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Conserved domains on  [gi|1021312084|ref|NP_001310589|]
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zinc finger E-box-binding homeobox 1 isoform g [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
728-753 2.32e-07

Zinc-finger double domain;


:

Pssm-ID: 404364 [Multi-domain]  Cd Length: 26  Bit Score: 47.34  E-value: 2.32e-07
                          10        20
                  ....*....|....*....|....*.
gi 1021312084 728 HLIEHMRLHSGEKPYQCDKCGKRFSH 753
Cdd:pfam13465   1 NLKRHMRKHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
36-59 4.39e-07

Zinc-finger double domain;


:

Pssm-ID: 404364 [Multi-domain]  Cd Length: 26  Bit Score: 46.57  E-value: 4.39e-07
                          10        20
                  ....*....|....*....|....
gi 1021312084  36 HLKEHLRIHSGEKPYECPNCKKRF 59
Cdd:pfam13465   1 NLKRHMRKHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
22-44 2.03e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 44.60  E-value: 2.03e-06
                          10        20
                  ....*....|....*....|...
gi 1021312084  22 FKCTECGKAFKYKHHLKEHLRIH 44
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
714-736 1.78e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.90  E-value: 1.78e-05
                          10        20
                  ....*....|....*....|...
gi 1021312084 714 HECGICKKAFKHKHHLIEHMRLH 736
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
700-725 3.71e-05

Zinc-finger double domain;


:

Pssm-ID: 404364 [Multi-domain]  Cd Length: 26  Bit Score: 41.18  E-value: 3.71e-05
                          10        20
                  ....*....|....*....|....*.
gi 1021312084 700 SLLRHKYEHTGKRPHECGICKKAFKH 725
Cdd:pfam13465   1 NLKRHMRKHTGEKPYKCPECGKSFKS 26
homeodomain super family cl00084
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
363-411 5.58e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


The actual alignment was detected with superfamily member pfam00046:

Pssm-ID: 412151  Cd Length: 55  Bit Score: 38.63  E-value: 5.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1021312084 363 NLSPSQpplknlLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWF 411
Cdd:pfam00046   4 TFTPEQ------LEELEKEFQKNPYPSREEREELAAQLGLTERQVKVWF 46
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
728-753 2.32e-07

Zinc-finger double domain;


Pssm-ID: 404364 [Multi-domain]  Cd Length: 26  Bit Score: 47.34  E-value: 2.32e-07
                          10        20
                  ....*....|....*....|....*.
gi 1021312084 728 HLIEHMRLHSGEKPYQCDKCGKRFSH 753
Cdd:pfam13465   1 NLKRHMRKHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
36-59 4.39e-07

Zinc-finger double domain;


Pssm-ID: 404364 [Multi-domain]  Cd Length: 26  Bit Score: 46.57  E-value: 4.39e-07
                          10        20
                  ....*....|....*....|....
gi 1021312084  36 HLKEHLRIHSGEKPYECPNCKKRF 59
Cdd:pfam13465   1 NLKRHMRKHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
22-44 2.03e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 44.60  E-value: 2.03e-06
                          10        20
                  ....*....|....*....|...
gi 1021312084  22 FKCTECGKAFKYKHHLKEHLRIH 44
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
714-736 1.78e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.90  E-value: 1.78e-05
                          10        20
                  ....*....|....*....|...
gi 1021312084 714 HECGICKKAFKHKHHLIEHMRLH 736
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
700-725 3.71e-05

Zinc-finger double domain;


Pssm-ID: 404364 [Multi-domain]  Cd Length: 26  Bit Score: 41.18  E-value: 3.71e-05
                          10        20
                  ....*....|....*....|....*.
gi 1021312084 700 SLLRHKYEHTGKRPHECGICKKAFKH 725
Cdd:pfam13465   1 NLKRHMRKHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
22-44 2.31e-04

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 38.99  E-value: 2.31e-04
                           10        20
                   ....*....|....*....|...
gi 1021312084   22 FKCTECGKAFKYKHHLKEHLRIH 44
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
Homeobox pfam00046
Homeobox domain;
363-411 5.58e-04

Homeobox domain;


Pssm-ID: 395001  Cd Length: 55  Bit Score: 38.63  E-value: 5.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1021312084 363 NLSPSQpplknlLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWF 411
Cdd:pfam00046   4 TFTPEQ------LEELEKEFQKNPYPSREEREELAAQLGLTERQVKVWF 46
ZnF_C2H2 smart00355
zinc finger;
714-736 1.43e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.67  E-value: 1.43e-03
                           10        20
                   ....*....|....*....|...
gi 1021312084  714 HECGICKKAFKHKHHLIEHMRLH 736
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
728-753 2.32e-07

Zinc-finger double domain;


Pssm-ID: 404364 [Multi-domain]  Cd Length: 26  Bit Score: 47.34  E-value: 2.32e-07
                          10        20
                  ....*....|....*....|....*.
gi 1021312084 728 HLIEHMRLHSGEKPYQCDKCGKRFSH 753
Cdd:pfam13465   1 NLKRHMRKHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
36-59 4.39e-07

Zinc-finger double domain;


Pssm-ID: 404364 [Multi-domain]  Cd Length: 26  Bit Score: 46.57  E-value: 4.39e-07
                          10        20
                  ....*....|....*....|....
gi 1021312084  36 HLKEHLRIHSGEKPYECPNCKKRF 59
Cdd:pfam13465   1 NLKRHMRKHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
22-44 2.03e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 44.60  E-value: 2.03e-06
                          10        20
                  ....*....|....*....|...
gi 1021312084  22 FKCTECGKAFKYKHHLKEHLRIH 44
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
714-736 1.78e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 41.90  E-value: 1.78e-05
                          10        20
                  ....*....|....*....|...
gi 1021312084 714 HECGICKKAFKHKHHLIEHMRLH 736
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
700-725 3.71e-05

Zinc-finger double domain;


Pssm-ID: 404364 [Multi-domain]  Cd Length: 26  Bit Score: 41.18  E-value: 3.71e-05
                          10        20
                  ....*....|....*....|....*.
gi 1021312084 700 SLLRHKYEHTGKRPHECGICKKAFKH 725
Cdd:pfam13465   1 NLKRHMRKHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
22-44 2.31e-04

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 38.99  E-value: 2.31e-04
                           10        20
                   ....*....|....*....|...
gi 1021312084   22 FKCTECGKAFKYKHHLKEHLRIH 44
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
Homeobox pfam00046
Homeobox domain;
363-411 5.58e-04

Homeobox domain;


Pssm-ID: 395001  Cd Length: 55  Bit Score: 38.63  E-value: 5.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1021312084 363 NLSPSQpplknlLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWF 411
Cdd:pfam00046   4 TFTPEQ------LEELEKEFQKNPYPSREEREELAAQLGLTERQVKVWF 46
ZnF_C2H2 smart00355
zinc finger;
714-736 1.43e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.67  E-value: 1.43e-03
                           10        20
                   ....*....|....*....|...
gi 1021312084  714 HECGICKKAFKHKHHLIEHMRLH 736
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
22-44 2.39e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 404733  Cd Length: 24  Bit Score: 36.08  E-value: 2.39e-03
                          10        20
                  ....*....|....*....|...
gi 1021312084  22 FKCTECGKAFKYKHHLKEHLRIH 44
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
742-762 2.49e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 2.49e-03
                          10        20
                  ....*....|....*....|.
gi 1021312084 742 YQCDKCGKRFSHSGSYSQHMN 762
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLR 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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