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Conserved domains on  [gi|2216732113|ref|NP_001390691|]
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dymeclin isoform 3 [Mus musculus]

Protein Classification

dymeclin( domain architecture ID 10560863)

dymeclin is necessary for correct organization of Golgi apparatus

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Dymeclin pfam09742
Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) ...
1-585 0e+00

Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteriztically about 700 residues long and present in plants and animals. Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC, MIM 223800) which is an autosomal-recessive disorder characterized by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation. DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus.


:

Pssm-ID: 462873  Cd Length: 645  Bit Score: 614.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113   1 MGSNSSKISdlPKNEYLKKLSGPESISENDPFWNQLFSFSFPAPTSSSELKLLEEATISVCKSLVENNPRTGNLAALTKV 80
Cdd:pfam09742   1 MGASSSKLS--FRNAYLQLLSGTQPISADDPFWNQLLSFSLSIPLSSADVFLLEEALEPACEILALRNARTGNLATLLRK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113  81 FLSRTRELR--LSAEC-QNHIFIWQTHNALFIICCLLKVFIRELSEEELQLHFTYEEKSPG----SYSSDSEDLLEELLC 153
Cdd:pfam09742  79 FVERLVELKdsSRSASeQNDLFIWQALNALFLLRRILKYIIERASEEELLQHFEYENDDEGdedeEGSNRDLPLAESLLL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 154 SLVQLITDTPLLDITYEIAVEAISAMVVFLSCQLFHKEVLRQSISHKYLMQGPCL---PYTSKLVKTLLYNFIRQEKPPP 230
Cdd:pfam09742 159 ALVDLLFTVPLTDSTYALHTELLNLLLVLLSEQLYSPPSPADTSIFNPFMDGKCSadsSIALPLVTSLLNNFIAYDPVPS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 231 PGTHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGagSKAAASPELTSPLANQSL---------LLLLVLVNLTDAPDip 301
Cdd:pfam09742 239 NSLDSDGGSGVPYNHLLGLVSDLASSLWLLPTLGG--SSESESEGTPEPLADQSLqlllvlldhGPTEDPVKSPSGGD-- 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 302 NPYRQAVSSFKNTQDsspfpssiphtFQINFNSLYTALCEQQTSDQA-TLLLYTLLHQNSNVRTYVLARTDMENLVLPIL 380
Cdd:pfam09742 315 NPYRNALSRLHDVED-----------FQIVFSGLFRTLCNTVPSEQTlLLLLYKLLHSNSKFLNYVLSRSDVLDLLVPIL 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 381 EILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILRNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLH 460
Cdd:pfam09742 384 ELLYNARADNSHHIYMALIILLILSEDRNFNKRLHKPILKNVTWYSERVPTEISLGSLLILVLIRTIQYNHTRLRDKYLH 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 461 TNCLAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQSLRGPLSSSDVP----------------------- 517
Cdd:pfam09742 464 TNCLAILANMSPYFKNLSPYASQRLVSLFELLSKKHFKLLSLANGKASNDLGSDDLAqdlsvneevlrllleilnsilqy 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 518 ------------------------LPDY---------VISFFSSRLLQAGAE---LSVERVLEIIKQGVVALPKDrlKKF 561
Cdd:pfam09742 544 qldgnpnlvyallrkrevfhqfanHPSFqdplqnidrVLQFFSPRVEKACADsglLSVSEILDIIQKGTLVGLLP--KPF 621
                         650       660
                  ....*....|....*....|....
gi 2216732113 562 PELKFKYVEEEQPEEFFIPYVWSL 585
Cdd:pfam09742 622 PILKFKYVEEESPEEFFIPYVWSL 645
 
Name Accession Description Interval E-value
Dymeclin pfam09742
Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) ...
1-585 0e+00

Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteriztically about 700 residues long and present in plants and animals. Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC, MIM 223800) which is an autosomal-recessive disorder characterized by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation. DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus.


Pssm-ID: 462873  Cd Length: 645  Bit Score: 614.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113   1 MGSNSSKISdlPKNEYLKKLSGPESISENDPFWNQLFSFSFPAPTSSSELKLLEEATISVCKSLVENNPRTGNLAALTKV 80
Cdd:pfam09742   1 MGASSSKLS--FRNAYLQLLSGTQPISADDPFWNQLLSFSLSIPLSSADVFLLEEALEPACEILALRNARTGNLATLLRK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113  81 FLSRTRELR--LSAEC-QNHIFIWQTHNALFIICCLLKVFIRELSEEELQLHFTYEEKSPG----SYSSDSEDLLEELLC 153
Cdd:pfam09742  79 FVERLVELKdsSRSASeQNDLFIWQALNALFLLRRILKYIIERASEEELLQHFEYENDDEGdedeEGSNRDLPLAESLLL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 154 SLVQLITDTPLLDITYEIAVEAISAMVVFLSCQLFHKEVLRQSISHKYLMQGPCL---PYTSKLVKTLLYNFIRQEKPPP 230
Cdd:pfam09742 159 ALVDLLFTVPLTDSTYALHTELLNLLLVLLSEQLYSPPSPADTSIFNPFMDGKCSadsSIALPLVTSLLNNFIAYDPVPS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 231 PGTHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGagSKAAASPELTSPLANQSL---------LLLLVLVNLTDAPDip 301
Cdd:pfam09742 239 NSLDSDGGSGVPYNHLLGLVSDLASSLWLLPTLGG--SSESESEGTPEPLADQSLqlllvlldhGPTEDPVKSPSGGD-- 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 302 NPYRQAVSSFKNTQDsspfpssiphtFQINFNSLYTALCEQQTSDQA-TLLLYTLLHQNSNVRTYVLARTDMENLVLPIL 380
Cdd:pfam09742 315 NPYRNALSRLHDVED-----------FQIVFSGLFRTLCNTVPSEQTlLLLLYKLLHSNSKFLNYVLSRSDVLDLLVPIL 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 381 EILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILRNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLH 460
Cdd:pfam09742 384 ELLYNARADNSHHIYMALIILLILSEDRNFNKRLHKPILKNVTWYSERVPTEISLGSLLILVLIRTIQYNHTRLRDKYLH 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 461 TNCLAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQSLRGPLSSSDVP----------------------- 517
Cdd:pfam09742 464 TNCLAILANMSPYFKNLSPYASQRLVSLFELLSKKHFKLLSLANGKASNDLGSDDLAqdlsvneevlrllleilnsilqy 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 518 ------------------------LPDY---------VISFFSSRLLQAGAE---LSVERVLEIIKQGVVALPKDrlKKF 561
Cdd:pfam09742 544 qldgnpnlvyallrkrevfhqfanHPSFqdplqnidrVLQFFSPRVEKACADsglLSVSEILDIIQKGTLVGLLP--KPF 621
                         650       660
                  ....*....|....*....|....
gi 2216732113 562 PELKFKYVEEEQPEEFFIPYVWSL 585
Cdd:pfam09742 622 PILKFKYVEEESPEEFFIPYVWSL 645
 
Name Accession Description Interval E-value
Dymeclin pfam09742
Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) ...
1-585 0e+00

Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteriztically about 700 residues long and present in plants and animals. Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC, MIM 223800) which is an autosomal-recessive disorder characterized by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation. DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus.


Pssm-ID: 462873  Cd Length: 645  Bit Score: 614.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113   1 MGSNSSKISdlPKNEYLKKLSGPESISENDPFWNQLFSFSFPAPTSSSELKLLEEATISVCKSLVENNPRTGNLAALTKV 80
Cdd:pfam09742   1 MGASSSKLS--FRNAYLQLLSGTQPISADDPFWNQLLSFSLSIPLSSADVFLLEEALEPACEILALRNARTGNLATLLRK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113  81 FLSRTRELR--LSAEC-QNHIFIWQTHNALFIICCLLKVFIRELSEEELQLHFTYEEKSPG----SYSSDSEDLLEELLC 153
Cdd:pfam09742  79 FVERLVELKdsSRSASeQNDLFIWQALNALFLLRRILKYIIERASEEELLQHFEYENDDEGdedeEGSNRDLPLAESLLL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 154 SLVQLITDTPLLDITYEIAVEAISAMVVFLSCQLFHKEVLRQSISHKYLMQGPCL---PYTSKLVKTLLYNFIRQEKPPP 230
Cdd:pfam09742 159 ALVDLLFTVPLTDSTYALHTELLNLLLVLLSEQLYSPPSPADTSIFNPFMDGKCSadsSIALPLVTSLLNNFIAYDPVPS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 231 PGTHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGagSKAAASPELTSPLANQSL---------LLLLVLVNLTDAPDip 301
Cdd:pfam09742 239 NSLDSDGGSGVPYNHLLGLVSDLASSLWLLPTLGG--SSESESEGTPEPLADQSLqlllvlldhGPTEDPVKSPSGGD-- 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 302 NPYRQAVSSFKNTQDsspfpssiphtFQINFNSLYTALCEQQTSDQA-TLLLYTLLHQNSNVRTYVLARTDMENLVLPIL 380
Cdd:pfam09742 315 NPYRNALSRLHDVED-----------FQIVFSGLFRTLCNTVPSEQTlLLLLYKLLHSNSKFLNYVLSRSDVLDLLVPIL 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 381 EILYHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILRNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLH 460
Cdd:pfam09742 384 ELLYNARADNSHHIYMALIILLILSEDRNFNKRLHKPILKNVTWYSERVPTEISLGSLLILVLIRTIQYNHTRLRDKYLH 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 461 TNCLAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQSLRGPLSSSDVP----------------------- 517
Cdd:pfam09742 464 TNCLAILANMSPYFKNLSPYASQRLVSLFELLSKKHFKLLSLANGKASNDLGSDDLAqdlsvneevlrllleilnsilqy 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2216732113 518 ------------------------LPDY---------VISFFSSRLLQAGAE---LSVERVLEIIKQGVVALPKDrlKKF 561
Cdd:pfam09742 544 qldgnpnlvyallrkrevfhqfanHPSFqdplqnidrVLQFFSPRVEKACADsglLSVSEILDIIQKGTLVGLLP--KPF 621
                         650       660
                  ....*....|....*....|....
gi 2216732113 562 PELKFKYVEEEQPEEFFIPYVWSL 585
Cdd:pfam09742 622 PILKFKYVEEESPEEFFIPYVWSL 645
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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