NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6754254|ref|NP_034610|]
View 

heat shock protein HSP 90-alpha [Mus musculus]

Protein Classification

HSP90 family protein( domain architecture ID 1903338)

HSP90 (heat shock protein 90) family protein functions as a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
HSP90 super family cl46693
Hsp90 protein;
18-733 0e+00

Hsp90 protein;


The actual alignment was detected with superfamily member PTZ00272:

Pssm-ID: 481033  Cd Length: 701  Bit Score: 940.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    18 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTGIG 97
Cdd:PTZ00272   3 ETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGIG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    98 MTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTG 177
Cdd:PTZ00272  83 MTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVTSKNNSDESYVWESSAGGTFTITSTPE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   178 EPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEaeekeekeEEKEKEEKESDDKPE 257
Cdd:PTZ00272 163 SDMKRGTRITLHLKEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTDED--------EEDTKKADEDGEEPK 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   258 IEDVgsdEEEEEKKDGDKKKKKKIKEKYIDQeelNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEGQLE 337
Cdd:PTZ00272 235 VEEV---KEGDEGKKKKTKKVKEVTKEYEVQ---NKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLE 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   338 FRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNL 417
Cdd:PTZ00272 309 FRSIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNI 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   418 VKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITG 497
Cdd:PTZ00272 389 VKKCLEMFDEVAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKAGQKSIYYITG 468
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   498 ETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMK 577
Cdd:PTZ00272 469 DSKKKLETSPFIEQARRRGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMK 548
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   578 DILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKND 657
Cdd:PTZ00272 549 EVLGDKVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMELNPRHPIIKELRRRVGADEND 628
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6754254   658 KSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDptvDDTSAAVTEEMPPLEGDDDTSRMEEVD 733
Cdd:PTZ00272 629 KAVKDLVFLLFDTSLLTSGFQLEDPTGYAERINRMIKLGLSLDEEE---EEAAEAPVAETAPAEVTAGTSSMEQVD 701
 
Name Accession Description Interval E-value
PTZ00272 PTZ00272
heat shock protein 83 kDa (Hsp83); Provisional
18-733 0e+00

heat shock protein 83 kDa (Hsp83); Provisional


Pssm-ID: 240341  Cd Length: 701  Bit Score: 940.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    18 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTGIG 97
Cdd:PTZ00272   3 ETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGIG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    98 MTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTG 177
Cdd:PTZ00272  83 MTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVTSKNNSDESYVWESSAGGTFTITSTPE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   178 EPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEaeekeekeEEKEKEEKESDDKPE 257
Cdd:PTZ00272 163 SDMKRGTRITLHLKEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTDED--------EEDTKKADEDGEEPK 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   258 IEDVgsdEEEEEKKDGDKKKKKKIKEKYIDQeelNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEGQLE 337
Cdd:PTZ00272 235 VEEV---KEGDEGKKKKTKKVKEVTKEYEVQ---NKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLE 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   338 FRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNL 417
Cdd:PTZ00272 309 FRSIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNI 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   418 VKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITG 497
Cdd:PTZ00272 389 VKKCLEMFDEVAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKAGQKSIYYITG 468
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   498 ETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMK 577
Cdd:PTZ00272 469 DSKKKLETSPFIEQARRRGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMK 548
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   578 DILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKND 657
Cdd:PTZ00272 549 EVLGDKVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMELNPRHPIIKELRRRVGADEND 628
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6754254   658 KSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDptvDDTSAAVTEEMPPLEGDDDTSRMEEVD 733
Cdd:PTZ00272 629 KAVKDLVFLLFDTSLLTSGFQLEDPTGYAERINRMIKLGLSLDEEE---EEAAEAPVAETAPAEVTAGTSSMEQVD 701
HSP90 pfam00183
Hsp90 protein;
196-721 0e+00

Hsp90 protein;


Pssm-ID: 459703  Cd Length: 516  Bit Score: 825.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    196 EYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEEKEEEkekeekeSDDKPEIEDVGsdeeeeekKDGDK 275
Cdd:pfam00183   1 EYLEEKKIKELVKKYSEFINFPIYLWVEKEEEVEVPDEEEEEEEEEEEE-------EDDDPKVEEED--------EEEEK 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    276 KKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFRALLFVPRRAPFDLFEN 355
Cdd:pfam00183  66 KKTKKVKETVWEWELLNKTKPIWTRNPKEVTEEEYAEFYKSLSKDWEDPLAVKHFSVEGEVEFKSLLFIPKRAPFDLFEN 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    356 RKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENY 435
Cdd:pfam00183 146 KKKKNNIKLYVRRVFITDDFEDLIPEYLNFVKGVVDSDDLPLNVSRETLQQNKILKVIKKKLVRKALDMFKEIAEEKEDY 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    436 KKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAFVERLRKH 515
Cdd:pfam00183 226 KKFWKEFGKNLKLGIIEDSSNRNKLAKLLRFYSSKSGDELTSLDDYVSRMKEGQKHIYYITGESKEEVENSPFLERLKKK 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    516 GLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVT 595
Cdd:pfam00183 306 GYEVLYLTDPIDEYAVQQLKEFDGKKLVNVAKEGLELEEDEEEKKKDEELKKEFEPLTKWLKDVLGDKVEKVVVSNRLVD 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    596 SPCCIVTSTYGWTANMERIMKAQALR-DNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLS 674
Cdd:pfam00183 386 SPCVLVTSQYGWSANMERIMKAQALRkDSSMSSYMSSKKTLEINPRHPIIKELLKRVEADKDDKTAKDLALLLYETALLR 465
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 6754254    675 SGFSLEDPQTHANRIYRMIKLGLGIDEDDPTVDD----TSAAVTEEMPPLE 721
Cdd:pfam00183 466 SGFSLEDPASFASRIYRMLKLGLGIDEDEIVEEEdeieEEEEEEEEEPEEE 516
HtpG COG0326
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
16-698 0e+00

Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440095 [Multi-domain]  Cd Length: 616  Bit Score: 728.84  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   16 EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTG 95
Cdd:COG0326   2 AKETGEFQAEVKQLLDLMIHSLYSNKEIFLRELISNASDAIDKLRFLALTDPELKEEDGDLKIRIEVDKEAKTLTISDNG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   96 IGMTKADLINNLGTIAKSGTKAFMEALQ--AGADISMIGQFGVGFYSAYLVAEKVTVITKH--NDDEQYAWESSAGGSFT 171
Cdd:COG0326  82 IGMTREEVIENLGTIAKSGTREFLEKLKgdQKKDSDLIGQFGVGFYSAFMVADKVEVVTRSagEDAEAVRWESDGDGEYT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  172 VRTDTGEPmgRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVsddeaeekeekeeekekeeke 251
Cdd:COG0326 162 IEEAEKAE--RGTEITLHLKEDAEEFLEEWRLREIIKKYSDFIPVPIKMEGEEEETEED--------------------- 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  252 sddkpeiedvgsdeeeeekkdgdkkkkkkikekyidqEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFS 331
Cdd:COG0326 219 -------------------------------------ETINSATALWTRSKSEITDEEYKEFYKHLFHDFEDPLFWIHLN 261
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  332 VEGQLEFRALLFVPRRAPFDLFeNRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILK 411
Cdd:COG0326 262 VEGPFEYTGLLYIPKKAPFDLY-DRDRKGGIKLYVKRVFIMDDAEDLLPEYLRFVRGVVDSPDLPLNVSREILQEDRQLK 340
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  412 VIRKNLVKKCLELFTELAE-DKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSAsGDEMVSLKDYCTRMKENQK 490
Cdd:COG0326 341 KIRKAITKKVLDELEKLAKnDREKYEKFWKEFGLVLKEGALEDFKNREKIADLLRFESTK-EGGYVTLAEYVERMKEGQK 419
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  491 HIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKeGLELPEDEEEKKKQEEKKTKFE 570
Cdd:COG0326 420 KIYYITGESREAAEQSPHLEIFKAKGIEVLLLTDPIDEFLISHLEEFDGKKFKSVDS-GDLDLDKLEEKKESEEEEEEFK 498
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  571 NLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAqalrdnstMG--YMAAKKHLEINPDHSIIETLR 648
Cdd:COG0326 499 PLLERFKEALGDKVKDVRVSARLTDSPACLVADEGDMSRRMEKMLKA--------MGqdMPEAKPILEINPNHPLVKKLA 570
                       650       660       670       680       690
                ....*....|....*....|....*....|....*....|....*....|
gi 6754254  649 qkaeADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLG 698
Cdd:COG0326 571 ----AEEDEELFKDLAELLYDQALLAEGGLLEDPAAFVKRLNKLLEKALG 616
HATPase_Hsp90-like cd16927
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
28-214 3.32e-111

Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.


Pssm-ID: 340404 [Multi-domain]  Cd Length: 189  Bit Score: 334.49  E-value: 3.32e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   28 QLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTGIGMTKADLINNL 107
Cdd:cd16927   2 QLLDLIIHSLYSNKEIFLRELISNASDALDKLRYLSLTDPSLLDDDPELEIRISPDKENRTLTISDTGIGMTKEELINNL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  108 GTIAKSGTKAFMEALQAGA-DISMIGQFGVGFYSAYLVAEKVTVITKHN-DDEQYAWESSAGGSFTVRTDTGEPmGRGTK 185
Cdd:cd16927  82 GTIARSGTKAFLEALQEGAkDSDLIGQFGVGFYSAFMVADKVTVTTKSAgDDEGYRWESDGGGSYTIEEAEGEL-GRGTK 160
                       170       180
                ....*....|....*....|....*....
gi 6754254  186 VILHLKEDQTEYLEERRIKEIVKKHSQFI 214
Cdd:cd16927 161 ITLHLKEDAKEFLEEARIKELVKKYSDFI 189
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
40-191 6.40e-12

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 62.67  E-value: 6.40e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254      40 NKEIFLRELISNSSDALDKIRYEsltdpskldsGKELHINLIPSKQDRTLTIVDTGIGMTKADLinnlgtiaksgTKAFM 119
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPE----------GGRITVTLERDGDHVEITVEDNGPGIPPEDL-----------EKIFE 59
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754254     120 EALQAGADISMIGQFGVGFYSAYLVAEKVtvitkhnddeqyawessaGGSFTVRTDTgepmGRGTKVILHLK 191
Cdd:smart00387  60 PFFRTDKRSRKIGGTGLGLSIVKKLVELH------------------GGEISVESEP----GGGTTFTITLP 109
 
Name Accession Description Interval E-value
PTZ00272 PTZ00272
heat shock protein 83 kDa (Hsp83); Provisional
18-733 0e+00

heat shock protein 83 kDa (Hsp83); Provisional


Pssm-ID: 240341  Cd Length: 701  Bit Score: 940.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    18 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTGIG 97
Cdd:PTZ00272   3 ETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGIG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    98 MTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTG 177
Cdd:PTZ00272  83 MTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVTSKNNSDESYVWESSAGGTFTITSTPE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   178 EPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEaeekeekeEEKEKEEKESDDKPE 257
Cdd:PTZ00272 163 SDMKRGTRITLHLKEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTDED--------EEDTKKADEDGEEPK 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   258 IEDVgsdEEEEEKKDGDKKKKKKIKEKYIDQeelNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEGQLE 337
Cdd:PTZ00272 235 VEEV---KEGDEGKKKKTKKVKEVTKEYEVQ---NKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLE 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   338 FRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNL 417
Cdd:PTZ00272 309 FRSIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNI 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   418 VKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITG 497
Cdd:PTZ00272 389 VKKCLEMFDEVAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKAGQKSIYYITG 468
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   498 ETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMK 577
Cdd:PTZ00272 469 DSKKKLETSPFIEQARRRGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMK 548
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   578 DILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKND 657
Cdd:PTZ00272 549 EVLGDKVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMELNPRHPIIKELRRRVGADEND 628
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6754254   658 KSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDptvDDTSAAVTEEMPPLEGDDDTSRMEEVD 733
Cdd:PTZ00272 629 KAVKDLVFLLFDTSLLTSGFQLEDPTGYAERINRMIKLGLSLDEEE---EEAAEAPVAETAPAEVTAGTSSMEQVD 701
HSP90 pfam00183
Hsp90 protein;
196-721 0e+00

Hsp90 protein;


Pssm-ID: 459703  Cd Length: 516  Bit Score: 825.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    196 EYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEEKEEEkekeekeSDDKPEIEDVGsdeeeeekKDGDK 275
Cdd:pfam00183   1 EYLEEKKIKELVKKYSEFINFPIYLWVEKEEEVEVPDEEEEEEEEEEEE-------EDDDPKVEEED--------EEEEK 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    276 KKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFRALLFVPRRAPFDLFEN 355
Cdd:pfam00183  66 KKTKKVKETVWEWELLNKTKPIWTRNPKEVTEEEYAEFYKSLSKDWEDPLAVKHFSVEGEVEFKSLLFIPKRAPFDLFEN 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    356 RKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENY 435
Cdd:pfam00183 146 KKKKNNIKLYVRRVFITDDFEDLIPEYLNFVKGVVDSDDLPLNVSRETLQQNKILKVIKKKLVRKALDMFKEIAEEKEDY 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    436 KKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAFVERLRKH 515
Cdd:pfam00183 226 KKFWKEFGKNLKLGIIEDSSNRNKLAKLLRFYSSKSGDELTSLDDYVSRMKEGQKHIYYITGESKEEVENSPFLERLKKK 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    516 GLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVT 595
Cdd:pfam00183 306 GYEVLYLTDPIDEYAVQQLKEFDGKKLVNVAKEGLELEEDEEEKKKDEELKKEFEPLTKWLKDVLGDKVEKVVVSNRLVD 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    596 SPCCIVTSTYGWTANMERIMKAQALR-DNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLS 674
Cdd:pfam00183 386 SPCVLVTSQYGWSANMERIMKAQALRkDSSMSSYMSSKKTLEINPRHPIIKELLKRVEADKDDKTAKDLALLLYETALLR 465
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 6754254    675 SGFSLEDPQTHANRIYRMIKLGLGIDEDDPTVDD----TSAAVTEEMPPLE 721
Cdd:pfam00183 466 SGFSLEDPASFASRIYRMLKLGLGIDEDEIVEEEdeieEEEEEEEEEPEEE 516
PRK05218 PRK05218
heat shock protein 90; Provisional
16-698 0e+00

heat shock protein 90; Provisional


Pssm-ID: 235366 [Multi-domain]  Cd Length: 613  Bit Score: 748.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    16 EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTG 95
Cdd:PRK05218   2 AMETGEFQAEVKQLLHLMIHSLYSNKEIFLRELISNASDAIDKLRFEALTDPALYEGDGDLKIRISFDKEARTLTISDNG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    96 IGMTKADLINNLGTIAKSGTKAFMEALQ--AGADISMIGQFGVGFYSAYLVAEKVTVITKH--NDDEQYAWESSAGGSFT 171
Cdd:PRK05218  82 IGMTREEVIENLGTIAKSGTKEFLEKLKgdQKKDSQLIGQFGVGFYSAFMVADKVTVITRSagPAAEAVRWESDGEGEYT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   172 VRTDTGEPmgRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKErdkevsddeaeekeekeeekekeeke 251
Cdd:PRK05218 162 IEEIEKEE--RGTEITLHLKEDEDEFLDEWRIRSIIKKYSDFIPVPIKLEKEEE-------------------------- 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   252 sddkpeiedvgsdeeeeekkdgdkkkkkkikekyidqEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFS 331
Cdd:PRK05218 214 -------------------------------------ETINSASALWTRSKSEITDEEYKEFYKHLAHDFDDPLFWIHNN 256
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   332 VEGQLEFRALLFVPRRAPFDLFeNRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILK 411
Cdd:PRK05218 257 VEGPFEYTGLLYIPKKAPFDLF-NRDRKGGLKLYVKRVFIMDDAEELLPEYLRFVKGVIDSEDLPLNVSREILQEDRVVK 335
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   412 VIRKNLVKKCLELFTELAE-DKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGdEMVSLKDYCTRMKENQK 490
Cdd:PRK05218 336 KIRKAITKKVLDELEKLAKnDREKYEKFWKEFGPVLKEGLYEDFANREKLAKLLRFASTHEG-KYVSLAEYVERMKEGQK 414
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   491 HIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLE-LPEDEEEKKKQEEKKTKF 569
Cdd:PRK05218 415 KIYYITGDSREAAKNSPHLELFKKKGIEVLLLTDPIDEFWISYLEEFDGKPFKSVARGDLDlGKEDEEEKEEKEEAEEEF 494
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   570 ENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQAlrdnstMGYMAAKKHLEINPDHSIIETLRQ 649
Cdd:PRK05218 495 KPLLERLKEALGDKVKDVRLSHRLTDSPACLVADEGDMSTQMEKLLKAAG------QEVPESKPILEINPNHPLVKKLAD 568
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*....
gi 6754254   650 kaeaDKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLG 698
Cdd:PRK05218 569 ----EADEAKFKDLAELLYDQALLAEGGSLEDPAAFVKRLNELLLKLLA 613
HtpG COG0326
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
16-698 0e+00

Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440095 [Multi-domain]  Cd Length: 616  Bit Score: 728.84  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   16 EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTG 95
Cdd:COG0326   2 AKETGEFQAEVKQLLDLMIHSLYSNKEIFLRELISNASDAIDKLRFLALTDPELKEEDGDLKIRIEVDKEAKTLTISDNG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   96 IGMTKADLINNLGTIAKSGTKAFMEALQ--AGADISMIGQFGVGFYSAYLVAEKVTVITKH--NDDEQYAWESSAGGSFT 171
Cdd:COG0326  82 IGMTREEVIENLGTIAKSGTREFLEKLKgdQKKDSDLIGQFGVGFYSAFMVADKVEVVTRSagEDAEAVRWESDGDGEYT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  172 VRTDTGEPmgRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVsddeaeekeekeeekekeeke 251
Cdd:COG0326 162 IEEAEKAE--RGTEITLHLKEDAEEFLEEWRLREIIKKYSDFIPVPIKMEGEEEETEED--------------------- 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  252 sddkpeiedvgsdeeeeekkdgdkkkkkkikekyidqEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFS 331
Cdd:COG0326 219 -------------------------------------ETINSATALWTRSKSEITDEEYKEFYKHLFHDFEDPLFWIHLN 261
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  332 VEGQLEFRALLFVPRRAPFDLFeNRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILK 411
Cdd:COG0326 262 VEGPFEYTGLLYIPKKAPFDLY-DRDRKGGIKLYVKRVFIMDDAEDLLPEYLRFVRGVVDSPDLPLNVSREILQEDRQLK 340
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  412 VIRKNLVKKCLELFTELAE-DKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSAsGDEMVSLKDYCTRMKENQK 490
Cdd:COG0326 341 KIRKAITKKVLDELEKLAKnDREKYEKFWKEFGLVLKEGALEDFKNREKIADLLRFESTK-EGGYVTLAEYVERMKEGQK 419
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  491 HIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKeGLELPEDEEEKKKQEEKKTKFE 570
Cdd:COG0326 420 KIYYITGESREAAEQSPHLEIFKAKGIEVLLLTDPIDEFLISHLEEFDGKKFKSVDS-GDLDLDKLEEKKESEEEEEEFK 498
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  571 NLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAqalrdnstMG--YMAAKKHLEINPDHSIIETLR 648
Cdd:COG0326 499 PLLERFKEALGDKVKDVRVSARLTDSPACLVADEGDMSRRMEKMLKA--------MGqdMPEAKPILEINPNHPLVKKLA 570
                       650       660       670       680       690
                ....*....|....*....|....*....|....*....|....*....|
gi 6754254  649 qkaeADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLG 698
Cdd:COG0326 571 ----AEEDEELFKDLAELLYDQALLAEGGLLEDPAAFVKRLNKLLEKALG 616
PTZ00130 PTZ00130
heat shock protein 90; Provisional
3-731 1.79e-164

heat shock protein 90; Provisional


Pssm-ID: 185466 [Multi-domain]  Cd Length: 814  Bit Score: 494.56  E-value: 1.79e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254     3 EETQTQDQPMEEeeVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIP 82
Cdd:PTZ00130  53 PEIEDGEKPTSG--IEQHQYQTEVTRLMDIIVNSLYTQKEVFLRELISNAADALEKIRFLSLSDESVLGEEKKLEIRISA 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    83 SKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEAL-QAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYA 161
Cdd:PTZ00130 131 NKEKNILSITDTGIGMTKEDLINNLGTIAKSGTSNFLEAIsKSGGDMSLIGQFGVGFYSAFLVADKVIVYTKNNNDEQYI 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   162 WESSAGGSFTVRTDT-GEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEE 240
Cdd:PTZ00130 211 WESTADAKFTIYKDPrGSTLKRGTRISLHLKEDATNLMNDKKLVDLISKYSQFIQYPIYLLHENVYTEEVLADIAKEMEN 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   241 KEEEKEKEEKESDDKpeiedvgsdeeeeekkdgdKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTND 320
Cdd:PTZ00130 291 DPNYDSVKVEETDDP-------------------NKKTRTVEKKVKKWKLMNEQKPIWLRPPKELTDEDYKKFFSVLSGF 351
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   321 WEEHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNIS 400
Cdd:PTZ00130 352 NDEPLYHIHFFAEGEIEFKCLIYIPSRAPSINDHLFTKQNSIKLYVRRVLVADEFVEFLPRYMSFVKGVVDSDDLPLNVS 431
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   401 REMLQQSKILKVIRKNLVKKCLE----LFTELAEDKEN--------------------------YKKFYEQFSKNIKLGI 450
Cdd:PTZ00130 432 REQLQQNKILKAVSKRIVRKILDtfrtLYKEGKKNKETlraelaketdeekkkeiqkkinepstYKLIYKEYRKYLKTGC 511
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   451 HEDSQNRKKLSELLRYYTSASgDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYC 530
Cdd:PTZ00130 512 YEDDINRNKIVKLLLFKTMLH-PKSISLDTYIENMKPDQKFIYYASGDSYEYLSKIPQLQIFKKKNIDVVFLTESVDESC 590
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   531 VQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTAN 610
Cdd:PTZ00130 591 VQRVQEYDGKKFKSIQKGEITFELTEDEKKKEEKVKKMYKALIDVISDTLRNQIFKVEISRRLVDAPCAVVSTEWGLSGQ 670
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   611 MERIMKAQaLRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIY 690
Cdd:PTZ00130 671 MEKLMKIN-VNNSDQIKAMSGQKILEINPDHPIMIDLLKRSVSNPKDSQLTESIKIIYQSAKLASGFDLEDTADLAQIVY 749
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|....*..
gi 6754254   691 RMIKLGLGIDED------DPTVDDTSAAVTEEMPplegddDTSRMEE 731
Cdd:PTZ00130 750 DHINQKLGVDNNlkiddlDPAIFETKKIEQEDSP------DGQKFHE 790
HATPase_Hsp90-like cd16927
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
28-214 3.32e-111

Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.


Pssm-ID: 340404 [Multi-domain]  Cd Length: 189  Bit Score: 334.49  E-value: 3.32e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   28 QLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTGIGMTKADLINNL 107
Cdd:cd16927   2 QLLDLIIHSLYSNKEIFLRELISNASDALDKLRYLSLTDPSLLDDDPELEIRISPDKENRTLTISDTGIGMTKEELINNL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254  108 GTIAKSGTKAFMEALQAGA-DISMIGQFGVGFYSAYLVAEKVTVITKHN-DDEQYAWESSAGGSFTVRTDTGEPmGRGTK 185
Cdd:cd16927  82 GTIARSGTKAFLEALQEGAkDSDLIGQFGVGFYSAFMVADKVTVTTKSAgDDEGYRWESDGGGSYTIEEAEGEL-GRGTK 160
                       170       180
                ....*....|....*....|....*....
gi 6754254  186 VILHLKEDQTEYLEERRIKEIVKKHSQFI 214
Cdd:cd16927 161 ITLHLKEDAKEFLEEARIKELVKKYSDFI 189
PRK14083 PRK14083
HSP90 family protein; Provisional
21-417 4.82e-31

HSP90 family protein; Provisional


Pssm-ID: 237603 [Multi-domain]  Cd Length: 601  Bit Score: 128.91  E-value: 4.82e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254    21 AFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDAldkIRYESLTDPSklDSGKeLHINLiPSKQDRTLTIVDTGIGMTK 100
Cdd:PRK14083   4 RFQVDLRGVIDLLSRHLYSSPRVYVRELLQNAVDA---ITARRALDPT--APGR-IRIEL-TDAGGGTLIVEDNGIGLTE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   101 ADLINNLGTIAKSGTKAfmEALQAGADiSMIGQFGVGFYSAYLVAEKVTVITKHNDDEQ-YAWESSAGGSFTVRTDTGEP 179
Cdd:PRK14083  77 EEVHEFLATIGRSSKRD--ENLGFARN-DFLGQFGIGLLSCFLVADEIVVVSRSAKDGPaVEWRGKADGTYSVRKLETER 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   180 MGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERdkevsddeaeekeekeeekekeekesddkpeie 259
Cdd:PRK14083 154 AEPGTTVYLRPRPDAEEWLERETVEELAKKYGSLLPVPIRVEGEKGG--------------------------------- 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   260 dvgsdeeeeekkdgdkkkkkkikekyidqeeLNKTKPIWTRNPDDITNE-----EYGEfyKSLTNDWEEH--LAVKHFSV 332
Cdd:PRK14083 201 -------------------------------VNETPPPWTRDYPDPETRreallAYGE--ELLGFTPLDVipLDVPSGGL 247
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254   333 EGqlefraLLFV-PRRAPFdlfeNRKKKNniKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILK 411
Cdd:PRK14083 248 EG------VAYVlPYAVSP----AARRKH--RVYLKRMLLSEEAENLLPDWAFFVRCVVNTDELRPTASREALYEDDALA 315

                 ....*.
gi 6754254   412 VIRKNL 417
Cdd:PRK14083 316 AVREEL 321
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
40-191 6.40e-12

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 62.67  E-value: 6.40e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254      40 NKEIFLRELISNSSDALDKIRYEsltdpskldsGKELHINLIPSKQDRTLTIVDTGIGMTKADLinnlgtiaksgTKAFM 119
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPE----------GGRITVTLERDGDHVEITVEDNGPGIPPEDL-----------EKIFE 59
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754254     120 EALQAGADISMIGQFGVGFYSAYLVAEKVtvitkhnddeqyawessaGGSFTVRTDTgepmGRGTKVILHLK 191
Cdd:smart00387  60 PFFRTDKRSRKIGGTGLGLSIVKKLVELH------------------GGEISVESEP----GGGTTFTITLP 109
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
42-159 5.18e-08

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 52.33  E-value: 5.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254     42 EIFLRELISNSSDAldkiryesltdpskldSGKELHINLIPSKQDRT-LTIVDTGIGMTKADLINNLGtIAKSGTKafme 120
Cdd:pfam13589   2 EGALAELIDNSIDA----------------DATNIKIEVNKNRGGGTeIVIEDDGHGMSPEELINALR-LATSAKE---- 60
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6754254    121 alqAGADISMIGQFGVGFYSAYLV-AEKVTVITKHNDDEQ 159
Cdd:pfam13589  61 ---AKRGSTDLGRYGIGLKLASLSlGAKLTVTSKKEGKSS 97
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
40-194 1.01e-05

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 45.05  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754254     40 NKEIFLRELISNSSDALDKIRYEsltdpskldsGKELHINLIPsKQDRTLTIVDTGIGMTKADLinnlgtiAKSGTKaFM 119
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAK----------AGEITVTLSE-GGELTLTVEDNGIGIPPEDL-------PRIFEP-FS 61
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6754254    120 EalqagADISMIGQFGVGFYSAYLVAEKVtvitkhnddeqyawessaGGSFTVRTDTgepmGRGTKVILHLKEDQ 194
Cdd:pfam02518  62 T-----ADKRGGGGTGLGLSIVRKLVELL------------------GGTITVESEP----GGGTTVTLTLPLAQ 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH