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Conserved domains on  [gi|1109663844|ref|NP_001334587|]
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ataxin-2-like protein isoform 2 [Mus musculus]

Protein Classification

SM-ATX and LsmAD domain-containing protein( domain architecture ID 13860551)

SM-ATX and LsmAD domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 35-108 3.06e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 82.99  E-value: 3.06e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1109663844  35 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVLLVHFR 108
Cdd:pfam14438   1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 176-238 1.44e-17

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.44e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1109663844 176 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 238
Cdd:pfam06741   1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 669-888 9.78e-11

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 65.83  E-value: 9.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 669 PPQRSDQHQPASAPPMMQAAAAAAGPPLVAATPYSSyiPYNPQQFPGQPAMMQPMA--------------HYPSQPVFAP 734
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRT--GYEKYKEPEPIPDLQVDAslwgvapkkaaapaPAPQPAAQPA 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 735 MLQSNPRMLTS--------------------GSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSYPHHATQL--HGHQPQ 792
Cdd:pfam09770 185 SLPAPSRKMMSleeveaamraqakkpaqqpaPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVT 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 793 PATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPqssfPQPAavyaiHPHQQL 872
Cdd:pfam09770 265 ILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQ----PAPA-----HQAHRQ 335

                         250
                  ....*....|....*.
gi 1109663844 873 PHGFTNMAHVTQAHVQ 888
Cdd:pfam09770 336 QGSFGRQAPIITHPQQ 351
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 315-860 2.22e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.88  E-value: 2.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  315 GGPSRMSPKAQRPLRGAKTL--SSPSNRPSGEA--------SVPPTSAAlPFLPVGRMYPPRSPKSAAPAPVSASCPEPP 384
Cdd:PHA03247  2549 GDPPPPLPPAAPPAAPDRSVppPRPAPRPSEPAvtsrarrpDAPPQSAR-PRAPVDDRGDPRGPAPPSPLPPDTHAPDPP 2627

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  385 I--GSAVASSASIPVTSSVVDPGAGSISPASPKLSLtptdvkelptkePSRnleAQELARIAGKVPGLQNEQKRfqleel 462
Cdd:PHA03247  2628 PpsPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR------------PRR---ARRLGRAAQASSPPQRPRRR------ 2686

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  463 rkfgaqfKLQPSSSPETGL-DPFPsrilkeeakgkekevdglltsdPMGSPVSSktesildkedkvPMAGVGGTEGPeql 541
Cdd:PHA03247  2687 -------AARPTVGSLTSLaDPPP----------------------PPPTPEPA------------PHALVSATPLP--- 2722

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  542 PAPCPSQTGSPPVGLikgdekeeGPVTEQVKKSTLNPNAKEFNPTKPLlsvnksTSTPTSPGPrthstPSIPVlTAGQSG 621
Cdd:PHA03247  2723 PGPAAARQASPALPA--------APAPPAVPAGPATPGGPARPARPPT------TAGPPAPAP-----PAAPA-AGPPRR 2782

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  622 LYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPmmqaaaaaagpplvaatP 701
Cdd:PHA03247  2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG-----------------P 2845

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  702 YSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSY 779
Cdd:PHA03247  2846 PPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQ 2922

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  780 PHHATqlhghQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLP-PGPSAQSPQSSFP 858
Cdd:PHA03247  2923 PPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqPAPSREAPASSTP 2994


                   ..
gi 1109663844  859 QP 860
Cdd:PHA03247  2995 PL 2996
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 35-108 3.06e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 82.99  E-value: 3.06e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1109663844  35 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVLLVHFR 108
Cdd:pfam14438   1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 176-238 1.44e-17

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.44e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1109663844 176 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 238
Cdd:pfam06741   1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 669-888 9.78e-11

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 65.83  E-value: 9.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 669 PPQRSDQHQPASAPPMMQAAAAAAGPPLVAATPYSSyiPYNPQQFPGQPAMMQPMA--------------HYPSQPVFAP 734
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRT--GYEKYKEPEPIPDLQVDAslwgvapkkaaapaPAPQPAAQPA 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 735 MLQSNPRMLTS--------------------GSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSYPHHATQL--HGHQPQ 792
Cdd:pfam09770 185 SLPAPSRKMMSleeveaamraqakkpaqqpaPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVT 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 793 PATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPqssfPQPAavyaiHPHQQL 872
Cdd:pfam09770 265 ILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQ----PAPA-----HQAHRQ 335

                         250
                  ....*....|....*.
gi 1109663844 873 PHGFTNMAHVTQAHVQ 888
Cdd:pfam09770 336 QGSFGRQAPIITHPQQ 351
PHA03247 PHA03247
large tegument protein UL36; Provisional
 315-860 2.22e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.88  E-value: 2.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  315 GGPSRMSPKAQRPLRGAKTL--SSPSNRPSGEA--------SVPPTSAAlPFLPVGRMYPPRSPKSAAPAPVSASCPEPP 384
Cdd:PHA03247  2549 GDPPPPLPPAAPPAAPDRSVppPRPAPRPSEPAvtsrarrpDAPPQSAR-PRAPVDDRGDPRGPAPPSPLPPDTHAPDPP 2627

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  385 I--GSAVASSASIPVTSSVVDPGAGSISPASPKLSLtptdvkelptkePSRnleAQELARIAGKVPGLQNEQKRfqleel 462
Cdd:PHA03247  2628 PpsPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR------------PRR---ARRLGRAAQASSPPQRPRRR------ 2686

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  463 rkfgaqfKLQPSSSPETGL-DPFPsrilkeeakgkekevdglltsdPMGSPVSSktesildkedkvPMAGVGGTEGPeql 541
Cdd:PHA03247  2687 -------AARPTVGSLTSLaDPPP----------------------PPPTPEPA------------PHALVSATPLP--- 2722

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  542 PAPCPSQTGSPPVGLikgdekeeGPVTEQVKKSTLNPNAKEFNPTKPLlsvnksTSTPTSPGPrthstPSIPVlTAGQSG 621
Cdd:PHA03247  2723 PGPAAARQASPALPA--------APAPPAVPAGPATPGGPARPARPPT------TAGPPAPAP-----PAAPA-AGPPRR 2782

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  622 LYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPmmqaaaaaagpplvaatP 701
Cdd:PHA03247  2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG-----------------P 2845

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  702 YSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSY 779
Cdd:PHA03247  2846 PPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQ 2922

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  780 PHHATqlhghQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLP-PGPSAQSPQSSFP 858
Cdd:PHA03247  2923 PPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqPAPSREAPASSTP 2994


                   ..
gi 1109663844  859 QP 860
Cdd:PHA03247  2995 PL 2996
PHA03247 PHA03247
large tegument protein UL36; Provisional
 538-951 4.81e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 4.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  538 PEQLPAPCPSQTGSPPVGLIKGDEKEEGPVTEQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVlta 617
Cdd:PHA03247  2619 PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSL--- 2695

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  618 gqSGLYSPQyisyipqihmgPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAAGPPLV 697
Cdd:PHA03247  2696 --TSLADPP-----------PPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  698 AATPYSSYIPYNPqqfpgqPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYATVHQ 777
Cdd:PHA03247  2763 TAGPPAPAPPAAP------AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  778 SYPHHATQlhghQPQPATTPTGS---------QPQSQHAAPSPVQHQAGQAPHLGSGQPQQNlyhPGALTGTPPSLPPGP 848
Cdd:PHA03247  2837 TAPPPPPG----PPPPSLPLGGSvapggdvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRS---TESFALPPDQPERPP 2909

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  849 SAQSPQSSFPQPAAVYAIHPHQQLPhgftnmahvtqahvqtgvTAAPPPHPGAPHPPQVMLLHPPQGHGGPPQGAVPPSG 928
Cdd:PHA03247  2910 QPQAPPPPQPQPQPPPPPQPQPPPP------------------PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGR 2971

                          410       420
                   ....*....|....*....|...
gi 1109663844  929 VPALSASTPSPYPYIGHPQGEQP 951
Cdd:PHA03247  2972 VAVPRFRVPQPAPSREAPASSTP 2994
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 35-108 3.06e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 82.99  E-value: 3.06e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1109663844  35 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVLLVHFR 108
Cdd:pfam14438   1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 176-238 1.44e-17

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.44e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1109663844 176 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 238
Cdd:pfam06741   1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 669-888 9.78e-11

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 65.83  E-value: 9.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 669 PPQRSDQHQPASAPPMMQAAAAAAGPPLVAATPYSSyiPYNPQQFPGQPAMMQPMA--------------HYPSQPVFAP 734
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRT--GYEKYKEPEPIPDLQVDAslwgvapkkaaapaPAPQPAAQPA 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 735 MLQSNPRMLTS--------------------GSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSYPHHATQL--HGHQPQ 792
Cdd:pfam09770 185 SLPAPSRKMMSleeveaamraqakkpaqqpaPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVT 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 793 PATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPqssfPQPAavyaiHPHQQL 872
Cdd:pfam09770 265 ILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQ----PAPA-----HQAHRQ 335

                         250
                  ....*....|....*.
gi 1109663844 873 PHGFTNMAHVTQAHVQ 888
Cdd:pfam09770 336 QGSFGRQAPIITHPQQ 351
PHA03247 PHA03247
large tegument protein UL36; Provisional
 315-860 2.22e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.88  E-value: 2.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  315 GGPSRMSPKAQRPLRGAKTL--SSPSNRPSGEA--------SVPPTSAAlPFLPVGRMYPPRSPKSAAPAPVSASCPEPP 384
Cdd:PHA03247  2549 GDPPPPLPPAAPPAAPDRSVppPRPAPRPSEPAvtsrarrpDAPPQSAR-PRAPVDDRGDPRGPAPPSPLPPDTHAPDPP 2627

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  385 I--GSAVASSASIPVTSSVVDPGAGSISPASPKLSLtptdvkelptkePSRnleAQELARIAGKVPGLQNEQKRfqleel 462
Cdd:PHA03247  2628 PpsPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR------------PRR---ARRLGRAAQASSPPQRPRRR------ 2686

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  463 rkfgaqfKLQPSSSPETGL-DPFPsrilkeeakgkekevdglltsdPMGSPVSSktesildkedkvPMAGVGGTEGPeql 541
Cdd:PHA03247  2687 -------AARPTVGSLTSLaDPPP----------------------PPPTPEPA------------PHALVSATPLP--- 2722

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  542 PAPCPSQTGSPPVGLikgdekeeGPVTEQVKKSTLNPNAKEFNPTKPLlsvnksTSTPTSPGPrthstPSIPVlTAGQSG 621
Cdd:PHA03247  2723 PGPAAARQASPALPA--------APAPPAVPAGPATPGGPARPARPPT------TAGPPAPAP-----PAAPA-AGPPRR 2782

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  622 LYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPmmqaaaaaagpplvaatP 701
Cdd:PHA03247  2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG-----------------P 2845

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  702 YSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSY 779
Cdd:PHA03247  2846 PPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQ 2922

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  780 PHHATqlhghQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLP-PGPSAQSPQSSFP 858
Cdd:PHA03247  2923 PPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqPAPSREAPASSTP 2994


                   ..
gi 1109663844  859 QP 860
Cdd:PHA03247  2995 PL 2996
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 709-947 1.86e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 51.96  E-value: 1.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 709 NPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSG----SHPQAI----VSSS------TPQYPAAEQPTPQALYAT 774
Cdd:pfam09770 106 QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGyekyKEPEPIpdlqVDASlwgvapKKAAAPAPAPQPAAQPAS 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 775 VHQSYPHHAT------QLHGHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGP 848
Cdd:pfam09770 186 LPAPSRKMMSleeveaAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTI 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 849 SaQSPQSSFPQPAAVYA-IHPHQQLPHGFTNMAHVTQAHVQTGVtaappphpgaphppQVMLLHPPQGHGGPPQGAVPPS 927
Cdd:pfam09770 266 L-QRPQSPQPDPAQPSIqPQAQQFHQQPPPVPVQPTQILQNPNR--------------LSAARVGYPQNPQPGVQPAPAH 330

                         250       260
                  ....*....|....*....|
gi 1109663844 928 GVPALSASTPSPYPYIGHPQ 947
Cdd:pfam09770 331 QAHRQQGSFGRQAPIITHPQ 350
PHA03247 PHA03247
large tegument protein UL36; Provisional
 252-647 5.45e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 5.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  252 PSLVSREGKYIPLPQRVRegPRGGVRCSSSRGGRPGLSSLPPrGPHHLDNSSPGPGSEARGINGGPSRMSPKAQRPLRG- 330
Cdd:PHA03247  2580 PAVTSRARRPDAPPQSAR--PRAPVDDRGDPRGPAPPSPLPP-DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDp 2656

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  331 ----------------AKTLSSPSNRPSGEASVPP----TSAALPFLPVGRMYP------PRSPKSAAPAPVSASCPEPP 384
Cdd:PHA03247  2657 apgrvsrprrarrlgrAAQASSPPQRPRRRAARPTvgslTSLADPPPPPPTPEPaphalvSATPLPPGPAAARQASPALP 2736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  385 IGSAVASSASIPVTSSVVDPGAGSISPASPKLSLTPTDvkelPTKEPSRNLEAQELARIAGKVPGLQNEQKRFQLEELRK 464
Cdd:PHA03247  2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA----PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL 2812

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  465 fGAQFKLQPSSSPETGLDPFPSrilkeeakgkekevdGLLTSDPMGSPVSSKTESIldkEDKVPMAGVGGTEGPEQLPAP 544
Cdd:PHA03247  2813 -APAAALPPAASPAGPLPPPTS---------------AQPTAPPPPPGPPPPSLPL---GGSVAPGGDVRRRPPSRSPAA 2873

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  545 CPSQTGSPPVGLIKGDEKEEGPVTEQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVL----TAGQS 620
Cdd:PHA03247  2874 KPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLApttdPAGAG 2953

                          410       420       430
                   ....*....|....*....|....*....|.
gi 1109663844  621 ----GLYSPQYISYIPQIHMGPAVQAPQMYP 647
Cdd:PHA03247  2954 epsgAVPQPWLGALVPGRVAVPRFRVPQPAP 2984
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 286-613 3.80e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.76  E-value: 3.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 286 PGLSSLPPRGPHHlDNSSPGPGSEARGINGGPSRMSPKAQRPLRGAKtlsSPSNRPSGEASVPPTSAALPFLPVGRMYP- 364
Cdd:PTZ00449  514 PEASGLPPKAPGD-KEGEEGEHEDSKESDEPKEGGKPGETKEGEVGK---KPGPAKEHKPSKIPTLSKKPEFPKDPKHPk 589

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 365 -PRSPKSAApAPVSASCPEPPIGSAVASSASIPVTSSVVDPGAGSISPASPKLSLT---PTDVKELPTKEPSRnleaqel 440
Cdd:PTZ00449  590 dPEEPKKPK-RPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSperPEGPKIIKSPKPPK------- 661

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 441 ariAGKVPglqneqkrFQLEELRKFGAQFKLQPSSSPETGLDPFPSRILKEEAKGKEKEVDGLLTSDPMG-SPVSSKTES 519
Cdd:PTZ00449  662 ---SPKPP--------FDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPlPPKLPRDEE 730

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 520 ILDKEDKVPMAgvggtegpeqlPAPCPSQTGSPPVGL------IKGDEKEEGPVTEQVKKSTLNPNAKEfnPTKPLLSVN 593
Cdd:PTZ00449  731 FPFEPIGDPDA-----------EQPDDIEFFTPPEEErtffheTPADTPLPDILAEEFKEEDIHAETGE--PDEAMKRPD 797

                         330       340
                  ....*....|....*....|.
gi 1109663844 594 KSTS-TPTSPGprTHstPSIP 613
Cdd:PTZ00449  798 SPSEhEDKPPG--DH--PSLP 814
PHA03247 PHA03247
large tegument protein UL36; Provisional
 538-951 4.81e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 4.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  538 PEQLPAPCPSQTGSPPVGLIKGDEKEEGPVTEQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVlta 617
Cdd:PHA03247  2619 PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSL--- 2695

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  618 gqSGLYSPQyisyipqihmgPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAAGPPLV 697
Cdd:PHA03247  2696 --TSLADPP-----------PPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  698 AATPYSSYIPYNPqqfpgqPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYATVHQ 777
Cdd:PHA03247  2763 TAGPPAPAPPAAP------AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  778 SYPHHATQlhghQPQPATTPTGS---------QPQSQHAAPSPVQHQAGQAPHLGSGQPQQNlyhPGALTGTPPSLPPGP 848
Cdd:PHA03247  2837 TAPPPPPG----PPPPSLPLGGSvapggdvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRS---TESFALPPDQPERPP 2909

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  849 SAQSPQSSFPQPAAVYAIHPHQQLPhgftnmahvtqahvqtgvTAAPPPHPGAPHPPQVMLLHPPQGHGGPPQGAVPPSG 928
Cdd:PHA03247  2910 QPQAPPPPQPQPQPPPPPQPQPPPP------------------PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGR 2971

                          410       420
                   ....*....|....*....|...
gi 1109663844  929 VPALSASTPSPYPYIGHPQGEQP 951
Cdd:PHA03247  2972 VAVPRFRVPQPAPSREAPASSTP 2994
PHA03247 PHA03247
large tegument protein UL36; Provisional
 467-956 6.35e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 6.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  467 AQFKLQPSSSPETGLDPFPSrilKEEAKGKEKEVDGLLTSDPMGSPVSSKTESILDKEDKVPMAGVGGTEGP--EQLPAP 544
Cdd:PHA03247  2486 ARFPFAAGAAPDPGGGGPPD---PDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPlpPAAPPA 2562

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  545 CPSQTGSPPvglikgdEKEEGPVTEQVKKSTLNPNAKEfNPTKPLLSVNKSTSTPTSPGPrTHSTPSIPVLTAGQSGLYS 624
Cdd:PHA03247  2563 APDRSVPPP-------RPAPRPSEPAVTSRARRPDAPP-QSARPRAPVDDRGDPRGPAPP-SPLPPDTHAPDPPPPSPSP 2633

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  625 PQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQ-QGKYRGAKGSLPPQRSDQHQ---PASAPPMMQAAAAAAGPPLVAAT 700
Cdd:PHA03247  2634 AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRaRRLGRAAQASSPPQRPRRRAarpTVGSLTSLADPPPPPPTPEPAPH 2713

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  701 PYSSYIPYNP-QQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPAAeQPTPQALYATVhqsy 779
Cdd:PHA03247  2714 ALVSATPLPPgPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAA-GPPRRLTRPAV---- 2788

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  780 phhatqlhghqpQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQS------- 852
Cdd:PHA03247  2789 ------------ASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSlplggsv 2856

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  853 -----------PQSSFPQPAAVYAIhPHQQLPHGFTNMAHVTQAHVQTGVTAAPPPHPGAPHPPQVMLLHPPQGHGGPPQ 921
Cdd:PHA03247  2857 apggdvrrrppSRSPAAKPAAPARP-PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP 2935

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 1109663844  922 GAVPPSGVPALSASTPSPYPYIGHPQGEQPGQAPG 956
Cdd:PHA03247  2936 PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPG 2970
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
788-863 1.15e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 45.92  E-value: 1.15e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1109663844 788 GHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAphlgSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAV 863
Cdd:PRK14971  389 APQPSAAAAASPSPSQSSAAAQPSAPQSATQP----AGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPV 460
Herpes_TAF50 pfam03326
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 ...
 538-834 1.94e-04

Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.


Pssm-ID: 308764 [Multi-domain]  Cd Length: 568  Bit Score: 45.08  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 538 PEQLPAPCPSQTGSPP----VGLIKGDEKEEGPVTEQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIP 613
Cdd:pfam03326 269 PQRLQAPGFSRSTSRPargqTAQYFLAAQQHGVVSLFPSTATLVPIAGSTGVTEVVSYGHNSTSPSSTPCPSTAVTEADH 348

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 614 VLTAGQSGLYSPQYISYipQIHMGPAVQAPQMYPYPvsnsvpgqqGKYRGAKGsLPPQRSDQHQPAsappmmqAAAAAAG 693
Cdd:pfam03326 349 QTEPEVPWIATAHQESD--QRPIGPGPEKPTFLPPV---------GGKQFFQG-LRDSRSTSFLTA-------PEATSAI 409

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 694 PPLVAATPYSSYIPYNPQQFPGQPammqpmahypsqpvfapmlqSNPRMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYA 773
Cdd:pfam03326 410 SDVFQGTEVCQPKRIRALHPPGSP--------------------SANRPLPSSLAPTPTGPVHEPGSSLTPATVPQPLDA 469

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1109663844 774 T--VHQSYPHHATQLHGHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHP 834
Cdd:pfam03326 470 ApvATPEASHELQPPDEETPQPLDEDQALCGQQDASHPPPRGQLDELTTTLESMTEDLNLDSP 532
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 759-961 2.02e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.41  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 759 QYPAAEQPTPQALYATVHQSYPHHATQLHGHQPQPATT---------------------PTGSQPQSQHAAPSPVQHQAG 817
Cdd:pfam09770 105 QQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTgyekykepepipdlqvdaslwGVAPKKAAAPAPAPQPAAQPA 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 818 QAPHLG-------------SGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIHPHQQLPHGFTNMAHVTQ 884
Cdd:pfam09770 185 SLPAPSrkmmsleeveaamRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVT 264

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1109663844 885 AHVQTGVTAAPPPHPGAPHPPQVMLLHPPQGHGGPPQGAVPPSGVPALSASTPSPYPYIGHPQGEQPG--QAPGFPGGA 961
Cdd:pfam09770 265 ILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAHQAhrQQGSFGRQA 343
PRK10927 PRK10927
cell division protein FtsN;
759-862 2.61e-04

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 44.29  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 759 QYPAAEQPTPQalyatvHQSYPHHATQLHGHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALT 838
Cdd:PRK10927  144 QTPEQRQQTLQ------RQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQPYQDLLQTPAHT 217

                          90       100
                  ....*....|....*....|....*
gi 1109663844 839 GTPPSLP-PGPSAQSPQSsfPQPAA 862
Cdd:PRK10927  218 TAQSKPQqAAPVTRAADA--PKPTA 240
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 711-868 3.60e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.69  E-value: 3.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  711 QQFPG-QPAMMQPMAHypSQPVFAPMlqsnPRMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSYPHHATQLHGH 789
Cdd:PRK10263   709 QRYSGeQPAGANPFSL--DDFEFSPM----KALLDDGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQ 782

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1109663844  790 QPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQnlyhpgaltgtpPSLPPGPSAQSPQSSFPQPAAVYaIHP 868
Cdd:PRK10263   783 QPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQ------------PVAPQPQYQQPQQPVAPQPQDTL-LHP 848
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 651-958 4.90e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 4.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 651 SNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAAGPPLVAATPYSSYIPYNPQQFP-GQPAMMQPMAHYPSQ 729
Cdd:pfam03154 145 SPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPqGSPATSQPPNQTQST 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 730 PVFAPMLQSNPRMltsgsHPQAIVSSSTPQYPAAEQPTPQALYATVHQSYPHHATQLHGHQPQPATTPTGSQPQSQHAAP 809
Cdd:pfam03154 225 AAPHTLIQQTPTL-----HPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFP 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 810 SPVQHQAGQAPHLgsgqPQQNLYHPGALTG-TPPSLPPGPSAQSPQSSFPQPAAVYAIH----PHQQLPHGFTNMAHVTQ 884
Cdd:pfam03154 300 LTPQSSQSQVPPG----PSPAAPGQSQQRIhTPPSQSQLQSQQPPREQPLPPAPLSMPHikppPTTPIPQLPNPQSHKHP 375

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 885 AHVQT----GVTAAPPPHPGAPHPPQVMLLHPPQGHGGP----PQGA---VPPSGVPALSASTPSPYPYIGHPQGEQPGQ 953
Cdd:pfam03154 376 PHLSGpspfQMNSNLPPPPALKPLSSLSTHHPPSAHPPPlqlmPQSQqlpPPPAQPPVLTQSQSLPPPAASHPPTSGLHQ 455


                  ....*
gi 1109663844 954 APGFP 958
Cdd:pfam03154 456 VPSQS 460
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 247-432 2.02e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.98  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 247 SGRESPSLVSREGKYIPLPQRVREGPRGGvRCSSSRGGRPglSSLP-----PRGP----HHLDNSSPGPGSEARGINGGP 317
Cdd:PTZ00449  531 EGEHEDSKESDEPKEGGKPGETKEGEVGK-KPGPAKEHKP--SKIPtlskkPEFPkdpkHPKDPEEPKKPKRPRSAQRPT 607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 318 SRMSPKAQRPLRGAKTLSSPSNRPSGEASVPPTSAALPFLPVGrmypPRSPKSAAPaPVSascPEPPIG----------- 386
Cdd:PTZ00449  608 RPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEG----PKIIKSPKP-PKS---PKPPFDpkfkekfyddy 679

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1109663844 387 SAVASSASIPVTSSVVDPGAGSISPAS-PKLSLTP-TDVKELPTKEPS 432
Cdd:PTZ00449  680 LDAAAKSKETKTTVVLDESFESILKETlPETPGTPfTTPRPLPPKLPR 727
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
327-469 3.50e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.30  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 327 PLRGAKTLSSPSNrpSGEASVPPTSAAlpflPVGRMYPPRS---PKSAAPAPVSASCPEPPIGSaVASSASIPVTSSVVD 403
Cdd:PRK14971  371 GGRGPKQHIKPVF--TQPAAAPQPSAA----AAASPSPSQSsaaAQPSAPQSATQPAGTPPTVS-VDPPAAVPVNPPSTA 443

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1109663844 404 PGAGSISPASPKLSLTPTDV--KELPTKEPSRNLEAQELARIAGKVPGLQNEQkrFQLEELRKFGAQF 469
Cdd:PRK14971  444 PQAVRPAQFKEEKKIPVSKVssLGPSTLRPIQEKAEQATGNIKEAPTGTQKEI--FTEEDLQYYWQEF 509
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 306-472 4.26e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.85  E-value: 4.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 306 PGSEARGINGGPSRMSPKAQRPLRGAKTLSSPsnRPSGEASVPPTSAAlPFLPVGRMYPPRSPKSAAPAPVSASCPEPPI 385
Cdd:PRK14951  374 APAEKKTPARPEAAAPAAAPVAQAAAAPAPAA--APAAAASAPAAPPA-AAPPAPVAAPAAAAPAAAPAAAPAAVALAPA 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 386 GSAVASS--ASIPVTSSV---VDPGAGSISPASPKLSLTPTD--------VKELPTKEPSRNLeAQELAriagkvpgLQN 452
Cdd:PRK14951  451 PPAQAAPetVAIPVRVAPepaVASAAPAPAAAPAAARLTPTEegdvwhatVQQLAAAEAITAL-ARELA--------LQS 521

                         170       180
                  ....*....|....*....|....*....
gi 1109663844 453 E---------QKRFQLEELRKFGAQFKLQ 472
Cdd:PRK14951  522 ElvardgdqwLLRVERESLNQPGARERLR 550
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
301-441 4.35e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 4.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 301 NSSPGPGSEARGINGGPSRMSPKAQRPLRGAKTLSSPSNRPSGEASVPPTSA------ALPFLPVGRMYPPRSPKSA-AP 373
Cdd:PRK12323  371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAparrspAPEALAAARQASARGPGGApAP 450

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1109663844 374 APVSASCPEPPIGSAVASSASIPVTSSVVDPGAGSISPASPKLSLTPTdVKELPTKEPSRNLEAQELA 441
Cdd:PRK12323  451 APAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPP-WEELPPEFASPAPAQPDAA 517
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 745-964 4.39e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 745 SGSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSyphhatqlhghQPQPATTPTGSQPQSQHAAPSPVQHqAGQAPHLGS 824
Cdd:PRK07764  592 PGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPA-----------APAPAGAAAAPAEASAAPAPGVAAP-EHHPKHVAV 659

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 825 GQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIHPHQQLPHGFTNMAHVTQAHVQTGVTAAPPPHPGAPHP 904
Cdd:PRK07764  660 PDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPV 739

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 905 PQVMLLHPPQGHGGPPQGAVPPSGVPALSASTPSPYPYIGHPQGEQPGQAPGFPGGADDR 964
Cdd:PRK07764  740 PLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRR 799
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
669-862 4.94e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 4.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 669 PPQRSDQHQPASAPPMMQAAAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSH 748
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844 749 PQAIVSSSTP-------QYPAAEQPTPQALYATVHQSYPHHATQlhgHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPH 821
Cdd:PRK12323  445 GGAPAPAPAPaaapaaaARPAAAGPRPVAAAAAAAPARAAPAAA---PAPADDDPPPWEELPPEFASPAPAQPDAAPAGW 521

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1109663844 822 LGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAA 862
Cdd:PRK12323  522 VAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVA 562
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 239-433 6.65e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 6.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  239 HSAVQRQGSGRESPSLVSREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGP---------HHLDNSSPGPGSE 309
Cdd:PHA03307   171 QAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAaddagasssDSSSSESSGCGWG 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109663844  310 ARGINGGPSRMSPKAQRPLRGAKTLSSPSNRPSGEASVPPTSAALPflPVGRMYPPRSPKSAAPAPVSASCPEPPIGSAV 389
Cdd:PHA03307   251 PENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSP--SPSPSSPGSGPAPSSPRASSSSSSSRESSSSS 328

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1109663844  390 ASSASIPVTSSVVDPGAGSISPASPKLSLTPTDVKELPTKEPSR 433
Cdd:PHA03307   329 TSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPS 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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