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Conserved domains on  [gi|1315370117|ref|NP_001346015|]
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zinc finger protein 869 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-56 8.54e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 76.74  E-value: 8.54e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1315370117  15 LVSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRNFTAVG 56
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-510 2.91e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 177 KKLYVCQECGKAFRYPSALQLHERIHTGEKPYECKD--CGKAFRGLSALHLHERIHTGEKPYECKQCGR----------- 243
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskassssl 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 244 -----AFTYLSALQLH-------------ERIHTEERPCECKQCGKTFR----------------------YSRALKLHE 283
Cdd:COG5048   111 sssssNSNDNNLLSSHslppssrdpqlpdLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 284 RIHTGEKPYECKQCGKFFRSHRTLKLHKRIHTGEKPYECKECGKAFRWLTSLKLHEKIHTGEKPYECQECGKAFRCQASY 363
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 364 HRHKITH-------GGETLYECKECGKSFIYPSLLQVHERT--HTGE--KPFEC--KLCGKAFRCQSSLRLHERTHTGEK 430
Cdd:COG5048   271 QSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 431 PYECK--HCGKAFSSYN------YLRFHERSHTgEKPYEC--KECGKTFTHRSYLRSHERRHTGEKPYQC--GQCGRSFS 498
Cdd:COG5048   351 PAKEKllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                         410
                  ....*....|..
gi 1315370117 499 RHSSFKRHQSVH 510
Cdd:COG5048   430 RHYNLIPHKKIH 441
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-56 8.54e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 76.74  E-value: 8.54e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1315370117  15 LVSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRNFTAVG 56
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
16-58 1.99e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.48  E-value: 1.99e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1315370117   16 VSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRNFTAVGYE 58
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 16-51 7.71e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 62.57  E-value: 7.71e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1315370117  16 VSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRN 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYEN 36
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-510 2.91e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 177 KKLYVCQECGKAFRYPSALQLHERIHTGEKPYECKD--CGKAFRGLSALHLHERIHTGEKPYECKQCGR----------- 243
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskassssl 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 244 -----AFTYLSALQLH-------------ERIHTEERPCECKQCGKTFR----------------------YSRALKLHE 283
Cdd:COG5048   111 sssssNSNDNNLLSSHslppssrdpqlpdLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 284 RIHTGEKPYECKQCGKFFRSHRTLKLHKRIHTGEKPYECKECGKAFRWLTSLKLHEKIHTGEKPYECQECGKAFRCQASY 363
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 364 HRHKITH-------GGETLYECKECGKSFIYPSLLQVHERT--HTGE--KPFEC--KLCGKAFRCQSSLRLHERTHTGEK 430
Cdd:COG5048   271 QSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 431 PYECK--HCGKAFSSYN------YLRFHERSHTgEKPYEC--KECGKTFTHRSYLRSHERRHTGEKPYQC--GQCGRSFS 498
Cdd:COG5048   351 PAKEKllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                         410
                  ....*....|..
gi 1315370117 499 RHSSFKRHQSVH 510
Cdd:COG5048   430 RHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
418-443 1.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.89e-04
                          10        20
                  ....*....|....*....|....*.
gi 1315370117 418 SLRLHERTHTGEKPYECKHCGKAFSS 443
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-56 8.54e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 76.74  E-value: 8.54e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1315370117  15 LVSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRNFTAVG 56
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
16-58 1.99e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.48  E-value: 1.99e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1315370117   16 VSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRNFTAVGYE 58
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 16-51 7.71e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 62.57  E-value: 7.71e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1315370117  16 VSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRN 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYEN 36
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-510 2.91e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 177 KKLYVCQECGKAFRYPSALQLHERIHTGEKPYECKD--CGKAFRGLSALHLHERIHTGEKPYECKQCGR----------- 243
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskassssl 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 244 -----AFTYLSALQLH-------------ERIHTEERPCECKQCGKTFR----------------------YSRALKLHE 283
Cdd:COG5048   111 sssssNSNDNNLLSSHslppssrdpqlpdLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 284 RIHTGEKPYECKQCGKFFRSHRTLKLHKRIHTGEKPYECKECGKAFRWLTSLKLHEKIHTGEKPYECQECGKAFRCQASY 363
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 364 HRHKITH-------GGETLYECKECGKSFIYPSLLQVHERT--HTGE--KPFEC--KLCGKAFRCQSSLRLHERTHTGEK 430
Cdd:COG5048   271 QSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 431 PYECK--HCGKAFSSYN------YLRFHERSHTgEKPYEC--KECGKTFTHRSYLRSHERRHTGEKPYQC--GQCGRSFS 498
Cdd:COG5048   351 PAKEKllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                         410
                  ....*....|..
gi 1315370117 499 RHSSFKRHQSVH 510
Cdd:COG5048   430 RHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-417 8.38e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 8.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 170 EDKIHTGKKLYVCQECGKAFRYPSALQLHERIHTgEKPYECKDCGKAFRGLSALHLHERIHTGEKPYECKQCGRAFTYLS 249
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 250 ALQLHERIHTEER-------PCECKQCGKTFRYSRALKLHER--IHTGE--KPYEC--KQCGKFFRSHRTLKLHKRIHTG 316
Cdd:COG5048   269 SSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 317 EKPYECKEC-------GKAFRWLTSLKLHEKIHTGEKPYEC--QECGKAFRCQASYHRHKITHGGETLYECK--ECGKSF 385
Cdd:COG5048   349 ISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1315370117 386 IYPSLLQVHERTHTGEKPFECKLCGKAFRCQS 417
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
418-443 1.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.89e-04
                          10        20
                  ....*....|....*....|....*.
gi 1315370117 418 SLRLHERTHTGEKPYECKHCGKAFSS 443
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-471 2.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.09e-04
                          10        20
                  ....*....|....*....|....*.
gi 1315370117 446 YLRFHERSHTGEKPYECKECGKTFTH 471
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-367 2.50e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 206 KPYECKDCGKAFRGLSALHLHER--IHTGE--KPYEC--KQCGRAFTYLSALQLHERIHT--EERPCECKQCGKTFR--- 274
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTsiSPAKEKLLNSSSKFSpll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 275 --YSRALKLHERIHTGEKPYEC--KQCGKFFRSHRTLKLHKRIHTGEKPYECK--ECGKAFRWLTSLKLHEKIHTGEKPY 348
Cdd:COG5048   368 nnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 1315370117 349 ECQECGKAFRCQASYHRHK 367
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-443 2.53e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 191 YPSALQLHERIHTGEKPYECKDCGKAFRGLSALHLHERIHTGEKPYECKQCGRAFTYLSALQLHERIHTEERPCECKQCG 270
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 271 KTFRYSRALKLHERIHTGE-------KPYECKQCGK-FFRSHrTLKLHKR--IHTGE--KPYECKE--CGKAFRWLTSLK 336
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNIsFSRSS-PLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315370117 337 LHEKIHTGEKPYEC--QECGKAF-------RCQASYHRHKITHGGETLYECKECGKSFIYPSLLQVHERTHTGEKP--FE 405
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFspllnnePPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1315370117 406 CKLCGKAFRCQSSLRLHERTHTGEKPYECKHCGKAFSS 443
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
307-329 3.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.54e-04
                          10        20
                  ....*....|....*....|...
gi 1315370117 307 LKLHKRIHTGEKPYECKECGKAF 329
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
334-359 4.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.15e-04
                          10        20
                  ....*....|....*....|....*.
gi 1315370117 334 SLKLHEKIHTGEKPYECQECGKAFRC 359
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
391-415 4.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*
gi 1315370117 391 LQVHERTHTGEKPFECKLCGKAFRC 415
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
474-499 5.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.40e-04
                          10        20
                  ....*....|....*....|....*.
gi 1315370117 474 YLRSHERRHTGEKPYQCGQCGRSFSR 499
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
278-303 5.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.73e-04
                          10        20
                  ....*....|....*....|....*.
gi 1315370117 278 ALKLHERIHTGEKPYECKQCGKFFRS 303
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
194-217 6.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.20e-04
                          10        20
                  ....*....|....*....|....
gi 1315370117 194 ALQLHERIHTGEKPYECKDCGKAF 217
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 400-455 1.18e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1315370117 400 GEKPFECKL--CGKAFRCQSSLRLH---------------ERTHTG----EKPYECKHCGKAFSSYNYLRFHeRSHT 455
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
226-247 3.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.13e-03
                          10        20
                  ....*....|....*....|..
gi 1315370117 226 HERIHTGEKPYECKQCGRAFTY 247
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 460-482 4.85e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.85e-03
                          10        20
                  ....*....|....*....|...
gi 1315370117 460 YECKECGKTFTHRSYLRSHERRH 482
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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