represents the RUN domain of FYCO1.


Pssm-ID: 439060  Cd Length: 158  Bit Score: 62.02  E-value: 2.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  74 NMAKLSIKGLIESALNLGRTLDSDYAP-------LQQFFVVMEHCLKHGLKSKKTFLGQNKSFWGplELVEKLTPEAG-- 144
Cdd:cd17698   2 SQLQKIIRDLQDCVTELKKEFEETGEPitddsttLHKFCAKLEYLLQFDQKEKTTLLGGRKDYWD--YFCECLAKVKGln 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62122857 145 EITASVKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKT-IINRKDLLGEFYEPNALMMEEEGAVIAGLLVGLNVIDANL 222
Cdd:cd17698  80 DGIRFVKSLKEVRTSLGKGRAFIRYSLVHQRLADTLQQcVMNGKVTSDWYYPRSVFLNHKYSSDIINSLYDLNEVQFDL 158
RUN_PLEKHM2 cd17680
RUN domain found in pleckstrin homology domain-containing family M member 2 (PLEKHM2) and ...
 79-200 2.28e-10

RUN domain found in pleckstrin homology domain-containing family M member 2 (PLEKHM2) and similar proteins; PLEKHM2, also called PH domain-containing family M member 2, or Salmonella-induced filaments A (SifA) and Kinesin-Interacting Protein (SKIP), is the lysosome, melanosome and lytic granule cargo adaptor that controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain. In addition to kinesin-1, it also interacts with several Rabs to affect endosomal trafficking. This model represents the RUN domain of PLEKHM2.


Pssm-ID: 439042  Cd Length: 145  Bit Score: 58.79  E-value: 2.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  79 SIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKSKktflgqNKSFWGpleLVEKLTPEagEITASVKDLPGLKT 158
Cdd:cd17680  12 SLQSYSSSQEEEDVLITNENRELQRLCEALDHALLHGLRRG------NRGYWP---FVKEFTHK--ETIKQIENLPNVTT 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 62122857 159 PLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALM 200
Cdd:cd17680  81 DLGRGRAWLYLALNEGSLESYLRSFLENRKLVKKFYHKHALL 122
RUN1_DENND5 cd17677
RUN1 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 ...
 114-219 8.60e-09

RUN1 domain found in DENN domain-containing protein 5 (DENND5) and similar proteins; DENND5 has been characterized as Rab6-interacting protein which is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. It functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. DENND5 has two isoforms, DENND5A and DENND5B. This model represents the first RUN domain of DENND5.


Pssm-ID: 439039  Cd Length: 183  Bit Score: 55.10  E-value: 8.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 114 HGLKSKktflgQNKS-FWGPL----ELVEKLTPEAGEITA---SVKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIIN 185
Cdd:cd17677  65 HGLQTK-----QGKSaLWSHLlayqENEERLKPLPESLLFdmkNVQNMKEIKTDVGYARAWIRLALEKKLLSKHLKTLLS 139

                        90       100       110
                ....*....|....*....|....*....|....*
gi 62122857 186 RKDLLGEFYEPNA-LMMEEEGAVIAGLLVGLNVID 219
Cdd:cd17677 140 NQDLLRSLYKRYAfLRCEDEREQFLYHLLSLNAVD 174
RUN_SGSM1_like cd17687
RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; ...
 109-219 2.65e-08

RUN domain found in small G protein signaling modulators, SGSM1, SGSM2, and similar proteins; SGSM1, also called RUN and TBC1 domain-containing protein 2 (RUTBC2), interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. It is a Rab9A effector and GTPase-activating protein for Rab36, and links Rab9A function to Rab36 function in the endosomal system. SGSM2, also called RUN and TBC1 domain-containing protein 1 (RUTBC1), is a GTPase-activating protein for Rab32/38, and regulates melanogenic enzyme trafficking in melanocytes. It also acts as a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. This model contains the RUN domain of SGSM1 and SGSM2.


Pssm-ID: 439049  Cd Length: 161  Bit Score: 53.06  E-value: 2.65e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 109 EHCLKHGLKSKK-TFLGQNKSFwGPLELVEKLTPEAGEITASVKDL------PGLKTPLGRGRA-------------WLR 168
Cdd:cd17687  31 DACLLHGLRKRAlGLFRSSSTF-SLLQKVAKSCPPAADILRKVQEIenlsenKRSSSSSGSNSSnshgnsssnrkilWIR 109

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 62122857 169 LALMQKKLSDYMKTIINRKDllgEFYEPNALMME-EEGAVIAGLLVGLNVID 219
Cdd:cd17687 110 IALFEKVLDKIVDYLVENAS---KYYEKEALMADpVDGPLLASLLVGPCALD 158
RUN_RUBCN cd17686
RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing ...
 88-221 3.77e-08

RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) and similar proteins; RUBCN, also called rubicon, or beclin-1 associated RUN domain containing protein (Baron), is part of a Beclin-1-Vps34-containing autophagy complex. It negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. It is also an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion. This model contains the RUN domain of RUBCN.


Pssm-ID: 439048  Cd Length: 151  Bit Score: 52.27  E-value: 3.77e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857  88 LNLGRTLD--SDYAPLQQFFVVMEHCLKHGLKSKKTFLGQNkSFWGPLELVEKLTPEAGEITASVKDLPGLKTP-LGRGR 164
Cdd:cd17686   6 LLLSRSSNvwSTYGGLQRLCRAVENILQHGLKEFQGLNKEI-DDWEFVQGLRWLQPTLAPSIEQQSRSSPSESEvSDKGR 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62122857 165 AWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNALMMEEEGAviAGLLVGLNVIDAN 221
Cdd:cd17686  85 LWLRQSLQQHCLSSQLQWLVSDKELLRKYYEDEAFLRQEGYA--TALLICLTAVELN 139
RUN1_DENND5B cd17691
RUN1 domain found in DENN domain-containing protein 5B (DENND5B) and similar proteins; DENND5B, ...
 150-219 1.71e-06

RUN1 domain found in DENN domain-containing protein 5B (DENND5B) and similar proteins; DENND5B, also called Rab6-interacting protein 1 (Rab6IP1)-like protein, functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. It is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. This model represents the first RUN domain of DENND5B.


Pssm-ID: 439053 [Multi-domain]  Cd Length: 206  Bit Score: 48.51  E-value: 1.71e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62122857 150 VKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNA-LMMEEEGAVIAGLLVGLNVID 219
Cdd:cd17691 127 IQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQALTKKLYKRYAfLRCEEEKEQFLYHLLSLNAVD 197
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 257-464 2.76e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.30  E-value: 2.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 257 QITAILDQKNYVEELNRHLSASVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEELERVKEEGSYFVESSRKASRADG 336
Cdd:COG4942  42 ELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPP 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 337 TA---NGQVLGETRKQLKEETQLRLDVEKELELQIGMKQEMELSMKMLEKDICEKHDALVELRQQLDDVRTLNHELSVKS 413
Cdd:COG4942 122 LAlllSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLL 201

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 62122857 414 QSSESSAKQKSDIIGRLEEKTNQMGSIIKQLESSEKDMAKQARTLNTAAGK 464
Cdd:COG4942 202 ARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALK 252
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 255-470 1.02e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.05  E-value: 1.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    255 DGQITAILDQKNYVEELNRH---LSASVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEELERVKEEGSYFVESSRKA 331
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKieeLEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    332 SrADGTANGQVLGETRKQLKEETQLRLDVEKELELQIGMKQEMELSMKMLEKDICEKHDALVELRQQLDDVRTLNHELSV 411
Cdd:TIGR02168  746 E-ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRE 824

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 62122857    412 KSQSSESSAKQKSDIIGRLEEKTNQMGSIIKQLESSEKDMAKQARTLNTAAGKLLQRQQ 470
Cdd:TIGR02168  825 RLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERA 883
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 263-463 1.46e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 1.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 263 DQKNYVEELNRhLSASVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEELERVKEEGSYFVESSRKASRADGT----- 337
Cdd:COG3883  31 ELEAAQAELDA-LQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYRSGGSVSYldvll 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 338 --------------------ANGQVLGETRKQLKEETQLRLDVEKELELQIGMKQEMELSMKMLEKDICEKHDALVELRQ 397
Cdd:COG3883 110 gsesfsdfldrlsalskiadADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSA 189

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62122857 398 QLDDVRTLNHELSVKSQSSESSAKQKSDIIGRLEEKTNQMGSIIKQLESSEKDMAKQARTLNTAAG 463
Cdd:COG3883 190 EEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAA 255
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 256-465 1.46e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 1.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 256 GQITAILDQKNYVEELNRHLSAsvnnLQAKVDALEKSNTKLTEELAVANNRIITLQEELERVKEEgsyfvessRKASRAD 335
Cdd:COG4942  17 AQADAAAEAEAELEQLQQEIAE----LEKELAALKKEEKALLKQLAALERRIAALARRIRALEQE--------LAALEAE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 336 GTANGQVLGETRKQLKEETQL---RLDVEKELELQIGMK--------QEMELSMKMLEKDICEKHDALVELRQQLDDVRT 404
Cdd:COG4942  85 LAELEKEIAELRAELEAQKEElaeLLRALYRLGRQPPLAlllspedfLDAVRRLQYLKYLAPARREQAEELRADLAELAA 164

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62122857 405 LNHELSVKSQSSESSAKQKSDIIGRLEEKTNQMGSIIKQLESSEKDMAKQARTLNTAAGKL 465
Cdd:COG4942 165 LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 257-470 3.53e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 3.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 257 QITAILDQKNYVEELNRHLSASVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEELERVK------EEGSYFVESSRK 330
Cdd:COG1196 233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLaelarlEQDIARLEERRR 312

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 331 ASRADGTANGQVLGETRKQLKEETQLRLDVEKELELQIGMKQEMELSMKMLEKDICEKHDALVELRQQLDDVR----TLN 406
Cdd:COG1196 313 ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAeellEAL 392

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62122857 407 HELSVKSQSSESSAKQKSDIIGRLEEKTNQMGSIIKQLESSEKDMAKQARTLNTAAGKLLQRQQ 470
Cdd:COG1196 393 RAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEE 456
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 257-470 4.60e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.00  E-value: 4.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 257 QITAILDQKNYVEELNRHLSASVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEELERVKEEGSYFVESSRKASRADG 336
Cdd:COG1196 296 ELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELA 375

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 337 TANGQVLGETRKQLKEETQLRLDVEKELELQIGMKQEMElsmkmlekdicEKHDALVELRQQLDDVRTLNHELSVKSQSS 416
Cdd:COG1196 376 EAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLE-----------RLERLEEELEELEEALAELEEEEEEEEEAL 444

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 62122857 417 ESSAKQKSDIIGRLEEKTNQMGSIIKQLESSEKDMAKQARTLNTAAGKLLQRQQ 470
Cdd:COG1196 445 EEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLE 498
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 248-459 6.37e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 6.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    248 SSKSTEGDGQITAILDQKNYVEELNRHLSASVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEELERVKEEGSYFVES 327
Cdd:TIGR02168  725 SRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREA 804

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    328 SRKASRADGTANGQVLGETRKQLKEETQLRlDVEKELELQIGMKQEMELSMKMLEKDICEKHDALVELRQQLD------- 400
Cdd:TIGR02168  805 LDELRAELTLLNEEAANLRERLESLERRIA-ATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEallnera 883

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62122857    401 ----DVRTLNHELSVKSQSSESSAKQKSDIIGRLEEKTNQMGSIIKQLESSEKDMAKQARTLN 459
Cdd:TIGR02168  884 sleeALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLS 946
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 227-446 8.18e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 8.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    227 EDLDSQVGVIDFSM-YLEDgahssKSTEGDGQITAILDQKNYVEELNRHLSASVNNLQAKVDALEKSNTKLTEELAVANN 305
Cdd:TIGR02168  298 SRLEQQKQILRERLaNLER-----QLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELES 372

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    306 RIITLQEELERVKEEgsyFVESSRKASRADGTangQVLGETRKQLKEETQLRLDVEKElelqigmkqemELSMKMLEKDI 385
Cdd:TIGR02168  373 RLEELEEQLETLRSK---VAQLELQIASLNNE---IERLEARLERLEDRRERLQQEIE-----------ELLKKLEEAEL 435

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62122857    386 CEKHDALVELRQQLDDVRTLNHELSVKSQSSESSAKQKSDIIGRLEEKTNQMGSIIKQLES 446
Cdd:TIGR02168  436 KELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLER 496
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 246-450 1.43e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 1.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    246 AHSSKSTEGDGQITAILDQKNYVEELNRHLSASVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEELERvkeegsyfV 325
Cdd:TIGR02168  257 ELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEE--------L 328

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    326 ESSRKASRADGTANGQVLGETRKQLKEEtqlrldvEKELELQIGMKQEMELSMKMLEKDICEKHDALVELRQQLddvRTL 405
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESL-------EAELEELEAELEELESRLEELEEQLETLRSKVAQLELQI---ASL 398

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 62122857    406 NHELSVKSqssessaKQKSDIIGRLEEKTNQMGSIIKQLESSEKD 450
Cdd:TIGR02168  399 NNEIERLE-------ARLERLEDRRERLQQEIEELLKKLEEAELK 436
RUN1_DENND5A cd17690
RUN1 domain found in DENN domain-containing protein 5A (DENND5A) and similar proteins; DENND5A, ...
 150-219 1.71e-03

RUN1 domain found in DENN domain-containing protein 5A (DENND5A) and similar proteins; DENND5A, also called Rab6-interacting protein 1 (Rab6IP1), is present predominantly in developing neuronal tissue, and functions in membrane trafficking at a crossroads between the Golgi and the endosomal system. It is composed of an N-terminal DENN (Differentially Expressed in Normal and Neoplastic cells) domain followed by two RUN (RPIP8 [RaP2-interacting protein 8], UNC-14, and NESCA [new molecule containing SH3 at the carboxyl terminus]) domains flanking a PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain. This model represents the first RUN domain of DENND5A.


Pssm-ID: 439052 [Multi-domain]  Cd Length: 209  Bit Score: 39.61  E-value: 1.71e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62122857 150 VKDLPGLKTPLGRGRAWLRLALMQKKLSDYMKTIINRKDLLGEFYEPNA-LMMEEEGAVIAGLLVGLNVID 219
Cdd:cd17690 130 IQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAfLRCDDEKEQFLYHLLSFNAVD 200
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 273-470 1.84e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 1.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 273 RHLSASVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEELERVKEEgsyfvesSRKASRADGTANGQVLGETRKQLKE 352
Cdd:COG1196 228 ELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE-------LEELELELEEAQAEEYELLAELARL 300

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 353 ETQLRLDVEKELELQiGMKQEMELSMKMLEKDICEKHDALVELRQQLDD----VRTLNHELSVKSQSSESSAKQKSDIIG 428
Cdd:COG1196 301 EQDIARLEERRRELE-ERLEELEEELAELEEELEELEEELEELEEELEEaeeeLEEAEAELAEAEEALLEAEAELAEAEE 379

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 62122857 429 RLEEKTNQMGSIIKQLESSEKDMAKQARTLNTAAGKLLQRQQ 470
Cdd:COG1196 380 ELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEE 421
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 264-465 3.04e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 40.10  E-value: 3.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    264 QKNYVEELNRHLSASVNNLQAKVDALEKSNTKLTEelavANNRIITLQEELERVKEEGSYF--VESSRKASRADGTANGQ 341
Cdd:pfam15921  487 KKMTLESSERTVSDLTASLQEKERAIEATNAEITK----LRSRVDLKLQELQHLKNEGDHLrnVQTECEALKLQMAEKDK 562

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857    342 VLGETRKQLKEETQL---------RLDVEK-ELELQIGmKQEMELSMKMLEKDiceKHDALV-ELRQQLDDVRTLNHELS 410
Cdd:pfam15921  563 VIEILRQQIENMTQLvgqhgrtagAMQVEKaQLEKEIN-DRRLELQEFKILKD---KKDAKIrELEARVSDLELEKVKLV 638

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 62122857    411 VKSQSSESSAK----QKSDIIGRLEEKTNQMGSIIKQLESSEKDMAKQARTLNTAAGKL 465
Cdd:pfam15921  639 NAGSERLRAVKdikqERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKL 697
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 341-470 5.13e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 38.37  E-value: 5.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62122857 341 QVLGETRKQLKEETQLRLDVEKELELQIGMKQEMELSMKMLEKDICEKHDALVELRQQLDDVRT------LNHELSVKSQ 414
Cdd:COG1579  24 HRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNnkeyeaLQKEIESLKR 103

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62122857 415 SSESSAKQKSDIIGRLEEKTNQMGSIIKQLESSEKDMAKQARTLNTAAGKLLQRQQ 470
Cdd:COG1579 104 RISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELE 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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