|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
270-560 |
2.67e-51 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 182.46 E-value: 2.67e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 270 IVHLLLERNKSGTVPSDSQGATPLHYAAQSNFAETVKVFLTHPSVRDDSDLEGRTSFMWAAGKGSDDVLrtMLSLKSDID 349
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 350 INMADKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 429
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 430 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 157817598 510 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 560
Cdd:COG0666 240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
19-240 |
1.18e-36 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 140.09 E-value: 1.18e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 19 HAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMK 98
Cdd:COG0666 58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 99 LLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfmAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIP 178
Cdd:COG0666 138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE--AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157817598 179 DVEGKIPLHWAANHKDASAVHtvrcILDAAptESLLNWQDYEGRTPLHFAVADGNLTVVDVL 240
Cdd:COG0666 216 DNDGKTALDLAAENGNLEIVK----LLLEA--GADLNAKDKDGLTALLLAAAAGAALIVKLL 271
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
336-554 |
2.59e-22 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 100.89 E-value: 2.59e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 336 DVLRTMLslKSDIDINMADKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 408
Cdd:PHA03100 49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 409 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 486
Cdd:PHA03100 127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157817598 487 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 554
Cdd:PHA03100 190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
394-486 |
6.48e-22 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 90.95 E-value: 6.48e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 394 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 473
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 157817598 474 VLMENNADPNIQD 486
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
62-262 |
4.28e-19 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 91.18 E-value: 4.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 62 DCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGE 141
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 142 VdtQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKdasavhtvRCILDAAPTESLLNWQDYEG 221
Cdd:PHA02874 185 V--KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN--------RSAIELLINNASINDQDIDG 254
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 157817598 222 RTPLHFAVA-DGNLTVVDVLTsYESCNITSYDNLFRTPLHWA 262
Cdd:PHA02874 255 STPLHHAINpPCDIDIIDILL-YHKADISIKDNKGENPIDTA 295
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
85-179 |
1.57e-18 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 81.32 E-value: 1.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 85 LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDtqdkNKQTALHWSAYYNNPEH 164
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD----NGRTALHYAARSGHLEI 76
|
90
....*....|....*
gi 157817598 165 AKLLIKHDSNIGIPD 179
Cdd:pfam12796 77 VKLLLEKGADINVKD 91
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
612-877 |
1.03e-10 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 66.35 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 612 PDTDPPRPQVLPCPPSPQNEPSRQSAAPSKQPPASHTVQSPDPEQGRPAGQCPGRASHRDCSSDLQGTASRKPSESPREH 691
Cdd:PHA03307 180 EETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPR 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 692 --------CRGASAGVHPRSCEDGDSYRHQGTSSAekcRGETSGEHQRCEQGPSRARQ------PVSTGSAGPAEKGEDS 757
Cdd:PHA03307 260 papitlptRIWEASGWNGPSSRPGPASSSSSPRER---SPSPSPSSPGSGPAPSSPRAssssssSRESSSSSTSSSSESS 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 758 SPAITSASQ-RDRPRKPSkrqDGAPRSRGASQKRRTHQLRDRCSPAGSS-RPGSAKAEVARADQSSVHHDTPRnkvtqdk 835
Cdd:PHA03307 337 RGAAVSPGPsPSRSPSPS---RPPPPADPSSPRKRPRPSRAPSSPAASAgRPTRRRARAAVAGRARRRDATGR------- 406
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 157817598 836 LVGGVSSDVPLSTEELGSGCQKLYEDLCAS----------PENNVAHGP----RPG 877
Cdd:PHA03307 407 FPAGRPRPSPLDAGAASGAFYARYPLLTPSgepwpgspppPPGRVRYGGlgdsRPG 462
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
166-294 |
1.21e-08 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 58.87 E-value: 1.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 166 KLLIKHDSNIGIPDVEGKIPLHWAA--NHKDASAVhtvrcILDAAPTesLLNW----QDYEGRTPLHFAVADGNLTVVDV 239
Cdd:cd22192 35 KLLKCPSCDLFQRGALGETALHVAAlyDNLEAAVV-----LMEAAPE--LVNEpmtsDLYQGETALHIAVVNQNLNLVRE 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157817598 240 LTSYESCNIT----------SYDNLF---RTPLHWAALLGHAQIVHLLLERNKSgTVPSDSQGATPLH 294
Cdd:cd22192 108 LIARGADVVSpratgtffrpGPKNLIyygEHPLSFAACVGNEEIVRLLIEHGAD-IRAQDSLGNTVLH 174
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
291-497 |
1.36e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 55.79 E-value: 1.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 291 TPLHYAAQSNFAETVKVFLTHPSVrddsDLE-----GRTSFMWAAGKGSDDVLRTMLSLKSDIdINMA---DKYGG-TAL 361
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLKCPSC----DLFqrgalGETALHVAALYDNLEAAVVLMEAAPEL-VNEPmtsDLYQGeTAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 362 HAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLIKGGArvDLVDQD--GH 424
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLIEHGA--DIRAQDslGN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 425 SLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENnadpniqdkegRTALH 494
Cdd:cd22192 171 TVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK-----------RRHIQ 239
|
...
gi 157817598 495 WSC 497
Cdd:cd22192 240 WTY 242
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
221-275 |
5.50e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 44.57 E-value: 5.50e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 157817598 221 GRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAALLGHAQIVHLLL 275
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
900-925 |
5.65e-05 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 40.99 E-value: 5.65e-05
10 20
....*....|....*....|....*.
gi 157817598 900 RKELFRRKNKAAAVIQRAWRSYQLRK 925
Cdd:cd23767 1 EEEELQRMNRAATLIQALWRGYKVRK 26
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
215-312 |
9.50e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 46.43 E-value: 9.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 215 NWQDYEGRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAALLGHAQIVHLLlernkSGTVPSDSQG---AT 291
Cdd:PTZ00322 109 NCRDYDGRTPLHIACANGHVQVVRVLLEF-GADPTLLDKDGKTPLELAEENGFREVVQLL-----SRHSQCHFELganAK 182
|
90 100
....*....|....*....|.
gi 157817598 292 PLHYAAQSNFAETVKVFLTHP 312
Cdd:PTZ00322 183 PDSFTGKPPSLEDSPISSHHP 203
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
48-76 |
1.80e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 39.49 E-value: 1.80e-04
10 20
....*....|....*....|....*....
gi 157817598 48 GRTPLMYCVLADRLDCADALLKAGADVNK 76
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
422-451 |
3.92e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 38.72 E-value: 3.92e-04
10 20 30
....*....|....*....|....*....|
gi 157817598 422 DGHSLLHWAALGGNADVCQILIENKINPNV 451
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| PspC_subgroup_1 |
NF033838 |
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ... |
595-688 |
4.92e-04 |
|
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.
Pssm-ID: 468201 [Multi-domain] Cd Length: 684 Bit Score: 44.23 E-value: 4.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 595 KKREEENKRKEAEQK--GQPDTDPPRPQVLPCPPSPQNEPSRQSAAPSKQPPAShtvQSPDPEQGRPAGQCPGRASHRdc 672
Cdd:NF033838 396 KKAEEEAKRKAAEEDkvKEKPAEQPQPAPAPQPEKPAPKPEKPAEQPKAEKPAD---QQAEEDYARRSEEEYNRLTQQ-- 470
|
90
....*....|....*.
gi 157817598 673 ssdlQGTASRKPSESP 688
Cdd:NF033838 471 ----QPPKTEKPAQPS 482
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
553-579 |
6.86e-04 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 37.91 E-value: 6.86e-04
10 20
....*....|....*....|....*..
gi 157817598 553 AIQDIAAFKIQAVYKGYKVRKAFRDRK 579
Cdd:cd23767 6 QRMNRAATLIQALWRGYKVRKELKKKK 32
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
150-366 |
1.11e-03 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 43.15 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 150 QTALHWSAYYNNP-EHAKLLIKHDSNIgipdVEGKIPLHWAA-NHKDAsavhtvrcildaapTESLLNW--QDYEGRTPL 225
Cdd:TIGR00870 53 RSALFVAAIENENlELTELLLNLSCRG----AVGDTLLHAISlEYVDA--------------VEAILLHllAAFRKSGPL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 226 HFAVadgnltvvDVLTSYESCNITsydnlfrtPLHWAALLGHAQIVHLLLERnksgtvpsdsqGATpLHYAAQSNFaetv 305
Cdd:TIGR00870 115 ELAN--------DQYTSEFTPGIT--------ALHLAAHRQNYEIVKLLLER-----------GAS-VPARACGDF---- 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157817598 306 kvFLTHPSVrdDSDLEGRTSFMWAAGKGSDDVLRtmLSLKSDIDINMADKYGGTALHAAAL 366
Cdd:TIGR00870 163 --FVKSQGV--DSFYHGESPLNAAACLGSPSIVA--LLSEDPADILTADSLGNTLLHLLVM 217
|
|
| FAM217 |
pfam15344 |
FAM217 family; This family of proteins is found in eukaryotes. Proteins in this family are ... |
617-747 |
1.66e-03 |
|
FAM217 family; This family of proteins is found in eukaryotes. Proteins in this family are typically between 329 and 507 amino acids in length. There is a conserved YPDFLP sequence motif.
Pssm-ID: 464662 Cd Length: 234 Bit Score: 41.25 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 617 PRPQVLPCPPSPQNEPSRQSAAPSKQPpashtvQSPDPEQGRPAGQCPGRASHRDCSsdlqgtaSRKPSESPREHCRGAS 696
Cdd:pfam15344 114 ARPPTAPGTPGALKSPGSSKLIASALP------SKKLPHQEGLSKSGPSRKKEKHCE-------EHHPSYAFETHPRPSD 180
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 157817598 697 AGVHPRSCedgdSYRHqgtsSAEKCRGETSGEHQRCEQGPSRARQPVSTGS 747
Cdd:pfam15344 181 VLSSSRLC----SQKQ----SASKWRVRSEEKKKKSSKSPKLKSQPTDLSS 223
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
256-280 |
3.54e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.03 E-value: 3.54e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
270-560 |
2.67e-51 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 182.46 E-value: 2.67e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 270 IVHLLLERNKSGTVPSDSQGATPLHYAAQSNFAETVKVFLTHPSVRDDSDLEGRTSFMWAAGKGSDDVLrtMLSLKSDID 349
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 350 INMADKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 429
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 430 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 157817598 510 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 560
Cdd:COG0666 240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
335-594 |
2.04e-48 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 174.37 E-value: 2.04e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 335 DDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGA 414
Cdd:COG0666 32 LLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 494
Cdd:COG0666 112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 495 WSCNNGYLDAIKLLLDFAAFPNQMenNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKA 574
Cdd:COG0666 192 LAAENGHLEIVKLLLEAGADVNAK--DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVK 269
|
250 260
....*....|....*....|
gi 157817598 575 FRDRKNLLMKHEQLRKDAAA 594
Cdd:COG0666 270 LLLLALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
247-493 |
2.43e-44 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 162.43 E-value: 2.43e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 247 NITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTVPSDSQGATPLHYAAQSNFAETVKVFLTHPSVRDDSDLEGRTSF 326
Cdd:COG0666 45 LALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 327 MWAAGKGSDDVLRtMLsLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVI 406
Cdd:COG0666 125 HLAAYNGNLEIVK-LL-LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 407 QTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 486
Cdd:COG0666 203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
|
....*..
gi 157817598 487 KEGRTAL 493
Cdd:COG0666 283 LDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
19-240 |
1.18e-36 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 140.09 E-value: 1.18e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 19 HAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMK 98
Cdd:COG0666 58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 99 LLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfmAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIP 178
Cdd:COG0666 138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE--AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157817598 179 DVEGKIPLHWAANHKDASAVHtvrcILDAAptESLLNWQDYEGRTPLHFAVADGNLTVVDVL 240
Cdd:COG0666 216 DNDGKTALDLAAENGNLEIVK----LLLEA--GADLNAKDKDGLTALLLAAAAGAALIVKLL 271
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
33-324 |
5.90e-35 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 135.47 E-value: 5.90e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 33 LIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDL 112
Cdd:COG0666 6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 113 EEMTPLHLSTRHRSPKCLALLLKfmAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANH 192
Cdd:COG0666 86 GGNTLLHAAARNGDLEIVKLLLE--AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 193 KDasaVHTVRCILDAAPTeslLNWQDYEGRTPLHFAVADGNLTVVDVLTSYEScNITSYDNLFRTPLHWAALLGHAQIVH 272
Cdd:COG0666 164 GN---LEIVKLLLEAGAD---VNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVK 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 157817598 273 LLLERNKSGTvPSDSQGATPLHYAAQSNFAETVKVFLTHPSVRDDSDLEGRT 324
Cdd:COG0666 237 LLLEAGADLN-AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
64-355 |
1.15e-32 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 128.53 E-value: 1.15e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 64 ADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPgeVD 143
Cdd:COG0666 4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGAD--IN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 144 TQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDasaVHTVRCILDA-APteslLNWQDYEGR 222
Cdd:COG0666 82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN---LEIVKLLLEAgAD----VNAQDNDGN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 223 TPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTVPsDSQGATPLHYAAQSNFA 302
Cdd:COG0666 155 TPLHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK-DNDGKTALDLAAENGNL 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 157817598 303 ETVKVFLTHPSVRDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Cdd:COG0666 233 EIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
19-186 |
1.76e-23 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 101.95 E-value: 1.76e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 19 HAAAVNGDKGALQRLIvGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMK 98
Cdd:COG0666 125 HLAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVK 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 99 LLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIP 178
Cdd:COG0666 204 LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA--DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281
|
....*...
gi 157817598 179 DVEGKIPL 186
Cdd:COG0666 282 LLDLLTLL 289
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
336-554 |
2.59e-22 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 100.89 E-value: 2.59e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 336 DVLRTMLslKSDIDINMADKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 408
Cdd:PHA03100 49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 409 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 486
Cdd:PHA03100 127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157817598 487 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 554
Cdd:PHA03100 190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
394-486 |
6.48e-22 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 90.95 E-value: 6.48e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 394 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 473
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 157817598 474 VLMENNADPNIQD 486
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
427-518 |
8.27e-22 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 90.56 E-value: 8.27e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 427 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEnNADPNIQDkEGRTALHWSCNNGYLDAIK 506
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|..
gi 157817598 507 LLLDFAAFPNQM 518
Cdd:pfam12796 79 LLLEKGADINVK 90
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
361-453 |
6.31e-21 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 88.25 E-value: 6.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 361 LHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKgGARVDLVDqDGHSLLHWAALGGNADVCQ 440
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 157817598 441 ILIENKINPNVQD 453
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
214-548 |
2.17e-19 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 93.97 E-value: 2.17e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 214 LNWQDYEGRTPLHFAVADGNLTVVDVLTSYES-CNITSYD-------------------------NLFRTPLHWAALLGH 267
Cdd:PHA02876 171 VNAKDIYCITPIHYAAERGNAKMVNLLLSYGAdVNIIALDdlsvlecavdsknidtikaiidnrsNINKNDLSLLKAIRN 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 268 AQIVHLLLERNKSGTVPS-DSQGATPLHYAAQS-NFAETVKVFLTHPSVRDDSDLEGRTSFMWAAGKGSD-DVLRTMLSL 344
Cdd:PHA02876 251 EDLETSLLLYDAGFSVNSiDDCKNTPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDtENIRTLIML 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 345 KSDIdiNMADKYGGTALH-AAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDG 423
Cdd:PHA02876 331 GADV--NAADRLYITPLHqASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKI 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 424 HSLLHWAALGGNAdvcqilienkinpnvqdyagrtplqcaayggYINcMAVLMENNADPNIQDKEGRTALHWSC-NNGYL 502
Cdd:PHA02876 409 GTALHFALCGTNP-------------------------------YMS-VKTLIDRGANVNSKNKDLSTPLHYACkKNCKL 456
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 157817598 503 DAIKLLLDFAAFPNQMeNNEERYtPLDYALlgERHEVIQFMLEHGA 548
Cdd:PHA02876 457 DVIEMLLDNGADVNAI-NIQNQY-PLLIAL--EYHGIVNILLHYGA 498
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
293-387 |
3.22e-19 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 83.24 E-value: 3.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 293 LHYAAQSNFAETVKVFLTHPSVRDDSDLEGRTSFMWAAGKGSDDVLRTMLSLksdIDINMADkYGGTALHAAALSGHVST 372
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKD-NGRTALHYAARSGHLEI 76
|
90
....*....|....*
gi 157817598 373 VKLLLDNDAQVDATD 387
Cdd:pfam12796 77 VKLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
460-548 |
3.28e-19 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 83.24 E-value: 3.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 460 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFpnqmENNEERYTPLDYALLGERHEV 539
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV----NLKDNGRTALHYAARSGHLEI 76
|
....*....
gi 157817598 540 IQFMLEHGA 548
Cdd:pfam12796 77 VKLLLEKGA 85
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
62-262 |
4.28e-19 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 91.18 E-value: 4.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 62 DCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGE 141
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 142 VdtQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKdasavhtvRCILDAAPTESLLNWQDYEG 221
Cdd:PHA02874 185 V--KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN--------RSAIELLINNASINDQDIDG 254
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 157817598 222 RTPLHFAVA-DGNLTVVDVLTsYESCNITSYDNLFRTPLHWA 262
Cdd:PHA02874 255 STPLHHAINpPCDIDIIDILL-YHKADISIKDNKGENPIDTA 295
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
59-416 |
6.48e-19 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 92.43 E-value: 6.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 59 DRLDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKfma 138
Cdd:PHA02876 156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID--- 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 139 pgevDTQDKNKQTALHWSAYYNNPEHAKLLIkHDSNIGIP--DVEGKIPLHWAANHKDASavhtvRCILDAAPTESLLNW 216
Cdd:PHA02876 233 ----NRSNINKNDLSLLKAIRNEDLETSLLL-YDAGFSVNsiDDCKNTPLHHASQAPSLS-----RLVPKLLERGADVNA 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 217 QDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAALLG-HAQIVHLLLERNkSGTVPSDSQGATPLHY 295
Cdd:PHA02876 303 KNIKGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELG-ANVNARDYCDKTPIHY 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 296 AAQSNFAETVKVFLTHpsvrdDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDID----INMADKYGGTALHAAALSG-HV 370
Cdd:PHA02876 382 AAVRNNVVIINTLLDY-----GADIEALSQKIGTALHFALCGTNPYMSVKTLIDrganVNSKNKDLSTPLHYACKKNcKL 456
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 157817598 371 STVKLLLDNDAQVDATDVMKHTPLFRAceMGHRDVIQTLIKGGARV 416
Cdd:PHA02876 457 DVIEMLLDNGADVNAINIQNQYPLLIA--LEYHGIVNILLHYGAEL 500
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
85-179 |
1.57e-18 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 81.32 E-value: 1.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 85 LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDtqdkNKQTALHWSAYYNNPEH 164
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD----NGRTALHYAARSGHLEI 76
|
90
....*....|....*
gi 157817598 165 AKLLIKHDSNIGIPD 179
Cdd:pfam12796 77 VKLLLEKGADINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
252-495 |
6.87e-18 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 87.77 E-value: 6.87e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 252 DNLFRTPLHwaaLLGH------AQIVHLLLERNKSGTVPsDSQGATPLHYAAQsnFAETVkvflthpsvrddsdlegrts 325
Cdd:PHA03095 44 GEYGKTPLH---LYLHyssekvKDIVRLLLEAGADVNAP-ERCGFTPLHLYLY--NATTL-------------------- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 326 fmwaagkgsdDVLRTMLSLKSDIdiNMADKYGGTALHAAaLSG---HVSTVKLLLDNDAQVDATDVMKHTPL-----FRA 397
Cdd:PHA03095 98 ----------DVIKLLIKAGADV--NAKDKVGRTPLHVY-LSGfniNPKVIRLLLRKGADVNALDLYGMTPLavllkSRN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 398 CEMghrDVIQTLIKGGARVDLVDQDGHSLLHWAALG--GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGyiNCMAVL 475
Cdd:PHA03095 165 ANV---ELLRLLIDAGADVYAVDDRFRSLLHHHLQSfkPRARIVRELIRAGCDPAATDMLGNTPLHSMATGS--SCKRSL 239
|
250 260
....*....|....*....|....
gi 157817598 476 M----ENNADPNIQDKEGRTALHW 495
Cdd:PHA03095 240 VlpllIAGISINARNRYGQTPLHY 263
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
32-315 |
1.57e-17 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 87.00 E-value: 1.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 32 RLIVGNSALKDKEDQFGRTPLMYCV---LADRLDCADALLKAGADVNKTDHSRRTALHLAAQKGN-YRFMKLLLTRRANW 107
Cdd:PHA03095 31 RRLLAAGADVNFRGEYGKTPLHLYLhysSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADV 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 108 MQKDLEEMTPLH--LSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHwsAYYN----NPEHAKLLIKHDSNIGIPDVE 181
Cdd:PHA03095 111 NAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGA--DVNALDLYGMTPLA--VLLKsrnaNVELLRLLIDAGADVYAVDDR 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 182 GKIPLHWAAN--HKDASAVHT-VRCILDAAPTESLlnwqdyeGRTPLHFAVADG---NLTVVDVLTSYESCNITsyDNLF 255
Cdd:PHA03095 187 FRSLLHHHLQsfKPRARIVRElIRAGCDPAATDML-------GNTPLHSMATGSsckRSLVLPLLIAGISINAR--NRYG 257
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157817598 256 RTPLHWAALLGHAQIVHLLLERNKSGTVPSDSqGATPLHYAAQSNFAETVKVFL-THPSVR 315
Cdd:PHA03095 258 QTPLHYAAVFNNPRACRRLIALGADINAVSSD-GNTPLSLMVRNNNGRAVRAALaKNPSAE 317
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
120-421 |
5.30e-17 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 84.72 E-value: 5.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 120 LSTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKdasavh 199
Cdd:PHA03100 6 VLTKSRIIKVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIK------ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 200 tvrcildaaptesllnwqdyegrtplhfAVADGNLTVVDVLTSYEScNITSYDNLFRTPLHWAA--LLGHAQIVHLLLER 277
Cdd:PHA03100 80 ----------------------------YNLTDVKEIVKLLLEYGA-NVNAPDNNGITPLLYAIskKSNSYSIVEYLLDN 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 278 NKSgTVPSDSQGATPLHYAAQSNFAET--VKVFLTHpsvrdDSDLEGRTSFmwaagkgsdDVLrtmlsLKSDIDINMADK 355
Cdd:PHA03100 131 GAN-VNIKNSDGENLLHLYLESNKIDLkiLKLLIDK-----GVDINAKNRV---------NYL-----LSYGVPINIKDV 190
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157817598 356 YGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQ 421
Cdd:PHA03100 191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
211-448 |
6.68e-16 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 81.25 E-value: 6.68e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 211 ESLLNWQDYEGRTPLHFAVADGNLTVVDVLTsYESCNITSYDNLFRTPLHWAALLGHAQ-----IVHLLLERNKSGTVPs 285
Cdd:PHA03100 25 DDLNDYSYKKPVLPLYLAKEARNIDVVKILL-DNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAP- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 286 DSQGATPLHYAAQ--SNFAETVKVFLTHPSVRDDSDLEGRTSFMWAAGKGSDD--VLRTMLslKSDIDINMADKyggtal 361
Cdd:PHA03100 103 DNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLI--DKGVDINAKNR------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 362 haaalsghvstVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
Cdd:PHA03100 175 -----------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKL 243
|
....*..
gi 157817598 442 LIENKIN 448
Cdd:PHA03100 244 LLNNGPS 250
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
225-311 |
1.38e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 72.84 E-value: 1.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 225 LHFAVADGNLTVVDVLTSYEsCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGtvpSDSQGATPLHYAAQSNFAET 304
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARSGHLEI 76
|
....*..
gi 157817598 305 VKVFLTH 311
Cdd:pfam12796 77 VKLLLEK 83
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
52-146 |
2.52e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 72.07 E-value: 2.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 52 LMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQkdLEEMTPLHLSTRHRSPKCLA 131
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK--DNGRTALHYAARSGHLEIVK 78
|
90
....*....|....*
gi 157817598 132 LLLKFMApgEVDTQD 146
Cdd:pfam12796 79 LLLEKGA--DINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
19-111 |
2.94e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 72.07 E-value: 2.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 19 HAAAVNGDKGALQRLIVGNSAlKDKEDQFGRTPLMYCVLADRLDCADALLKaGADVNKTDHsRRTALHLAAQKGNYRFMK 98
Cdd:pfam12796 2 HLAAKNGNLELVKLLLENGAD-ANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 157817598 99 LLLTRRANWMQKD 111
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
344-548 |
4.19e-15 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 79.30 E-value: 4.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 344 LKSDIDINMADKYGGTALHAAALSGH---VSTVKLLLDNDAQVDATDVMKHTPLFraCEMGH---RDVIQTLIKGGARVD 417
Cdd:PHA03095 34 LAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLH--LYLYNattLDVIKLLIKAGADVN 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 418 LVDQDGHSLLHwAALGG---NADVCQILIENKINPNVQDYAGRTPLqcAAYGGYINC----MAVLMENNADPNIQDKEGR 490
Cdd:PHA03095 112 AKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDAGADVYAVDDRFR 188
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 491 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE--RHEVIQFMLEHGA 548
Cdd:PHA03095 189 SLLHHHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGI 248
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
215-451 |
5.20e-15 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 78.49 E-value: 5.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 215 NWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLfRTPLHWAALLGHAQIVHLLLERNKSGTVPSDSQGATPLH 294
Cdd:PHA02875 29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDI-ESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLH 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 295 YAAQSNfaetvKVflthpsvrddsdlegrtsfmwaagkgsdDVLRTMLSLKSDIDINMADKYggTALHAAALSGHVSTVK 374
Cdd:PHA02875 108 LATILK-----KL----------------------------DIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDIKGIE 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157817598 375 LLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGH-SLLHWAALGGNADVCQILIENKINPNV 451
Cdd:PHA02875 153 LLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADCNI 230
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
166-460 |
3.17e-14 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 76.60 E-value: 3.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 166 KLLIKHDSNIGIPDVEGKIPLHWAANHKDASAVHTVRCILDAApteSLLNWQDYEGRTPLHFAVADGN-LTVVDVLTSYe 244
Cdd:PHA03095 31 RRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLLEAG---ADVNAPERCGFTPLHLYLYNATtLDVIKLLIKA- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 245 SCNITSYDNLFRTPLHwAALLG---HAQIVHLLLERNKSGTVpSDSQGATPLHyaaqsnfaetvkVFLTHPSVrddsdle 321
Cdd:PHA03095 107 GADVNAKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNA-LDLYGMTPLA------------VLLKSRNA------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 322 grtsfmwaagkgSDDVLRTMLslKSDIDINMADKYGGTALHAAALSGHVST--VKLLLDNDAQVDATDVMKHTPLFRACE 399
Cdd:PHA03095 166 ------------NVELLRLLI--DAGADVYAVDDRFRSLLHHHLQSFKPRAriVRELIRAGCDPAATDMLGNTPLHSMAT 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157817598 400 MG--HRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPL 460
Cdd:PHA03095 232 GSscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
370-548 |
3.49e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 75.86 E-value: 3.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 370 VSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAA-----LGGNADVCQILIE 444
Cdd:PHA03100 15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikynLTDVKEIVKLLLE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 445 NKINPNVQDYAGRTPLQCAAYG--GYINCMAVLMENNADPNIQDKEGRTALHW--SCNNGYLDAIKLLLDFAAFPNQMEN 520
Cdd:PHA03100 95 YGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLylESNKIDLKILKLLIDKGVDINAKNR 174
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 157817598 521 --------------NEERYTPLDYALLGERHEVIQFMLEHGA 548
Cdd:PHA03100 175 vnyllsygvpinikDVYGFTPLHYAVYNNNPEFVKYLLDLGA 216
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
224-493 |
3.64e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 76.46 E-value: 3.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 224 PLHFAVADGNLTVVDVLTSyESCNITSYDNLFRTPLHWAALLGHAQ-IVHLLLERNKSGTVPSDSQGATPLHYaaqsNFA 302
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLT-RGHNVNQPDHRDLTPLHIICKEPNKLgMKEMIRSINKCSVFYTLVAIKDAFNN----RNV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 303 ETVKVFLT--HPSVRDDSDLEGRTsfmwaagKGSDDVLRTM---LSLKSDIDINMADKYGG-TALHAAALSGHVSTVKLL 376
Cdd:PHA02878 115 EIFKIILTnrYKNIQTIDLVYIDK-------KSKDDIIEAEitkLLLSYGADINMKDRHKGnTALHYATENKDQRLTELL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 377 LDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWA-ALGGNADVCQILIENKINPNVQDYA 455
Cdd:PHA02878 188 LSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSYI 267
|
250 260 270
....*....|....*....|....*....|....*....
gi 157817598 456 -GRTPLQCAAYGGYIncMAVLMENNADPNIQDKEGRTAL 493
Cdd:PHA02878 268 lGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPL 304
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
153-252 |
3.93e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 68.99 E-value: 3.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 153 LHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDasaVHTVRCILDAAPTESllnwqDYEGRTPLHFAVADG 232
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGH---LEIVKLLLEHADVNL-----KDNGRTALHYAARSG 72
|
90 100
....*....|....*....|
gi 157817598 233 NLTVVDVLTSYEsCNITSYD 252
Cdd:pfam12796 73 HLEIVKLLLEKG-ADINVKD 91
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
361-529 |
4.00e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 75.80 E-value: 4.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 361 LHAAALSGHVSTVKLLLDNDAQVDatDVM---KHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 437
Cdd:PHA02875 72 LHDAVEEGDVKAVEELLDLGKFAD--DVFykdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 438 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR-TALHWSCNNGYLDAIKLLLDFAAFPN 516
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADCN 229
|
170
....*....|....
gi 157817598 517 QMENNE-ERYTPLD 529
Cdd:PHA02875 230 IMFMIEgEECTILD 243
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
257-532 |
4.45e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 75.77 E-value: 4.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 257 TPLHWAALLGHAQIVHLLLernKSGTVPS--DSQGATPLHYAAQSNFAETVKVFLTH---PSVRDDSDLEgrtsfmwaag 331
Cdd:PHA02874 37 TPLIDAIRSGDAKIVELFI---KHGADINhiNTKIPHPLLTAIKIGAHDIIKLLIDNgvdTSILPIPCIE---------- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 332 kgsDDVLRTMLslKSDIDINMADKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 411
Cdd:PHA02874 104 ---KDMIKTIL--DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 412 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYggYINCMAVLMENNADPNIQDKEGRT 491
Cdd:PHA02874 179 KGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGST 256
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 157817598 492 ALHWSCNNG-YLDAIKLLLDFAAFPNQMENNEEryTPLDYAL 532
Cdd:PHA02874 257 PLHHAINPPcDIDIIDILLYHKADISIKDNKGE--NPIDTAF 296
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
350-557 |
6.92e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 75.00 E-value: 6.92e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 350 INMADKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMG-----------------------HRDVI 406
Cdd:PHA02874 28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGahdiikllidngvdtsilpipciEKDMI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 407 QTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 486
Cdd:PHA02874 108 KTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKD 187
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157817598 487 KEGRTALHWSCNNGYLDAIKLLLDFAAfpNQMENNEERYTPLDYALLGERhEVIQFMLEHGALSiaaIQDI 557
Cdd:PHA02874 188 NNGESPLHNAAEYGDYACIKLLIDHGN--HIMNKCKNGFTPLHNAIIHNR-SAIELLINNASIN---DQDI 252
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
186-278 |
8.24e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 67.83 E-value: 8.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 186 LHWAANHKDASAVHT-VRCILDAaptesllNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDnlfRTPLHWAAL 264
Cdd:pfam12796 1 LHLAAKNGNLELVKLlLENGADA-------NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNG---RTALHYAAR 70
|
90
....*....|....
gi 157817598 265 LGHAQIVHLLLERN 278
Cdd:pfam12796 71 SGHLEIVKLLLEKG 84
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
17-201 |
1.27e-13 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 74.68 E-value: 1.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 17 QVHAAAVNGDKGALQRLIVGNSALKDKeDQFGRTPLMycVLADRLDCADALLK----AGADVNKTDHSRRTALHLAAQ-- 90
Cdd:PHA03095 122 HVYLSGFNINPKVIRLLLRKGADVNAL-DLYGMTPLA--VLLKSRNANVELLRllidAGADVYAVDDRFRSLLHHHLQsf 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 91 KGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLaLLLKFMAPG-EVDTQDKNKQTALHWSAYYNNPEHAKLLI 169
Cdd:PHA03095 199 KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRS-LVLPLLIAGiSINARNRYGQTPLHYAAVFNNPRACRRLI 277
|
170 180 190
....*....|....*....|....*....|..
gi 157817598 170 KHDSNIGIPDVEGKIPLHWAANHKDASAVHTV 201
Cdd:PHA03095 278 ALGADINAVSSDGNTPLSLMVRNNNGRAVRAA 309
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
92-477 |
7.92e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 71.92 E-value: 7.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 92 GNYRFMKLLLTRRANWMQKDLEE-MTPLHLSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHWSAYYNNPEHAKLLIK 170
Cdd:PHA02874 12 GDIEAIEKIIKNKGNCINISVDEtTTPLIDAIRSGDAKIVELFIKHGA--DINHINTKIPHPLLTAIKIGAHDIIKLLID 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 171 H--DSNI-GIPDVEGKiplhwaanhkdasavhTVRCILDAAPTeslLNWQDYEGRTPLHFAVADGNLTVVDVLTSYES-C 246
Cdd:PHA02874 90 NgvDTSIlPIPCIEKD----------------MIKTILDCGID---VNIKDAELKTFLHYAIKKGDLESIKMLFEYGAdV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 247 NItsydnlfrtplhwaallghaqivhlllernksgtvpSDSQGATPLHYAAQSNFAETVKVFLThpsvrddsdlegrtsf 326
Cdd:PHA02874 151 NI------------------------------------EDDNGCYPIHIAIKHNFFDIIKLLLE---------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 327 mwaagKGSddvlrtmlslksdiDINMADKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACeMGHRDVI 406
Cdd:PHA02874 179 -----KGA--------------YANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI-IHNRSAI 238
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157817598 407 QTLIKgGARVDLVDQDGHSLLHWA-ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAygGYINCMAVLME 477
Cdd:PHA02874 239 ELLIN-NASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAF--KYINKDPVIKD 307
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
61-366 |
3.72e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 69.91 E-value: 3.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 61 LDCADALLKAGADVNKTDHSRRTA-------LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHrsPKCLAll 133
Cdd:PHA02878 10 TDNYETILKYIEYIDHTENYSTSAslipfipLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKE--PNKLG-- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLI--KHDSNIGIPDVEGKiplhwAANHKDASAVHTVRCILDAAPTE 211
Cdd:PHA02878 86 MKEMIRSINKCSVFYTLVAIKDAFNNRNVEIFKIILtnRYKNIQTIDLVYID-----KKSKDDIIEAEITKLLLSYGADI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 212 SLLNwqDYEGRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAALLGHAQIVHLLLeRNKSGTVPSDSQGAT 291
Cdd:PHA02878 161 NMKD--RHKGNTALHYATENKDQRLTELLLSY-GANVNIPDKTNNSPLHHAVKHYNKPIVHILL-ENGASTDARDKCGNT 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157817598 292 PLHYAAQSNFA-ETVKVFLTH-PSVRDDSDLEGRTSFMWAAgkGSDDVLRTMLSLKSdiDINMADKYGGTALHAAAL 366
Cdd:PHA02878 237 PLHISVGYCKDyDILKLLLEHgVDVNAKSYILGLTALHSSI--KSERKLKLLLEYGA--DINSLNSYKLTPLSSAVK 309
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
612-877 |
1.03e-10 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 66.35 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 612 PDTDPPRPQVLPCPPSPQNEPSRQSAAPSKQPPASHTVQSPDPEQGRPAGQCPGRASHRDCSSDLQGTASRKPSESPREH 691
Cdd:PHA03307 180 EETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPR 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 692 --------CRGASAGVHPRSCEDGDSYRHQGTSSAekcRGETSGEHQRCEQGPSRARQ------PVSTGSAGPAEKGEDS 757
Cdd:PHA03307 260 papitlptRIWEASGWNGPSSRPGPASSSSSPRER---SPSPSPSSPGSGPAPSSPRAssssssSRESSSSSTSSSSESS 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 758 SPAITSASQ-RDRPRKPSkrqDGAPRSRGASQKRRTHQLRDRCSPAGSS-RPGSAKAEVARADQSSVHHDTPRnkvtqdk 835
Cdd:PHA03307 337 RGAAVSPGPsPSRSPSPS---RPPPPADPSSPRKRPRPSRAPSSPAASAgRPTRRRARAAVAGRARRRDATGR------- 406
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 157817598 836 LVGGVSSDVPLSTEELGSGCQKLYEDLCAS----------PENNVAHGP----RPG 877
Cdd:PHA03307 407 FPAGRPRPSPLDAGAASGAFYARYPLLTPSgepwpgspppPPGRVRYGGlgdsRPG 462
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
49-212 |
1.25e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 64.69 E-value: 1.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 49 RTPLMYC-----VLADRLDCADALLKAGADVNKTDHSRRTALHLAAQK--GNYRFMKLLLTRRANWMQKDLEEMTPLHLS 121
Cdd:PHA03100 69 STPLHYLsnikyNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLY 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 122 TRHRSPKC------------------LALLLKFMAPgeVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGK 183
Cdd:PHA03100 149 LESNKIDLkilkllidkgvdinaknrVNYLLSYGVP--INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGD 226
|
170 180 190
....*....|....*....|....*....|.
gi 157817598 184 IPLHWAA--NHKDasavhTVRCILDAAPTES 212
Cdd:PHA03100 227 TPLHIAIlnNNKE-----IFKLLLNNGPSIK 252
|
|
| PHA02798 |
PHA02798 |
ankyrin-like protein; Provisional |
370-529 |
1.89e-10 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222931 [Multi-domain] Cd Length: 489 Bit Score: 64.47 E-value: 1.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 370 VSTVKLLLdndAQVDATDVMKHTPLFRacEMGHR-----DVIQTLIKGGARVDLVDQDGHS-----LLHWAALGGNADVC 439
Cdd:PHA02798 18 LSTVKLLI---KSCNPNEIVNEYSIFQ--KYLQRdspstDIVKLFINLGANVNGLDNEYSTplctiLSNIKDYKHMLDIV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL---MENNADPNIQDKEGRTALH---WSCNNGYLDAIKLLLDFAA 513
Cdd:PHA02798 93 KILIENGADINKKNSDGETPLYCLLSNGYINNLEILlfmIENGADTTLLDKDGFTMLQvylQSNHHIDIEIIKLLLEKGV 172
|
170
....*....|....*.
gi 157817598 514 FPNQMeNNEERYTPLD 529
Cdd:PHA02798 173 DINTH-NNKEKYDTLH 187
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
262-477 |
2.04e-10 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 64.89 E-value: 2.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 262 AALLGHAQIVHLLLERNKSGTVpSDSQGATPLHYAAQSNFAETVKVFLTHPSVRDDSDLEGRTSfMW------------- 328
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDI-GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTA-LWnaisakhhkifri 609
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 329 -------------------AAGKGSDDVLRTMLslKSDIDINMADKYGGTALHAAALSGHVSTVKLLLDNDAQVDAT--- 386
Cdd:PLN03192 610 lyhfasisdphaagdllctAAKRNDLTAMKELL--KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAntd 687
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 387 DVMKHTPLFRAC---EMGHRDVIqtlikggarVDLVDQDgHSLLHWAALGGNADVCQILIENKINPNVQDYAG----RTP 459
Cdd:PLN03192 688 DDFSPTELRELLqkrELGHSITI---------VDSVPAD-EPDLGRDGGSRPGRLQGTSSDNQCRPRVSIYKGhpllRNE 757
|
250
....*....|....*...
gi 157817598 460 LQCAAYGGYINCMAVLME 477
Cdd:PLN03192 758 RCCNEAGKLINLPPSLEE 775
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
16-175 |
4.32e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 63.09 E-value: 4.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLAAQKGNYR 95
Cdd:PHA02875 70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 96 FMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHWSAYYNN-PEHAKLLIKH--D 172
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA--NIDYFGKNGCVAALCYAIENNkIDIVRLFIKRgaD 227
|
...
gi 157817598 173 SNI 175
Cdd:PHA02875 228 CNI 230
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
423-475 |
4.35e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 56.13 E-value: 4.35e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 157817598 423 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
357-410 |
6.31e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 55.74 E-value: 6.31e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157817598 357 GGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLI 410
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
48-101 |
1.12e-09 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 54.97 E-value: 1.12e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157817598 48 GRTPLMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLL 101
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
456-509 |
1.31e-09 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 54.59 E-value: 1.31e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157817598 456 GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
316-481 |
4.20e-09 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 60.65 E-value: 4.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDInmADKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLF 395
Cdd:PLN03192 519 EHDDPNMASNLLTVASTGNAALLEELLKAKLDPDI--GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 396 RACEMGHRDVIQTLIKGGARVDlvDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475
Cdd:PLN03192 597 NAISAKHHKIFRILYHFASISD--PHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLL 674
|
....*.
gi 157817598 476 MENNAD 481
Cdd:PLN03192 675 IMNGAD 680
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
34-280 |
5.35e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 59.68 E-value: 5.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 34 IVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLAAQ-----KGNYRFMKLLLTRRANWM 108
Cdd:PHA03100 21 IIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNikynlTDVKEIVKLLLEYGANVN 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 109 QKDLEEMTPLH--LSTRHRSPKCLALLLKFMApgevDTQDKNK--QTALHWSAYYNNPEH--AKLLIKHDSNIgipdveg 182
Cdd:PHA03100 101 APDNNGITPLLyaISKKSNSYSIVEYLLDNGA----NVNIKNSdgENLLHLYLESNKIDLkiLKLLIDKGVDI------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 183 kiplhwaaNHKDasavhTVRCILDAApteSLLNWQDYEGRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWA 262
Cdd:PHA03100 170 --------NAKN-----RVNYLLSYG---VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDL-GANPNLVNKYGDTPLHIA 232
|
250
....*....|....*...
gi 157817598 263 ALLGHAQIVHLLLERNKS 280
Cdd:PHA03100 233 ILNNNKEIFKLLLNNGPS 250
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
322-377 |
5.48e-09 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 53.05 E-value: 5.48e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 157817598 322 GRTSFMWAAGKGSDDVLRTMLSLKsdIDINMADKYGGTALHAAALSGHVSTVKLLL 377
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKG--ADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
335-558 |
6.13e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 60.08 E-value: 6.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 335 DDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGA 414
Cdd:PHA02876 156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 415 RV---DL--------VDQDGHSLLHWAALGGNA-DVCQ------------------ILIENKINPNVQDYAGRTPLQCAA 464
Cdd:PHA02876 236 NInknDLsllkairnEDLETSLLLYDAGFSVNSiDDCKntplhhasqapslsrlvpKLLERGADVNAKNIKGETPLYLMA 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 465 YGGY-INCMAVLMENNADPNIQDKEGRTALHWSCN-NGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQF 542
Cdd:PHA02876 316 KNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDK--TPIHYAAVRNNVVIINT 393
|
250
....*....|....*.
gi 157817598 543 MLEHGALSIAAIQDIA 558
Cdd:PHA02876 394 LLDYGADIEALSQKIG 409
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
426-509 |
6.77e-09 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 59.91 E-value: 6.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 426 LLHWAAlGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAI 505
Cdd:PTZ00322 86 LCQLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV 164
|
....
gi 157817598 506 KLLL 509
Cdd:PTZ00322 165 QLLS 168
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
360-548 |
7.06e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 59.23 E-value: 7.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 360 ALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA-DV 438
Cdd:PHA02875 5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVkAV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 439 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqM 518
Cdd:PHA02875 85 EELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLD-I 163
|
170 180 190
....*....|....*....|....*....|
gi 157817598 519 ENNEErYTPLDYALLGERHEVIQFMLEHGA 548
Cdd:PHA02875 164 EDCCG-CTPLIIAMAKGDIAICKMLLDSGA 192
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
474-546 |
8.61e-09 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 59.53 E-value: 8.61e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157817598 474 VLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQFMLEH 546
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK--TPLELAEENGFREVVQLLSRH 170
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
612-830 |
1.01e-08 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 59.80 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 612 PDTDPPRPQVLPCPPSPQNEPSRQSAAPSKQPP--ASHTVQSPDP----EQGRPAGQCPGRASH-RDCSSDLQGTASRKP 684
Cdd:PHA03307 128 PSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAavASDAASSRQAalplSSPEETARAPSSPPAePPPSTPPAAASPRPP 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 685 SESPREHCRGASAGvhPRSCEDGDSYRHQGTSSAEKCRGETSGEHQRCEQGPSRARQPVSTGSAGPAEKGEDSSPAITSA 764
Cdd:PHA03307 208 RRSSPISASASSPA--PAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPA 285
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157817598 765 SQRDRPRKPS-KRQDGAPRSRGASQKRRT--HQLRDRCSPAGSSRPGSAKAEVARADQSSVHHDTPRNK 830
Cdd:PHA03307 286 SSSSSPRERSpSPSPSSPGSGPAPSSPRAssSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS 354
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
222-400 |
1.10e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 58.46 E-value: 1.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 222 RTPLHFAVADGNLTVVDVLTSYEscniTSYDNLF----RTPLHWAALLGHAQIVHLLLERNKSGTVPSDSQgATPLHYAA 297
Cdd:PHA02875 69 ESELHDAVEEGDVKAVEELLDLG----KFADDVFykdgMTPLHLATILKKLDIMKLLIARGADPDIPNTDK-FSPLHLAV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 298 QSNFAETVKVFLTHPSVRDDSDLEGRTSFMWAAGKGSDDVLRTMLSlkSDIDINMADKYGGTALHAAALSGH-VSTVKLL 376
Cdd:PHA02875 144 MMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD--SGANIDYFGKNGCVAALCYAIENNkIDIVRLF 221
|
170 180
....*....|....*....|....*..
gi 157817598 377 LDNDAQVD-ATDVM--KHTPLFRACEM 400
Cdd:PHA02875 222 IKRGADCNiMFMIEgeECTILDMICNM 248
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
166-294 |
1.21e-08 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 58.87 E-value: 1.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 166 KLLIKHDSNIGIPDVEGKIPLHWAA--NHKDASAVhtvrcILDAAPTesLLNW----QDYEGRTPLHFAVADGNLTVVDV 239
Cdd:cd22192 35 KLLKCPSCDLFQRGALGETALHVAAlyDNLEAAVV-----LMEAAPE--LVNEpmtsDLYQGETALHIAVVNQNLNLVRE 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157817598 240 LTSYESCNIT----------SYDNLF---RTPLHWAALLGHAQIVHLLLERNKSgTVPSDSQGATPLH 294
Cdd:cd22192 108 LIARGADVVSpratgtffrpGPKNLIyygEHPLSFAACVGNEEIVRLLIEHGAD-IRAQDSLGNTVLH 174
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
48-248 |
1.62e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 58.08 E-value: 1.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 48 GRTPLMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTrrANWMQKDL---EEMTPLHLSTRH 124
Cdd:PHA02875 35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLD--LGKFADDVfykDGMTPLHLATIL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 125 RSPKCLALLLKFMAPGEVDTQDKNkqTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDasaVHTVRCI 204
Cdd:PHA02875 113 KKLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGD---IAICKML 187
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 157817598 205 LDAAPTesllnwQDYEGRTP----LHFAVADGNLTVVDVLTSYES-CNI 248
Cdd:PHA02875 188 LDSGAN------IDYFGKNGcvaaLCYAIENNKIDIVRLFIKRGAdCNI 230
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
18-189 |
2.00e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 58.05 E-value: 2.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQfGRTPLMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFM 97
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYGADVNIEDDN-GCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACI 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 98 KLLLTRRANWMQKDLEEMTPLHLSTRH-RSpkCLALLLKfmaPGEVDTQDKNKQTALHWSAYYN-NPEHAKLLIKHDSNI 175
Cdd:PHA02874 207 KLLIDHGNHIMNKCKNGFTPLHNAIIHnRS--AIELLIN---NASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADI 281
|
170
....*....|....
gi 157817598 176 GIPDVEGKIPLHWA 189
Cdd:PHA02874 282 SIKDNKGENPIDTA 295
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
430-516 |
8.69e-08 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 56.41 E-value: 8.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 430 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611
|
....*..
gi 157817598 510 DFAAFPN 516
Cdd:PLN03192 612 HFASISD 618
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
292-548 |
1.20e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 55.66 E-value: 1.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 292 PLHYAAQSNFAETVKVFLTHPSVRDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHaaalSGHVS 371
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAFN----NRNVE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 372 TVKLLLDNDAQVDATDVMKHTplfraCEMGHRDVIQT-----LIKGGARVDLVDQD-GHSLLHWAALGGNADVCQILIEN 445
Cdd:PHA02878 116 IFKIILTNRYKNIQTIDLVYI-----DKKSKDDIIEAeitklLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSY 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 446 KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCnnGYLdaikllldfaafpnqmenneery 525
Cdd:PHA02878 191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYC----------------------- 245
|
250 260
....*....|....*....|...
gi 157817598 526 tpLDYallgerhEVIQFMLEHGA 548
Cdd:PHA02878 246 --KDY-------DILKLLLEHGV 259
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
291-497 |
1.36e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 55.79 E-value: 1.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 291 TPLHYAAQSNFAETVKVFLTHPSVrddsDLE-----GRTSFMWAAGKGSDDVLRTMLSLKSDIdINMA---DKYGG-TAL 361
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLKCPSC----DLFqrgalGETALHVAALYDNLEAAVVLMEAAPEL-VNEPmtsDLYQGeTAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 362 HAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLIKGGArvDLVDQD--GH 424
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLIEHGA--DIRAQDslGN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 425 SLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENnadpniqdkegRTALH 494
Cdd:cd22192 171 TVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK-----------RRHIQ 239
|
...
gi 157817598 495 WSC 497
Cdd:cd22192 240 WTY 242
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
392-443 |
1.38e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 49.20 E-value: 1.38e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 157817598 392 TPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 443
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
239-323 |
2.02e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 55.29 E-value: 2.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 239 VLTSYESCNITSYDNlfRTPLHWAALLGHAQIVHLLLERNKSGTVpSDSQGATPLHYAAQSNFAETVKVFLTHPsvRDDS 318
Cdd:PTZ00322 101 LLTGGADPNCRDYDG--RTPLHIACANGHVQVVRVLLEFGADPTL-LDKDGKTPLELAEENGFREVVQLLSRHS--QCHF 175
|
....*
gi 157817598 319 DLEGR 323
Cdd:PTZ00322 176 ELGAN 180
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
442-494 |
8.62e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 46.96 E-value: 8.62e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157817598 442 LIENK-INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 494
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
334-411 |
1.43e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 52.21 E-value: 1.43e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157817598 334 SDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 411
Cdd:PTZ00322 92 SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
365-442 |
2.48e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 51.44 E-value: 2.48e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157817598 365 ALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQIL 442
Cdd:PTZ00322 90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
256-309 |
2.51e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 45.34 E-value: 2.51e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157817598 256 RTPLHWAALLGHAQIVHLLLERNKSGTVpSDSQGATPLHYAAQSNFAETVKVFL 309
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKGADINA-VDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
479-531 |
3.15e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 45.42 E-value: 3.15e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 157817598 479 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYA 531
Cdd:pfam13857 6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLN--LKDEEGLTALDLA 56
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
67-120 |
3.40e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 45.03 E-value: 3.40e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 157817598 67 LLKAG-ADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
412-463 |
3.98e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 45.03 E-value: 3.98e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 157817598 412 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 463
Cdd:pfam13857 5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
21-236 |
4.41e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 50.78 E-value: 4.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGAD-VNKTDHSR----RTALHLAAQKGNYR 95
Cdd:cd22192 24 AAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMTSDlyqgETALHIAVVNQNLN 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 96 FMKLLLTRRAnwmqkdlEEMTPLHLSTR-HRSPKClalLLKFmapGEvdtqdknkqTALHWSAYYNNPEHAKLLIKHDSN 174
Cdd:cd22192 104 LVRELIARGA-------DVVSPRATGTFfRPGPKN---LIYY---GE---------HPLSFAACVGNEEIVRLLIEHGAD 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157817598 175 IGIPDVEGKIPLH---WAANHKDASAVHTVRCILDA----APTESLLNwqdYEGRTPLHFAVADGNLTV 236
Cdd:cd22192 162 IRAQDSLGNTVLHilvLQPNKTFACQMYDLILSYDKeddlQPLDLVPN---NQGLTPFKLAAKEGNIVM 227
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
489-544 |
4.61e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 44.57 E-value: 4.61e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 157817598 489 GRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYALLGERHEVIQFML 544
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADIN--AVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
221-275 |
5.50e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 44.57 E-value: 5.50e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 157817598 221 GRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAALLGHAQIVHLLL 275
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
616-855 |
6.30e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 50.55 E-value: 6.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 616 PPRPQVLPCPPSPQNEPSRQSAAPSKQPPASHtvqspdPEQGRPAGQCPGRASHRDCSSDLQGTASRKPSESPREHCRGA 695
Cdd:PHA03307 99 SPAREGSPTPPGPSSPDPPPPTPPPASPPPSP------APDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQA 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 696 S-----------AGVHPRSCEDGDSYRHQGTSSAEKcRGETSGEHQRCEqGPSRARQPVSTGSAGPAEKGEDSSPAITSA 764
Cdd:PHA03307 173 AlplsspeetarAPSSPPAEPPPSTPPAAASPRPPR-RSSPISASASSP-APAPGRSAADDAGASSSDSSSSESSGCGWG 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 765 SQRDRPRKPSKRQDGAPRSRGASQKRRThqlRDRCSPAGSSRPGSAKA-EVARADQSSVHHDTPRNKVTQDKLVGGVSSD 843
Cdd:PHA03307 251 PENECPLPRPAPITLPTRIWEASGWNGP---SSRPGPASSSSSPRERSpSPSPSSPGSGPAPSSPRASSSSSSSRESSSS 327
|
250
....*....|..
gi 157817598 844 VPLSTEELGSGC 855
Cdd:PHA03307 328 STSSSSESSRGA 339
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
40-204 |
7.08e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 49.88 E-value: 7.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 40 LKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLH 119
Cdd:PHA02878 160 INMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 120 LST-RHRSPKCLALLLKFMAPGEVDTQDKNkQTALHWSayYNNPEHAKLLIKHDSNIGIPDVEGKIPLhwaanhkdASAV 198
Cdd:PHA02878 240 ISVgYCKDYDILKLLLEHGVDVNAKSYILG-LTALHSS--IKSERKLKLLLEYGADINSLNSYKLTPL--------SSAV 308
|
....*.
gi 157817598 199 HTVRCI 204
Cdd:PHA02878 309 KQYLCI 314
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
81-134 |
1.68e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.03 E-value: 1.68e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157817598 81 RRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLL 134
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02791 |
PHA02791 |
ankyrin-like protein; Provisional |
218-411 |
1.95e-05 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165154 [Multi-domain] Cd Length: 284 Bit Score: 47.73 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 218 DYEGRTPLHFAVADGNLTVVDVLTsyescNITSYDNLFRT--PLHWAALLGHAQIVHLLLernKSGTVPS--DSQGATPL 293
Cdd:PHA02791 27 DVHGHSALYYAIADNNVRLVCTLL-----NAGALKNLLENefPLHQAATLEDTKIVKILL---FSGMDDSqfDDKGNTAL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 294 HYAAQSNFAETVKVFLTHP-SVRDDSDLEGRTSFMWAAGKGSDDVLRTMLS-LKSDIDINMADkyggTALHAAALSGHVS 371
Cdd:PHA02791 99 YYAVDSGNMQTVKLFVKKNwRLMFYGKTGWKTSFYHAVMLNDVSIVSYFLSeIPSTFDLAILL----SCIHITIKNGHVD 174
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 157817598 372 TVKLLLDNDAQVDATDVMKHTPLFR-ACEMGHRDVIQTLIK 411
Cdd:PHA02791 175 MMILLLDYMTSTNTNNSLLFIPDIKlAIDNKDLEMLQALFK 215
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
613-820 |
2.01e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.17 E-value: 2.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 613 DTDPPRPQVLPCPPSPQNEPSRqSAAPSKQPPAS-----HTVQSPDPEQGRPAgQCPGRAS-HRDCSSDLQGTASRKPSE 686
Cdd:PHA03247 2604 DRGDPRGPAPPSPLPPDTHAPD-PPPPSPSPAANepdphPPPTVPPPERPRDD-PAPGRVSrPRRARRLGRAAQASSPPQ 2681
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 687 SPREHCRGASAG-----VHPRSCEDGDSYRHQGTSSAEKCRGETSGEHQRCEQGP-SRARQPVSTGSAGPAEKGEDSSPA 760
Cdd:PHA03247 2682 RPRRRAARPTVGsltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaAPAPPAVPAGPATPGGPARPARPP 2761
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157817598 761 ITS-----ASQRDRPRKPSKRqdgAPRSRGASQKRRTHQLRDRCSPAGSSRPGSAKAEVARADQS 820
Cdd:PHA03247 2762 TTAgppapAPPAAPAAGPPRR---LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
139-189 |
2.68e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 42.72 E-value: 2.68e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 157817598 139 PGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWA 189
Cdd:pfam13857 6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
13-153 |
2.86e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 47.95 E-value: 2.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 13 SLASQVHAAAVNGDKgALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLAAQK- 91
Cdd:PHA02878 167 KGNTALHYATENKDQ-RLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYc 245
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157817598 92 GNYRFMKLLLTRRANW-MQKDLEEMTPLHLSTrhRSPKCLALLLKFMApgEVDTQDKNKQTAL 153
Cdd:PHA02878 246 KDYDILKLLLEHGVDVnAKSYILGLTALHSSI--KSERKLKLLLEYGA--DINSLNSYKLTPL 304
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
900-925 |
5.65e-05 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 40.99 E-value: 5.65e-05
10 20
....*....|....*....|....*.
gi 157817598 900 RKELFRRKNKAAAVIQRAWRSYQLRK 925
Cdd:cd23767 1 EEEELQRMNRAATLIQALWRGYKVRK 26
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
406-476 |
5.94e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 47.20 E-value: 5.94e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157817598 406 IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM 476
Cdd:PTZ00322 98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
389-548 |
7.96e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 46.52 E-value: 7.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 389 MKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Cdd:PHA02875 1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 469 INCMAVLMENNADPN-IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQmeNNEERYTPLDYALLGERHEVIQFMLEHG 547
Cdd:PHA02875 81 VKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDI--PNTDKFSPLHLAVMMGDIKGIELLIDHK 158
|
.
gi 157817598 548 A 548
Cdd:PHA02875 159 A 159
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
215-312 |
9.50e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 46.43 E-value: 9.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 215 NWQDYEGRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAALLGHAQIVHLLlernkSGTVPSDSQG---AT 291
Cdd:PTZ00322 109 NCRDYDGRTPLHIACANGHVQVVRVLLEF-GADPTLLDKDGKTPLELAEENGFREVVQLL-----SRHSQCHFELganAK 182
|
90 100
....*....|....*....|.
gi 157817598 292 PLHYAAQSNFAETVKVFLTHP 312
Cdd:PTZ00322 183 PDSFTGKPPSLEDSPISSHHP 203
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
356-387 |
1.53e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 39.97 E-value: 1.53e-04
10 20 30
....*....|....*....|....*....|...
gi 157817598 356 YGGTALHAAALS-GHVSTVKLLLDNDAQVDATD 387
Cdd:pfam00023 1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
612-827 |
1.79e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.08 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 612 PDTDPPRPQVLPCPPSPQnepSRQSAAPSKQPPASHTVQSPDPEQGRPAGQCPGRASHRDcssdlqGTASRKPSESPREH 691
Cdd:PHA03247 2564 PDRSVPPPRPAPRPSEPA---VTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPD------THAPDPPPPSPSPA 2634
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 692 CRGASAGVHPRSCEDGDSYRHQGTSSAEKCRGETS-GEHQRCEQGPSRARQPVSTGSAGPAEKGEDSSPAITSASQRDRP 770
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRlGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHA 2714
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 157817598 771 RKPSKRQDGAPRSRGASQKRRTHQLRDRCSPAGSSRPGSAKAEVARADQSSVHHDTP 827
Cdd:PHA03247 2715 LVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
48-76 |
1.80e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 39.49 E-value: 1.80e-04
10 20
....*....|....*....|....*....
gi 157817598 48 GRTPLMYCVLADRLDCADALLKAGADVNK 76
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
48-79 |
2.60e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 39.19 E-value: 2.60e-04
10 20 30
....*....|....*....|....*....|...
gi 157817598 48 GRTPLMYCVL-ADRLDCADALLKAGADVNKTDH 79
Cdd:pfam00023 2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
33-88 |
2.81e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 39.64 E-value: 2.81e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 157817598 33 LIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLA 88
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
422-451 |
3.92e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 38.72 E-value: 3.92e-04
10 20 30
....*....|....*....|....*....|
gi 157817598 422 DGHSLLHWAALGGNADVCQILIENKINPNV 451
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
243-296 |
4.20e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 39.25 E-value: 4.20e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157817598 243 YESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTVpSDSQGATPLHYA 296
Cdd:pfam13857 4 HGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNL-KDEEGLTALDLA 56
|
|
| PRK12678 |
PRK12678 |
transcription termination factor Rho; Provisional |
555-798 |
4.69e-04 |
|
transcription termination factor Rho; Provisional
Pssm-ID: 237171 [Multi-domain] Cd Length: 672 Bit Score: 44.12 E-value: 4.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 555 QDIAAFKI---QAVYKGYKVRKAFRDRKNLLMK--HEQLRKDAAAKKREEENKRKEAEQKGQPDTDPPRPQVLPCPPSPQ 629
Cdd:PRK12678 21 GGLAGMKLpelRALAKQLGIKGTSGMRKGELIAaiKEARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 630 NEPSRQSAAPSKQPPASHTVQSPD-PEQGRPAGQCPGRASHRDCSSDLQGTASRKPSESPREHCRGASAGVHPRSCEDGD 708
Cdd:PRK12678 101 KAEAAPAARAAAAAAAEAASAPEAaQARERRERGEAARRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDRED 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 709 SYRHQGTSSAEKcRGETSGEHQRCEQGPSRARQPVSTGSAGPAEKGEDSSPAITSASQRDRPRKPSKRQDGAPRSRGASQ 788
Cdd:PRK12678 181 RQAEAERGERGR-REERGRDGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDGEGRG 259
|
250
....*....|
gi 157817598 789 KRRTHQLRDR 798
Cdd:PRK12678 260 GRRGRRFRDR 269
|
|
| PspC_subgroup_1 |
NF033838 |
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ... |
595-688 |
4.92e-04 |
|
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.
Pssm-ID: 468201 [Multi-domain] Cd Length: 684 Bit Score: 44.23 E-value: 4.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 595 KKREEENKRKEAEQK--GQPDTDPPRPQVLPCPPSPQNEPSRQSAAPSKQPPAShtvQSPDPEQGRPAGQCPGRASHRdc 672
Cdd:NF033838 396 KKAEEEAKRKAAEEDkvKEKPAEQPQPAPAPQPEKPAPKPEKPAEQPKAEKPAD---QQAEEDYARRSEEEYNRLTQQ-- 470
|
90
....*....|....*.
gi 157817598 673 ssdlQGTASRKPSESP 688
Cdd:NF033838 471 ----QPPKTEKPAQPS 482
|
|
| PHA03309 |
PHA03309 |
transcriptional regulator ICP4; Provisional |
623-880 |
5.02e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 165564 [Multi-domain] Cd Length: 2033 Bit Score: 44.46 E-value: 5.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 623 PC-----PPSPQNEPSRQSAAPSKQPPASHTVQspdpeQGRPAGQCPGRAShrdCSSDLQGTASRKPSESPREHCRGASA 697
Cdd:PHA03309 1435 PClaegtPSAPSCRDAARATAPLSGDPVAHRLL-----MHRPAKPLVGEEA---CAALLGGKAGRRGQDVPLPFLTAATL 1506
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 698 GVHPRSCEDGDSYRHQGTSSAEKC------------RGETSGEHQRCEQGPSRarqpvstgsagPAEKGEDSSPAITSAS 765
Cdd:PHA03309 1507 RKVARVARELDPGWGHGDLGCESAvvfppaappgpeLADRHADRRRSTKGPQR-----------PGGKRPRSSSSSSSAS 1575
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 766 QRDRPRKPSKRQDGAPRSRGASQKRRTHQLRDRCSPAGSSRPGSAKA-EVARA--DQSSVHHDTPRNkvtQDKLVGGVSS 842
Cdd:PHA03309 1576 HDRSPSSSSRRRDGRPSSRRRPSRRMSARPPSRPPAAVILRASWRYAeEVAREmlDAAASRFDEADG---EDPLPPAACG 1652
|
250 260 270
....*....|....*....|....*....|....*...
gi 157817598 843 DVPLSTEELGSGCQKLYEDLCASPEnnvAHGPRPGQSV 880
Cdd:PHA03309 1653 GKPIAPETLVALCEQRGRGPTSLPR---APTPRSGEAL 1687
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
553-579 |
6.86e-04 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 37.91 E-value: 6.86e-04
10 20
....*....|....*....|....*..
gi 157817598 553 AIQDIAAFKIQAVYKGYKVRKAFRDRK 579
Cdd:cd23767 6 QRMNRAATLIQALWRGYKVRKELKKKK 32
|
|
| recX |
PRK14136 |
recombination regulator RecX; Provisional |
628-816 |
6.87e-04 |
|
recombination regulator RecX; Provisional
Pssm-ID: 237620 [Multi-domain] Cd Length: 309 Bit Score: 43.07 E-value: 6.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 628 PQNEPSRQSAAPSKQPPASHTVQSPDPEQGRPAGQCPGRASHrDCSSDLQGTASRKP---SESPREHCRG---ASAGVHP 701
Cdd:PRK14136 10 PQEADHPARAARAGRPHASRETDRTVSGEGRPAGRTATRASD-DALVSFEIAAPDEPfddDESFDAHDRArrrVSGVGVR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 702 RSCEDGDSYRHQGTS--SAEKCRGETSGEH-QRCEQGPSRARQpvstgSAGPAEkgEDSSPAITSASqrdrprkpskrqD 778
Cdd:PRK14136 89 DAGAPGGRAADARAAnlSSAAKRAEAAGDVyTRTSQHPRRTRR-----AAGPFH--SDSSPSASSED------------D 149
|
170 180 190
....*....|....*....|....*....|....*...
gi 157817598 779 GAPRSRGASQKRRThqLRDRcSPAGSSRPGSAKAEVAR 816
Cdd:PRK14136 150 GAARSRASSRPARS--LKGR-ALGYLSRREYSRAELAR 184
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
488-516 |
7.64e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 37.95 E-value: 7.64e-04
10 20
....*....|....*....|....*....
gi 157817598 488 EGRTALHWSCNNGYLDAIKLLLDFAAFPN 516
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
347-394 |
9.60e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.10 E-value: 9.60e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 157817598 347 DIDINMADKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPL 394
Cdd:pfam13857 6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
592-790 |
1.11e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.91 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 592 AAAKKREEENKRKEAEQKGQPDTDPPRPQVLPCPPSPQNEPSRQSAAPSKQPPASHTVQSPdpeqgrPAGQCPGRASHRd 671
Cdd:PRK07003 434 ATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAP------RAAAPSAATPAA- 506
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 672 cSSDLQGTASRKPSESPREHCRGASAGVHPRSCEDGDSYRHQGTSSA-EKCRgeTSGEHQRCEQGPSRARQPVSTGSAGP 750
Cdd:PRK07003 507 -VPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAAlDVLR--NAGMRVSSDRGARAAAAAKPAAAPAA 583
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 157817598 751 AEKGEDSSPAITSASQRDRPRKPSKRQDGAPRSRGASQKR 790
Cdd:PRK07003 584 APKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESR 623
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
150-366 |
1.11e-03 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 43.15 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 150 QTALHWSAYYNNP-EHAKLLIKHDSNIgipdVEGKIPLHWAA-NHKDAsavhtvrcildaapTESLLNW--QDYEGRTPL 225
Cdd:TIGR00870 53 RSALFVAAIENENlELTELLLNLSCRG----AVGDTLLHAISlEYVDA--------------VEAILLHllAAFRKSGPL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 226 HFAVadgnltvvDVLTSYESCNITsydnlfrtPLHWAALLGHAQIVHLLLERnksgtvpsdsqGATpLHYAAQSNFaetv 305
Cdd:TIGR00870 115 ELAN--------DQYTSEFTPGIT--------ALHLAAHRQNYEIVKLLLER-----------GAS-VPARACGDF---- 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157817598 306 kvFLTHPSVrdDSDLEGRTSFMWAAGKGSDDVLRtmLSLKSDIDINMADKYGGTALHAAAL 366
Cdd:TIGR00870 163 --FVKSQGV--DSFYHGESPLNAAACLGSPSIVA--LLSEDPADILTADSLGNTLLHLLVM 217
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
422-451 |
1.13e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 37.24 E-value: 1.13e-03
10 20 30
....*....|....*....|....*....|
gi 157817598 422 DGHSLLHWAALGGNADVCQILIENKINPNV 451
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
422-453 |
1.14e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 37.27 E-value: 1.14e-03
10 20 30
....*....|....*....|....*....|...
gi 157817598 422 DGHSLLHWAAL-GGNADVCQILIENKINPNVQD 453
Cdd:pfam00023 1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
456-487 |
1.39e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 37.27 E-value: 1.39e-03
10 20 30
....*....|....*....|....*....|...
gi 157817598 456 GRTPLQCAAY-GGYINCMAVLMENNADPNIQDK 487
Cdd:pfam00023 2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
456-484 |
1.45e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 37.18 E-value: 1.45e-03
10 20
....*....|....*....|....*....
gi 157817598 456 GRTPLQCAAYGGYINCMAVLMENNADPNI 484
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| FAM217 |
pfam15344 |
FAM217 family; This family of proteins is found in eukaryotes. Proteins in this family are ... |
617-747 |
1.66e-03 |
|
FAM217 family; This family of proteins is found in eukaryotes. Proteins in this family are typically between 329 and 507 amino acids in length. There is a conserved YPDFLP sequence motif.
Pssm-ID: 464662 Cd Length: 234 Bit Score: 41.25 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 617 PRPQVLPCPPSPQNEPSRQSAAPSKQPpashtvQSPDPEQGRPAGQCPGRASHRDCSsdlqgtaSRKPSESPREHCRGAS 696
Cdd:pfam15344 114 ARPPTAPGTPGALKSPGSSKLIASALP------SKKLPHQEGLSKSGPSRKKEKHCE-------EHHPSYAFETHPRPSD 180
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 157817598 697 AGVHPRSCedgdSYRHqgtsSAEKCRGETSGEHQRCEQGPSRARQPVSTGS 747
Cdd:pfam15344 181 VLSSSRLC----SQKQ----SASKWRVRSEEKKKKSSKSPKLKSQPTDLSS 223
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
47-76 |
2.21e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.47 E-value: 2.21e-03
10 20 30
....*....|....*....|....*....|
gi 157817598 47 FGRTPLMYCVLADRLDCADALLKAGADVNK 76
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
65-318 |
2.29e-03 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 42.16 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 65 DALLKAGADVNKTDHSRRTALHLAAQKGNyrfmkllltrranwmqkdlEEmtplhlstrhrspkCLALLLKFMApgEVDT 144
Cdd:PLN03192 542 EELLKAKLDPDIGDSKGRTPLHIAASKGY-------------------ED--------------CVLVLLKHAC--NVHI 586
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 145 QDKNKQTALhWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIpLHWAANHKDASAVHT-VRCILDaapteslLNWQDYEGRT 223
Cdd:PLN03192 587 RDANGNTAL-WNAISAKHHKIFRILYHFASISDPHAAGDL-LCTAAKRNDLTAMKElLKQGLN-------VDSEDHQGAT 657
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 224 PLHFAVADGNLTVVDVL-TSYESCNITSYDNLFrTPLHWAALLGHAQIVHLLLERNKSGTVPSD---SQGATPLHYAAQS 299
Cdd:PLN03192 658 ALQVAMAEDHVDMVRLLiMNGADVDKANTDDDF-SPTELRELLQKRELGHSITIVDSVPADEPDlgrDGGSRPGRLQGTS 736
|
250 260
....*....|....*....|..
gi 157817598 300 NFAET---VKVFLTHPSVRDDS 318
Cdd:PLN03192 737 SDNQCrprVSIYKGHPLLRNER 758
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
359-385 |
2.44e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.41 E-value: 2.44e-03
10 20
....*....|....*....|....*..
gi 157817598 359 TALHAAALSGHVSTVKLLLDNDAQVDA 385
Cdd:smart00248 4 TPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
148-175 |
2.56e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.41 E-value: 2.56e-03
10 20
....*....|....*....|....*...
gi 157817598 148 NKQTALHWSAYYNNPEHAKLLIKHDSNI 175
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
356-385 |
3.21e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.08 E-value: 3.21e-03
10 20 30
....*....|....*....|....*....|
gi 157817598 356 YGGTALHAAALSGHVSTVKLLLDNDAQVDA 385
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
405-581 |
3.31e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 41.59 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 405 VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNI 484
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINK 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 485 QDkegrTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGER-HEVIQFMLEHGAlsiaaiqDIAAFKIQ 563
Cdd:PHA02876 240 ND----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKN--TPLHHASQAPSlSRLVPKLLERGA-------DVNAKNIK 306
|
170
....*....|....*...
gi 157817598 564 AVYKGYKVRKAFRDRKNL 581
Cdd:PHA02876 307 GETPLYLMAKNGYDTENI 324
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
256-280 |
3.54e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.03 E-value: 3.54e-03
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
82-106 |
3.65e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.03 E-value: 3.65e-03
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
316-364 |
3.89e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 36.56 E-value: 3.89e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 157817598 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLslKSDIDINMADKYGGTALHAA 364
Cdd:pfam13857 10 NRLDGEGYTPLHVAAKYGALEIVRVLL--AYGVDLNLKDEEGLTALDLA 56
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
114-169 |
3.92e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.48 E-value: 3.92e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 157817598 114 EMTPLHLSTRHRSPKCLALLLKFMAPgeVDTQDKNKQTALHWSAYYNNPEHAKLLI 169
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGAD--INAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
213-262 |
4.93e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 36.17 E-value: 4.93e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 157817598 213 LLNWQDYEGRTPLHFAVADGNLTVVDVLTSYEsCNITSYDNLFRTPLHWA 262
Cdd:pfam13857 8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
256-278 |
5.74e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 35.31 E-value: 5.74e-03
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
151-199 |
6.36e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 35.71 E-value: 6.36e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 157817598 151 TALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDASAVH 199
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLK 51
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
336-497 |
6.40e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 40.63 E-value: 6.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 336 DVLRTMLSLKSDIDINMADKY--GGTALHAAALSGHVSTVKLLLDNDAQVDAT---DVMKHTPL-----------FRACe 399
Cdd:cd21882 50 EAAPDSGNPKELVNAPCTDEFyqGQTALHIAIENRNLNLVRLLVENGADVSARatgRFFRKSPGnlfyfgelplsLAAC- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 400 MGHRDVIQTLIKGGARV-DLVDQD--GHSLLHWAALGGN------ADVCQ-----ILIENKINPNVQ-----DYAGRTPL 460
Cdd:cd21882 129 TNQEEIVRLLLENGAQPaALEAQDslGNTVLHALVLQADntpensAFVCQmynllLSYGAHLDPTQQleeipNHQGLTPL 208
|
170 180 190
....*....|....*....|....*....|....*..
gi 157817598 461 QCAAYGGYINCMAVLMENNADPNIQDKEgRTALHWSC 497
Cdd:cd21882 209 KLAAVEGKIVMFQHILQREFSGPYQPLS-RKFTEWTY 244
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
55-135 |
6.52e-03 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 40.65 E-value: 6.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 55 CVLADRLDCADA--LLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLAL 132
Cdd:PTZ00322 87 CQLAASGDAVGAriLLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166
|
...
gi 157817598 133 LLK 135
Cdd:PTZ00322 167 LSR 169
|
|
| PHA02884 |
PHA02884 |
ankyrin repeat protein; Provisional |
50-123 |
6.57e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165212 [Multi-domain] Cd Length: 300 Bit Score: 39.97 E-value: 6.57e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157817598 50 TPLMYCVLADRLDCADALLKAGADVNK-TDHSRRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTR 123
Cdd:PHA02884 72 NPLIYAIDCDNDDAAKLLIRYGADVNRyAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALM 146
|
|
| dnaA |
PRK14086 |
chromosomal replication initiator protein DnaA; |
613-750 |
7.24e-03 |
|
chromosomal replication initiator protein DnaA;
Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 40.19 E-value: 7.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 613 DTDPPRPQVLPCPPSPQNEPSRQSAAPSKQPPASHTVQSPDPEQGR-PAGQCPGRASHRDCSSDLQGTASRKPSESPREH 691
Cdd:PRK14086 149 YQQRPEPGAWPRAADDYGWQQQRLGFPPRAPYASPASYAPEQERDRePYDAGRPEYDQRRRDYDHPRPDWDRPRRDRTDR 228
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 157817598 692 CRGASAGVHPRSCEDGDSyrhqGTSSAEKCRGETSGEhqrceqGPSRARQPVSTGSAGP 750
Cdd:PRK14086 229 PEPPPGAGHVHRGGPGPP----ERDDAPVVPIRPSAP------GPLAAQPAPAPGPGEP 277
|
|
| FRG2 |
pfam15315 |
Facioscapulohumeral muscular dystrophy candidate 2; This family of proteins is found in ... |
693-864 |
9.47e-03 |
|
Facioscapulohumeral muscular dystrophy candidate 2; This family of proteins is found in eukaryotes. The family is localized close to the D4Z4 repeats on chromosome 4 and 10 that are associated with the autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). FRG2 are transcriptionally upregulated in FSHD myoblast cultures suggesting involvement in the pathogenesis of FSHD.
Pssm-ID: 464640 Cd Length: 183 Bit Score: 38.30 E-value: 9.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 693 RGASAGVHPRSCEDGDSYRHQGTSSAEK-CRGETSGEHQRCEQGPSRARQPVSTGsaGPAEKGEDSSPAitsasqrdRPR 771
Cdd:pfam15315 19 RSSIAGSESESSSDRESSRKRKISSSDSsCQGTGNSPGDERSVTLEKKTRPVSDA--GHSSEIQETADA--------HPR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 772 KPSKRQDGAPRsrgasqkrrthqlRDRCSPAGSSRPGSAKAEVA--RADQSSVHHDTPRNKVTQdklvggvsSDVPLSTE 849
Cdd:pfam15315 89 RNSRAGSGRSR-------------RRRSRSPGDRPPPLRKSLVTslRALSEAIYQDLAQVQAQQ--------AHSPLTWE 147
|
170
....*....|....*
gi 157817598 850 ELgSGCQKLYEDLCA 864
Cdd:pfam15315 148 QL-FGLAQLRGPLCA 161
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
650-832 |
9.58e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 40.15 E-value: 9.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 650 QSPDPEQGRPAGQCPGRASHRDCSS---------DLQGTASRKPSESPREHCRGASAGVHPRSCEDGDSYRHQGTSSAEK 720
Cdd:PHA03307 739 YSPRRARARASAWDITDALFSNPSLvpaklaealALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASK 818
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817598 721 cRGETSGEHQRCEQGPSRARQPVSTGSAGPAEKGEDSspaitsasqrdrprkPSKRQDGAPRSRGASQKRRTHQLRDRCS 800
Cdd:PHA03307 819 -RKSRSHTPDGGSESSGPARPPGAAARPPPARSSESS---------------KSKPAAAGGRARGKNGRRRPRPPEPRAR 882
|
170 180 190
....*....|....*....|....*....|..
gi 157817598 801 PAGSSRPGSAKAEVARADQSSVHHDTPRNKVT 832
Cdd:PHA03307 883 PGAAAPPKAAAAAPPAGAPAPRPRPAPRVKLG 914
|
|
| |
