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Conserved domains on  [gi|2458603077|ref|NP_001404946|]
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regucalcin [Mus musculus]

Protein Classification

SMP-30/gluconolactonase/LRE family protein( domain architecture ID 12093833)

SMP-30/gluconolactonase/LRE family protein similar to vertebrate senescence marker protein 30 (SMP-30) and to Pseudomonas putida 6-deoxy-6-sulfogluconolactonase, which catalyzes the hydrolysis of 6-deoxy-6-sulfo-D-glucono-1,5-lactone to form 6-deoxy-6-sulfo-D-gluconate

EC:  3.1.1.99
Gene Ontology:  GO:0046872|GO:0016787

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 16-264 2.01e-96

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


:

Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 284.15  E-value: 2.01e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077  16 CGESPVWEEASQSLLFVDIPSKIICRWDTVSNQVQRVAVDAPVSSVALRQLGGYVATIGTKFCALNWENQSVFVLAMVDE 95
Cdd:pfam08450   1 LGEGPVWDEEEGALYWVDILGGRIHRLDPATGKETVWDTPGPVGAIAPRDDGGLIVALKDGVALLDLATGELTPLADPED 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077  96 D-KKNNRFNDGKVDPAGRYFAGTMAEETAPAvleRHQGSLYSLFPDHSVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYT 174
Cdd:pfam08450  81 DdWPLNRFNDGKVDPDGRFWFGTMGDDEAPG---GDPGALYRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSPARK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077 175 VDAFDYDLQTGQISNRRIVYKMEKDEQIPDGMCIDAEGKLWVACYNGGRVIRLDPEtGKRLQTVKLPVDKTTSCCFGGKD 254
Cdd:pfam08450 158 IWAYDYDLDGGLISNRRVFADFKPGLGRPDGMAVDAEGNVWVARWGGGKVVRFDPD-GKLLREIELPAKRPTSCAFGGPD 236

                         250
                  ....*....|
gi 2458603077 255 YSEMYVTCAR 264
Cdd:pfam08450 237 LRTLYVTSAR 246
 
Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 16-264 2.01e-96

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 284.15  E-value: 2.01e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077  16 CGESPVWEEASQSLLFVDIPSKIICRWDTVSNQVQRVAVDAPVSSVALRQLGGYVATIGTKFCALNWENQSVFVLAMVDE 95
Cdd:pfam08450   1 LGEGPVWDEEEGALYWVDILGGRIHRLDPATGKETVWDTPGPVGAIAPRDDGGLIVALKDGVALLDLATGELTPLADPED 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077  96 D-KKNNRFNDGKVDPAGRYFAGTMAEETAPAvleRHQGSLYSLFPDHSVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYT 174
Cdd:pfam08450  81 DdWPLNRFNDGKVDPDGRFWFGTMGDDEAPG---GDPGALYRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSPARK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077 175 VDAFDYDLQTGQISNRRIVYKMEKDEQIPDGMCIDAEGKLWVACYNGGRVIRLDPEtGKRLQTVKLPVDKTTSCCFGGKD 254
Cdd:pfam08450 158 IWAYDYDLDGGLISNRRVFADFKPGLGRPDGMAVDAEGNVWVARWGGGKVVRFDPD-GKLLREIELPAKRPTSCAFGGPD 236

                         250
                  ....*....|
gi 2458603077 255 YSEMYVTCAR 264
Cdd:pfam08450 237 LRTLYVTSAR 246
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 9-291 1.34e-77

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 237.10  E-value: 1.34e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077   9 VLRENYRCGESPVWEEAsQSLLFVDIPSKIICRWDTVSNQVQRVAVDAP-VSSVALRQLGG-YVATIGTKFCALNWENQS 86
Cdd:COG3386     2 LADAGFRLGEGPVWDPD-GRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGrPNGLAFDPDGRlLVADHGRGLVRFDPADGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077  87 VFVLAMvDEDKKNNRFNDGKVDPAGRYFAGTMAEETAPavlerhqGSLYSLFPDHSVKKYFDQVDISNGLDWSLDHKIFY 166
Cdd:COG3386    81 VTVLAD-EYGKPLNRPNDGVVDPDGRLYFTDMGEYLPT-------GALYRVDPDGSLRVLADGLTFPNGIAFSPDGRTLY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077 167 YIDSLSYTVDAFDYDlQTGQISNRRIVYKMEKDEQIPDGMCIDAEGKLWVACYNGGRVIRLDPeTGKRLQTVKLPVDKTT 246
Cdd:COG3386   153 VADTGAGRIYRFDLD-ADGTLGNRRVFADLPDGPGGPDGLAVDADGNLWVALWGGGGVVRFDP-DGELLGRIELPERRPT 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2458603077 247 SCCFGGKDYSEMYVTCARDGlnaegllrqPDAGNIFKITgLGVKG 291
Cdd:COG3386   231 NVAFGGPDLRTLYVTTARSL---------PLAGALFRVR-VDVPG 265
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 166-237 6.07e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 37.65  E-value: 6.07e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2458603077 166 YYIDSLSYTVDAFDYDLQTGqisnRRIVYKMEKDEQI--PDGMCIDAEGKLWVACYNGGRVIRLDPeTGKRLQT 237
Cdd:cd14956    27 YVADARNGRIQVFDKDGTFL----RRFGTTGDGPGQFgrPRGLAVDKDGWLYVADYWGDRIQVFTL-TGELQTI 95
 
Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 16-264 2.01e-96

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 284.15  E-value: 2.01e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077  16 CGESPVWEEASQSLLFVDIPSKIICRWDTVSNQVQRVAVDAPVSSVALRQLGGYVATIGTKFCALNWENQSVFVLAMVDE 95
Cdd:pfam08450   1 LGEGPVWDEEEGALYWVDILGGRIHRLDPATGKETVWDTPGPVGAIAPRDDGGLIVALKDGVALLDLATGELTPLADPED 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077  96 D-KKNNRFNDGKVDPAGRYFAGTMAEETAPAvleRHQGSLYSLFPDHSVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYT 174
Cdd:pfam08450  81 DdWPLNRFNDGKVDPDGRFWFGTMGDDEAPG---GDPGALYRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSPARK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077 175 VDAFDYDLQTGQISNRRIVYKMEKDEQIPDGMCIDAEGKLWVACYNGGRVIRLDPEtGKRLQTVKLPVDKTTSCCFGGKD 254
Cdd:pfam08450 158 IWAYDYDLDGGLISNRRVFADFKPGLGRPDGMAVDAEGNVWVARWGGGKVVRFDPD-GKLLREIELPAKRPTSCAFGGPD 236

                         250
                  ....*....|
gi 2458603077 255 YSEMYVTCAR 264
Cdd:pfam08450 237 LRTLYVTSAR 246
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 9-291 1.34e-77

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 237.10  E-value: 1.34e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077   9 VLRENYRCGESPVWEEAsQSLLFVDIPSKIICRWDTVSNQVQRVAVDAP-VSSVALRQLGG-YVATIGTKFCALNWENQS 86
Cdd:COG3386     2 LADAGFRLGEGPVWDPD-GRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGrPNGLAFDPDGRlLVADHGRGLVRFDPADGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077  87 VFVLAMvDEDKKNNRFNDGKVDPAGRYFAGTMAEETAPavlerhqGSLYSLFPDHSVKKYFDQVDISNGLDWSLDHKIFY 166
Cdd:COG3386    81 VTVLAD-EYGKPLNRPNDGVVDPDGRLYFTDMGEYLPT-------GALYRVDPDGSLRVLADGLTFPNGIAFSPDGRTLY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077 167 YIDSLSYTVDAFDYDlQTGQISNRRIVYKMEKDEQIPDGMCIDAEGKLWVACYNGGRVIRLDPeTGKRLQTVKLPVDKTT 246
Cdd:COG3386   153 VADTGAGRIYRFDLD-ADGTLGNRRVFADLPDGPGGPDGLAVDADGNLWVALWGGGGVVRFDP-DGELLGRIELPERRPT 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2458603077 247 SCCFGGKDYSEMYVTCARDGlnaegllrqPDAGNIFKITgLGVKG 291
Cdd:COG3386   231 NVAFGGPDLRTLYVTTARSL---------PLAGALFRVR-VDVPG 265
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
180-241 1.03e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 55.03  E-value: 1.03e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2458603077 180 YDLQTGQISnrriVYKMEKDEQIPDGMCIDAEGKLWVACYNGGRVIRLDPETGKrLQTVKLP 241
Cdd:COG4257   128 LDPATGEVT----EFPLPTGGAGPYGIAVDPDGNLWVTDFGANAIGRIDPDTGT-LTEYALP 184
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
180-241 1.76e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 54.26  E-value: 1.76e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2458603077 180 YDLQTGQISnrriVYKMEKDEQIPDGMCIDAEGKLWVACYNGGRVIRLDPETGKrLQTVKLP 241
Cdd:COG4257   171 IDPDTGTLT----EYALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFDPKTGT-VTEYPLP 227
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
107-266 1.97e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077 107 VDPAGRYFAGTMAEETAPAVLERHQGSLYSLFPDHSVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYTVDAFDydLQTGQ 186
Cdd:COG3391    24 AVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVID--LATGK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077 187 ISNRRIVYKMekdeqiPDGMCIDAEGK-LWVACYNGGRVIRLDPETGKRLQTVklPVDKTTSCCFGGKDYSEMYVTCARD 265
Cdd:COG3391   102 VVATIPVGGG------PRGLAVDPDGGrLYVADSGNGRVSVIDTATGKVVATI--PVGAGPHGIAVDPDGKRLYVANSGS 173


                  .
gi 2458603077 266 G 266
Cdd:COG3391   174 N 174
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
180-243 4.93e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 46.94  E-value: 4.93e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2458603077 180 YDLQTGQISnrriVYKMEKDEQIPDGMCIDAEGKLWVACYNGGRVIRLDPETGKrLQTVKLPVD 243
Cdd:COG4257    85 IDPKTGEIT----TFALPGGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGE-VTEFPLPTG 143
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
203-241 8.30e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 46.17  E-value: 8.30e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2458603077 203 PDGMCIDAEGKLWVACYNGGRVIRLDPETGKrLQTVKLP 241
Cdd:COG4257    61 PHGIAVDPDGNLWFTDNGNNRIGRIDPKTGE-ITTFALP 98
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
180-241 1.50e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 45.40  E-value: 1.50e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2458603077 180 YDLQTGQISNrrivYKMEKDEQIPDGMCIDAEGKLWVACYNGGRVIRLDPETGkrLQTVKLP 241
Cdd:COG4257   214 FDPKTGTVTE----YPLPGGGARPYGVAVDGDGRVWFAESGANRIVRFDPDTE--LTEYVLP 269
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
194-233 2.50e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.93  E-value: 2.50e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2458603077 194 YKMEKDEQIPDGMCIDAEGKLWVACYNGGRVIRLDPETGK 233
Cdd:COG4257    10 YPVPAPGSGPRDVAVDPDGAVWFTDQGGGRIGRLDPATGE 49
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
88-233 7.57e-04

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 41.13  E-value: 7.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077  88 FVLAMVDEDKKNNRFNDGKVDPAGRYFAGTmaeetapavlerhQGSLYSLFPDHSVKKYFDQVDISNGLDWSL----DHK 163
Cdd:COG3292   112 FTRYPLDPGLPNNSIRSIAEDSDGNIWVGT-------------SNGLYRYDPKTGKFKRFTLDGLPSNTITSLaedaDGN 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077 164 IF----------------YYIDSLSYTVDAFDYDLQTGQISNRRIVYkmekdeqipdgMCIDAEGKLWVACYNGGrVIRL 227
Cdd:COG3292   179 LWvdsdgnlwigtdgnglYRLDPNTGKFEHITHDPDPNSLSSNSIYS-----------LFEDREGNLWVGTYGGG-LNYL 246


                  ....*.
gi 2458603077 228 DPETGK 233
Cdd:COG3292   247 DPNNSK 252
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
140-266 1.91e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.91  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2458603077 140 DHSVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYTVDAFDydLQTGQISNRRIVYKMekdeqiPDGMCIDAEGK-LWVAC 218
Cdd:COG3391    99 TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVID--TATGKVVATIPVGAG------PHGIAVDPDGKrLYVAN 170

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2458603077 219 YNGGRVI----RLDPETGKRLQTVklPVDKTTSCCFGGKDYSEMYVTCARDG 266
Cdd:COG3391   171 SGSNTVSvivsVIDTATGKVVATI--PVGGGPVGVAVSPDGRRLYVANRGSN 220
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 166-237 6.07e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 37.65  E-value: 6.07e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2458603077 166 YYIDSLSYTVDAFDYDLQTGqisnRRIVYKMEKDEQI--PDGMCIDAEGKLWVACYNGGRVIRLDPeTGKRLQT 237
Cdd:cd14956    27 YVADARNGRIQVFDKDGTFL----RRFGTTGDGPGQFgrPRGLAVDKDGWLYVADYWGDRIQVFTL-TGELQTI 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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