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Conserved domains on  [gi|4504991|ref|NP_002300|]
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leukemia inhibitory factor isoform 1 precursor [Homo sapiens]

Protein Classification

LIF_OSM domain-containing protein( domain architecture ID 10637944)

LIF_OSM domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LIF_OSM smart00080
leukemia inhibitory factor; OSM, Oncostatin M
34-191 3.13e-98

leukemia inhibitory factor; OSM, Oncostatin M


:

Pssm-ID: 197505  Cd Length: 157  Bit Score: 281.71  E-value: 3.13e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504991      34 CAIRHPCHNNLMNQIRSQLAQLNGSANALFILYYTAQGEPFPNnLDKLCGPNVTDFPPFHANGTEKAKLVELYRIVVYLG 113
Cdd:smart00080   1 CAIRHPCHGNLMNQIQNQLAQLNGSANALFIPYITAQGEPFPN-LDKLCRPNPTDFPSFHANGTEKTKLVELYRIVAYLG 79
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504991     114 TSLGNITRDQKILNPSALSLHSKLNATADILRGLLSNVLCRLCSKYHVGHVDVTYGPDTSGKDVFQKKKLGCQLLGKY 191
Cdd:smart00080  80 ASLGNITRDQQVLNPTAASLQSKLNATRDNIRGLLSNVLCRLCLKYHVEHVDVAYGPDTSGKDVFQRKKLGCQLLGGY 157
 
Name Accession Description Interval E-value
LIF_OSM smart00080
leukemia inhibitory factor; OSM, Oncostatin M
34-191 3.13e-98

leukemia inhibitory factor; OSM, Oncostatin M


Pssm-ID: 197505  Cd Length: 157  Bit Score: 281.71  E-value: 3.13e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504991      34 CAIRHPCHNNLMNQIRSQLAQLNGSANALFILYYTAQGEPFPNnLDKLCGPNVTDFPPFHANGTEKAKLVELYRIVVYLG 113
Cdd:smart00080   1 CAIRHPCHGNLMNQIQNQLAQLNGSANALFIPYITAQGEPFPN-LDKLCRPNPTDFPSFHANGTEKTKLVELYRIVAYLG 79
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504991     114 TSLGNITRDQKILNPSALSLHSKLNATADILRGLLSNVLCRLCSKYHVGHVDVTYGPDTSGKDVFQKKKLGCQLLGKY 191
Cdd:smart00080  80 ASLGNITRDQQVLNPTAASLQSKLNATRDNIRGLLSNVLCRLCLKYHVEHVDVAYGPDTSGKDVFQRKKLGCQLLGGY 157
LIF_OSM pfam01291
LIF / OSM family;
43-202 6.78e-76

LIF / OSM family;


Pssm-ID: 396039  Cd Length: 162  Bit Score: 225.13  E-value: 6.78e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504991     43 NLMNQIRSQLAQLNGSAnALFILYYTAQGEPFPNnLDKLCGPNVTDFPpFHANGTEKAKLVELYRIVVYLGTSLGNITRD 122
Cdd:pfam01291   1 NLLNQLQNQADLLNDTA-SLLIPYIRLQGLPFPN-LRKLCRPNPTDFP-SEDTLRELSRLVFLYTLNATLGAVLYNLTAL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504991    123 QKILNPSALSLHSKLNATADILRGLLSNVLCRLCSKYHVG-HVDVT----YGPDTSGKDVFQKKKLGCQLLGKYKQIIAV 197
Cdd:pfam01291  78 QQVLNKTAHFLQVKLQSARDNIRGLRNNVLCMACLLYHSSiHEPTQtgsgPSPDTSTKDVFQRKKLGCGFLGGYHRFMGS 157

                  ....*
gi 4504991    198 LAQAF 202
Cdd:pfam01291 158 VGQVF 162
 
Name Accession Description Interval E-value
LIF_OSM smart00080
leukemia inhibitory factor; OSM, Oncostatin M
34-191 3.13e-98

leukemia inhibitory factor; OSM, Oncostatin M


Pssm-ID: 197505  Cd Length: 157  Bit Score: 281.71  E-value: 3.13e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504991      34 CAIRHPCHNNLMNQIRSQLAQLNGSANALFILYYTAQGEPFPNnLDKLCGPNVTDFPPFHANGTEKAKLVELYRIVVYLG 113
Cdd:smart00080   1 CAIRHPCHGNLMNQIQNQLAQLNGSANALFIPYITAQGEPFPN-LDKLCRPNPTDFPSFHANGTEKTKLVELYRIVAYLG 79
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504991     114 TSLGNITRDQKILNPSALSLHSKLNATADILRGLLSNVLCRLCSKYHVGHVDVTYGPDTSGKDVFQKKKLGCQLLGKY 191
Cdd:smart00080  80 ASLGNITRDQQVLNPTAASLQSKLNATRDNIRGLLSNVLCRLCLKYHVEHVDVAYGPDTSGKDVFQRKKLGCQLLGGY 157
LIF_OSM pfam01291
LIF / OSM family;
43-202 6.78e-76

LIF / OSM family;


Pssm-ID: 396039  Cd Length: 162  Bit Score: 225.13  E-value: 6.78e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504991     43 NLMNQIRSQLAQLNGSAnALFILYYTAQGEPFPNnLDKLCGPNVTDFPpFHANGTEKAKLVELYRIVVYLGTSLGNITRD 122
Cdd:pfam01291   1 NLLNQLQNQADLLNDTA-SLLIPYIRLQGLPFPN-LRKLCRPNPTDFP-SEDTLRELSRLVFLYTLNATLGAVLYNLTAL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504991    123 QKILNPSALSLHSKLNATADILRGLLSNVLCRLCSKYHVG-HVDVT----YGPDTSGKDVFQKKKLGCQLLGKYKQIIAV 197
Cdd:pfam01291  78 QQVLNKTAHFLQVKLQSARDNIRGLRNNVLCMACLLYHSSiHEPTQtgsgPSPDTSTKDVFQRKKLGCGFLGGYHRFMGS 157

                  ....*
gi 4504991    198 LAQAF 202
Cdd:pfam01291 158 VGQVF 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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