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Conserved domains on  [gi|157278549|ref|NP_001098375|]
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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [Oryzias latipes]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 77-350 1.43e-161

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23971:

Pssm-ID: 480271  Cd Length: 271  Bit Score: 452.87  E-value: 1.43e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549  77 DNYHQFRSQLNSKCHGLEKAIITQANTPQGTKLVYDAERKRTLVVNAEVFNTFIKENPFPNKTWDTCAVVGNGGILANSS 156
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 157 CGKTIDSAQFVIRCNLPPLSNgfEKDVGIKSDIVTANPSIITEKYFSLMRHRRPFAEAMRIYGNSMVLLPAFSFGHNTAL 236
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 237 SMRAFYTLEDFESSARAVYFNPEYLKNLANFWRSEGLKSPRLSTGIMMASIALEVCSEVHLYGFWPFDVHPySHQGLTNH 316
Cdd:cd23971  159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISHH 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 157278549 317 YYDDRKAKNKFHAMPTEFNLLLQLHRKGVLRLHL 350
Cdd:cd23971  238 YYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 77-350 1.43e-161

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 452.87  E-value: 1.43e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549  77 DNYHQFRSQLNSKCHGLEKAIITQANTPQGTKLVYDAERKRTLVVNAEVFNTFIKENPFPNKTWDTCAVVGNGGILANSS 156
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 157 CGKTIDSAQFVIRCNLPPLSNgfEKDVGIKSDIVTANPSIITEKYFSLMRHRRPFAEAMRIYGNSMVLLPAFSFGHNTAL 236
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 237 SMRAFYTLEDFESSARAVYFNPEYLKNLANFWRSEGLKSPRLSTGIMMASIALEVCSEVHLYGFWPFDVHPySHQGLTNH 316
Cdd:cd23971  159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISHH 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 157278549 317 YYDDRKAKNKFHAMPTEFNLLLQLHRKGVLRLHL 350
Cdd:cd23971  238 YYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 97-345 3.63e-99

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 293.74  E-value: 3.63e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549   97 IITQANTPQGTKLVYdAERKRTLVVNAEVFNTFIKENPFPNKTWDTCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLs 176
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549  177 NGFEKDVGIKSDIVTANP-SIITEKYFSLMR--HRRPFAEAMRIY--GNSMVLLPAFSFGHNTALSMRAFYTLEDFESSA 251
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFshPRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549  252 ---RAVYFNPEYLKNLANFW-RSEGLKSPRLSTGIMMASIALEVCSEVHLYGFWPFDvhpySHQGLTNHYYDDRKAK--- 324
Cdd:pfam00777 159 dpdKVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFL----DSRGNSHHYYDNVLMKkgg 234

                         250       260
                  ....*....|....*....|..
gi 157278549  325 -NKFHAMPTEFNLLLQLHRKGV 345
Cdd:pfam00777 235 fYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 77-350 1.43e-161

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 452.87  E-value: 1.43e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549  77 DNYHQFRSQLNSKCHGLEKAIITQANTPQGTKLVYDAERKRTLVVNAEVFNTFIKENPFPNKTWDTCAVVGNGGILANSS 156
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 157 CGKTIDSAQFVIRCNLPPLSNgfEKDVGIKSDIVTANPSIITEKYFSLMRHRRPFAEAMRIYGNSMVLLPAFSFGHNTAL 236
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 237 SMRAFYTLEDFESSARAVYFNPEYLKNLANFWRSEGLKSPRLSTGIMMASIALEVCSEVHLYGFWPFDVHPySHQGLTNH 316
Cdd:cd23971  159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISHH 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 157278549 317 YYDDRKAKNKFHAMPTEFNLLLQLHRKGVLRLHL 350
Cdd:cd23971  238 YYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 79-350 2.86e-118

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 343.27  E-value: 2.86e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549  79 YHQFRSQLNSKCHGLEKAIITQANTPQGTKLVYDAERKRTLVVNAEVFNTFIKENPFPNKTWDTCAVVGNGGILANSSCG 158
Cdd:cd23991    3 HENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 159 KTIDSAQFVIRCNLPPLSNGFEKDVGIKSDIVTANPSIITEKYFSLMRHRRPFAEAMRIYGNSMVLLPAFSFGHNTALSM 238
Cdd:cd23991   83 AEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 239 RAFYTLEDFESSARAVYFNPEYLKNLANFWRSEGLKSPRLSTGIMMASIALEVCSEVHLYGFWPF----DVHPYSHqglt 314
Cdd:cd23991  163 KVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFskntEGKPISH---- 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 157278549 315 nHYYDDRKAKNKFHAMPTEFNLLLQLHRKGVLRLHL 350
Cdd:cd23991  239 -HYYDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQF 273
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 81-349 1.98e-100

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 297.90  E-value: 1.98e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549  81 QFRSQLNSKCHGLEKAIITQANTPQGTKLVYDAERKRTLVVNAEVFNTFIKENPFPNKTWDTCAVVGNGGILANSSCGKT 160
Cdd:cd23990    5 AFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGRE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 161 IDSAQFVIRCNLPPLSNGFEKDVGIKSDIVTANPSIITEKYFSLMRHRRPFAEAMRIYGNSMVLLPAFSFGHNTALSMRA 240
Cdd:cd23990   85 IDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVSIRV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 241 FYTLEDFESSARAVYFNPEYLKNLANFWRSEGLKSPRLSTGIMMASIALEVCSEVHLYGFWPFDVHPySHQGLTNHYYDD 320
Cdd:cd23990  165 KYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNP-SGIFITHHYYDN 243

                        250       260
                 ....*....|....*....|....*....
gi 157278549 321 RKAKNKFHAMPTEFNLLLQLHRKGVLRLH 349
Cdd:cd23990  244 VKPRPGFHAMPSEIFNFLHMHSRGILRVH 272
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 97-345 3.63e-99

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 293.74  E-value: 3.63e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549   97 IITQANTPQGTKLVYdAERKRTLVVNAEVFNTFIKENPFPNKTWDTCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLs 176
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549  177 NGFEKDVGIKSDIVTANP-SIITEKYFSLMR--HRRPFAEAMRIY--GNSMVLLPAFSFGHNTALSMRAFYTLEDFESSA 251
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFshPRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549  252 ---RAVYFNPEYLKNLANFW-RSEGLKSPRLSTGIMMASIALEVCSEVHLYGFWPFDvhpySHQGLTNHYYDDRKAK--- 324
Cdd:pfam00777 159 dpdKVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFL----DSRGNSHHYYDNVLMKkgg 234

                         250       260
                  ....*....|....*....|..
gi 157278549  325 -NKFHAMPTEFNLLLQLHRKGV 345
Cdd:pfam00777 235 fYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 81-350 5.32e-99

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 294.17  E-value: 5.32e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549  81 QFRSQLNSKCHgLEKAIITQANTPQGTKLVYDAERKRTLVVNAEVFNTFIKENPFPNKTWDTCAVVGNGGILANSSCGKT 160
Cdd:cd23963    5 KFRKELERLLN-TRKLFLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 161 IDSAQFVIRCNLPPLSnGFEKDVGIKSDIVTANPSIITEKYFSLMRHRRP--FAEAMRIYGNSMVLLPAFSFGHNTALSM 238
Cdd:cd23963   84 IDSHDFVIRCNLPPIK-GFEKDVGRKTNLTTLNPSILKRRYNSLKKNRDRdkFLNRLKEYNGSILWYPKFSFKSSTNLLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 239 RAFYTLEDFESSARAVYFNPEYLKNLANFWRSEGLkSPRLSTGIMMASIALEVCSEVHLYGFWPFDVHPyshQG--LTNH 316
Cdd:cd23963  163 KAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDP---NGrpVPYH 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 157278549 317 YYDDRKAK--NKFHAMPTEFNLLLQLHRKGVLRLHL 350
Cdd:cd23963  239 YYDDLSPStkNKVHNMPEEFKLLRELHKKGVLKLHT 274
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 82-350 1.73e-95

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 285.19  E-value: 1.73e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549  82 FRSQLNSKCHGLEKAIITQANTPQGTKLVYDAERKRTLVVNAEVFNTFIKENPFPnKTWDTCAVVGNGGILANSSCGKTI 161
Cdd:cd23989    6 FRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQQI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 162 DSAQFVIRCNLPPLSNGFEKDVGIKSDIVTANPSIITEKYFSLMRHRRPFAEAMRIYGNSMVLLPAFSFGHNTALSMRAF 241
Cdd:cd23989   85 DRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVY 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 242 YTLEDFESSARAVYFNPEYLKNLANFWRSEGLKSPRLSTGIMMASIALEVCSEVHLYGFWPFDVHPYShQGLTNHYYDDR 321
Cdd:cd23989  165 YTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDE-RTISHHYYDNV 243

                        250       260
                 ....*....|....*....|....*....
gi 157278549 322 KAKNKFHAMPTEFNLLLQLHRKGVLRLHL 350
Cdd:cd23989  244 LPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 134-350 5.44e-68

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 215.34  E-value: 5.44e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 134 PFPNKTWDTCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLSnGFEKDVGIKSDIVTANPSIITEKYFSLM--RHRRPF 211
Cdd:cd23970   62 PFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTE-GFEKDVGRKTNLTTFNPSILEKYYNNLLtiQDRNNF 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 212 AEAMRIYGNSMVLLPAFSFgHNTALSMRafyTLEDF-----ESSARAVYFNPEYLKNLANFWRSEGLKSPRLSTGIMMAS 286
Cdd:cd23970  141 FLSLKKLDGAILWIPAFFF-HTSATVTR---TLVDFfvehrGQLKVQLAWPGNIMQHVNRYWKTKHLSPKRLSTGILMYT 216

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157278549 287 IALEVCSEVHLYGFWPFDVHPySHQGLTNHYYDDRKAK-----NKFHAMPTEFNLLLQLHRKGVLRLHL 350
Cdd:cd23970  217 LASAICEEIHLYGFWPFGFDP-TGTPLPYHYYDKKGTKfttkwQESHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 98-349 8.53e-67

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 211.89  E-value: 8.53e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549  98 ITQANTPQGTKLVYDAERKRTLVVNAEVFNTFIKENPFPNKTWDTCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLSn 177
Cdd:cd23969   22 VLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVE- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 178 GFEKDVGIKSDIVTANPSIITEKYFSLM--RHRRPFAEAMRIYGNSMVLLPAFSfghNTALSMRAFYTLE---DFESSAR 252
Cdd:cd23969  101 GYEKDVGTKSNLTTMNPSVIPHAYGDLVnaTDKEKFVERLRQLGDSILWIPAFV---SKGGEEHVQWTNEiilKHKLNVK 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 253 AVYFNPEYLKNLANFWRSEGLKSPRLSTGIMMASIALEVCSEVHLYGFWPFDVHPYShQGLTNHYYDDRK--AKNKFHAM 330
Cdd:cd23969  178 TAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNG-RAVKYHYYDNRKylTTARPHKM 256

                        250
                 ....*....|....*....
gi 157278549 331 PTEFNLLLQLHRKGVLRLH 349
Cdd:cd23969  257 PEEFRALRSLHQRGALRLH 275
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 98-348 2.45e-50

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 169.75  E-value: 2.45e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549  98 ITQANTPQGTKLVYDAERKRTLVVNAEVFNTFIKENPFPNKTWDTCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLSn 177
Cdd:cd23988   22 VVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVV- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 178 GFEKDVGIKSDIVTANPSIITEKYFSLMRH--RRPFAEAMRIYGNSMVLLPAFSF-GHNTALSMRAFYTLEDfESSARAV 254
Cdd:cd23988  101 EFAADVGTKSDFITMNPSVVQRAFGGFRNEsdREKFVHRLSMLNDSVLWIPAFMVkGGEKHVEWVNALILKN-KLKVRTA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 255 YFNPEYLKNLANFWRSEGLKSPRLSTGIMMASIALEVCSEVHLYGFWPF--DVHpysHQGLTNHYYDDRKAK----NKFH 328
Cdd:cd23988  180 YPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFpkDAN---GNPVKYHYYDDLKYRyfsnAGPH 256

                        250       260
                 ....*....|....*....|
gi 157278549 329 AMPTEFNLLLQLHRKGVLRL 348
Cdd:cd23988  257 RMPLEFKTLNVLHNRGALKL 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 111-350 4.19e-47

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 161.26  E-value: 4.19e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 111 YDAERKRTLVVNAEVFNTFIKENPFPNKTWDTCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLSNgFEKDVGIKSDIV 190
Cdd:cd23987   35 YVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGTKTDLV 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 191 TANPSIITEKYFSLMRH--RRPFAEAMRIYGNSMVLLPAFSFGHNTALSMRAFYTLEDFESSARAVYFNPEYLKNLANFW 268
Cdd:cd23987  114 TMNPSVVQRAFEDLVNEtwKEKFLQRLQSLNGSILWIPAFMAKGGEERVEWVNDLILKHHINVRTAYPSLRLLHAVRGYW 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 269 RSEGLKSPRLSTGIMMASIALEVCSEVHLYGFWPFDvHPYSHQGLTNHYYDDRK----AKNKFHAMPTEFNLLLQLHRKG 344
Cdd:cd23987  194 LTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFP-RDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKALKNLHQQG 272


                 ....*.
gi 157278549 345 VLRLHL 350
Cdd:cd23987  273 ALKLTV 278
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 143-340 7.86e-29

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 110.53  E-value: 7.86e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 143 CAVVGNGGILANSSCGKTIDSAQFVIRCNLPPlSNGFEKDVGIKSDIVTANPSIITEKYFSLMRHRRPFAEAMRIY---- 218
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAP-TKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPLEEEVVlils 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 219 ----GNSMVLLPAFSFGHNTALSMRAfyTLEDFESSARAVYFNPEYLKnlanfwrSEGLKSPrlSTGIMMASIALEVCSE 294
Cdd:cd19952   80 raaaADFKRLKRRKKRHDNAVLLLTD--PAPDLLSYVRKRLEKLGLKS-------FFGGNAP--SSGLLAVLLALQLCDS 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 157278549 295 VHLYGFWPFdvhPYSHQGLTNHYYDDRKA--KNKFHAMPTEFNLLLQL 340
Cdd:cd19952  149 VDLYGFGVD---SGHAPKVPYHYYDLVEAeeGTAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 142-351 4.47e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 92.12  E-value: 4.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 142 TCAVVGNGGILANSSCGKTIDSAQFVIRCNlPPLSNGFEKDVGIKSDI-------VTANPSIITEKYFSLMRHRRP---- 210
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVN-GAVIKGYEEDVGTRTSFyvhtahsITSSLMILQKRGFKNIPQDKDikyi 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 211 -FAEAMRIYG--NSMVLLPAFSFGHNTALSMRAFYTlEDFESSaRAVYFNPEYLKNLAN-FWRSEGLKSP-----RLSTG 281
Cdd:cd23973  164 lFPEGPRDYQwlEALLKNKTIPSGAYYGRRPRSYFS-GDFTED-KYLVLHPDFLRYVKNrFLRSKTLKGKywaiyRPTTG 241

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157278549 282 IMMASIALEVCSEVHLYGFWPFDVHPYShqgltNHYYDDRKAKNKF---HAMPTEFNLLLQLHRKGVLRLHLG 351
Cdd:cd23973  242 AFLLLTALHLCDTVSAYGFITEDYRKYP-----DHYYDKKKTKLVFyinHDFRLEKKLWKRLHDEKIIKLYQR 309
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 142-349 1.02e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 88.08  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 142 TCAVVGNGGILANSSCGKTIDSAQFVIRCNLpPLSNGFEKDVGIKSDIVTANPsiitekyFSLMRHRR------------ 209
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNH-ALTKGFEKDVGTKTSFYTFFP-------ESLHNSLLkhvpqdkdtkyl 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 210 --PFAEAMRIYGNSMVL---LPAFSFGHNTALSMRA-FYTLEDFESsaravyFNPEYLKNLANFWrsegLKSP---RLST 280
Cdd:cd23964  156 fiPFKIRDYDYLDAVLSgkpVPDGCDKGKRPPPLFGpKLNATNVRL------LHPDFIRYLFNRW----LNSStsyRPTT 225

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157278549 281 GIMMASIALEVCSEVHLYGFwpfdvhpYSHQGLTNHYYDD-RKAKNKF---HAMPTEFNLLLQLHRKGVLRLH 349
Cdd:cd23964  226 GALMLLTALHTCDQVSVYGF-------GYDPRFSLHYYDKtFVKFTVFyanHDFTNERKLWRKLHEEGIINLY 291
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 143-350 6.05e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 85.96  E-value: 6.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 143 CAVVGNGGILANSSCGKTIDSAQFVIRCNlPPLSNGFEKDVG-------------------IKSDIVTANPSIITEKYFS 203
Cdd:cd23974   87 CAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGrrtsfytfstntlmnslraYAGVGFNGPPQSKETRYIF 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 204 LMRHRRPFAEAMRIYGNSMVLL-------PAFSFGHNTalsmrafyTLEDFEssaravYFNPEYLKNLAN-FWRSEGLKS 275
Cdd:cd23974  166 LPDHDRDYLLVKAALTHTPIDRgrdkskrPSKYFGKDV--------TAEKFK------IYHPDFIRYLRNrFLWSPILNT 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 276 P-----RLSTGIMMASIALEVCSEVHLYGFWPFDVHPYShqgltNHYYDDRKAKNKF---HAMPTEFNLLLQLHRKGVLR 347
Cdd:cd23974  232 KqrdiyRPSTGAVMLLAALHTCDQVSAYGFMTPDYGKYS-----DHYYDKTYHKVVFyanHDLRLEMQLWQKLHKAGLIK 306


                 ...
gi 157278549 348 LHL 350
Cdd:cd23974  307 LYM 309
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 142-349 2.51e-17

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 80.79  E-value: 2.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 142 TCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLSnGFEKDVGIKSDivtanpsiitekyfslmrHRRPFAE-AMRIYGN 220
Cdd:cd23966   79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTK-GFEKDVGSKTT------------------HHFMYPEsAVDLDPG 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 221 -SMVLLP-----------AFSFGH--NTALSMRAFYTLedfeSSARAVYFNPEYLKNLANFWRSEGLKSPrlSTGIMMAS 286
Cdd:cd23966  140 vHLVLVPfkvldlqwlisALTTGEitRTYTPVKRFIKA----DKDKVLVINPAFIKYVHDNWTEHHGRYP--STGFLALI 213

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157278549 287 IALEVCSEVHLYGFWPfdvhpySHQGLTNHYYDDRKAKNKF-----HAMPTEFNLLLQLHRKGVLRLH 349
Cdd:cd23966  214 FALHICDEVSVFGFGA------DSKGNWHHYWEKNRSAGAFrktgvHDADFESDIIKKLAKEGKIRVY 275
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 143-349 2.73e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 81.41  E-value: 2.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 143 CAVVGNGGILANSSCGKTIDSAQFVIRCNlPPLSNGFEKDVGIKSD-----IVTANPSIITekYFSLMRHRRPFAEAMR- 216
Cdd:cd23972   85 CAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSfygftVNTMKNSLIS--YWNLGFTRTPQGQDLQy 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 217 ----------IYGNSMVLLPAFSFGHNTALSMRAFYTLEdfESSARAVYFNPEYLKNLAN-FWRSEGLKS-------Prl 278
Cdd:cd23972  162 ifipsdirdyVMLRSAILGVPVPEGLDKGDRPHKYFGPE--ASAKKFKLLHPDFISYLTDrFLKSKLLNThyghlymP-- 237

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157278549 279 STGIMMASIALEVCSEVHLYGFWPFDVHPYShqgltNHYYDDRKAKNKF---HAMPTEFNLLLQLHRKGVLRLH 349
Cdd:cd23972  238 STGALMLLTALHTCDQVSAYGFITSNYWKFS-----DHYYERKKKPLVFyanHDMLLEAALWRRLHKAGILQLY 306
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 113-348 1.82e-16

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 78.08  E-value: 1.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 113 AERKRTLVVNAEVFNTFI-KENPFPN------KTWDTCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLSnGFEKDVGI 185
Cdd:cd23968   11 AAPFSTLRKTTSPFKDLLsLRYPFPEsslentKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTK-GFEKDVGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 186 KSDIVTANPSIITEKYFSLMrhRRPfaeamrIYGNSMVLlpAFSFGHNTAlSMRAFYTLEDFES-----SARAVYFN-PE 259
Cdd:cd23968   90 KTTLRLINSQILSKPEFNFL--TDP------LYRNVTLL--VWDPSSYNV-NLEKWYKKPDFDFfpnyiKYRRRHPEePF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 260 YLKNLANFWR--------SEGLKSPRL-STGIMMASIALEVCSEVHLYGFWPfdvhpySHQgLTN--HYYDDRKAKNK-- 326
Cdd:cd23968  159 YLIDPRFLWRlwdilqeyTPEKIKPNPpSSGFIGIVLMLHLCDWVDVYEYVP------SVR-QTDrcHYYDVEKDLACtl 231

                        250       260       270
                 ....*....|....*....|....*....|..
gi 157278549 327 --FHAMPTEFNLLLQLH--------RKGVLRL 348
Cdd:cd23968  232 gaWHPLAAEKLLVRHLNvgsdddifRKGRATL 263
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 142-340 2.45e-16

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 76.71  E-value: 2.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 142 TCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLSnGFEKDVGIKSDIVTANPsiitEKYFSLMRHRRPfaeamriygNS 221
Cdd:cd23984    4 KCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVI-GYENDVGKRTTFRLCYP----ESIFSDPSHYDP---------NT 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 222 MVLLPAF------------------SFGHNTALSMRAFYTLEDFEssaravYFNPEYLK----NLANFWRSEGLKSPRL- 278
Cdd:cd23984   70 TVVLIPFkphdlrwlldllmgkkvsAKGFWKKPALNLIYKPNQIR------ILNPFILRiaayELLHFPKRFPKEKKPKh 143

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157278549 279 -STGIMMASIALEVCSEVHLYGFwpfdvhPYSHQGLTN--HYYDDRK----AKNKFHAMPTEFNLLLQL 340
Cdd:cd23984  144 pTTGIIAITLALHICNEVHIAGF------KYDFSNLNStlHYYGNETmsvmTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 141-324 2.80e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 74.20  E-value: 2.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 141 DTCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLSnGFEKDVGIKSDI-VTAN---PSIITEKYFSLMRHRRPfaEAMR 216
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTR-GYEKDVGRRTTIrVVSHsslPRLLRNAILLLAGTRAP--TVVV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 217 IYGNSMVLLPAFSFGHNTALSMRA------FYTL-EDFESSARAVYFNpEYLKNL--ANFWrseglksprLSTGIMMASI 287
Cdd:cd23965   79 FWGPETKMNKDGAGKYNLLRSLSKkypdveFYSLtPEKMDYADELFEK-ETGKSRikSGTW---------LSTGWFTMLL 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 157278549 288 ALEVCSEVHLYGF--------WPFDVHPYshqgltnHYYDDRKAK 324
Cdd:cd23965  149 ALDVCDEIKVYGMvpenycreHPNSKVPY-------HYYEPGGLK 186
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 143-324 2.84e-15

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 73.48  E-value: 2.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 143 CAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLSnGFEKDVGIKSDIVTANPSiitekyfSLMRHRRPFaeamriYGNSM 222
Cdd:cd23967    5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVK-GYEKDVGSKTTFRMFYPE-------SAFRDPEEY------DSDWL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 223 VLLPAFSfghntALSMRAFYTL---ED-------FESSARAV--------YFNPEYLKNLAN----FWRSEGLKSPRLST 280
Cdd:cd23967   71 LVLVPFK-----SMDLLWLQAVikgKKpngkggfWKKIATSVpkppkkirILNPYILQEAAFdligLPMNGKQGKNVPTT 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 157278549 281 GIMMASIALEVCSEVHLYGFWpfdvHPYSHQGLTNHYYDDRKAK 324
Cdd:cd23967  146 GIIAIVMALHYCDEVDIAGFG----YDPSDPNAPLHYYDSLTMK 185
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 142-340 6.41e-12

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 63.91  E-value: 6.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 142 TCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLSnGFEKDVGIKSDI-------VTANPSIitekyfslmrhrRPFAEA 214
Cdd:cd23982    4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVR-GFEKDVGSKTTIrlfypesAQFDPGI------------ENDPDT 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 215 MriygnsMVLLP----AFSFGHNTaLSMRAFYTLEDFESSARAVYFNPEYLKNLANFWRSE-----------GLKSPRLS 279
Cdd:cd23982   71 L------LVLVPfkplDFYWLYEI-LSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVaatkllqvpgqRKKKQKPT 143

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157278549 280 TGIMMASIALEVCSEVHLYGF-WPFDVHPYShqglTNHYYDD---RKAKNKFHAMPTEFNLLLQL 340
Cdd:cd23982  144 TGLLAITLALHLCDEVHIAGFgYPDNGNSNQ----PIHYYNQitlKSMANSGHNLNAEAQAIQRL 204
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 142-340 9.71e-12

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 64.90  E-value: 9.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 142 TCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPlSNGFEKDVGIKsdivtanpsiiTEKYFSLMRHRRPFAEAMriygnS 221
Cdd:cd23980   83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADVGSK-----------TTHHFVYPESFRELAQNV-----S 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 222 MVLLPAFSFGHNTALSMRAFYTLEDFE---------SSARAVYFNPEYLKNLANFWRSEGLKSPrlSTGIMMASIALEVC 292
Cdd:cd23980  146 MILVPFKTLDLEWVISATTTGTISHTYvpvprkikvKKEKILIYHPAFIKYVFDRWLQGHGRYP--STGILSVIFSLHVC 223

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157278549 293 SEVHLYGFWPfdvhpySHQGLTNHYYDDRKAKNKF-----HAMPTEFNLLLQL 340
Cdd:cd23980  224 DEVDLYGFGA------DSKGNWHHYWENNPSAGAFrktgvHDGDFESNVTTIL 270
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 121-327 2.94e-11

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 63.35  E-value: 2.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 121 VNAEVFNTFIKENPFpnKTWDT-----CAVVGNGGILANSSCGKTIDSAQFVIRCNLPPlSNGFEKDVGiksdivtanps 195
Cdd:cd23979   58 VLSKLFQIIPGENPY--RSWDPsrcrrCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVG----------- 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 196 iitekyfSLMRHRRPFAE-AMRIYGN-SMVLLP-----------AFSFGH--NTALSMRAFYTLEdfesSARAVYFNPEY 260
Cdd:cd23979  124 -------SRTTHHFMYPEsAKNLPANvSFVLVPfktldllwitsALSTGQirFTYAPVKQFLRVD----KDKVQIYNPAF 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157278549 261 LKNLANFWRSEGLKSPrlSTGIMMASIALEVCSEVHLYGFWPfdvhpySHQGLTNHYYDDRKAKNKF 327
Cdd:cd23979  193 FKYIHDRWTEHHGRYP--STGMLVLFFALHVCDEVNVYGFGA------DSRGNWHHYWENNRYAGEF 251
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 143-321 2.25e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 57.17  E-value: 2.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 143 CAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLSnGFEKDVGIKSDI-VTANPSIitekyFSLMRHRRPF----AEAMRI 217
Cdd:cd23978    4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTT-GYEKDVGNKTTLrVVAHSSV-----YRVLRRPQEFlnrtPETTLI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 218 YGNSMVLLPAFSFGHNTALSMRAFYTLEDFEssarAVYFNPEYLKNLANFWRSEGLKSPR-----LSTGIMMASIALEVC 292
Cdd:cd23978   78 FWGPPNKMQKDGKSNLFRIIQRASMTFPNMS----AFVVSPRRMRQFDDLFRGETGRDRKkshswLSTGWFTMVIAVELC 153

                        170       180       190
                 ....*....|....*....|....*....|.
gi 157278549 293 SEVHLYGFWPFDV--HPYSHQGLTNHYYDDR 321
Cdd:cd23978  154 DNVHVYGMVPPNYcsKRPTPKKMPYHYYEPK 184
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 143-194 2.82e-09

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 56.47  E-value: 2.82e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157278549 143 CAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLsNGFEKDVGIKSDIVTANP 194
Cdd:cd23981    5 CIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPV-KGFEKDVGSKTTLRITYP 55
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 143-340 8.11e-09

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 55.13  E-value: 8.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 143 CAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLsNGFEKDVGIKSDIVTANP-----SII----TEKYFSLMRHRRPFA- 212
Cdd:cd23983    5 CVVVGSGGILHGLELGHLLDQFDIVIRLNNAPV-QGYSQDVGNKTTIRMTYPegapkSEQeydpTSLFVAVLFKSVDFAw 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 213 -EAMrIYGNSMVLLPAFSFGHNTALSMRafYTLEDFEssaravYFNPEYLK----NLANF------WRSEGLKSPRLstG 281
Cdd:cd23983   84 lKAM-VKKEPLSFWSRLFFWKEVADSIP--LKPSQFR------ILNPLIIKetalDILQYpepqsrLWGWDKNVPTL--G 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157278549 282 IMMASIALEVCSEVHLYGFwPFDVhpySHQGLTNHYYDDRK--AKNK--FHAMPTEFNLLLQL 340
Cdd:cd23983  153 VTAVVLATHLCDEVSLAGF-GYDL---SQPHAPLHYYDSVCmaAMNTqtMHNVTKETKFLKKL 211
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 118-198 2.58e-08

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 54.33  E-value: 2.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 118 TLVVNAEVFNTFIKENPFPNKT-------WDTCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPLSnGFEKDVGIKSDIV 190
Cdd:cd23985   16 MLEGTDFPFNTSEWEGYLPKKSlreevgpLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTA-GFQQDVGTKTTIR 94


                 ....*...
gi 157278549 191 TANPSIIT 198
Cdd:cd23985   95 LINSQLVT 102
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 142-198 4.09e-08

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 53.69  E-value: 4.09e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 157278549 142 TCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPlSNGFEKDVGIKSDIVTANPSIIT 198
Cdd:cd23986   51 SCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILT 106
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 142-319 1.37e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 49.10  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 142 TCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPlSNGFEKDVGIKSDI-VTANPSI--ITEKYFSL--MRHRRPF----- 211
Cdd:cd23976   17 SCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLrVIAHSSIqrILRNRNELlnVSQGTVFifwgp 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 212 AEAMRIYGNSMV---------LLPAFSFGHNTALSMRAFYTLEDFESSARavyfnpeylKNLANFWrseglksprLSTGI 282
Cdd:cd23976   96 SNYMRRDGKGLVynnlqlmnqILPKLKVYTITRHKMLQFDELFKRETGKD---------RKISNTW---------LSTGW 157

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 157278549 283 MMASIALEVCSEVHLYGFWPFD-VHPYSHQGLTNHYYD 319
Cdd:cd23976  158 FTMIIALELCDRINVYGMVPPDfCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 143-299 1.64e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 45.62  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 143 CAVVGNGGILANSSCGKTIDSAQFVIRCNLPPlSNGFEKDVGIKSDI-VTANPSIITekyfsLMRHRRPFAEAMR--IYg 219
Cdd:cd23977    4 CAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLrVVSHTSVPL-----LLRNQGYFFQQSRdtKY- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 220 nsMVLLPAFSFGH-NTALSMRAFYTLEDFESSARAVYFNPEYLKNLANFWRSEGLKSPR-----LSTGIMMASIALEVCS 293
Cdd:cd23977   77 --VIWGPERNMDRdGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMksgsfLSTGWFTMILALELCE 154


                 ....*.
gi 157278549 294 EVHLYG 299
Cdd:cd23977  155 EILVYG 160
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 141-299 2.47e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 41.84  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 141 DTCAVVGNGGILANSSCGKTIDSAQFVIRCNLPPlSNGFEKDVGIKSDIV----TANPSIITE-KYF------SLMRHRR 209
Cdd:cd23975    2 DLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAP-TKGYEEDVGKRTTIRvvshTSVPLLLKNpDYFfketneTIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278549 210 PFaEAMRIYGNSMV--LLPAFSFGHNTAlsmRAFYTLEDFESSARAVyFNPEYLKNLANfwrseglKSPRLSTGIMMASI 287
Cdd:cd23975   81 PF-RNMRKDGKGIVynMLKKAVESYPQA---KIYVTTEKRMSYCDTV-FKKETGKDRVQ-------SGSYLSTGWFTLIL 148

                        170
                 ....*....|..
gi 157278549 288 ALEVCSEVHLYG 299
Cdd:cd23975  149 AMDACYGIHVYG 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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