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Conserved domains on  [gi|31981962|ref|NP_033389|]
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trefoil factor 2 precursor [Mus musculus]

Protein Classification

Trefoil domain-containing protein( domain architecture ID 11082583)

Trefoil domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 79-124 2.07e-13

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


:

Pssm-ID: 197472  Cd Length: 46  Bit Score: 60.09  E-value: 2.07e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 31981962     79 EQCVMEVSARKNCGYPGISPEDCASRNCCFSNLIFEVPWCFFPQSV 124
Cdd:smart00018   1 AQCSVPPSERINCGPPGITEAECEARGCCFDSSISGVPWCFYPNTV 46
Trefoil pfam00088
Trefoil (P-type) domain;
31-72 9.33e-12

Trefoil (P-type) domain;


:

Pssm-ID: 459666  Cd Length: 43  Bit Score: 55.79  E-value: 9.33e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 31981962    31 CSRLTPHNRKNCGFPGITSEQCFDLGCCFDSSV-AGVPWCFHP 72
Cdd:pfam00088   1 CSSVPPSDRFDCGYPGITQEECEARGCCWDPSVdPGVPWCFYP 43
 
Name Accession Description Interval E-value
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 79-124 2.07e-13

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


Pssm-ID: 197472  Cd Length: 46  Bit Score: 60.09  E-value: 2.07e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 31981962     79 EQCVMEVSARKNCGYPGISPEDCASRNCCFSNLIFEVPWCFFPQSV 124
Cdd:smart00018   1 AQCSVPPSERINCGPPGITEAECEARGCCFDSSISGVPWCFYPNTV 46
Trefoil cd00111
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated ...
 79-121 1.11e-12

P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.


Pssm-ID: 238059  Cd Length: 44  Bit Score: 58.12  E-value: 1.11e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 31981962  79 EQCVMEVSARKNCGYPGISPEDCASRNCCFSNLIFEVPWCFFP 121
Cdd:cd00111   1 EWCSVPPSERIDCGPPGITQEECEARGCCFDPSISGVPWCFYP 43
Trefoil pfam00088
Trefoil (P-type) domain;
31-72 9.33e-12

Trefoil (P-type) domain;


Pssm-ID: 459666  Cd Length: 43  Bit Score: 55.79  E-value: 9.33e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 31981962    31 CSRLTPHNRKNCGFPGITSEQCFDLGCCFDSSV-AGVPWCFHP 72
Cdd:pfam00088   1 CSSVPPSDRFDCGYPGITQEECEARGCCWDPSVdPGVPWCFYP 43
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 36-72 9.90e-12

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


Pssm-ID: 197472  Cd Length: 46  Bit Score: 55.47  E-value: 9.90e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 31981962     36 PHNRKNCGFPGITSEQCFDLGCCFDSSVAGVPWCFHP 72
Cdd:smart00018   7 PSERINCGPPGITEAECEARGCCFDSSISGVPWCFYP 43
Trefoil cd00111
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated ...
 36-72 3.32e-10

P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.


Pssm-ID: 238059  Cd Length: 44  Bit Score: 51.58  E-value: 3.32e-10
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 31981962  36 PHNRKNCGFPGITSEQCFDLGCCFDSSVAGVPWCFHP 72
Cdd:cd00111   7 PSERIDCGPPGITQEECEARGCCFDPSISGVPWCFYP 43
Trefoil pfam00088
Trefoil (P-type) domain;
82-121 6.78e-09

Trefoil (P-type) domain;


Pssm-ID: 459666  Cd Length: 43  Bit Score: 48.08  E-value: 6.78e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 31981962    82 VMEVSARKNCGYPGISPEDCASRNCCFSNLI-FEVPWCFFP 121
Cdd:pfam00088   3 SVPPSDRFDCGYPGITQEECEARGCCWDPSVdPGVPWCFYP 43
 
Name Accession Description Interval E-value
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 79-124 2.07e-13

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


Pssm-ID: 197472  Cd Length: 46  Bit Score: 60.09  E-value: 2.07e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 31981962     79 EQCVMEVSARKNCGYPGISPEDCASRNCCFSNLIFEVPWCFFPQSV 124
Cdd:smart00018   1 AQCSVPPSERINCGPPGITEAECEARGCCFDSSISGVPWCFYPNTV 46
Trefoil cd00111
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated ...
 79-121 1.11e-12

P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.


Pssm-ID: 238059  Cd Length: 44  Bit Score: 58.12  E-value: 1.11e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 31981962  79 EQCVMEVSARKNCGYPGISPEDCASRNCCFSNLIFEVPWCFFP 121
Cdd:cd00111   1 EWCSVPPSERIDCGPPGITQEECEARGCCFDPSISGVPWCFYP 43
Trefoil pfam00088
Trefoil (P-type) domain;
31-72 9.33e-12

Trefoil (P-type) domain;


Pssm-ID: 459666  Cd Length: 43  Bit Score: 55.79  E-value: 9.33e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 31981962    31 CSRLTPHNRKNCGFPGITSEQCFDLGCCFDSSV-AGVPWCFHP 72
Cdd:pfam00088   1 CSSVPPSDRFDCGYPGITQEECEARGCCWDPSVdPGVPWCFYP 43
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 36-72 9.90e-12

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


Pssm-ID: 197472  Cd Length: 46  Bit Score: 55.47  E-value: 9.90e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 31981962     36 PHNRKNCGFPGITSEQCFDLGCCFDSSVAGVPWCFHP 72
Cdd:smart00018   7 PSERINCGPPGITEAECEARGCCFDSSISGVPWCFYP 43
Trefoil cd00111
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated ...
 36-72 3.32e-10

P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.


Pssm-ID: 238059  Cd Length: 44  Bit Score: 51.58  E-value: 3.32e-10
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 31981962  36 PHNRKNCGFPGITSEQCFDLGCCFDSSVAGVPWCFHP 72
Cdd:cd00111   7 PSERIDCGPPGITQEECEARGCCFDPSISGVPWCFYP 43
Trefoil pfam00088
Trefoil (P-type) domain;
82-121 6.78e-09

Trefoil (P-type) domain;


Pssm-ID: 459666  Cd Length: 43  Bit Score: 48.08  E-value: 6.78e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 31981962    82 VMEVSARKNCGYPGISPEDCASRNCCFSNLI-FEVPWCFFP 121
Cdd:pfam00088   3 SVPPSDRFDCGYPGITQEECEARGCCWDPSVdPGVPWCFYP 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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