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Conserved domains on  [gi|239052131|ref|NP_034006|]
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cyclin-dependent kinase inhibitor 1C isoform 2 [Mus musculus]

Protein Classification

cyclin-dependent kinase inhibitor( domain architecture ID 10491403)

cyclin-dependent kinase inhibitor is an important regulator of cell cycle progression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDI pfam02234
Cyclin-dependent kinase inhibitor; Cell cycle progression is negatively controlled by ...
 22-68 9.81e-12

Cyclin-dependent kinase inhibitor; Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (CDIs). CDIs are involved in cell cycle arrest at the G1 phase.


:

Pssm-ID: 460503  Cd Length: 46  Bit Score: 59.08  E-value: 9.81e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 239052131   22 LFGPVDHEELGRELRMRLAELNAEDQNRWDFNFQQDVPLrgPGRLQW 68
Cdd:pfam02234   1 LFGPVDHEELEEFFQAALREQQERFSEKWNFDFVNDTPL--PGRYEW 45
PTZ00341 super family cl31759
Ring-infected erythrocyte surface antigen; Provisional
 184-268 2.49e-04

Ring-infected erythrocyte surface antigen; Provisional


The actual alignment was detected with superfamily member PTZ00341:

Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 42.85  E-value: 2.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239052131  184 EEQVPEQVSEQGEESGAEPGDELGTEPVSEQgeEQGAEPVEEKDEEPEEEQGAEPVEEQGAEPVEEQNGEPVEEQDENQE 263
Cdd:PTZ00341 1000 EENIEENVEENVEENIEENVEEYDEENVEEV--EENVEEYDEENVEEIEENAEENVEENIEENIEEYDEENVEEIEENIE 1077


                  ....*
gi 239052131  264 QRGQE 268
Cdd:PTZ00341 1078 ENIEE 1082
 
Name Accession Description Interval E-value
CDI pfam02234
Cyclin-dependent kinase inhibitor; Cell cycle progression is negatively controlled by ...
 22-68 9.81e-12

Cyclin-dependent kinase inhibitor; Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (CDIs). CDIs are involved in cell cycle arrest at the G1 phase.


Pssm-ID: 460503  Cd Length: 46  Bit Score: 59.08  E-value: 9.81e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 239052131   22 LFGPVDHEELGRELRMRLAELNAEDQNRWDFNFQQDVPLrgPGRLQW 68
Cdd:pfam02234   1 LFGPVDHEELEEFFQAALREQQERFSEKWNFDFVNDTPL--PGRYEW 45
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 184-268 2.49e-04

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 42.85  E-value: 2.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239052131  184 EEQVPEQVSEQGEESGAEPGDELGTEPVSEQgeEQGAEPVEEKDEEPEEEQGAEPVEEQGAEPVEEQNGEPVEEQDENQE 263
Cdd:PTZ00341 1000 EENIEENVEENVEENIEENVEEYDEENVEEV--EENVEEYDEENVEEIEENAEENVEENIEENIEEYDEENVEEIEENIE 1077


                  ....*
gi 239052131  264 QRGQE 268
Cdd:PTZ00341 1078 ENIEE 1082
 
Name Accession Description Interval E-value
CDI pfam02234
Cyclin-dependent kinase inhibitor; Cell cycle progression is negatively controlled by ...
 22-68 9.81e-12

Cyclin-dependent kinase inhibitor; Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (CDIs). CDIs are involved in cell cycle arrest at the G1 phase.


Pssm-ID: 460503  Cd Length: 46  Bit Score: 59.08  E-value: 9.81e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 239052131   22 LFGPVDHEELGRELRMRLAELNAEDQNRWDFNFQQDVPLrgPGRLQW 68
Cdd:pfam02234   1 LFGPVDHEELEEFFQAALREQQERFSEKWNFDFVNDTPL--PGRYEW 45
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 184-268 2.49e-04

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 42.85  E-value: 2.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239052131  184 EEQVPEQVSEQGEESGAEPGDELGTEPVSEQgeEQGAEPVEEKDEEPEEEQGAEPVEEQGAEPVEEQNGEPVEEQDENQE 263
Cdd:PTZ00341 1000 EENIEENVEENVEENIEENVEEYDEENVEEV--EENVEEYDEENVEEIEENAEENVEENIEENIEEYDEENVEEIEENIE 1077


                  ....*
gi 239052131  264 QRGQE 268
Cdd:PTZ00341 1078 ENIEE 1082
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 184-272 7.02e-04

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 41.70  E-value: 7.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239052131  184 EEQVPEQVSEQGEESgAEPGDELGTEPVSEQGEE---QGAEPVEEKDEEPEEEQGAEPVEEQGAEPVEEQNGEPVEEQDE 260
Cdd:PTZ00341 1046 EENAEENVEENIEEN-IEEYDEENVEEIEENIEEnieENVEENVEENVEEIEENVEENVEENAEENAEENAEENAEEYDD 1124

                          90
                  ....*....|..
gi 239052131  261 NQEQRGQELKDQ 272
Cdd:PTZ00341 1125 ENPEEHNEEYDE 1136
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 171-268 3.49e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 39.38  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239052131  171 IPDANPDVATRDGEEQVPEQVSEQGEESGAEPGDELGTEPVSEQGEEQgaepVEEKDEEPEEEQGAEPVEEQGAEPVEEQ 250
Cdd:PTZ00341  947 IEEDAEENVEEDAEENVEENVEENVEENVEENVEENVEENVEENVEEN----VEENVEENIEENVEENVEENIEENVEEY 1022

                          90
                  ....*....|....*...
gi 239052131  251 NGEPVEEQDENQEQRGQE 268
Cdd:PTZ00341 1023 DEENVEEVEENVEEYDEE 1040
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 161-264 9.09e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 37.84  E-value: 9.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239052131  161 VATSDPTPDPIPDANPDVATRDGEEQVPEQVSEQGEESGAEPGDEL------GTEPVSEQGEEQGAEPVEEKDEEPEEEQ 234
Cdd:PTZ00341 1027 VEEVEENVEEYDEENVEEIEENAEENVEENIEENIEEYDEENVEEIeenieeNIEENVEENVEENVEEIEENVEENVEEN 1106

                          90       100       110
                  ....*....|....*....|....*....|
gi 239052131  235 GAEPVEEQGAEPVEEQNGEPVEEQDENQEQ 264
Cdd:PTZ00341 1107 AEENAEENAEENAEEYDDENPEEHNEEYDE 1136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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