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Conserved domains on  [gi|1109663867|ref|NP_001334585|]
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CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 2 [Mus musculus]

Protein Classification

CDP-alcohol phosphatidyltransferase family protein( domain architecture ID 10001704)

CDP-alcohol phosphatidyltransferase family protein similar to enzymes that catalyze the transfer of a substituted phosphate group from a cytidine-5'-diphosphate-linked donor to an alcohol acceptor, an essential reaction in the biosynthesis of phospholipids

EC:  2.7.8.-
Gene Ontology:  GO:0016780|GO:0008654|GO:0005886|GO:0000287
SCOP:  3002413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 7-103 5.24e-15

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 68.73  E-value: 5.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663867   7 FLFVPNLIGYARIVFA--IISFYFMPCCPFTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCATMCLLVNLA 84
Cdd:COG0558     8 LLNIPNQLTLLRILLVpvFALLLLLGGALLLALVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLLDAAALLGLV 87

                          90
                  ....*....|....*....
gi 1109663867  85 LLYPRATLLFQLSMSLDVA 103
Cdd:COG0558    88 LLGLLPAWLALLILLRELL 106
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 7-103 5.24e-15

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 68.73  E-value: 5.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663867   7 FLFVPNLIGYARIVFA--IISFYFMPCCPFTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCATMCLLVNLA 84
Cdd:COG0558     8 LLNIPNQLTLLRILLVpvFALLLLLGGALLLALVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLLDAAALLGLV 87

                          90
                  ....*....|....*....
gi 1109663867  85 LLYPRATLLFQLSMSLDVA 103
Cdd:COG0558    88 LLGLLPAWLALLILLRELL 106
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 10-88 3.18e-13

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 63.34  E-value: 3.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663867  10 VPNLIGYARI--VFAIISFYFMPCCPFTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCATMCLLVNLALLY 87
Cdd:pfam01066   3 LPNLLTLLRIllVPVFVVLLLGPGNRILAAVVFALAALTDFLDGKIARKLNQVTDFGKFLDPLADKLLVAAALIALSILG 82


                  .
gi 1109663867  88 P 88
Cdd:pfam01066  83 L 83
PRK10832 PRK10832
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
10-93 3.39e-06

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


Pssm-ID: 182763 [Multi-domain]  Cd Length: 182  Bit Score: 44.84  E-value: 3.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663867  10 VPNLIGYARIV---FAIISFYF-MPCCPFTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCATMCLLVNLAL 85
Cdd:PRK10832    5 IPTLLTLFRVIlipFFVLVFYLpFTWAPFVCALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADKVMVAIAMVLVTE 84

                          90
                  ....*....|....*
gi 1109663867  86 LY-------PRATLL 93
Cdd:PRK10832   85 HYhswwvtlPAATMI 99
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
 10-86 5.57e-06

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 44.26  E-value: 5.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663867  10 VPNLIGYARIV---FAIISFY----FMPCCPFTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRcatmcLLVN 82
Cdd:TIGR00560   3 IPNWLTLFRIIalpIFILFFLenvlPIQVSPFIGALLFIFAAVTDWLDGYLARKWNQVSNFGKFLDPLADK-----VLVL 77


                  ....
gi 1109663867  83 LALL 86
Cdd:TIGR00560  78 AVLI 81
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 7-103 5.24e-15

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 68.73  E-value: 5.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663867   7 FLFVPNLIGYARIVFA--IISFYFMPCCPFTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCATMCLLVNLA 84
Cdd:COG0558     8 LLNIPNQLTLLRILLVpvFALLLLLGGALLLALVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLLDAAALLGLV 87

                          90
                  ....*....|....*....
gi 1109663867  85 LLYPRATLLFQLSMSLDVA 103
Cdd:COG0558    88 LLGLLPAWLALLILLRELL 106
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 10-88 3.18e-13

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 63.34  E-value: 3.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663867  10 VPNLIGYARI--VFAIISFYFMPCCPFTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCATMCLLVNLALLY 87
Cdd:pfam01066   3 LPNLLTLLRIllVPVFVVLLLGPGNRILAAVVFALAALTDFLDGKIARKLNQVTDFGKFLDPLADKLLVAAALIALSILG 82


                  .
gi 1109663867  88 P 88
Cdd:pfam01066  83 L 83
PRK10832 PRK10832
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
10-93 3.39e-06

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


Pssm-ID: 182763 [Multi-domain]  Cd Length: 182  Bit Score: 44.84  E-value: 3.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663867  10 VPNLIGYARIV---FAIISFYF-MPCCPFTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCATMCLLVNLAL 85
Cdd:PRK10832    5 IPTLLTLFRVIlipFFVLVFYLpFTWAPFVCALIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADKVMVAIAMVLVTE 84

                          90
                  ....*....|....*
gi 1109663867  86 LY-------PRATLL 93
Cdd:PRK10832   85 HYhswwvtlPAATMI 99
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
 10-86 5.57e-06

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 44.26  E-value: 5.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663867  10 VPNLIGYARIV---FAIISFY----FMPCCPFTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRcatmcLLVN 82
Cdd:TIGR00560   3 IPNWLTLFRIIalpIFILFFLenvlPIQVSPFIGALLFIFAAVTDWLDGYLARKWNQVSNFGKFLDPLADK-----VLVL 77


                  ....
gi 1109663867  83 LALL 86
Cdd:TIGR00560  78 AVLI 81
PssA COG1183
Phosphatidylserine synthase [Lipid transport and metabolism];
6-72 3.40e-05

Phosphatidylserine synthase [Lipid transport and metabolism];


Pssm-ID: 440796 [Multi-domain]  Cd Length: 237  Bit Score: 42.49  E-value: 3.40e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1109663867   6 IFLFVPNLI-------GYARIVFAIISFYFMpccpftASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTD 72
Cdd:COG1183     8 AIYLLPNLFtllnlfcGFLAIVAAIEGDFEL------AALLILLAAVFDGLDGRVARLLNVQSEFGAELDSLAD 75
PLN02558 PLN02558
CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase
 7-80 1.54e-03

CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase


Pssm-ID: 166199  Cd Length: 203  Bit Score: 37.70  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663867   7 FLFVPNLIGYARIV---FAIISFYFMPCCPFTAS-SFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDR---CATMCL 79
Cdd:PLN02558    8 VLTLPTVLTLGRVAavpLLVATFYVDSWWGRTATtSIFIAAAITDWLDGYLARKMKLGTAFGAFLDPVADKlmvAAALIL 87


                  .
gi 1109663867  80 L 80
Cdd:PLN02558   88 L 88
PLN02794 PLN02794
cardiolipin synthase
 7-88 3.57e-03

cardiolipin synthase


Pssm-ID: 178391  Cd Length: 341  Bit Score: 36.75  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663867   7 FLFVPNLIGYARIVFAIIsFYFMPCCPFTASSFYLL--SGLLDAFDGHAARALNQGTRFGAMLDMLTDRCATMCL---LV 81
Cdd:PLN02794  141 FVNLPNLISISRLVSGPV-IGWMIVNEMYLSAFVGLaiSGASDWLDGYVARKMGINSVVGSYLDPLADKVLIGCValaMV 219


                  ....*..
gi 1109663867  82 NLALLYP 88
Cdd:PLN02794  220 EKDLLHP 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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