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Conserved domains on  [gi|84000446|ref|NP_001033109|]
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mucosal addressin cell adhesion molecule 1 precursor [Ovis aries]

Protein Classification

Ig and Adhes-Ig_like domain-containing protein( domain architecture ID 10310037)

Ig and Adhes-Ig_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adhes-Ig_like pfam09085
Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal ...
 112-220 2.77e-60

Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal cellular adhesion proteins and adopt an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology. They are essential for recruitment of lymphocytes to specific tissues.


:

Pssm-ID: 430399  Cd Length: 110  Bit Score: 191.17  E-value: 2.77e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84000446   112 AFPDQLSVSPEAVVPGRDQEVACTAHNVTPAGPDTLSMSLLLGGRELEGVEAF-PDMTEEPQEGEDPLFQVTQRWLLPAS 190
Cdd:pfam09085   1 AFPDQLTVSPVTLVPGQDQEVACTAHNVTPADPDTLSFSLLLGDQELEGVQALgPEPEEEPQEGEDLLFRVTQRWLLPPL 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 84000446   191 ETSSLHTLHCQVTMRLPGLELTRHRSIPVL 220
Cdd:pfam09085  81 GTPLPPTLHCQATMRLPGLELSHRRAIPVL 110
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 23-111 1.90e-32

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20942:

Pssm-ID: 472250  Cd Length: 88  Bit Score: 117.92  E-value: 1.90e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84000446  23 PLEVDPPESQVAMAVGESRNFTCRMTCADgRAASVLWRGLDTSLGAVQSSAGLSVLYVINASLSAAGTRVCVGSCGDVVL 102
Cdd:cd20942   1 PLQVEPPEPVVAVALGASRQLTCRLACAD-RGASVQWRGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTF 79


                ....*....
gi 84000446 103 QHRVRLLVF 111
Cdd:cd20942  80 QHTVQLLVY 88
 
Name Accession Description Interval E-value
Adhes-Ig_like pfam09085
Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal ...
 112-220 2.77e-60

Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal cellular adhesion proteins and adopt an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology. They are essential for recruitment of lymphocytes to specific tissues.


Pssm-ID: 430399  Cd Length: 110  Bit Score: 191.17  E-value: 2.77e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84000446   112 AFPDQLSVSPEAVVPGRDQEVACTAHNVTPAGPDTLSMSLLLGGRELEGVEAF-PDMTEEPQEGEDPLFQVTQRWLLPAS 190
Cdd:pfam09085   1 AFPDQLTVSPVTLVPGQDQEVACTAHNVTPADPDTLSFSLLLGDQELEGVQALgPEPEEEPQEGEDLLFRVTQRWLLPPL 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 84000446   191 ETSSLHTLHCQVTMRLPGLELTRHRSIPVL 220
Cdd:pfam09085  81 GTPLPPTLHCQATMRLPGLELSHRRAIPVL 110
IgI_MAdCAM-1 cd20942
Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of ...
 23-111 1.90e-32

Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of the I-set of IgSF domains; The members here include the immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1). MadCAM-1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. MadCAM-1 is expressed primarily on HEV of Peyer's patches and on venules in small intestinal lamina propria, on the marginal sinus of the spleen, and on HEV of embryonic lymph nodes. It is a member of the immunoglobulin superfamily (IgSF), which is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of MAdCAM-1 is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous, but lacks a C" strand.


Pssm-ID: 409535  Cd Length: 88  Bit Score: 117.92  E-value: 1.90e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84000446  23 PLEVDPPESQVAMAVGESRNFTCRMTCADgRAASVLWRGLDTSLGAVQSSAGLSVLYVINASLSAAGTRVCVGSCGDVVL 102
Cdd:cd20942   1 PLQVEPPEPVVAVALGASRQLTCRLACAD-RGASVQWRGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTF 79


                ....*....
gi 84000446 103 QHRVRLLVF 111
Cdd:cd20942  80 QHTVQLLVY 88
 
Name Accession Description Interval E-value
Adhes-Ig_like pfam09085
Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal ...
 112-220 2.77e-60

Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal cellular adhesion proteins and adopt an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology. They are essential for recruitment of lymphocytes to specific tissues.


Pssm-ID: 430399  Cd Length: 110  Bit Score: 191.17  E-value: 2.77e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84000446   112 AFPDQLSVSPEAVVPGRDQEVACTAHNVTPAGPDTLSMSLLLGGRELEGVEAF-PDMTEEPQEGEDPLFQVTQRWLLPAS 190
Cdd:pfam09085   1 AFPDQLTVSPVTLVPGQDQEVACTAHNVTPADPDTLSFSLLLGDQELEGVQALgPEPEEEPQEGEDLLFRVTQRWLLPPL 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 84000446   191 ETSSLHTLHCQVTMRLPGLELTRHRSIPVL 220
Cdd:pfam09085  81 GTPLPPTLHCQATMRLPGLELSHRRAIPVL 110
IgI_MAdCAM-1 cd20942
Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of ...
 23-111 1.90e-32

Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of the I-set of IgSF domains; The members here include the immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1). MadCAM-1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. MadCAM-1 is expressed primarily on HEV of Peyer's patches and on venules in small intestinal lamina propria, on the marginal sinus of the spleen, and on HEV of embryonic lymph nodes. It is a member of the immunoglobulin superfamily (IgSF), which is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of MAdCAM-1 is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous, but lacks a C" strand.


Pssm-ID: 409535  Cd Length: 88  Bit Score: 117.92  E-value: 1.90e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84000446  23 PLEVDPPESQVAMAVGESRNFTCRMTCADgRAASVLWRGLDTSLGAVQSSAGLSVLYVINASLSAAGTRVCVGSCGDVVL 102
Cdd:cd20942   1 PLQVEPPEPVVAVALGASRQLTCRLACAD-RGASVQWRGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTF 79


                ....*....
gi 84000446 103 QHRVRLLVF 111
Cdd:cd20942  80 QHTVQLLVY 88
IgI_1_NCAM-1_like cd04977
First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1, and similar ...
 24-99 2.89e-04

First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1. NCAM-1 plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM) and heterophilic (NCAM-nonNCAM) interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves the Ig1, Ig2, and Ig3 domains. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain. Also included in this group is NCAM-2 (also known as OCAM/mamFas II and RNCAM). NCAM-2 is differentially expressed in the developing and mature olfactory epithelium (OE). This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409366  Cd Length: 95  Bit Score: 39.93  E-value: 2.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84000446  24 LEVDPPESQVAMAVGESRNFTCRmtcADGRAASVLWRG--------LDTSLGAVQSSAGLSVLYVINASLSAAGTRVCVG 95
Cdd:cd04977   1 LQVKIIPSYAEISVGESKFFLCK---VSGDAKNINWVSpngekvltKHGNLKVVNHGSVLSSLTIYNANINDAGIYKCVA 77


                ....
gi 84000446  96 SCGD 99
Cdd:cd04977  78 TNGK 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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