C-X-C motif chemokine 2 precursor [Mus musculus]
Protein Classification
CXC family chemokine( domain architecture ID 10084510)
CXC family chemokine such as interleukin-8, also called C-X-C motif chemokine 8, that is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes, and is involved in neutrophil activation
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Chemokine_CXC | cd00273 | Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
33-95 | 7.02e-26 | ||
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups. : Pssm-ID: 238171 Cd Length: 64 Bit Score: 91.17 E-value: 7.02e-26
|
||||||
| Name | Accession | Description | Interval | E-value | ||
| Chemokine_CXC | cd00273 | Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
33-95 | 7.02e-26 | ||
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups. Pssm-ID: 238171 Cd Length: 64 Bit Score: 91.17 E-value: 7.02e-26
|
||||||
| SCY | smart00199 | Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ... |
33-93 | 4.23e-14 | ||
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response. Pssm-ID: 197570 Cd Length: 59 Bit Score: 61.11 E-value: 4.23e-14
|
||||||
| IL8 | pfam00048 | Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ... |
34-93 | 1.22e-12 | ||
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds. Pssm-ID: 459650 Cd Length: 60 Bit Score: 57.28 E-value: 1.22e-12
|
||||||
| Name | Accession | Description | Interval | E-value | ||
| Chemokine_CXC | cd00273 | Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
33-95 | 7.02e-26 | ||
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups. Pssm-ID: 238171 Cd Length: 64 Bit Score: 91.17 E-value: 7.02e-26
|
||||||
| Chemokine | cd00169 | Chemokine: small cytokines, including a number of secreted growth factors and interferons ... |
37-94 | 1.10e-17 | ||
Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups. Pssm-ID: 238098 Cd Length: 59 Bit Score: 70.06 E-value: 1.10e-17
|
||||||
| SCY | smart00199 | Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ... |
33-93 | 4.23e-14 | ||
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response. Pssm-ID: 197570 Cd Length: 59 Bit Score: 61.11 E-value: 4.23e-14
|
||||||
| IL8 | pfam00048 | Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ... |
34-93 | 1.22e-12 | ||
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds. Pssm-ID: 459650 Cd Length: 60 Bit Score: 57.28 E-value: 1.22e-12
|
||||||
| Chemokine_C | cd00271 | Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on ... |
27-93 | 7.58e-04 | ||
Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on the arrangement of two N-terminal, conserved cysteine residues. Most of the known chemokines (cd00169) belong to either the CC (cd00272) or CXC (cd00273) subclass. The two other subclasses each have a single known member: fractalkine for the CX3C (cd00274) class and lymphotactin for the C (cd00271) class. Chemokine_Cs differ structurally since they contain only one of the two disulfide bridges that are conserved in all other chemokines and they possess a unique C-terminal extension, which is required for biological activity and thought to play a role in receptor binding. Lymphotactin, a mediator of mucosal immunity, has been found to chemoattract neutrophils and B cells through the XCR1 receptor and thought to be a factor in acute allograft rejection and inflammatory bowel disease. Pssm-ID: 238169 Cd Length: 72 Bit Score: 35.22 E-value: 7.58e-04
|
||||||
| Blast search parameters | ||||
|
