|
Name |
Accession |
Description |
Interval |
E-value |
| PRK13357 |
PRK13357 |
branched-chain amino acid aminotransferase; Provisional |
52-391 |
1.52e-138 |
|
branched-chain amino acid aminotransferase; Provisional
Pssm-ID: 237363 Cd Length: 356 Bit Score: 399.52 E-value: 1.52e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 52 KKKPDPSSLVFGASFTDHMLMVEWTSKyGWDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMK 131
Cdd:PRK13357 14 KRAIDWANLGFGYVFTDHMVVIDYKDG-KWHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDGSIVLFRPDANAK 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 132 RMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWV-PYSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNG 210
Cdd:PRK13357 93 RLQRSADRLLMPELPEELFLEAVKQLVKADRDWVpPYGEGASLYLRPFMIATEPFLGVKPAEEYIFCVIASPVGAYFKGG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 211 tFSPVSLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYGKENR-ITEVGTMNLFLywINKDGEEel 289
Cdd:PRK13357 173 -VKPVSIWVSDEYDRAAPGGTGAAKVGGNYAASLLAQAEAKEKGCDQVLYLDAVEHTyIEEVGGMNFFF--ITKDGTV-- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 290 aTPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTALEENRVKEMFGSGTACVVCPVASILYKGQMLHIPTME 369
Cdd:PRK13357 248 -TPPLSGSILPGITRDSLLQLAEDLG-LTVEERPVSIDEWQADAASGEFTEAFACGTAAVITPIGGIKYKDKEFVIGDGE 325
|
330 340
....*....|....*....|..
gi 2017952465 370 NGhKLSSRIMAKLTDIQYGRIK 391
Cdd:PRK13357 326 VG-PVTQKLYDELTGIQFGDVE 346
|
|
| BCAT_beta_family |
cd01557 |
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ... |
93-388 |
5.75e-127 |
|
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.
Pssm-ID: 238798 Cd Length: 279 Bit Score: 366.91 E-value: 5.75e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 93 SIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSAS 172
Cdd:cd01557 1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 173 LYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGtFSPVSLWANPkFVRSWKGGTGDFKMGCNYGSSLLAQCEAAE 252
Cdd:cd01557 81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGG-EKGVSALVSS-FRRAAPGGPGAAKAGGNYAASLLAQKEAAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 253 NGCHQVLWLYGKENRITEVGTMNLFLYWINkdgeeELATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTA 332
Cdd:cd01557 159 KGYDQALWLDGAHGYVAEVGTMNIFFVKDG-----ELITPPLDGSILPGITRDSILELARDLG-IKVEERPITRDELYEA 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2017952465 333 leenrvKEMFGSGTACVVCPVASILYKGQmlhIPTMENGHKLSSRIMAKLTDIQYG 388
Cdd:cd01557 233 ------DEVFATGTAAVVTPVGEIDYRGK---EPGEGEVGPVTKKLYDLLTDIQYG 279
|
|
| ilvE_II |
TIGR01123 |
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ... |
81-398 |
1.71e-102 |
|
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 233278 Cd Length: 313 Bit Score: 305.91 E-value: 1.71e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 81 WDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQL 160
Cdd:TIGR01123 1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 161 DREWVP-YSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGtFSPVSLWANPKFVRSWKGGTGDFKMGCN 239
Cdd:TIGR01123 81 NKDWVPpYGSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGG-LAPVSIFVTTEYDRAAPGGTGAVKVGGN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 240 YGSSLLAQCEAAENGCHQVLWLYGKENR-ITEVGTMNLFLywINKDGeeELATPPLDGVILPGVTRQSILELGEEWGeFK 318
Cdd:TIGR01123 160 YAASLLAQAKAAEQGCDQVVYLDPVEHTyIEEVGAMNFFF--ITGDG--ELVTPPLSGSILPGITRDSLLQLAKDLG-ME 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 319 VCERHITMDDLSTALEenRVKEMFGSGTACVVCPVASILYKGQMLHIPTMENGhKLSSRIMAKLTDIQYGRIKSE--WTL 396
Cdd:TIGR01123 235 VEERRIDIDELKAFVE--AGEIVFACGTAAVITPVGEIQHGGKEVVFASGQPG-EVTKALYDELTDIQYGDFEDPygWIV 311
|
..
gi 2017952465 397 EL 398
Cdd:TIGR01123 312 EV 313
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
81-390 |
1.61e-72 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 228.15 E-value: 1.61e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 81 WDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGvdnkiRLFRPDLNMKRMCRSAVRTTLP-EFDKEELLQCVLQLIQ 159
Cdd:COG0115 4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDG-----RLFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 160 LDREwvpystsASLYIRPTFIGIEPSLGVKKP-SKALLFVILSPVGSYFSNGTFSPVSLWANPkFVRSWKGGTGDFKmGC 238
Cdd:COG0115 79 ANGL-------EDGYIRPQVTRGVGGRGVFAEeYEPTVIIIASPLPAYPAEAYEKGVRVITSP-YRRAAPGGLGGIK-TG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 239 NYGSSLLAQCEAAENGCHQVLWLyGKENRITEVGTMNLFLYwinKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFK 318
Cdd:COG0115 150 NYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIV---KDGV--LVTPPLSGGILPGITRDSVIELARELG-IP 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017952465 319 VCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASIlyKGQmlHIPTMENGhKLSSRIMAKLTDIQYGRI 390
Cdd:COG0115 223 VEERPISLEELYTA------DEVFLTGTAAEVTPVTEI--DGR--PIGDGKPG-PVTRRLRELYTDIVRGEA 283
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
107-356 |
2.09e-33 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 124.39 E-value: 2.09e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 107 LFEGLKAFRGvdnkiRLFRPDLNMKRMCRSAVRTTLP-EFDKEELLQCVLQLIQLDREWVPYstsaslyIRPT-FIGIEP 184
Cdd:pfam01063 2 VFETLRVYNG-----KIFFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVGR-------LRLTvSRGPGG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 185 SLGVKKPSKALLFVILSPVGSYFSNGTFSPVSLWANPKFVRSwkggtgDFKmGCNYGSSLLAQCEAAENGCHQVLwLYGK 264
Cdd:pfam01063 70 FGLPTSDPTLAIFVSALPPPPESKKKGVISSLVRRNPPSPLP------GAK-TLNYLENVLARREAKAQGADDAL-LLDE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 265 ENRITEVGTMNLFLYwinKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenrvKEMFGS 344
Cdd:pfam01063 142 DGNVTEGSTSNVFLV---KGGT--LYTPPLESGILPGITRQALLDLAKALG-LEVEERPITLADLQEA------DEAFLT 209
|
250
....*....|..
gi 2017952465 345 GTACVVCPVASI 356
Cdd:pfam01063 210 NSLRGVTPVSSI 221
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK13357 |
PRK13357 |
branched-chain amino acid aminotransferase; Provisional |
52-391 |
1.52e-138 |
|
branched-chain amino acid aminotransferase; Provisional
Pssm-ID: 237363 Cd Length: 356 Bit Score: 399.52 E-value: 1.52e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 52 KKKPDPSSLVFGASFTDHMLMVEWTSKyGWDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMK 131
Cdd:PRK13357 14 KRAIDWANLGFGYVFTDHMVVIDYKDG-KWHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDGSIVLFRPDANAK 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 132 RMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWV-PYSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNG 210
Cdd:PRK13357 93 RLQRSADRLLMPELPEELFLEAVKQLVKADRDWVpPYGEGASLYLRPFMIATEPFLGVKPAEEYIFCVIASPVGAYFKGG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 211 tFSPVSLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYGKENR-ITEVGTMNLFLywINKDGEEel 289
Cdd:PRK13357 173 -VKPVSIWVSDEYDRAAPGGTGAAKVGGNYAASLLAQAEAKEKGCDQVLYLDAVEHTyIEEVGGMNFFF--ITKDGTV-- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 290 aTPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTALEENRVKEMFGSGTACVVCPVASILYKGQMLHIPTME 369
Cdd:PRK13357 248 -TPPLSGSILPGITRDSLLQLAEDLG-LTVEERPVSIDEWQADAASGEFTEAFACGTAAVITPIGGIKYKDKEFVIGDGE 325
|
330 340
....*....|....*....|..
gi 2017952465 370 NGhKLSSRIMAKLTDIQYGRIK 391
Cdd:PRK13357 326 VG-PVTQKLYDELTGIQFGDVE 346
|
|
| BCAT_beta_family |
cd01557 |
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ... |
93-388 |
5.75e-127 |
|
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.
Pssm-ID: 238798 Cd Length: 279 Bit Score: 366.91 E-value: 5.75e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 93 SIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSAS 172
Cdd:cd01557 1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 173 LYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGtFSPVSLWANPkFVRSWKGGTGDFKMGCNYGSSLLAQCEAAE 252
Cdd:cd01557 81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGG-EKGVSALVSS-FRRAAPGGPGAAKAGGNYAASLLAQKEAAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 253 NGCHQVLWLYGKENRITEVGTMNLFLYWINkdgeeELATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTA 332
Cdd:cd01557 159 KGYDQALWLDGAHGYVAEVGTMNIFFVKDG-----ELITPPLDGSILPGITRDSILELARDLG-IKVEERPITRDELYEA 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2017952465 333 leenrvKEMFGSGTACVVCPVASILYKGQmlhIPTMENGHKLSSRIMAKLTDIQYG 388
Cdd:cd01557 233 ------DEVFATGTAAVVTPVGEIDYRGK---EPGEGEVGPVTKKLYDLLTDIQYG 279
|
|
| ilvE_II |
TIGR01123 |
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ... |
81-398 |
1.71e-102 |
|
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 233278 Cd Length: 313 Bit Score: 305.91 E-value: 1.71e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 81 WDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQL 160
Cdd:TIGR01123 1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 161 DREWVP-YSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGtFSPVSLWANPKFVRSWKGGTGDFKMGCN 239
Cdd:TIGR01123 81 NKDWVPpYGSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGG-LAPVSIFVTTEYDRAAPGGTGAVKVGGN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 240 YGSSLLAQCEAAENGCHQVLWLYGKENR-ITEVGTMNLFLywINKDGeeELATPPLDGVILPGVTRQSILELGEEWGeFK 318
Cdd:TIGR01123 160 YAASLLAQAKAAEQGCDQVVYLDPVEHTyIEEVGAMNFFF--ITGDG--ELVTPPLSGSILPGITRDSLLQLAKDLG-ME 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 319 VCERHITMDDLSTALEenRVKEMFGSGTACVVCPVASILYKGQMLHIPTMENGhKLSSRIMAKLTDIQYGRIKSE--WTL 396
Cdd:TIGR01123 235 VEERRIDIDELKAFVE--AGEIVFACGTAAVITPVGEIQHGGKEVVFASGQPG-EVTKALYDELTDIQYGDFEDPygWIV 311
|
..
gi 2017952465 397 EL 398
Cdd:TIGR01123 312 EV 313
|
|
| PLPDE_IV |
cd00449 |
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ... |
98-382 |
1.23e-75 |
|
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.
Pssm-ID: 238254 [Multi-domain] Cd Length: 256 Bit Score: 235.19 E-value: 1.23e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 98 ASVLHYAVELFEGLKAFRGvdnkiRLFRPDLNMKRMCRSAVRTTLP-EFDKEELLQCVLQLIQLdrewvpySTSASLYIR 176
Cdd:cd00449 1 DRGLHYGDGVFEGLRAGKG-----RLFRLDEHLDRLNRSAKRLGLPiPYDREELREALKELVAA-------NNGASLYIR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 177 PTFIGIEPSLGV--KKPSKALLFVILSPVGSYFSNGtFSPVSLWANPKFVRSWKGGTGDFKMGCNYGSsLLAQCEAAENG 254
Cdd:cd00449 69 PLLTRGVGGLGVapPPSPEPTFVVFASPVGAYAKGG-EKGVRLITSPDRRRAAPGGTGDAKTGGNLNS-VLAKQEAAEAG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 255 CHQVLWLYGkENRITEVGTMNLFLYwinKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAle 334
Cdd:cd00449 147 ADEALLLDD-NGYVTEGSASNVFIV---KDGE--LVTPPLDGGILPGITRDSVIELAKELG-IKVEERPISLDELYAA-- 217
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2017952465 335 enrvKEMFGSGTACVVCPVASILYKGQmlhipTMENGHKLSSRIMAKL 382
Cdd:cd00449 218 ----DEVFLTGTAAEVTPVTEIDGRGI-----GDGKPGPVTRKLRELL 256
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
81-390 |
1.61e-72 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 228.15 E-value: 1.61e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 81 WDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGvdnkiRLFRPDLNMKRMCRSAVRTTLP-EFDKEELLQCVLQLIQ 159
Cdd:COG0115 4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDG-----RLFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 160 LDREwvpystsASLYIRPTFIGIEPSLGVKKP-SKALLFVILSPVGSYFSNGTFSPVSLWANPkFVRSWKGGTGDFKmGC 238
Cdd:COG0115 79 ANGL-------EDGYIRPQVTRGVGGRGVFAEeYEPTVIIIASPLPAYPAEAYEKGVRVITSP-YRRAAPGGLGGIK-TG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 239 NYGSSLLAQCEAAENGCHQVLWLyGKENRITEVGTMNLFLYwinKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFK 318
Cdd:COG0115 150 NYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIV---KDGV--LVTPPLSGGILPGITRDSVIELARELG-IP 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017952465 319 VCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASIlyKGQmlHIPTMENGhKLSSRIMAKLTDIQYGRI 390
Cdd:COG0115 223 VEERPISLEELYTA------DEVFLTGTAAEVTPVTEI--DGR--PIGDGKPG-PVTRRLRELYTDIVRGEA 283
|
|
| PLN02782 |
PLN02782 |
Branched-chain amino acid aminotransferase |
31-398 |
2.20e-64 |
|
Branched-chain amino acid aminotransferase
Pssm-ID: 215418 Cd Length: 403 Bit Score: 211.25 E-value: 2.20e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 31 SEASTQTFRAKDLiitkadvlkkkpDPSSLVFGASFTDHMLMVEWTSKYGWDKPHIKPFENLSIHPAASVLHYAVELFEG 110
Cdd:PLN02782 58 SSSYTEVTELADI------------DWDNLGFGLVPTDYMYIMKCNRDGEFSKGELQRFGNIELSPSAGVLNYGQGLFEG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 111 LKAFRGVDNKIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSASLYIRPTFIGIEPSLGVkK 190
Cdd:PLN02782 126 LKAYRKEDGNILLFRPEENAIRMRNGAERMCMPAPTVEQFVEAVKETVLANKRWVPPPGKGSLYIRPLLMGSGAVLGL-A 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 191 PSKALLFVI-LSPVGSYFSNGTfSPVSLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYGKENR-I 268
Cdd:PLN02782 205 PAPEYTFLIyVSPVGNYFKEGV-APINLIVENEFHRATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYLDCVHKKyL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 269 TEVGTMNLFlywINKDgeEELATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenrvKEMFGSGTAC 348
Cdd:PLN02782 284 EEVSSCNIF---IVKD--NVISTPAIKGTILPGITRKSIIDVARSQG-FQVEERNVTVDELLEA------DEVFCTGTAV 351
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2017952465 349 VVCPVASILYKGQmlhipTMENGHK----LSSRIMAKLTDIQYGRIKS--EWTLEL 398
Cdd:PLN02782 352 VVSPVGSITYKGK-----RVSYGEGgfgtVSQQLYTVLTSLQMGLIEDnmNWTVEL 402
|
|
| PLN03117 |
PLN03117 |
Branched-chain-amino-acid aminotransferase; Provisional |
40-398 |
1.33e-60 |
|
Branched-chain-amino-acid aminotransferase; Provisional
Pssm-ID: 178664 Cd Length: 355 Bit Score: 199.77 E-value: 1.33e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 40 AKDLIITKADVLKKKPDPSSLVFGASFTDHMLMVEWTSKYGWDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDN 119
Cdd:PLN03117 5 SSPLPTSKADEKYANVKWEELGFALVPTDYMYVAKCKQGESFSEGKIVPYGDISISPCAGILNYGQGLFEGLKAYRTEDG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 120 KIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSASLYIRPTFIGIEPSLGVKKPSKALLFVI 199
Cdd:PLN03117 85 RITLFRPDQNALRMQTGADRLCMTPPSLEQFVEAVKQTVLANKKWVPPPGKGTLYIRPLLIGSGAVLGVAPAPEYTFLIY 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 200 LSPVGSYFSNGtfSPVSLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYGKENR-ITEVGTMNLFL 278
Cdd:PLN03117 165 ASPVGNYHKAS--SGLNLKVDHKHRRAHSGGTGGVKSCTNYSPVVKSLIEAKSSGFSDVLFLDAATGKnIEELSACNIFI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 279 YWINKdgeeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASILY 358
Cdd:PLN03117 243 LKGNI-----VSTPPTSGTILPGVTRKSISELARDIG-YQVEERDVSVDELLEA------EEVFCTGTAVVVKAVETVTF 310
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2017952465 359 KGQMLHIPTMENGhkLSSRIMAKLTDIQYGRI--KSEWTLEL 398
Cdd:PLN03117 311 HDKKVKYRTGEEA--LSTKLHLILTNIQMGVVedKKGWMVEI 350
|
|
| PLN02259 |
PLN02259 |
branched-chain-amino-acid aminotransferase 2 |
56-391 |
2.86e-50 |
|
branched-chain-amino-acid aminotransferase 2
Pssm-ID: 177901 Cd Length: 388 Bit Score: 173.75 E-value: 2.86e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 56 DPSSLVFGASFTDHMLMVEWTSKYGWDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCR 135
Cdd:PLN02259 57 DWDNLGFGLNPADYMYVMKCSKDGEFTQGELSPYGNIQLSPSAGVLNYGQAIYEGTKAYRKENGKLLLFRPDHNAIRMKL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 136 SAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGtFSPV 215
Cdd:PLN02259 137 GAERMLMPSPSVDQFVNAVKQTALANKRWVPPAGKGTLYIRPLLMGSGPILGLGPAPEYTFIVYASPVGNYFKEG-MAAL 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 216 SLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYG-KENRITEVGTMNLFLYwinkdGEEELATPPL 294
Cdd:PLN02259 216 NLYVEEEYVRAAPGGAGGVKSITNYAPVLKALSRAKSRGFSDVLYLDSvKKKYLEEASSCNVFVV-----KGRTISTPAT 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 295 DGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASILYKGQMLHIPTMEngHKL 374
Cdd:PLN02259 291 NGTILEGITRKSVMEIASDQG-YQVVEKAVHVDEVMDA------DEVFCTGTAVVVAPVGTITYQEKRVEYKTGD--ESV 361
|
330
....*....|....*..
gi 2017952465 375 SSRIMAKLTDIQYGRIK 391
Cdd:PLN02259 362 CQKLRSVLVGIQTGLIE 378
|
|
| PLN02883 |
PLN02883 |
Branched-chain amino acid aminotransferase |
56-398 |
7.22e-49 |
|
Branched-chain amino acid aminotransferase
Pssm-ID: 178471 Cd Length: 384 Bit Score: 169.90 E-value: 7.22e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 56 DPSSLVFGASFTDHMLMVEWTSKYGWDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCR 135
Cdd:PLN02883 53 DWDKLGFSLVRTDFMFATKSCRDGNFEQGYLSRYGNIELNPAAGILNYGQGLIEGMKAYRGEDGRILLFRPELNAMRMKI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 136 SAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGTfSPV 215
Cdd:PLN02883 133 GAERMCMHSPSVHQFIEGVKQTVLANRRWVPPPGKGSLYLRPLLFGSGASLGVAAAPEYTFLVFGSPVQNYFKEGT-AAL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 216 SLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYGKENR-ITEVGTMNLFLYWINKdgeeeLATPPL 294
Cdd:PLN02883 212 NLYVEEVIPRAYLGGTGGVKAISNYGPVLEVMRRAKSRGFSDVLYLDADTGKnIEEVSAANIFLVKGNI-----IVTPAT 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 295 DGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASILYKGQMLHIPTMENghKL 374
Cdd:PLN02883 287 SGTILGGITRKSIIEIALDLG-YKVEERRVPVEELKEA------EEVFCTGTAAGVASVGSITFKNTRTEYKVGDG--IV 357
|
330 340
....*....|....*....|....*.
gi 2017952465 375 SSRIMAKLTDIQYGRIK--SEWTLEL 398
Cdd:PLN02883 358 TQQLRSILLGIQTGSIQdtKDWVLQI 383
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
107-356 |
2.09e-33 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 124.39 E-value: 2.09e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 107 LFEGLKAFRGvdnkiRLFRPDLNMKRMCRSAVRTTLP-EFDKEELLQCVLQLIQLDREWVPYstsaslyIRPT-FIGIEP 184
Cdd:pfam01063 2 VFETLRVYNG-----KIFFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVGR-------LRLTvSRGPGG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 185 SLGVKKPSKALLFVILSPVGSYFSNGTFSPVSLWANPKFVRSwkggtgDFKmGCNYGSSLLAQCEAAENGCHQVLwLYGK 264
Cdd:pfam01063 70 FGLPTSDPTLAIFVSALPPPPESKKKGVISSLVRRNPPSPLP------GAK-TLNYLENVLARREAKAQGADDAL-LLDE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 265 ENRITEVGTMNLFLYwinKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenrvKEMFGS 344
Cdd:pfam01063 142 DGNVTEGSTSNVFLV---KGGT--LYTPPLESGILPGITRQALLDLAKALG-LEVEERPITLADLQEA------DEAFLT 209
|
250
....*....|..
gi 2017952465 345 GTACVVCPVASI 356
Cdd:pfam01063 210 NSLRGVTPVSSI 221
|
|
| PRK06606 |
PRK06606 |
branched-chain amino acid transaminase; |
88-356 |
1.00e-29 |
|
branched-chain amino acid transaminase;
Pssm-ID: 235841 Cd Length: 306 Bit Score: 116.78 E-value: 1.00e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 88 PFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIrLFRPDLNMKRMCRSA--VRTTLPeFDKEELLQCVLQLIQ---LDr 162
Cdd:PRK06606 17 PWEDAKVHVLTHALHYGTGVFEGIRAYDTPKGPA-IFRLREHTKRLFNSAkiLRMEIP-YSVDELMEAQREVVRknnLK- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 163 ewvpystsaSLYIRP-TFIGIEpSLGVKKPS-KALLFVILSPVGSY-----FSNGTFSPVSLWA----NPKFVRSwkggt 231
Cdd:PRK06606 94 ---------SAYIRPlVFVGDE-GLGVRPHGlPTDVAIAAWPWGAYlgeeaLEKGIRVKVSSWTrhapNSIPTRA----- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 232 gdfKMGCNYGSSLLAQCEAAENGCHQVLWLyGKENRITEVGTMNLFlywINKDGEeeLATPPLDGVILPGVTRQSILELG 311
Cdd:PRK06606 159 ---KASGNYLNSILAKTEARRNGYDEALLL-DVEGYVSEGSGENIF---IVRDGV--LYTPPLTSSILEGITRDTVITLA 229
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2017952465 312 EEWGeFKVCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASI 356
Cdd:PRK06606 230 KDLG-IEVIERRITRDELYIA------DEVFFTGTAAEVTPIREV 267
|
|
| ilvE_I |
TIGR01122 |
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ... |
88-356 |
6.94e-28 |
|
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 130192 Cd Length: 298 Bit Score: 111.30 E-value: 6.94e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 88 PFENLSIHPAASVLHYAVELFEGLKAFRGvDNKIRLFRPDLNMKRMCRSAVRTTLP-EFDKEELLQCVLQLIQLdrewvp 166
Cdd:TIGR01122 8 DWEDAKVHVLTHALHYGTGVFEGIRAYDT-DKGPAIFRLKEHIQRLYDSAKIYRMEiPYSKEELMEATRETLRK------ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 167 ySTSASLYIRP-TFIGIEpSLGVKKPSKAL--LFVILSPVGSY-----FSNGTFSPVSLW--ANPKFVrswkggTGDFKM 236
Cdd:TIGR01122 81 -NNLRSAYIRPlVFRGDG-DLGLNPRAGYKpdVIIAAWPWGAYlgeeaLEKGIDAKVSSWrrNAPNTI------PTAAKA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 237 GCNYGSSLLAQCEAAENGCHQVLWLyGKENRITEVGTMNLFlywINKDGeeELATPPLDGVILPGVTRQSILELGEEWGe 316
Cdd:TIGR01122 153 GGNYLNSLLAKSEARRHGYDEAILL-DVEGYVAEGSGENIF---IVKDG--VLFTPPVTSSILPGITRDTVITLAKELG- 225
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2017952465 317 FKVCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASI 356
Cdd:TIGR01122 226 IEVVEQPISREELYTA------DEAFFTGTAAEITPIREV 259
|
|
| D-AAT_like |
cd01558 |
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ... |
86-356 |
1.72e-23 |
|
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.
Pssm-ID: 238799 [Multi-domain] Cd Length: 270 Bit Score: 98.82 E-value: 1.72e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 86 IKPFENLSIHPAASVLHYAVELFEGLKAFRGvdnkiRLFRPDLNMKRMCRSA--VRTTLPeFDKEELLQCVLQLIQLDRe 163
Cdd:cd01558 6 YVPREEAKVSVFDRGFLFGDGVYEVIRVYNG-----KPFALDEHLDRLYRSAkeLRIDIP-YTREELKELIRELVAKNE- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 164 wvpySTSASLYIRPTFiGIEP-SLGVKKPSKALLFVILSPVGSYFSNGTFSPVSL-------WANPkfvrswkggtgDFK 235
Cdd:cd01558 79 ----GGEGDVYIQVTR-GVGPrGHDFPKCVKPTVVIITQPLPLPPAELLEKGVRVitvpdirWLRC-----------DIK 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 236 MgCNYGSSLLAQCEAAENGCHQVlWLYGKENRITEVGTMNLFlywINKDGEeeLATPPLDGVILPGVTRQSILELGEEWG 315
Cdd:cd01558 143 S-LNLLNNVLAKQEAKEAGADEA-ILLDADGLVTEGSSSNVF---IVKNGV--LVTPPLDNGILPGITRATVIELAKELG 215
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2017952465 316 eFKVCERHITMDDLSTAleenrvKEMFGSGTACVVCPVASI 356
Cdd:cd01558 216 -IPVEERPFSLEELYTA------DEVFLTSTTAEVMPVVEI 249
|
|
| ADCL_like |
cd01559 |
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ... |
101-356 |
1.76e-14 |
|
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.
Pssm-ID: 238800 [Multi-domain] Cd Length: 249 Bit Score: 72.73 E-value: 1.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 101 LHYAVELFEGLKAFRGvdnkiRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQLdrewvpySTSASLYIRPTFI 180
Cdd:cd01559 4 FAYGDGVFETMRALDG-----RLFLLDAHLARLERSARRLGIPEPDLPRLRAALESLLAA-------NDIDEGRIRLILS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 181 ------GIEPSLGvkkPSKALLFVILSPVGSYFSNGT---FSPVSLWANPKFVRswkggtgdFKMgCNYGSSLLAQCEAA 251
Cdd:cd01559 72 rgpggrGYAPSVC---PGPALYVSVIPLPPAWRQDGVrliTCPVRLGEQPLLAG--------LKH-LNYLENVLAKREAR 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 252 ENGCHQVLWLYGkENRITEVGTMNLFlyWInKDGEeeLATPPLDGVILPGVTRQSILELGEEWGEFKVcERHITMDDLST 331
Cdd:cd01559 140 DRGADEALFLDT-DGRVIEGTASNLF--FV-KDGE--LVTPSLDRGGLAGITRQRVIELAAAKGYAVD-ERPLRLEDLLA 212
|
250 260
....*....|....*....|....*
gi 2017952465 332 AleenrvKEMFGSGTACVVCPVASI 356
Cdd:cd01559 213 A------DEAFLTNSLLGVAPVTAI 231
|
|
| PRK08320 |
PRK08320 |
branched-chain amino acid aminotransferase; Reviewed |
108-356 |
9.04e-14 |
|
branched-chain amino acid aminotransferase; Reviewed
Pssm-ID: 236238 [Multi-domain] Cd Length: 288 Bit Score: 71.06 E-value: 9.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 108 FEGLKAFRGvdnkiRLFRPDLNMKRMCRSA--VRTTLPeFDKEELLQCVLQLIQLDRewvpySTSAslYIRPTF------ 179
Cdd:PRK08320 33 FEGIRAYNG-----RVFRLKEHIDRLYDSAkaIMLEIP-LSKEEMTEIVLETLRKNN-----LRDA--YIRLVVsrgvgd 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 180 IGIEPslgvKKPSKALLFVILSPVGSY----FSNG----TFS-----PVSLwaNPKfVRSwkggtgdfkmgCNYGSSLLA 246
Cdd:PRK08320 100 LGLDP----RKCPKPTVVCIAEPIGLYpgelYEKGlkviTVStrrnrPDAL--SPQ-VKS-----------LNYLNNILA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 247 QCEAAENGCHQVLWLyGKENRITEVGTMNLFLYwinKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITM 326
Cdd:PRK08320 162 KIEANLAGVDEAIML-NDEGYVAEGTGDNIFIV---KNGK--LITPPTYAGALEGITRNAVIEIAKELG-IPVREELFTL 234
|
250 260 270
....*....|....*....|....*....|
gi 2017952465 327 DDLSTAleenrvKEMFGSGTACVVCPVASI 356
Cdd:PRK08320 235 HDLYTA------DEVFLTGTAAEVIPVVKV 258
|
|
| PRK13356 |
PRK13356 |
branched-chain amino acid aminotransferase; |
108-356 |
4.98e-13 |
|
branched-chain amino acid aminotransferase;
Pssm-ID: 237362 Cd Length: 286 Bit Score: 68.83 E-value: 4.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 108 FEGLKAFRGVdnkirlfRPDLNM--KRMCRSAVRTTL-PEFDKEELLQCVLQLIQldrewvPYSTSASLYIRPTFIGIEP 184
Cdd:PRK13356 37 FDGARAFEGV-------TPDLDLhcARVNRSAEALGLkPTVSAEEIEALAREGLK------RFDPDTALYIRPMYWAEDG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 185 SLGVKKPSK-----AL-LFVILSPVGSYFSnGTFSPvslwanpkFVRSW-KGGTGDFKMGCNYGSSLLAQCEAAENGCHQ 257
Cdd:PRK13356 104 FASGVAPDPestrfALcLEEAPMPEPTGFS-LTLSP--------FRRPTlEMAPTDAKAGCLYPNNARALREARSRGFDN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 258 VLWLYGKENrITEVGTMNLFlywINKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTAleenr 337
Cdd:PRK13356 175 ALVLDMLGN-VAETATSNVF---MVKDGV--VFTPVPNGTFLNGITRQRVIALLREDG-VTVVETTLTYEDFLEA----- 242
|
250
....*....|....*....
gi 2017952465 338 vKEMFGSGTACVVCPVASI 356
Cdd:PRK13356 243 -DEVFSTGNYSKVVPVTRF 260
|
|
| PRK07544 |
PRK07544 |
branched-chain amino acid aminotransferase; Validated |
250-356 |
8.15e-09 |
|
branched-chain amino acid aminotransferase; Validated
Pssm-ID: 181025 Cd Length: 292 Bit Score: 56.14 E-value: 8.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 250 AAEN-GCHQVLWL-YgkENRITEVGTMNLFLYwinKDGEeeLATPPLDgVILPGVTRQSILELGEEWGeFKVCERHITMD 327
Cdd:PRK07544 171 AAEAkGYADALMLdY--RGYVAEATGANIFFV---KDGV--IHTPTPD-CFLDGITRQTVIELAKRRG-IEVVERHIMPE 241
|
90 100
....*....|....*....|....*....
gi 2017952465 328 DLSTAleenrvKEMFGSGTACVVCPVASI 356
Cdd:PRK07544 242 ELAGF------SECFLTGTAAEVTPVSEI 264
|
|
| PRK12479 |
PRK12479 |
branched-chain-amino-acid transaminase; |
103-356 |
3.40e-08 |
|
branched-chain-amino-acid transaminase;
Pssm-ID: 183549 [Multi-domain] Cd Length: 299 Bit Score: 54.57 E-value: 3.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 103 YAVELFEGLKAFRGvdnkiRLFRPDLNMKRMCRSA--VRTTLPeFDKEELLQCVLQLIQLDrewvpysTSASLYIR---- 176
Cdd:PRK12479 29 YGDGVFEGIRSYGG-----NVFCLKEHVKRLYESAksILLTIP-LTVDEMEEAVLQTLQKN-------EYADAYIRlivs 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 177 --PTFIGIEPSlGVKKPSKALLFVILSPVGSYFSNGTFSPVSLWA--------NPKfVRSwkggtgdfkmgCNYGSSLLA 246
Cdd:PRK12479 96 rgKGDLGLDPR-SCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASrrntpdalDPR-IKS-----------MNYLNNVLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 247 QCEAAENGCHQVLWLyGKENRITEVGTMNLFlywINKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITM 326
Cdd:PRK12479 163 KIEAAQAGVLEALML-NQQGYVCEGSGDNVF---VVKDGK--VLTPPSYLGALEGITRNSVIELCERLS-IPCEERPFTR 235
|
250 260 270
....*....|....*....|....*....|
gi 2017952465 327 DDLSTAleenrvKEMFGSGTACVVCPVASI 356
Cdd:PRK12479 236 HDVYVA------DEVFLTGTAAELIPVVKV 259
|
|
| PLN02845 |
PLN02845 |
Branched-chain-amino-acid aminotransferase-like protein |
239-355 |
3.27e-06 |
|
Branched-chain-amino-acid aminotransferase-like protein
Pssm-ID: 215454 [Multi-domain] Cd Length: 336 Bit Score: 48.47 E-value: 3.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 239 NYGSSLLAQCEAAENGCHQVLWLyGKENRITEVGTMNL-FLywiNKDGeeELATPPLDGvILPGVTRQSILELGEEWGEF 317
Cdd:PLN02845 188 NYLPNALSQMEAEERGAFAGIWL-DEEGFVAEGPNMNVaFL---TNDG--ELVLPPFDK-ILSGCTARRVLELAPRLVSP 260
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2017952465 318 K----VCERHITMDDLSTAleenrvKEMFGSGTACVVCPVAS 355
Cdd:PLN02845 261 GdlrgVKQRKISVEEAKAA------DEMMLIGSGVPVLPIVS 296
|
|
| PRK06680 |
PRK06680 |
D-amino acid aminotransferase; Reviewed |
245-356 |
6.16e-06 |
|
D-amino acid aminotransferase; Reviewed
Pssm-ID: 180656 [Multi-domain] Cd Length: 286 Bit Score: 47.62 E-value: 6.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 245 LAQCEAAENGCHQVlWLYGkENRITEVGTMNLFLywINKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHI 324
Cdd:PRK06680 158 LAKQAAKEAGAQEA-WMVD-DGFVTEGASSNAWI--VTKDGK--LVTRPADNFILPGITRHTLIDLAKELG-LEVEERPF 230
|
90 100 110
....*....|....*....|....*....|..
gi 2017952465 325 TMDDLSTAleenrvKEMFGSGTACVVCPVASI 356
Cdd:PRK06680 231 TLQEAYAA------REAFITAASSFVFPVVQI 256
|
|
| PRK07546 |
PRK07546 |
hypothetical protein; Provisional |
268-332 |
1.21e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 169002 [Multi-domain] Cd Length: 209 Bit Score: 43.04 E-value: 1.21e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017952465 268 ITEVGTMNLFLywinKDGEEELATPPLDGVILPGVTRQSILELGeewgefKVCERHITMDDLSTA 332
Cdd:PRK07546 137 VCEGTITNVFL----DRGGGMLTTPPLSCGLLPGVLRAELLDAG------RAREAVLTVDDLKSA 191
|
|
| PRK07849 |
PRK07849 |
aminodeoxychorismate lyase; |
108-332 |
6.13e-04 |
|
aminodeoxychorismate lyase;
Pssm-ID: 236114 [Multi-domain] Cd Length: 292 Bit Score: 41.48 E-value: 6.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 108 FEGLKAFRGvdnKIRLFRPDLnmKRMCRSAVRTTLPEFDKEELLQCVLQLIqldREWvpYSTSASLYIRPTFigiepSLG 187
Cdd:PRK07849 42 FETLLVRDG---RPCNLEAHL--ERLARSAALLDLPEPDLDRWRRAVELAI---EEW--RAPEDEAALRLVY-----SRG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017952465 188 VKKPSKALLFVILSPVGSYFSNGTFSPVSLWANPkfvRSWKGGTGD----FKMGC---NYGSSLLAQCEAAENGCHQVLW 260
Cdd:PRK07849 107 RESGGAPTAWVTVSPVPERVARARREGVSVITLD---RGYPSDAAErapwLLAGAktlSYAVNMAALRYAARRGADDVIF 183
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017952465 261 LYGkENRITEVGTMNLFLYwinKDGEeeLATPPLDGVILPGVTRQSILELGEEWGeFKVCERHITMDDLSTA 332
Cdd:PRK07849 184 TST-DGYVLEGPTSTVVIA---TDDR--LLTPPPWYGILPGTTQAALFEVAREKG-WDCEYRALRPADLFAA 248
|
|
| |
