NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|938018757|ref|NP_001303248|]
View 

cystatin 14a, tandem duplicate 1 [Danio rerio]

Protein Classification

CY domain-containing protein( domain architecture ID 10440427)

CY domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 6-77 3.00e-16

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 67.36  E-value: 3.00e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 938018757    6 GGTSEAKDANEEVQKICDKMKADAEEKA-GRKFDVFTAKSFKTQVVAGTNYFVKVHVGDEDYV-HLRVYKTLPH 77
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPL 74
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 6-77 3.00e-16

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 67.36  E-value: 3.00e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 938018757    6 GGTSEAKDANEEVQKICDKMKADAEEKA-GRKFDVFTAKSFKTQVVAGTNYFVKVHVGDEDYV-HLRVYKTLPH 77
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPL 74
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 3-100 6.42e-12

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 56.67  E-value: 6.42e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938018757     3 LVRGGTSEAKDANEEVQKICDKMKADAEEKAGRKF--DVFTAKSFKTQVVAGTNYFVKVHVGDEDYVHLRVYKTLPHAGE 80
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYelRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLD 80

                           90       100
                   ....*....|....*....|
gi 938018757    81 TLQLtsIQTAKAHHDAIEYF 100
Cdd:smart00043  81 QGEK--FCTAKVWEKPWENK 98
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 6-63 3.08e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 47.08  E-value: 3.08e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 938018757   6 GGTSEAKDANEEVQKICDKMKADAEEKA-GRKFDVFTAKSFKTQVVAGTNYFVKVHVGD 63
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSnDKYLEFFKVLSAKSQVVAGTNYYITVEAGD 59
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 6-77 3.00e-16

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 67.36  E-value: 3.00e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 938018757    6 GGTSEAKDANEEVQKICDKMKADAEEKA-GRKFDVFTAKSFKTQVVAGTNYFVKVHVGDEDYV-HLRVYKTLPH 77
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPL 74
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 3-100 6.42e-12

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 56.67  E-value: 6.42e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938018757     3 LVRGGTSEAKDANEEVQKICDKMKADAEEKAGRKF--DVFTAKSFKTQVVAGTNYFVKVHVGDEDYVHLRVYKTLPHAGE 80
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYelRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLD 80

                           90       100
                   ....*....|....*....|
gi 938018757    81 TLQLtsIQTAKAHHDAIEYF 100
Cdd:smart00043  81 QGEK--FCTAKVWEKPWENK 98
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 6-63 3.08e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 47.08  E-value: 3.08e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 938018757   6 GGTSEAKDANEEVQKICDKMKADAEEKA-GRKFDVFTAKSFKTQVVAGTNYFVKVHVGD 63
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSnDKYLEFFKVLSAKSQVVAGTNYYITVEAGD 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH