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Conserved domains on  [gi|2235183350|ref|NP_001392895|]
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large ribosomal subunit protein uL22 isoform c [Mus musculus]

Protein Classification

60S ribosomal protein L17( domain architecture ID 10794330)

60S ribosomal protein L17 acts as a vascular smooth muscle cell growth inhibitor (akin to a tumor suppressor) and represents a potential therapeutic target to limit carotid intima-media thickening

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00178 PTZ00178
60S ribosomal protein L17; Provisional
 1-127 1.66e-78

60S ribosomal protein L17; Provisional


:

Pssm-ID: 240306  Cd Length: 181  Bit Score: 229.96  E-value: 1.66e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235183350   1 MHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQ 80
Cdd:PTZ00178   39 MKLARAQKYLEDVLAKKRCVPFRRFNGGVGRTAQAKEFGHTQGRWPEKSVKFVLSLLKNAEANAEAKGLDVEKLVISHVQ 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2235183350  81 VNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVA 127
Cdd:PTZ00178  119 VNRAPRGRRRTYRAHGRINPFMSSPCHIELIATEKDETVPKPKEAPK 165
 
Name Accession Description Interval E-value
PTZ00178 PTZ00178
60S ribosomal protein L17; Provisional
 1-127 1.66e-78

60S ribosomal protein L17; Provisional


Pssm-ID: 240306  Cd Length: 181  Bit Score: 229.96  E-value: 1.66e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235183350   1 MHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQ 80
Cdd:PTZ00178   39 MKLARAQKYLEDVLAKKRCVPFRRFNGGVGRTAQAKEFGHTQGRWPEKSVKFVLSLLKNAEANAEAKGLDVEKLVISHVQ 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2235183350  81 VNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVA 127
Cdd:PTZ00178  119 VNRAPRGRRRTYRAHGRINPFMSSPCHIELIATEKDETVPKPKEAPK 165
uL22_arch_euk TIGR01038
ribosomal protein uL22, eukaryotic/archaeal form; This model describes the ribosomal protein ...
 1-115 1.52e-63

ribosomal protein uL22, eukaryotic/archaeal form; This model describes the ribosomal protein uL22 of the eukaryotic cytosol and of the Archaea, previously designated as L17, L22, and L23. The corresponding bacterial form of uL22 is described by a separate model. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273409  Cd Length: 148  Bit Score: 191.13  E-value: 1.52e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235183350   1 MHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAkqWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQ 80
Cdd:TIGR01038  36 MELDKARKYLEDVIAMKRAVPFRRYNGKVGHRAGL--WGWTAGRYPVKAAKFILKVLQNAEANAEYKGLDVEKLKIIHIQ 113

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2235183350  81 VNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEK 115
Cdd:TIGR01038 114 ANKGPVIRRWMPRAFGRATPYNSSTTHIELVVEEK 148
Ribosomal_L22 pfam00237
Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and ...
 46-113 6.83e-34

Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.


Pssm-ID: 459725  Cd Length: 104  Bit Score: 114.42  E-value: 6.83e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2235183350  46 PKKSAEFLLHMLKNAESNAELKGL-DVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILT 113
Cdd:pfam00237  36 PKKAAKIVLKLLKSAIANAENKGNlDVDNLYISEIQVDKGPTLKRIRPRARGRAGPIRKRTSHITVVLK 104
Ribosomal_L22 cd00336
Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal ...
 46-112 1.60e-27

Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper folding and stabilizing the conformation of 23S rRNA. L22 is the largest protein contributor to the surface of the polypeptide exit channel, the tunnel through which the polypeptide product passes. L22 is also one of six proteins located at the putative translocon binding site on the exterior surface of the ribosome.


Pssm-ID: 238205  Cd Length: 105  Bit Score: 98.33  E-value: 1.60e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2235183350  46 PKKSAEFLLHMLKNAESNAELKGL-DVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMIL 112
Cdd:cd00336    38 PKKAAKIILKLLKSAEANAENNGLdDPDKLYIKHIQVNKGPTLKRRRPRARGRANPIRKRTCHITVVL 105
RplV COG0091
Ribosomal protein L22 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L22 ...
 45-115 2.32e-21

Ribosomal protein L22 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L22 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439861  Cd Length: 110  Bit Score: 82.40  E-value: 2.32e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2235183350  45 WPKKSAEFLLHMLKNAESNAELK-GLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEK 115
Cdd:COG0091    39 SPKKAARIVLKVLKSAIANAENNnGLDVDNLVVKEIFVDKGPTLKRFRPRARGRATRIRKRTSHITVVVSEK 110
 
Name Accession Description Interval E-value
PTZ00178 PTZ00178
60S ribosomal protein L17; Provisional
 1-127 1.66e-78

60S ribosomal protein L17; Provisional


Pssm-ID: 240306  Cd Length: 181  Bit Score: 229.96  E-value: 1.66e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235183350   1 MHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQ 80
Cdd:PTZ00178   39 MKLARAQKYLEDVLAKKRCVPFRRFNGGVGRTAQAKEFGHTQGRWPEKSVKFVLSLLKNAEANAEAKGLDVEKLVISHVQ 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2235183350  81 VNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVA 127
Cdd:PTZ00178  119 VNRAPRGRRRTYRAHGRINPFMSSPCHIELIATEKDETVPKPKEAPK 165
uL22_arch_euk TIGR01038
ribosomal protein uL22, eukaryotic/archaeal form; This model describes the ribosomal protein ...
 1-115 1.52e-63

ribosomal protein uL22, eukaryotic/archaeal form; This model describes the ribosomal protein uL22 of the eukaryotic cytosol and of the Archaea, previously designated as L17, L22, and L23. The corresponding bacterial form of uL22 is described by a separate model. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273409  Cd Length: 148  Bit Score: 191.13  E-value: 1.52e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235183350   1 MHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAkqWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQ 80
Cdd:TIGR01038  36 MELDKARKYLEDVIAMKRAVPFRRYNGKVGHRAGL--WGWTAGRYPVKAAKFILKVLQNAEANAEYKGLDVEKLKIIHIQ 113

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2235183350  81 VNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEK 115
Cdd:TIGR01038 114 ANKGPVIRRWMPRAFGRATPYNSSTTHIELVVEEK 148
rpl22p PRK04223
50S ribosomal protein L22P; Reviewed
 1-114 9.86e-38

50S ribosomal protein L22P; Reviewed


Pssm-ID: 179794  Cd Length: 153  Bit Score: 125.75  E-value: 9.86e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235183350   1 MHIRKATKYLKDVTLKKQCVPFRRYNGGVGRcaQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQ 80
Cdd:PRK04223   40 MKLDEAKAYLEDVIALKRAVPFKRHNKKVGH--RKGIDGWPAGRYPVKAAKAFLKLLENAEANAEYKGLDTEKLVIVHIA 117

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2235183350  81 VNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTE 114
Cdd:PRK04223  118 AHKGRVIKGYMPRAFGRATPKNTETVNIEVILEE 151
Ribosomal_L22 pfam00237
Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and ...
 46-113 6.83e-34

Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.


Pssm-ID: 459725  Cd Length: 104  Bit Score: 114.42  E-value: 6.83e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2235183350  46 PKKSAEFLLHMLKNAESNAELKGL-DVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILT 113
Cdd:pfam00237  36 PKKAAKIVLKLLKSAIANAENKGNlDVDNLYISEIQVDKGPTLKRIRPRARGRAGPIRKRTSHITVVLK 104
Ribosomal_L22 cd00336
Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal ...
 46-112 1.60e-27

Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper folding and stabilizing the conformation of 23S rRNA. L22 is the largest protein contributor to the surface of the polypeptide exit channel, the tunnel through which the polypeptide product passes. L22 is also one of six proteins located at the putative translocon binding site on the exterior surface of the ribosome.


Pssm-ID: 238205  Cd Length: 105  Bit Score: 98.33  E-value: 1.60e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2235183350  46 PKKSAEFLLHMLKNAESNAELKGL-DVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMIL 112
Cdd:cd00336    38 PKKAAKIILKLLKSAEANAENNGLdDPDKLYIKHIQVNKGPTLKRRRPRARGRANPIRKRTCHITVVL 105
RplV COG0091
Ribosomal protein L22 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L22 ...
 45-115 2.32e-21

Ribosomal protein L22 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L22 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439861  Cd Length: 110  Bit Score: 82.40  E-value: 2.32e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2235183350  45 WPKKSAEFLLHMLKNAESNAELK-GLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEK 115
Cdd:COG0091    39 SPKKAARIVLKVLKSAIANAENNnGLDVDNLVVKEIFVDKGPTLKRFRPRARGRATRIRKRTSHITVVVSEK 110
rplV_bact TIGR01044
ribosomal protein L22, bacterial type; This model decribes bacterial and chloroplast ribosomal ...
 46-108 1.98e-08

ribosomal protein L22, bacterial type; This model decribes bacterial and chloroplast ribosomal protein L22. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 130116  Cd Length: 103  Bit Score: 49.05  E-value: 1.98e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2235183350  46 PKKSAEFLLHMLKNAESNAELK-GLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHI 108
Cdd:TIGR01044  36 PKKASPIIEKVLASAIANAEHNyGLDANNLVVVTAFVDEGPTLKRIRPRAKGRASRIRKRTSHI 99
PRK12279 PRK12279
50S ribosomal protein L22/unknown domain fusion protein; Provisional
 46-127 9.91e-08

50S ribosomal protein L22/unknown domain fusion protein; Provisional


Pssm-ID: 138835 [Multi-domain]  Cd Length: 311  Bit Score: 49.69  E-value: 9.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235183350  46 PKKSAEFLLHMLKNAESNAEL--KGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKeqiVPKPE 123
Cdd:PRK12279   40 PKKFAPIVLKLLNSAISNVQHnsKDMDPSKLYIYKIVANQGPTMKRTLPRAKGSADQLFKRTTHLEIVLSDD---VNERE 116


                  ....
gi 2235183350 124 EEVA 127
Cdd:PRK12279  117 KELA 120
rpl22 CHL00034
ribosomal protein L22
 46-115 1.27e-05

ribosomal protein L22


Pssm-ID: 214342  Cd Length: 117  Bit Score: 41.84  E-value: 1.27e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2235183350  46 PKKSAEFLLHMLKNAESNAEL-KGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEK 115
Cdd:CHL00034   47 PYRACYPILKLVYSAAANASHnMGLNKANLFISKAEVDEGPTLKRFRPRAQGRSYPIKKPTCHITIVLKDI 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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