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Conserved domains on  [gi|312839888|ref|NP_001186175|]
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melanoma-associated antigen D2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
286-454 2.16e-31

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


:

Pssm-ID: 426270  Cd Length: 205  Bit Score: 121.22  E-value: 2.16e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  286 LVKYLLAKDQTKIPIRRSDMLKDIIKEY-TDVYPEIIERAGYSLEKVFGIQLKEIDKNDHL------------------- 345
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaakssrsk 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  346 -YILLSTLEPT--DAGILGTTK---------DSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRPGI---HHSLFG 410
Cdd:pfam01454  81 sYILVSTLPPEyrVPAIIWPSKapsfvldqdEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDTDGtkeIPPLNG 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 312839888  411 DVKKLItDEFVKQKYLDYARVPNSNP--PEYEFFWGLRSYYETSKM 454
Cdd:pfam01454 161 NTDDLL-KRLVKQGYLVRTKEGASDDgeEIIEYRVGPRAKVEFGPE 205
PRK13335 super family cl31400
superantigen-like protein SSL3; Reviewed;
32-125 7.29e-05

superantigen-like protein SSL3; Reviewed;


The actual alignment was detected with superfamily member PRK13335:

Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 45.50  E-value: 7.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  32 TVTQ--NLEVSETPKAEKAPEVSE----AAKAPKASgNPKATEVSKAPEASEAAATQASPTTQLSETQVLATENKSPAAD 105
Cdd:PRK13335  61 ATTQaaNTRQERTPKLEKAPNTNEektsASKIEKIS-QPKQEEQKSLNISATPAPKQEQSQTTTESTTPKTKVTTPPSTN 139
                         90       100
                 ....*....|....*....|
gi 312839888 106 TKTQKSDLQAMTmPTTPTKK 125
Cdd:PRK13335 140 TPQPMQSTKSDT-PQSPTIK 158
PRK13914 super family cl36314
invasion associated endopeptidase;
33-224 4.89e-04

invasion associated endopeptidase;


The actual alignment was detected with superfamily member PRK13914:

Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 42.87  E-value: 4.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  33 VTQNLEVSET-PKAEKAPEVSEAAkaPKASGNPKATEVSKAPEASEAAATQASPT---------------------TQLS 90
Cdd:PRK13914 154 VKKETTTQQAaPAAETKTEVKQTT--QATTPAPKVAETKETPVVDQNATTHAVKSgdtiwalsvkygvsvqdimswNNLS 231
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  91 ETQVL---------ATENKSPAADTKTQKSDLQAMTMP---------TTPTKKVSCGTDPKVNTKAP-ETEAPASQAGTD 151
Cdd:PRK13914 232 SSSIYvgqklaikqTANTATPKAEVKTEAPAAEKQAAPvvkentntnTATTEKKETTTQQQTAPKAPtEAAKPAPAPSTN 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888 152 EPEPEGTAVQVQENQDTRPKVKAKNTQKGKHPDGEEDGNSDQSQASEATGGRRVSKALMASMARRASR-------GPIAF 224
Cdd:PRK13914 312 TNANKTNTNTNTNTNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSSNNNSNSSASAIIAEAQKHLGKayswggnGPTTF 391
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
286-454 2.16e-31

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 121.22  E-value: 2.16e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  286 LVKYLLAKDQTKIPIRRSDMLKDIIKEY-TDVYPEIIERAGYSLEKVFGIQLKEIDKNDHL------------------- 345
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaakssrsk 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  346 -YILLSTLEPT--DAGILGTTK---------DSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRPGI---HHSLFG 410
Cdd:pfam01454  81 sYILVSTLPPEyrVPAIIWPSKapsfvldqdEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDTDGtkeIPPLNG 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 312839888  411 DVKKLItDEFVKQKYLDYARVPNSNP--PEYEFFWGLRSYYETSKM 454
Cdd:pfam01454 161 NTDDLL-KRLVKQGYLVRTKEGASDDgeEIIEYRVGPRAKVEFGPE 205
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
32-125 7.29e-05

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 45.50  E-value: 7.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  32 TVTQ--NLEVSETPKAEKAPEVSE----AAKAPKASgNPKATEVSKAPEASEAAATQASPTTQLSETQVLATENKSPAAD 105
Cdd:PRK13335  61 ATTQaaNTRQERTPKLEKAPNTNEektsASKIEKIS-QPKQEEQKSLNISATPAPKQEQSQTTTESTTPKTKVTTPPSTN 139
                         90       100
                 ....*....|....*....|
gi 312839888 106 TKTQKSDLQAMTmPTTPTKK 125
Cdd:PRK13335 140 TPQPMQSTKSDT-PQSPTIK 158
PRK13914 PRK13914
invasion associated endopeptidase;
33-224 4.89e-04

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 42.87  E-value: 4.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  33 VTQNLEVSET-PKAEKAPEVSEAAkaPKASGNPKATEVSKAPEASEAAATQASPT---------------------TQLS 90
Cdd:PRK13914 154 VKKETTTQQAaPAAETKTEVKQTT--QATTPAPKVAETKETPVVDQNATTHAVKSgdtiwalsvkygvsvqdimswNNLS 231
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  91 ETQVL---------ATENKSPAADTKTQKSDLQAMTMP---------TTPTKKVSCGTDPKVNTKAP-ETEAPASQAGTD 151
Cdd:PRK13914 232 SSSIYvgqklaikqTANTATPKAEVKTEAPAAEKQAAPvvkentntnTATTEKKETTTQQQTAPKAPtEAAKPAPAPSTN 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888 152 EPEPEGTAVQVQENQDTRPKVKAKNTQKGKHPDGEEDGNSDQSQASEATGGRRVSKALMASMARRASR-------GPIAF 224
Cdd:PRK13914 312 TNANKTNTNTNTNTNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSSNNNSNSSASAIIAEAQKHLGKayswggnGPTTF 391
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
286-454 2.16e-31

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 121.22  E-value: 2.16e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  286 LVKYLLAKDQTKIPIRRSDMLKDIIKEY-TDVYPEIIERAGYSLEKVFGIQLKEIDKNDHL------------------- 345
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaakssrsk 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  346 -YILLSTLEPT--DAGILGTTK---------DSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRPGI---HHSLFG 410
Cdd:pfam01454  81 sYILVSTLPPEyrVPAIIWPSKapsfvldqdEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDTDGtkeIPPLNG 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 312839888  411 DVKKLItDEFVKQKYLDYARVPNSNP--PEYEFFWGLRSYYETSKM 454
Cdd:pfam01454 161 NTDDLL-KRLVKQGYLVRTKEGASDDgeEIIEYRVGPRAKVEFGPE 205
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
32-125 7.29e-05

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 45.50  E-value: 7.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  32 TVTQ--NLEVSETPKAEKAPEVSE----AAKAPKASgNPKATEVSKAPEASEAAATQASPTTQLSETQVLATENKSPAAD 105
Cdd:PRK13335  61 ATTQaaNTRQERTPKLEKAPNTNEektsASKIEKIS-QPKQEEQKSLNISATPAPKQEQSQTTTESTTPKTKVTTPPSTN 139
                         90       100
                 ....*....|....*....|
gi 312839888 106 TKTQKSDLQAMTmPTTPTKK 125
Cdd:PRK13335 140 TPQPMQSTKSDT-PQSPTIK 158
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
34-173 1.27e-04

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 44.73  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  34 TQNLEVSETPKAEKAPEVSEAAKAPKASGNPKATEVSKAPEASEAAATQ-----ASPTTQLSETQVLATENKSPAADTKT 108
Cdd:PRK13335  35 STKVDKVPTLKAERLAMINITAGANSATTQAANTRQERTPKLEKAPNTNeektsASKIEKISQPKQEEQKSLNISATPAP 114
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312839888 109 QKSDLQAMTMPTTPTKKVScgTDPKVNtkapeTEAPASQAGTDEPEPEGTAvqvQENQDTRPKVK 173
Cdd:PRK13335 115 KQEQSQTTTESTTPKTKVT--TPPSTN-----TPQPMQSTKSDTPQSPTIK---QAQTDMTPKYE 169
PRK13914 PRK13914
invasion associated endopeptidase;
33-224 4.89e-04

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 42.87  E-value: 4.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  33 VTQNLEVSET-PKAEKAPEVSEAAkaPKASGNPKATEVSKAPEASEAAATQASPT---------------------TQLS 90
Cdd:PRK13914 154 VKKETTTQQAaPAAETKTEVKQTT--QATTPAPKVAETKETPVVDQNATTHAVKSgdtiwalsvkygvsvqdimswNNLS 231
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888  91 ETQVL---------ATENKSPAADTKTQKSDLQAMTMP---------TTPTKKVSCGTDPKVNTKAP-ETEAPASQAGTD 151
Cdd:PRK13914 232 SSSIYvgqklaikqTANTATPKAEVKTEAPAAEKQAAPvvkentntnTATTEKKETTTQQQTAPKAPtEAAKPAPAPSTN 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312839888 152 EPEPEGTAVQVQENQDTRPKVKAKNTQKGKHPDGEEDGNSDQSQASEATGGRRVSKALMASMARRASR-------GPIAF 224
Cdd:PRK13914 312 TNANKTNTNTNTNTNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSSNNNSNSSASAIIAEAQKHLGKayswggnGPTTF 391
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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