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Conserved domains on  [gi|6677957|ref|NP_033203|]
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CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 56-335 0e+00

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23980:

Pssm-ID: 480271  Cd Length: 280  Bit Score: 537.54  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957   56 CTCRHCISQDKVSYWFDQRFNKTMQPLLTVHNALMEEDTYRWWLRLQRERKPNNLSDTVKELFRLVPGNVDPMLNKRLVG 135
Cdd:cd23980   1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNVDPLLEKRLVS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  136 CRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVNMVLVPFKTTDLQWVI 215
Cdd:cd23980  81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  216 SATTTGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQGHGRYPSTGILSIIFSIHICDEVDLYGFGADSKGNWH 295
Cdd:cd23980 161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 6677957  296 HYWENNPSAGAFRKTGVHDGDFEYNITTTLAAINKIRIFK 335
Cdd:cd23980 241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
 
Name Accession Description Interval E-value
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 56-335 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 537.54  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957   56 CTCRHCISQDKVSYWFDQRFNKTMQPLLTVHNALMEEDTYRWWLRLQRERKPNNLSDTVKELFRLVPGNVDPMLNKRLVG 135
Cdd:cd23980   1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNVDPLLEKRLVS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  136 CRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVNMVLVPFKTTDLQWVI 215
Cdd:cd23980  81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  216 SATTTGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQGHGRYPSTGILSIIFSIHICDEVDLYGFGADSKGNWH 295
Cdd:cd23980 161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 6677957  296 HYWENNPSAGAFRKTGVHDGDFEYNITTTLAAINKIRIFK 335
Cdd:cd23980 241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 97-330 1.66e-87

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 263.31  E-value: 1.66e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957     97 WWLRLQRERKPNNlsdTVKELFRLVPgNVDPMLNKRlvgCRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEA 176
Cdd:pfam00777  11 EWIRYSEWWLPFT---VTEELLELLP-KVSPFDNKR---CRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957    177 DVGSRTTHHLVYPES-----FRELGE------NVNMVLVPFKTTDLQWVISA----TTTGTITHTYVPVPPKIKVKQEKI 241
Cdd:pfam00777  84 DVGSKTTLRTMNPESaidskYGNLGFshprdpFVEFVLVPFKGRDLLWLPAFltkgNVSRSLRVLYTLKEVKIPVDPDKV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957    242 LIYHPAFIKYVFDNWLQGHG---RYPSTGILSIIFSIHICDEVDLYGFGA--DSKGNWHHYWENNPSAgAFRKTGVHDGD 316
Cdd:pfam00777 164 LFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYYDNVLMK-KGGFYGVHDMP 242

                         250
                  ....*....|....
gi 6677957    317 FEYNITTTLAAINK 330
Cdd:pfam00777 243 FEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 56-335 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 537.54  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957   56 CTCRHCISQDKVSYWFDQRFNKTMQPLLTVHNALMEEDTYRWWLRLQRERKPNNLSDTVKELFRLVPGNVDPMLNKRLVG 135
Cdd:cd23980   1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNVDPLLEKRLVS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  136 CRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVNMVLVPFKTTDLQWVI 215
Cdd:cd23980  81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  216 SATTTGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQGHGRYPSTGILSIIFSIHICDEVDLYGFGADSKGNWH 295
Cdd:cd23980 161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 6677957  296 HYWENNPSAGAFRKTGVHDGDFEYNITTTLAAINKIRIFK 335
Cdd:cd23980 241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 58-335 5.99e-161

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 450.58  E-value: 5.99e-161
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957   58 CRHCISQDKVSYWFDQRFNKTMQPLLTVHNALMEEDTYRWWLRLQRERKpNNLSDTVKELFRLVPGNvDPMLNKRLVGCR 137
Cdd:cd23966   1 CRRCVQEGGDSDWFDERFNPSIEPLLTRKNKELPPDVLKWWLSLQSSKN-SDLREVLEKLFQVVPGE-NPYRTRDPNRCR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  138 RCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVNMVLVPFKTTDLQWVISA 217
Cdd:cd23966  79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVDLDPGVHLVLVPFKVLDLQWLISA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  218 TTTGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQGHGRYPSTGILSIIFSIHICDEVDLYGFGADSKGNWHHY 297
Cdd:cd23966 159 LTTGEITRTYTPVKRFIKADKDKVLVINPAFIKYVHDNWTEHHGRYPSTGFLALIFALHICDEVSVFGFGADSKGNWHHY 238

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 6677957  298 WENNPSAGAFRKTGVHDGDFEYNITTTLAAINKIRIFK 335
Cdd:cd23966 239 WEKNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRVYR 276
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 56-335 2.06e-126

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 363.42  E-value: 2.06e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957   56 CTCRHCISQDKVSYWFDQRFNKTMQPLLTVHNALMEEDTYRWWLRLQRERKPNNLSDTVKELFRLVPGNvDPMLNKRLVG 135
Cdd:cd23979   1 CACRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYWWMMLQPQFKPHNTKEVLSKLFQIIPGE-NPYRSWDPSR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  136 CRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVNMVLVPFKTTDLQWVI 215
Cdd:cd23979  80 CRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFKTLDLLWIT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  216 SATTTGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQGHGRYPSTGILSIIFSIHICDEVDLYGFGADSKGNWH 295
Cdd:cd23979 160 SALSTGQIRFTYAPVKQFLRVDKDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWH 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 6677957  296 HYWENNPSAGAFRKTGVHDGDFEYNITTTLAAINKIRIFK 335
Cdd:cd23979 240 HYWENNRYAGEFRKTGVHDADFEAHIIDMLAKAGKIKVYR 279
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 97-330 1.66e-87

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 263.31  E-value: 1.66e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957     97 WWLRLQRERKPNNlsdTVKELFRLVPgNVDPMLNKRlvgCRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEA 176
Cdd:pfam00777  11 EWIRYSEWWLPFT---VTEELLELLP-KVSPFDNKR---CRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957    177 DVGSRTTHHLVYPES-----FRELGE------NVNMVLVPFKTTDLQWVISA----TTTGTITHTYVPVPPKIKVKQEKI 241
Cdd:pfam00777  84 DVGSKTTLRTMNPESaidskYGNLGFshprdpFVEFVLVPFKGRDLLWLPAFltkgNVSRSLRVLYTLKEVKIPVDPDKV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957    242 LIYHPAFIKYVFDNWLQGHG---RYPSTGILSIIFSIHICDEVDLYGFGA--DSKGNWHHYWENNPSAgAFRKTGVHDGD 316
Cdd:pfam00777 164 LFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYYDNVLMK-KGGFYGVHDMP 242

                         250
                  ....*....|....
gi 6677957    317 FEYNITTTLAAINK 330
Cdd:pfam00777 243 FEFKLLQKLHKEGV 256
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 139-321 2.00e-54

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 176.78  E-value: 2.00e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  139 CAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVNMVLVPFKttDLQWVISAT 218
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLP--LEEEVVLIL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  219 TTGTITHTYVPVPPKIKVKQEKILIYHPA--FIKYVFDNWLQGH------GRYPSTGILSIIFSIHICDEVDLYGFGADS 290
Cdd:cd19952  79 SRAAAADFKRLKRRKKRHDNAVLLLTDPApdLLSYVRKRLEKLGlksffgGNAPSSGLLAVLLALQLCDSVDLYGFGVDS 158

                       170       180       190
                ....*....|....*....|....*....|....
gi 6677957  291 ---KGNWHHYWENnpsAGAFRKTGVHDGDFEYNI 321
Cdd:cd19952 159 ghaPKVPYHYYDL---VEAEEGTAVHSFDLEAEL 189
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 68-335 7.48e-53

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 175.91  E-value: 7.48e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957   68 SYWFDQRFNKTMQPLLTVHNAlmeedTYRWWLRLQRERKPNNLSDT----VKELFRLVPGNVDPMLNKRLVG---CRRCA 140
Cdd:cd23964  12 SPWFRERFIPDIKVLLDSEDF-----NPEEYNRLSHYKLPFGWGGLnrevVERLLRNLNLTSSRYMFVLRGGrprCIRCA 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  141 VVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRE-------LGENVNMVLVPFKTTDLQW 213
Cdd:cd23964  87 VVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNsllkhvpQDKDTKYLFIPFKIRDYDY 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  214 VISATT-----TGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQGH-GRYPSTGILSIIFSIHICDEVDLYGFG 287
Cdd:cd23964 167 LDAVLSgkpvpDGCDKGKRPPPLFGPKLNATNVRLLHPDFIRYLFNRWLNSStSYRPTTGALMLLTALHTCDQVSVYGFG 246

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 6677957  288 ADSKGNWHHYweNNPSAGAFRKTGVHDGDFEYNITTTLAAINKIRIFK 335
Cdd:cd23964 247 YDPRFSLHYY--DKTFVKFTVFYANHDFTNERKLWRKLHEEGIINLYR 292
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 135-318 5.83e-48

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 160.15  E-value: 5.83e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  135 GCRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPES-FR---ELGENVNMVLVPFKTTD 210
Cdd:cd23967   1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESaFRdpeEYDSDWLLVLVPFKSMD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  211 LQW---VISATTTGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQ------GHGRYPSTGILSIIFSIHICDEV 281
Cdd:cd23967  81 LLWlqaVIKGKKPNGKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGlpmngkQGKNVPTTGIIAIVMALHYCDEV 160

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6677957  282 DLYGFGADSK--GNWHHYWENNPSAGAFRKTGvHDGDFE 318
Cdd:cd23967 161 DIAGFGYDPSdpNAPLHYYDSLTMKAIKRSWT-HNVTKE 198
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 136-300 6.20e-40

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 139.41  E-value: 6.20e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  136 CRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPES--FRELGENVN---MVLVPFKTTD 210
Cdd:cd23982   2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESaqFDPGIENDPdtlLVLVPFKPLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  211 LQWV--ISATTTGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQ-----GHGRYPSTGILSIIFSIHICDEVDL 283
Cdd:cd23982  82 FYWLyeILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQvpgqrKKKQKPTTGLLAITLALHLCDEVHI 161

                       170       180
                ....*....|....*....|
gi 6677957  284 YGFGADSKGN---WHHYWEN 300
Cdd:cd23982 162 AGFGYPDNGNsnqPIHYYNQ 181
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 136-300 2.85e-34

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 124.86  E-value: 2.85e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  136 CRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESF----RELGENVNMVLVPFKTTDL 211
Cdd:cd23984   2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIfsdpSHYDPNTTVVLIPFKPHDL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  212 QWVISATTTGTITHT-YVPVPP-KIKVKQEKILIYHPAFIKYVFDNWL--------QGHGRYPSTGILSIIFSIHICDEV 281
Cdd:cd23984  82 RWLLDLLMGKKVSAKgFWKKPAlNLIYKPNQIRILNPFILRIAAYELLhfpkrfpkEKKPKHPTTGIIAITLALHICNEV 161

                       170       180
                ....*....|....*....|.
gi 6677957  282 DLYGFGAD--SKGNWHHYWEN 300
Cdd:cd23984 162 HIAGFKYDfsNLNSTLHYYGN 182
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 135-314 1.17e-31

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 117.92  E-value: 1.17e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  135 GCRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPE----SFRELGENVNMVLVPFKTTD 210
Cdd:cd23983   1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEgapkSEQEYDPTSLFVAVLFKSVD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  211 LQW---VISATTTGTITHTYV--PVPPKIKVKQEKILIYHPAFIK---YVFDNWLQGHGRY-------PSTGILSIIFSI 275
Cdd:cd23983  81 FAWlkaMVKKEPLSFWSRLFFwkEVADSIPLKPSQFRILNPLIIKetaLDILQYPEPQSRLwgwdknvPTLGVTAVVLAT 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 6677957  276 HICDEVDLYGFGAD--SKGNWHHYWENNPSAgAFRKTGVHD 314
Cdd:cd23983 161 HLCDEVSLAGFGYDlsQPHAPLHYYDSVCMA-AMNTQTMHN 200
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 74-321 1.71e-31

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 119.29  E-value: 1.71e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957   74 RFNKTMQPLLTVHNALMEEDTYRwwlrLQRERKPNNLSDTVKELFRlvpgNVDPMLNKRLvgcRRCAVVGNSGNLKDSSY 153
Cdd:cd23963  12 RLLNTRKLFLTQKNTPLGDVLYY----SYFKKKTFKITKSLYELLP----KTSPFSHKRY---KTCAVVGNSGILLGSGC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  154 GPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENvnmvlvPFKTTDLQWVISATTTGTITHTYVPVPP- 232
Cdd:cd23963  81 GKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRRYNS------LKKNRDRDKFLNRLKEYNGSILWYPKFSf 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  233 --------------KIKVKQEKILIYHPAFIKYVFDNW-LQGHGRYPSTGILSIIFSIHICDEVDLYGF---GADSKGNW 294
Cdd:cd23963 155 ksstnlllkaaralKKNGLNLTVVYSNPEHFLAVQKFWkRRGLEKRPSTGLYLVSLALTFCDEIHLYGFwpfPTDPNGRP 234

                       250       260
                ....*....|....*....|....*....
gi 6677957  295 --HHYWENNPSAGafrKTGVHDGDFEYNI 321
Cdd:cd23963 235 vpYHYYDDLSPST---KNKVHNMPEEFKL 260
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 136-300 5.14e-29

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 110.78  E-value: 5.14e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  136 CRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVN----MVLVPFKTTDL 211
Cdd:cd23981   2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEkdslFVLAGFKWQDF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  212 QW---------VISATTTGTITHTYVPVPPKikvkqeKILIYHPAFIKYV--------FDNWLQGHGRYPSTGILSIIFS 274
Cdd:cd23981  82 KWlkyivykekVSASDGFWKSVATRVPREPH------EIRILNPYFIQEAafsfiglpFNNGLMGRGNIPTLGSVAITMA 155

                       170       180
                ....*....|....*....|....*...
gi 6677957  275 IHICDEVDLYGFGAD--SKGNWHHYWEN 300
Cdd:cd23981 156 LHNCDEVAVAGFGYDmnTPNAPLHYYET 183
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 105-337 2.72e-28

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 110.44  E-value: 2.72e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  105 RKPNNLSDTVKELFRLVPGNVDPMLNKRL----VGCRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGS 180
Cdd:cd23968  10 KAAPFSTLRKTTSPFKDLLSLRYPFPESSlentKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGS 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  181 RTT-----HHLVYPESF----RELGENVNMVL---VPFKTTDLQWVISATTTGTithtyvpvPPKIKVKQ----EKILIY 244
Cdd:cd23968  90 KTTlrlinSQILSKPEFnfltDPLYRNVTLLVwdpSSYNVNLEKWYKKPDFDFF--------PNYIKYRRrhpeEPFYLI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  245 HPAFIKYVFDnWLQ------GHGRYPSTGILSIIFSIHICDEVDLYGF-GADSKGNWHHYWEN----NPSAGAFrktgvH 313
Cdd:cd23968 162 DPRFLWRLWD-ILQeytpekIKPNPPSSGFIGIVLMLHLCDWVDVYEYvPSVRQTDRCHYYDVekdlACTLGAW-----H 235

                       250       260
                ....*....|....*....|....*
gi 6677957  314 DGDFEYNITTTLAAINKIRIF-KGR 337
Cdd:cd23968 236 PLAAEKLLVRHLNVGSDDDIFrKGR 260
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 68-286 5.06e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 102.52  E-value: 5.06e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957   68 SYWFDQRFNKTMQPLLTVHNALMEEdtyrwWLRLQRERKP-----NNLSDtVKELFRLVPGNVDPML----NKRLVGCRR 138
Cdd:cd23973  12 SDWFKKLFLPNITLFLDKDHFNMSE-----WDRLEHFNPPfgfmgLNYTL-VKEVVELIPKPKEQQLlalsPPGGDGCIR 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  139 CAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPES-------FRELG-------ENVNMVLV 204
Cdd:cd23973  86 CAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSitsslmiLQKRGfknipqdKDIKYILF 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  205 PFKTTDLQWVISATTTGTithtyvpVPPKIKVKQ------------EKILIYHPAFIKYVFDNWLQG---HGRY-----P 264
Cdd:cd23973 166 PEGPRDYQWLEALLKNKT-------IPSGAYYGRrprsyfsgdfteDKYLVLHPDFLRYVKNRFLRSktlKGKYwaiyrP 238

                       250       260
                ....*....|....*....|..
gi 6677957  265 STGILSIIFSIHICDEVDLYGF 286
Cdd:cd23973 239 TTGAFLLLTALHLCDTVSAYGF 260
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 58-299 1.57e-24

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 101.44  E-value: 1.57e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957   58 CRHCISQD-KVSYWFDQRFNKTMqPLLtVHNALMEEDTyrwWLRLQRERKPNNLSD----TVKELFRLVPGNVdpmlNKR 132
Cdd:cd23972   1 CPHSLHLRiQRDPHFRGLFNFDI-PVL-LWGQHFTPAL---WDRLSQRKVPYGWKGlshqVVASTLSLLNDSA----NAK 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  133 LV-------GCRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHH----------LVypeSFREL 195
Cdd:cd23972  72 LFfprdtpgKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYgftvntmknsLI---SYWNL 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  196 G-------ENVNMVLVPFKTTDLQWVISATTTgtithtyVPVP--------------PKIKVKQEKILiyHPAFIKYVFD 254
Cdd:cd23972 149 GftrtpqgQDLQYIFIPSDIRDYVMLRSAILG-------VPVPegldkgdrphkyfgPEASAKKFKLL--HPDFISYLTD 219

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6677957  255 NWLQ--------GHGRYPSTGILSIIFSIHICDEVDLYGFGADSKGNWH-HYWE 299
Cdd:cd23972 220 RFLKskllnthyGHLYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSdHYYE 273
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 100-319 1.31e-23

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 98.26  E-value: 1.31e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  100 RLQRERKPNNLSDTVKELFRLVPgNVDPMLNKRLvgcRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVG 179
Cdd:cd23969  32 RMHYEIDRHKTVNITQDLYQLLP-EVSPLKGKHF---RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVG 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  180 SR----TTHHLVYPESFRELGEnvnmvlvpfkTTDLQWVISATTTGTITHTYVP--VPPKIKVKQE---KILIYHPAFIK 250
Cdd:cd23969 108 TKsnltTMNPSVIPHAYGDLVN----------ATDKEKFVERLRQLGDSILWIPafVSKGGEEHVQwtnEIILKHKLNVK 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  251 YVFDN----------WLQG--HGRYPSTGILSIIFSIHICDEVDLYG---FGADSKGN--WHHYWENNPSAGAFRKtgvH 313
Cdd:cd23969 178 TAYPPlrlnhairgyWLTTkfRIKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRavKYHYYDNRKYLTTARP---H 254


                ....*.
gi 6677957  314 DGDFEY 319
Cdd:cd23969 255 KMPEEF 260
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 136-301 4.32e-23

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 97.52  E-value: 4.32e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  136 CRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPE-------SFRELG-------ENVNM 201
Cdd:cd23974  84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNtlmnslrAYAGVGfngppqsKETRY 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  202 VLVPFKTTDLQWVISAtttgtitHTYVPV---------PPK---IKVKQEKILIYHPAFIKYVFDNWLQ------GHGRY 263
Cdd:cd23974 164 IFLPDHDRDYLLVKAA-------LTHTPIdrgrdkskrPSKyfgKDVTAEKFKIYHPDFIRYLRNRFLWspilntKQRDI 236

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 6677957  264 --PSTGILSIIFSIHICDEVDLYGFGADSKGNWH-HYWENN 301
Cdd:cd23974 237 yrPSTGAVMLLAALHTCDQVSAYGFMTPDYGKYSdHYYDKT 277
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 74-300 2.95e-22

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 94.64  E-value: 2.95e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957   74 RFNKTMQPLLTVHNALMEEDTYRWWLRlqrERKPNNLSDTvkeLFRLVPgNVDPMLNKRLvgcRRCAVVGNSGNLKDSSY 153
Cdd:cd23988  12 RFLDAERDVSVVKSSFKPGDVIHYVLD---RRRTLNISQN---LHSLLP-EVSPMKNRRF---KTCAVVGNSGILLDSGC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  154 GPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPE-------SFRELGENVNMVLVPFKTTDLQWVISATTTGTITHT 226
Cdd:cd23988  82 GKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqrafgGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  227 YVPVPPKIKVKQEKILIYHPA--FIKYVFDNWLQG--HGRYPSTGILSIIFSIHICDEVDLYG---FGADSKGN--WHHY 297
Cdd:cd23988 162 VEWVNALILKNKLKVRTAYPSlrLIHAVRGYWLTNkvNIKRPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNpvKYHY 241


                ...
gi 6677957  298 WEN 300
Cdd:cd23988 242 YDD 244
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 136-285 9.80e-22

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 91.92  E-value: 9.80e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  136 CRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELgeNVNMVLVPFKTTDLQWVI 215
Cdd:cd23965   1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRL--LRNAILLLAGTRAPTVVV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  216 ---SATTTGTITHTYVPVPPKIKVKQEKILIYHPAFIKY-----VFDN-----------WLqghgrypSTGILSIIFSIH 276
Cdd:cd23965  79 fwgPETKMNKDGAGKYNLLRSLSKKYPDVEFYSLTPEKMdyadeLFEKetgksriksgtWL-------STGWFTMLLALD 151


                ....*....
gi 6677957  277 ICDEVDLYG 285
Cdd:cd23965 152 VCDEIKVYG 160
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 115-314 6.28e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 90.39  E-value: 6.28e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  115 KELFRLVPgNVDPMLNKRLvgcRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPtVGFEADVGSRTthHLVY--PESF 192
Cdd:cd23971  47 EKLFSMLP-KESPFSNKPL---KTCAVVGNGGILKNSSCGREIDSADFVIRCNLPP-LNDSKDVGSKT--NLVTanPSIL 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  193 RELGENVNMVLVPFkttdlqwvISATTTGTITHTYVP-------VPPKIKVK--------QEKILIYHPAFIKYVFDNWL 257
Cdd:cd23971 120 REKFHNLKKRRRPF--------VERMKVYGNALLLLPafsytsnTEPSLRALytledfgsPQKVLFFNPEYLRNLSRYWK 191

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6677957  258 -QG-HGRYPSTGILSIIFSIHICDEVDLYGF---GADSKGNW--HHYWENNPSagafrKTGVHD 314
Cdd:cd23971 192 sKGlKARRLSTGLMLVSAALELCENVHLYGFwpfSTDLDGNPisHHYYDNVLP-----KKGVHA 250
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 136-299 1.15e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 88.77  E-value: 1.15e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  136 CRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLV-----------YPESFRELGENVNMVLV 204
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVshtsvplllrnQGYFFQQSRDTKYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  205 PFKTTDLqwvISATTTGTITHTYVPVPPKIKV---KQEKILIYHPAFIKYVFDNWLQGhGRYPSTGILSIIFSIHICDEV 281
Cdd:cd23977  81 PERNMDR---DGGGKTYRALLTLAKMYPHLQVytlTEEKMAYCDGVFQNETGKNRMKS-GSFLSTGWFTMILALELCEEI 156

                       170       180
                ....*....|....*....|....*
gi 6677957  282 DLYGFGADS--KGNWH-----HYWE 299
Cdd:cd23977 157 LVYGMVSDSycRNKNHssvpyHYYE 181
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 115-320 4.55e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 88.27  E-value: 4.55e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  115 KELFRLVPGN---VDPMLNkrlvgcrRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVG-FEADVGSRTTHHLVYPE 190
Cdd:cd23991  47 ENIFRMFPKSqpfRGYPYK-------QCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLVTANPS 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  191 SFRELGENVNMVLVPFKTT-----DLQWVISATTTGTITHTYVPVP---PKIKVKQeKILIYHPAFIKYVFDNWL-QGHG 261
Cdd:cd23991 120 IISIKYAKLNERRKPFLETvsvygDAFLLLPAFSYRSNTALSFKVYytlEDFKAKQ-KVIFFHPIYLKHLAQFWRsKGVQ 198

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6677957  262 RYP-STGILSIIFSIHICDEVDLYGFGADSKGN-----WHHYWENNPSagafrKTGVHDGDFEYN 320
Cdd:cd23991 199 VYRlSTGLMITSAALELCEEVKLYGFWPFSKNTegkpiSHHYYDNQLP-----KPGFHSMPKEFY 258
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 117-300 3.27e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 85.91  E-value: 3.27e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  117 LFRLVPgNVDPMLNKRLvgcRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELG 196
Cdd:cd23970  53 LRSLLP-EVSPFQNKHY---NTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYY 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  197 ENVnmvlvpFKTTDLQWVISATTTGTITHTYVPV--------PPKIKV-------KQEKILIYHPA-FIKYVFDNWLQGH 260
Cdd:cd23970 129 NNL------LTIQDRNNFFLSLKKLDGAILWIPAfffhtsatVTRTLVdffvehrGQLKVQLAWPGnIMQHVNRYWKTKH 202

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 6677957  261 G--RYPSTGILSIIFSIHICDEVDLYGF---GADSKGNW--HHYWEN 300
Cdd:cd23970 203 LspKRLSTGILMYTLASAICEEIHLYGFwpfGFDPTGTPlpYHYYDK 249
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 137-286 8.25e-18

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 81.68  E-value: 8.25e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  137 RRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVypesfrelgeNVNMVLVPfkttDLQWVIS 216
Cdd:cd23985  46 GRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLI----------NSQLVTTE----KHKFLKD 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  217 ATTTGTITHTYVPVP-----------P-----------KIKVKQEKILIYHPAFIKYVFDNWLQGHGRY-----PSTGIL 269
Cdd:cd23985 112 SLYNEGILIVWDPAPyhsdipewyknPdynffenyktyRRLNPNQPFYILHPQMQWELWDIIQENSPEEiqpnpPSSGML 191

                       170
                ....*....|....*..
gi 6677957  270 SIIFSIHICDEVDLYGF 286
Cdd:cd23985 192 GIILMMTLCDQVDVYEF 208
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 127-286 1.06e-17

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 81.42  E-value: 1.06e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  127 PMLNKRLVGCRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTT-------------HHLVYPESFR 193
Cdd:cd23986  40 PLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTiriinsqiltnpnHHFIDSSLYK 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  194 elgenvNMVLV-----PFKTTDLQWvisatttgTITHTYVPVPPKIKVKQ----EKILIYHPAFIKYVFDnWLQGHGRY- 263
Cdd:cd23986 120 ------DVILVawdpaPYSANLHKW--------YKKPDYNLFTPYVQYRKrnpnQPFYILHPKFIWQLWD-IIQENTQEk 184

                       170       180
                ....*....|....*....|....*...
gi 6677957  264 -----PSTGILSIIFSIHICDEVDLYGF 286
Cdd:cd23986 185 iqpnpPSSGFIGILIMMSMCREVHVYEY 212
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 115-286 1.57e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 78.44  E-value: 1.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  115 KELFRLVPgNVDPMLNKRLvgcRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRE 194
Cdd:cd23987  47 QNLYELLP-RTSPLKNKHF---KTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQR 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  195 LGEnvNMVLVPFKTTDLQWVISATTTGTITHTYVPVPPKIKVK--QEKILIYH-------PA--FIKYVFDNWLQG--HG 261
Cdd:cd23987 123 AFE--DLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEERVEwvNDLILKHHinvrtayPSlrLLHAVRGYWLTNkvHI 200

                       170       180
                ....*....|....*....|....*
gi 6677957  262 RYPSTGILSIIFSIHICDEVDLYGF 286
Cdd:cd23987 201 KRPTTGLLMYTLATRFCNRIHLYGF 225
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 126-307 3.02e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 77.56  E-value: 3.02e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  126 DPMLNKRLvgcRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAP-TVGFEADVGSRTthHLVypesfrelgeNVNMVLV 204
Cdd:cd23989  56 DTPLQLPL---KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKT--QLV----------TANPSII 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  205 PFKTTDLQW----VISATTTGTITHTYVP-------VPPKIKVKQ--------EKILIYHPAFIKYVFDNWLQG--HGRY 263
Cdd:cd23989 121 DKRFQNLLWsrksFVESMKVYGRSYIYMPafsmktgTDPSLRVYYtladvganQTVLFANPNFLRNVGKFWKSKgvHAKR 200

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 6677957  264 PSTGILSIIFSIHICDEVDLYGF-----GADSKGNWHHYWENNPSAGAF 307
Cdd:cd23989 201 LSTGLFLVSAALGLCEEVTIYGFwpfsvDLDERTISHHYYDNVLPDSGF 249
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 100-300 1.01e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 76.03  E-value: 1.01e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  100 RLQRERKPNNLSDTVKELFRLVPGNVdPMLNKRLvgcRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAP-TVGFEADV 178
Cdd:cd23990  32 KLKYEVDTSGIYHINSEIFKMFPKDM-PYSRSQF---KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDV 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  179 GSRTTHHLVYP----ESFRELG-------------ENVNMVLVPF---KTTDLQwvisatttgtithtyvpvppkIKVK- 237
Cdd:cd23990 108 GVKTDVVTINPsiitERFHKLEkwrrpfyevlqvyENASVVLPAFyntRNTDVS---------------------IRVKy 166

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6677957  238 -------QEKILIYHPAFIKYVFDNWL-QG-HGRYPSTGILSIIFSIHICDEVDLYGFGA---DSKGNW--HHYWEN 300
Cdd:cd23990 167 vlddfesQQAVYYFHPQYLLNVSRFWLrQGvRAKRISSGLMLVTAALELCEEVHLYGFWAfpmNPSGIFitHHYYDN 243
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 136-285 8.62e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 69.88  E-value: 8.62e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  136 CRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTT-----HHLVY-----PESFRELGEnvNMVLV- 204
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTlrvvaHSSVYrvlrrPQEFLNRTP--ETTLIf 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  205 ---------PFKTTDLQWVISATTTGTITHTYVpVPPKiKVKQekiliyhpafikyvFDNWLQGH-GR-------YPSTG 267
Cdd:cd23978  79 wgppnkmqkDGKSNLFRIIQRASMTFPNMSAFV-VSPR-RMRQ--------------FDDLFRGEtGRdrkkshsWLSTG 142

                       170
                ....*....|....*...
gi 6677957  268 ILSIIFSIHICDEVDLYG 285
Cdd:cd23978 143 WFTMVIAVELCDNVHVYG 160
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 136-299 2.91e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 65.34  E-value: 2.91e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  136 CRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPES-----------FRELGENVNMVLV 204
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSvplllknpdyfFKETNETIYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  205 PFKT--TDLQWVIsatttGTITHTYVPVPP--KIKVKQEKILIYHPA-FIKYVFDNWLQGhGRYPSTGILSIIFSIHICD 279
Cdd:cd23975  81 PFRNmrKDGKGIV-----YNMLKKAVESYPqaKIYVTTEKRMSYCDTvFKKETGKDRVQS-GSYLSTGWFTLILAMDACY 154

                       170       180
                ....*....|....*....|....*..
gi 6677957  280 EVDLYGFGADS-------KGNWHHYWE 299
Cdd:cd23975 155 GIHVYGMINDTycktegyRKVPYHYYE 181
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 136-285 1.14e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 61.04  E-value: 1.14e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  136 CRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVNMVL-VPFKTTDLQWV 214
Cdd:cd23976  15 CKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELLnVSQGTVFIFWG 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6677957  215 ISATTTG-------TITHTYVPVPPKIKV---KQEKILIYHPAFIK------YVFDNWLqghgrypSTGILSIIFSIHIC 278
Cdd:cd23976  95 PSNYMRRdgkglvyNNLQLMNQILPKLKVytiTRHKMLQFDELFKRetgkdrKISNTWL-------STGWFTMIIALELC 167


                ....*..
gi 6677957  279 DEVDLYG 285
Cdd:cd23976 168 DRINVYG 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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