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Conserved domains on  [gi|557357754|ref|NP_001273435|]
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radial spoke head 1 homolog isoform 2 [Homo sapiens]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
18-138 4.30e-32

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 118.91  E-value: 4.30e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357754  18 GGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAEtGS 97
Cdd:COG4642  139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAD-GD 217

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 557357754  98 KYVGTWVNGQQEGTAELIHLN-HRYQGKFLNKNPVGPGKYVF 138
Cdd:COG4642  218 RYEGEFKNGKRHGQGTLTYADgDRYEGEFKNGKRHGQGTMTY 259
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
18-138 4.30e-32

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 118.91  E-value: 4.30e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357754  18 GGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAEtGS 97
Cdd:COG4642  139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAD-GD 217

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 557357754  98 KYVGTWVNGQQEGTAELIHLN-HRYQGKFLNKNPVGPGKYVF 138
Cdd:COG4642  218 RYEGEFKNGKRHGQGTLTYADgDRYEGEFKNGKRHGQGTMTY 259
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 19-149 4.37e-18

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 83.73  E-value: 4.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357754  19 GIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAeTGSK 98
Cdd:PLN03185  24 GKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYP-NGDV 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 557357754  99 YVGTWVNGQQEgtaelihlnhryqgkflnknpvGPGKYVFDVGCEQHGEYR 149
Cdd:PLN03185 103 FEGSWIQGLQE----------------------GPGKYTWANGNVYLGDMK 131
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
50-71 4.28e-05

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 39.63  E-value: 4.28e-05
                           10        20
                   ....*....|....*....|..
gi 557357754    50 SRYEGEWANDLRHGHGVYYYIN 71
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 52-74 1.61e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 37.77  E-value: 1.61e-04
                          10        20
                  ....*....|....*....|...
gi 557357754   52 YEGEWANDLRHGHGVYYYINNDT 74
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
18-138 4.30e-32

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 118.91  E-value: 4.30e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357754  18 GGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAEtGS 97
Cdd:COG4642  139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAD-GD 217

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 557357754  98 KYVGTWVNGQQEGTAELIHLN-HRYQGKFLNKNPVGPGKYVF 138
Cdd:COG4642  218 RYEGEFKNGKRHGQGTLTYADgDRYEGEFKNGKRHGQGTMTY 259
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
19-105 2.79e-26

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 103.50  E-value: 2.79e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357754  19 GIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAeTGSK 98
Cdd:COG4642  186 GTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYA-DGSV 264


                 ....*..
gi 557357754  99 YVGTWVN 105
Cdd:COG4642  265 YEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
17-149 7.73e-26

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 102.34  E-value: 7.73e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357754  17 IGGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAeTG 96
Cdd:COG4642  115 GGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYA-NG 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 557357754  97 SKYVGTWVNGQQEGTAELIHLN-HRYQGKFLNKNPVGPGKYVFDVGCEQHGEYR 149
Cdd:COG4642  194 DVYEGEFKNGQRHGQGTYTYADgDRYEGEFKNGKRHGQGTLTYADGDRYEGEFK 247
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
18-149 2.93e-18

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 81.93  E-value: 2.93e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357754  18 GGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAEtGS 97
Cdd:COG4642   93 GGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYAD-GD 171

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 557357754  98 KYVGTWVNGQQEGTAELIHLN-HRYQGKFLNKNPVGPGKYVFDVGCEQHGEYR 149
Cdd:COG4642  172 RYEGEFKNGKRHGQGTLTYANgDVYEGEFKNGQRHGQGTYTYADGDRYEGEFK 224
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 19-149 4.37e-18

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 83.73  E-value: 4.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357754  19 GIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAeTGSK 98
Cdd:PLN03185  24 GKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYP-NGDV 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 557357754  99 YVGTWVNGQQEgtaelihlnhryqgkflnknpvGPGKYVFDVGCEQHGEYR 149
Cdd:PLN03185 103 FEGSWIQGLQE----------------------GPGKYTWANGNVYLGDMK 131
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 19-110 2.33e-14

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 72.56  E-value: 2.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357754  19 GIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAeTGSK 98
Cdd:PLN03185  70 GTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWV-SGDS 148

                         90
                 ....*....|..
gi 557357754  99 YVGTWVNGQQEG 110
Cdd:PLN03185 149 YEGQWLDGMMHG 160
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 19-90 5.42e-10

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 59.46  E-value: 5.42e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557357754  19 GIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTY 90
Cdd:PLN03185 116 GKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVF 187
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
15-149 2.25e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 56.89  E-value: 2.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357754  15 NDIGGIYKFKNGARYIGEYVR--NKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLY 92
Cdd:COG4642   65 GGGGEGGVTAAGGGGGGGGGKgdGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTF 144

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 557357754  93 AEtGSKYVGTWVNGQQEGTAELIHLN-HRYQGKFLNKNPVGPGKYVFDVGCEQHGEYR 149
Cdd:COG4642  145 PN-GDVYEGEFKNGKPHGQGTLTYADgDRYEGEFKNGKRHGQGTLTYANGDVYEGEFK 201
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
50-71 4.28e-05

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 39.63  E-value: 4.28e-05
                           10        20
                   ....*....|....*....|..
gi 557357754    50 SRYEGEWANDLRHGHGVYYYIN 71
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 19-68 7.08e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 44.05  E-value: 7.08e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 557357754  19 GIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYY 68
Cdd:PLN03185 139 GTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVFY 188
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 52-74 1.61e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 37.77  E-value: 1.61e-04
                          10        20
                  ....*....|....*....|...
gi 557357754   52 YEGEWANDLRHGHGVYYYINNDT 74
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 29-51 2.06e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 37.77  E-value: 2.06e-04
                          10        20
                  ....*....|....*....|...
gi 557357754   29 YIGEYVRNKKHGQGTFIYPDGSR 51
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
27-48 3.02e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.32  E-value: 3.02e-04
                           10        20
                   ....*....|....*....|..
gi 557357754    27 ARYIGEYVRNKKHGQGTFIYPD 48
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
3-111 4.91e-04

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 39.67  E-value: 4.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557357754   3 DLGSEELEEEGENDIGGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGS-RYEGEWANDLRHGHGVYYYIN-NDTYTGEWF 80
Cdd:COG2849   31 GYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTYYPNGQlKSEGTYKNGKLEGEWKEYYENgKLKSEGNYK 110

                         90       100       110
                 ....*....|....*....|....*....|.
gi 557357754  81 AHQRHGQGTYLYAETGSKYVGTWVNGQQEGT 111
Cdd:COG2849  111 NGKLHGEWKEYYENGKLKEEGNYKNGKKDGV 141
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
73-93 6.88e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 36.16  E-value: 6.88e-04
                           10        20
                   ....*....|....*....|.
gi 557357754    73 DTYTGEWFAHQRHGQGTYLYA 93
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYA 21
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
19-71 8.33e-03

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 36.20  E-value: 8.33e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 557357754  19 GIYKF--KNGA-RYIGEYVRNKKHGQGTFIYPDGS-RYEGEWANDLRHGHGVYYYIN 71
Cdd:COG2849   92 GEWKEyyENGKlKSEGNYKNGKLHGEWKEYYENGKlKEEGNYKNGKKDGVWKYYDEN 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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