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Conserved domains on  [gi|894216288|ref|NP_001297669|]
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sialic acid binding Ig-like lectin H isoform 3 precursor [Mus musculus]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 40-145 2.70e-36

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05712:

Pssm-ID: 472250  Cd Length: 119  Bit Score: 123.65  E-value: 2.70e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 894216288  40 SVTVQEGLCVLVPCHLiEYPMNRW-SDAAFGYWFHEGENTHPDSLVATNKPYQLVQKEMQSRFHFSGD-----CSLDIRD 113
Cdd:cd05712    8 SVTVQEGLCVLIPCSF-SYPADYWvSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDpgkknCSLSISD 86

                         90       100       110
                 ....*....|....*....|....*....|...
gi 894216288 114 AQKGDNGSYFFRLEKGGKT-WNFCEERISVHVT 145
Cdd:cd05712   87 ARPEDSGKYFFRVERGDSNkYSYLSNQLSLTVT 119
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 40-145 2.70e-36

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 123.65  E-value: 2.70e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 894216288  40 SVTVQEGLCVLVPCHLiEYPMNRW-SDAAFGYWFHEGENTHPDSLVATNKPYQLVQKEMQSRFHFSGD-----CSLDIRD 113
Cdd:cd05712    8 SVTVQEGLCVLIPCSF-SYPADYWvSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDpgkknCSLSISD 86

                         90       100       110
                 ....*....|....*....|....*....|...
gi 894216288 114 AQKGDNGSYFFRLEKGGKT-WNFCEERISVHVT 145
Cdd:cd05712   87 ARPEDSGKYFFRVERGDSNkYSYLSNQLSLTVT 119
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 40-123 7.12e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 46.30  E-value: 7.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 894216288   40 SVTVQEGLCVLVPCHLieypMNRWSDAAFG-YWFHEGENTHPDSLVATNKPYQLVQKEMQsRFHFSG-----DCSLDIRD 113
Cdd:pfam07686   5 EVTVALGGSVTLPCTY----SSSMSEASTSvYWYRQPPGKGPTFLIAYYSNGSEEGVKKG-RFSGRGdpsngDGSLTIQN 79

                          90
                  ....*....|
gi 894216288  114 AQKGDNGSYF 123
Cdd:pfam07686  80 LTLSDSGTYT 89
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 40-145 2.70e-36

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 123.65  E-value: 2.70e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 894216288  40 SVTVQEGLCVLVPCHLiEYPMNRW-SDAAFGYWFHEGENTHPDSLVATNKPYQLVQKEMQSRFHFSGD-----CSLDIRD 113
Cdd:cd05712    8 SVTVQEGLCVLIPCSF-SYPADYWvSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDpgkknCSLSISD 86

                         90       100       110
                 ....*....|....*....|....*....|...
gi 894216288 114 AQKGDNGSYFFRLEKGGKT-WNFCEERISVHVT 145
Cdd:cd05712   87 ARPEDSGKYFFRVERGDSNkYSYLSNQLSLTVT 119
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 40-123 7.12e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 46.30  E-value: 7.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 894216288   40 SVTVQEGLCVLVPCHLieypMNRWSDAAFG-YWFHEGENTHPDSLVATNKPYQLVQKEMQsRFHFSG-----DCSLDIRD 113
Cdd:pfam07686   5 EVTVALGGSVTLPCTY----SSSMSEASTSvYWYRQPPGKGPTFLIAYYSNGSEEGVKKG-RFSGRGdpsngDGSLTIQN 79

                          90
                  ....*....|
gi 894216288  114 AQKGDNGSYF 123
Cdd:pfam07686  80 LTLSDSGTYT 89
I-set pfam07679
Immunoglobulin I-set domain;
32-144 2.87e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 35.70  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 894216288   32 PSLTLELQSVTVQEGLCVLVPCHLIEYPMNRWSdaafgyWFHegenthPDSLVATNKPYQLVQKEmqsrfhfsGDCSLDI 111
Cdd:pfam07679   1 PKFTQKPKDVEVQEGESARFTCTVTGTPDPEVS------WFK------DGQPLRSSDRFKVTYEG--------GTYTLTI 60

                          90       100       110
                  ....*....|....*....|....*....|....
gi 894216288  112 RDAQKGDNGSYFFRLE-KGGKtwnfCEERISVHV 144
Cdd:pfam07679  61 SNVQPDDSGKYTCVATnSAGE----AEASAELTV 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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