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Conserved domains on  [gi|1247173937|ref|NP_001343210|]
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leucine-rich repeat-containing protein 19 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR19-TM pfam15176
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of ...
 251-364 7.48e-68

Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.


:

Pssm-ID: 464545  Cd Length: 115  Bit Score: 208.99  E-value: 7.48e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937 251 LTWTSEHEPLGKSWAFLVGVVATVLLTSLLIFIAIKCPVWYNILLSYNHHRLEEHEAETYENGLTRNPSSLSQITDTNSE 330
Cdd:pfam15176   2 LTPNSEHERSGKSWAFLVGVVVTVLMTSLLIAIAIKCPKWYNFLLSYNHHRLEEHEAETYESGDTGNPSSLSQLQATNPD 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1247173937 331 DTTVIFEQLHAFVVDDDGFIEDRYIDINEVHEEK 364
Cdd:pfam15176  82 DTTVIFEQLHSFVVDDDGFIEDKYIDTHELKEEN 115
LRR_8 pfam13855
Leucine rich repeat;
96-155 8.94e-13

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 8.94e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  96 NLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKILQLNPDTFVPLNNLKVLNLQGNLI 155
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
45-174 5.72e-10

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 5.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  45 TNVTILDLSYNRITlnaADSRVLQMYSLLTELYLMENNIIALyNSSFRNLLNLEILNICGNSISVIQQgSFVGLNELKQL 124
Cdd:COG4886   113 TNLESLDLSGNQLT---DLPEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKEL 187

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1247173937 125 FLCQNKILQLnPDTFVPLNNLKVLNLQGNLIRLFDAP--QLPHLEILTLDGN 174
Cdd:COG4886   188 DLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPlaNLTNLETLDLSNN 238
LRRCT smart00082
Leucine rich repeat C-terminal domain;
174-211 5.35e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 5.35e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1247173937  174 NPWNCTCGLLELHNWLNTSNVTLENENMtMCSYPDELK 211
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDL-RCASPSSLR 37
 
Name Accession Description Interval E-value
LRR19-TM pfam15176
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of ...
 251-364 7.48e-68

Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.


Pssm-ID: 464545  Cd Length: 115  Bit Score: 208.99  E-value: 7.48e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937 251 LTWTSEHEPLGKSWAFLVGVVATVLLTSLLIFIAIKCPVWYNILLSYNHHRLEEHEAETYENGLTRNPSSLSQITDTNSE 330
Cdd:pfam15176   2 LTPNSEHERSGKSWAFLVGVVVTVLMTSLLIAIAIKCPKWYNFLLSYNHHRLEEHEAETYESGDTGNPSSLSQLQATNPD 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1247173937 331 DTTVIFEQLHAFVVDDDGFIEDRYIDINEVHEEK 364
Cdd:pfam15176  82 DTTVIFEQLHSFVVDDDGFIEDKYIDTHELKEEN 115
LRR_8 pfam13855
Leucine rich repeat;
96-155 8.94e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 8.94e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  96 NLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKILQLNPDTFVPLNNLKVLNLQGNLI 155
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-174 5.72e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 5.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  45 TNVTILDLSYNRITlnaADSRVLQMYSLLTELYLMENNIIALyNSSFRNLLNLEILNICGNSISVIQQgSFVGLNELKQL 124
Cdd:COG4886   113 TNLESLDLSGNQLT---DLPEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKEL 187

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1247173937 125 FLCQNKILQLnPDTFVPLNNLKVLNLQGNLIRLFDAP--QLPHLEILTLDGN 174
Cdd:COG4886   188 DLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPlaNLTNLETLDLSNN 238
LRRCT smart00082
Leucine rich repeat C-terminal domain;
174-211 5.35e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 5.35e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1247173937  174 NPWNCTCGLLELHNWLNTSNVTLENENMtMCSYPDELK 211
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDL-RCASPSSLR 37
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-175 8.48e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 8.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  45 TNVTILDLSYNRITLNAAdsrvLQMYSLLTELYLMENNIIALYNssFRNLLNLEILNICGNSISVI-------------- 110
Cdd:cd21340    24 KNLKVLYLYDNKITKIEN----LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVeglenltnleelhi 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937 111 --QQ-----------GSFVGL-NELKQLFLCQNKILQLNPdtFVPLNNLKVLNLQGNLIRLFDA-----PQLPHLEILTL 171
Cdd:cd21340    98 enQRlppgekltfdpRSLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEElldllSSWPSLRELDL 175


                  ....
gi 1247173937 172 DGNP 175
Cdd:cd21340   176 TGNP 179
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 142-235 8.59e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 44.69  E-value: 8.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  142 LNNLKVLNLQ-GNLIRLFDAPQLphleilTLDGNPWNCTCGLLELHNWLNTSNVTLENENMTMCSYPDELKHDSIKSAP- 219
Cdd:TIGR00864    2 ISNNKISTIEeGICANLCNLSEI------DLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPl 75

                           90
                   ....*....|....*.
gi 1247173937  220 FTTECHSTFISTITED 235
Cdd:TIGR00864   76 LDSGCDEEYVACLKDN 91
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 45-156 2.59e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  45 TNVTILDLSYNRIT----LNAADSrvLQMYSLLTELYLMENNI-----IALYnSSFRNLLNLEILNICGNSISViqQG-- 113
Cdd:COG5238   292 TTLTSLDLSVNRIGdegaIALAEG--LQGNKTLHTLNLAYNGIgaqgaIALA-KALQENTTLHSLDLSDNQIGD--EGai 366

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1247173937 114 ----SFVGLNELKQLFLCQNKIlqlNPDTFVPL------NNLKVLNLQGNLIR 156
Cdd:COG5238   367 alakYLEGNTTLRELNLGKNNI---GKQGAEALidalqtNRLHTLILDGNLIG 416
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-153 5.94e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 5.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  47 VTILDLSYNRITLNAaDSRVLQMYSLlTELYLMENNIIALYNSSFRNLlNLEILNICGNSISVIQQGSFVGLNELKQLFL 126
Cdd:PLN00113  430 VYFLDISNNNLQGRI-NSRKWDMPSL-QMLSLARNKFFGGLPDSFGSK-RLENLDLSRNQFSGAVPRKLGSLSELMQLKL 506

                          90       100
                  ....*....|....*....|....*..
gi 1247173937 127 CQNKILQLNPDTFVPLNNLKVLNLQGN 153
Cdd:PLN00113  507 SENKLSGEIPDELSSCKKLVSLDLSHN 533
 
Name Accession Description Interval E-value
LRR19-TM pfam15176
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of ...
 251-364 7.48e-68

Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.


Pssm-ID: 464545  Cd Length: 115  Bit Score: 208.99  E-value: 7.48e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937 251 LTWTSEHEPLGKSWAFLVGVVATVLLTSLLIFIAIKCPVWYNILLSYNHHRLEEHEAETYENGLTRNPSSLSQITDTNSE 330
Cdd:pfam15176   2 LTPNSEHERSGKSWAFLVGVVVTVLMTSLLIAIAIKCPKWYNFLLSYNHHRLEEHEAETYESGDTGNPSSLSQLQATNPD 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1247173937 331 DTTVIFEQLHAFVVDDDGFIEDRYIDINEVHEEK 364
Cdd:pfam15176  82 DTTVIFEQLHSFVVDDDGFIEDKYIDTHELKEEN 115
LRR_8 pfam13855
Leucine rich repeat;
96-155 8.94e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 8.94e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  96 NLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKILQLNPDTFVPLNNLKVLNLQGNLI 155
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-174 5.72e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 5.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  45 TNVTILDLSYNRITlnaADSRVLQMYSLLTELYLMENNIIALyNSSFRNLLNLEILNICGNSISVIQQgSFVGLNELKQL 124
Cdd:COG4886   113 TNLESLDLSGNQLT---DLPEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKEL 187

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1247173937 125 FLCQNKILQLnPDTFVPLNNLKVLNLQGNLIRLFDAP--QLPHLEILTLDGN 174
Cdd:COG4886   188 DLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPlaNLTNLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
73-131 5.66e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 5.66e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1247173937  73 LTELYLMENNIIALYNSSFRNLLNLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKI 131
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-174 2.93e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 2.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  45 TNVTILDLSYNRITLNAADsrvlqmyslLTELYLMENNIIALyNSSFRNLLNLEILNICGNSISVIQQgSFVGLNELKQL 124
Cdd:COG4886    96 TNLTELDLSGNEELSNLTN---------LESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSL 164

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1247173937 125 FLCQNKILQLnPDTFVPLNNLKVLNLQGNLIRLFDAP--QLPHLEILTLDGN 174
Cdd:COG4886   165 DLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPlgNLTNLEELDLSGN 215
LRRCT smart00082
Leucine rich repeat C-terminal domain;
174-211 5.35e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 5.35e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1247173937  174 NPWNCTCGLLELHNWLNTSNVTLENENMtMCSYPDELK 211
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDL-RCASPSSLR 37
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-175 8.48e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 8.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  45 TNVTILDLSYNRITLNAAdsrvLQMYSLLTELYLMENNIIALYNssFRNLLNLEILNICGNSISVI-------------- 110
Cdd:cd21340    24 KNLKVLYLYDNKITKIEN----LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVeglenltnleelhi 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937 111 --QQ-----------GSFVGL-NELKQLFLCQNKILQLNPdtFVPLNNLKVLNLQGNLIRLFDA-----PQLPHLEILTL 171
Cdd:cd21340    98 enQRlppgekltfdpRSLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEElldllSSWPSLRELDL 175


                  ....
gi 1247173937 172 DGNP 175
Cdd:cd21340   176 TGNP 179
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
8-175 1.39e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937   8 FWLFSMLLPSVKSQASETEVPCNFSRRNYTLIPEGISTNVTILDLSYNRITLNAADSRVLQMYSLLTELYLMENNIIAL- 86
Cdd:COG4886    25 ILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLs 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  87 YNSSFRNLLNLEILNICGNSISVIQQgSFVGLNELKQLFLCQNKILQLnPDTFVPLNNLKVLNLQGNLIRLFDAP--QLP 164
Cdd:COG4886   105 GNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEElgNLT 182

                         170
                  ....*....|.
gi 1247173937 165 HLEILTLDGNP 175
Cdd:COG4886   183 NLKELDLSNNQ 193
LRR_8 pfam13855
Leucine rich repeat;
120-175 2.16e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.16e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1247173937 120 ELKQLFLCQNKILQLNPDTFVPLNNLKVLNLQGNLIRLFDAP---QLPHLEILTLDGNP 175
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGafsGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 142-235 8.59e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 44.69  E-value: 8.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  142 LNNLKVLNLQ-GNLIRLFDAPQLphleilTLDGNPWNCTCGLLELHNWLNTSNVTLENENMTMCSYPDELKHDSIKSAP- 219
Cdd:TIGR00864    2 ISNNKISTIEeGICANLCNLSEI------DLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPl 75

                           90
                   ....*....|....*.
gi 1247173937  220 FTTECHSTFISTITED 235
Cdd:TIGR00864   76 LDSGCDEEYVACLKDN 91
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 45-156 2.59e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  45 TNVTILDLSYNRIT----LNAADSrvLQMYSLLTELYLMENNI-----IALYnSSFRNLLNLEILNICGNSISViqQG-- 113
Cdd:COG5238   292 TTLTSLDLSVNRIGdegaIALAEG--LQGNKTLHTLNLAYNGIgaqgaIALA-KALQENTTLHSLDLSDNQIGD--EGai 366

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1247173937 114 ----SFVGLNELKQLFLCQNKIlqlNPDTFVPL------NNLKVLNLQGNLIR 156
Cdd:COG5238   367 alakYLEGNTTLRELNLGKNNI---GKQGAEALidalqtNRLHTLILDGNLIG 416
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-153 5.94e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 5.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1247173937  47 VTILDLSYNRITLNAaDSRVLQMYSLlTELYLMENNIIALYNSSFRNLlNLEILNICGNSISVIQQGSFVGLNELKQLFL 126
Cdd:PLN00113  430 VYFLDISNNNLQGRI-NSRKWDMPSL-QMLSLARNKFFGGLPDSFGSK-RLENLDLSRNQFSGAVPRKLGSLSELMQLKL 506

                          90       100
                  ....*....|....*....|....*..
gi 1247173937 127 CQNKILQLNPDTFVPLNNLKVLNLQGN 153
Cdd:PLN00113  507 SENKLSGEIPDELSSCKKLVSLDLSHN 533
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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