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Conserved domains on  [gi|14210534|ref|NP_115913|]
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keratin-associated protein 4-4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 15-166 1.32e-10

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 56.72  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14210534    15 CGLENCCRPSYCQTTCCRTTCCRPSCCVSSCCRPQCCQTTCCRTTCCHPSCCVSSCcrPQCCQSVCCQPTCCRPQCCQTT 94
Cdd:pfam01500   4 CGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQTG 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14210534    95 CCRTTCCRPSCCRPQCCQSVCCQPTCCCPSYCVSSCCRPQCCQTTCCRTTCCRPSCCVSRCYRPHCGQSLCC 166
Cdd:pfam01500  82 CGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACC 153
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 15-166 1.32e-10

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 56.72  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14210534    15 CGLENCCRPSYCQTTCCRTTCCRPSCCVSSCCRPQCCQTTCCRTTCCHPSCCVSSCcrPQCCQSVCCQPTCCRPQCCQTT 94
Cdd:pfam01500   4 CGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQTG 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14210534    95 CCRTTCCRPSCCRPQCCQSVCCQPTCCCPSYCVSSCCRPQCCQTTCCRTTCCRPSCCVSRCYRPHCGQSLCC 166
Cdd:pfam01500  82 CGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACC 153
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 15-166 1.32e-10

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 56.72  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14210534    15 CGLENCCRPSYCQTTCCRTTCCRPSCCVSSCCRPQCCQTTCCRTTCCHPSCCVSSCcrPQCCQSVCCQPTCCRPQCCQTT 94
Cdd:pfam01500   4 CGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQTG 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14210534    95 CCRTTCCRPSCCRPQCCQSVCCQPTCCCPSYCVSSCCRPQCCQTTCCRTTCCRPSCCVSRCYRPHCGQSLCC 166
Cdd:pfam01500  82 CGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACC 153
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 5-133 9.78e-10

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 54.41  E-value: 9.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14210534     5 CCGSVCSDQGCGLENCCRPSYCQTTCCRTTCCRPSCCVSSCCRPQCCQTTCCRTTCChpSCCVSSCCRPQCCQSVCCQPT 84
Cdd:pfam01500   4 CGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQ--PCCQTSCCQPTCCQTSSCQTG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14210534    85 C--------------------CRPQCCQTTCCRTTCCRPSCCRPQCCQSVCCQPTCCCPSYCVSSCCRP 133
Cdd:pfam01500  82 CggigygqegssgavssrtrwCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRP 150
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
75-133 3.99e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 49.69  E-value: 3.99e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 14210534    75 CCQSVCCQPTCCRPqccqttccrttccrpSCCRPQCCQSVCCQPTCCCPSYCVSSCCRP 133
Cdd:pfam13885   1 CCQPSCCQPSCCQP---------------SCCQPSCCQPSCCQPSCCRPSCCRSSCCQP 44
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
65-124 1.46e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.53  E-value: 1.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14210534    65 CCVSSCCRPQCCQSVCCQPTCCRPqccqttccrttccrpSCCRPQCCQSVCCQPTCCCPS 124
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQP---------------SCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
63-119 5.76e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.61  E-value: 5.76e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 14210534    63 PSCCVSSCCRPQCCQSVCCQPTCCRPqccqttccrttccrpSCCRPQCCQSVCCQPT 119
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQP---------------SCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
105-158 3.17e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 41.98  E-value: 3.17e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 14210534   105 CCRPQCCQSVCCQPTCCCPSYCVSSCCRPQCCqttccrttccRPSCCVSRCYRP 158
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCC----------RPSCCRSSCCQP 44
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
38-88 3.86e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 41.98  E-value: 3.86e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 14210534    38 PSCCVSSCCRPQCCqttccrttccHPSCCVSSCCRPQCCQSVCCQPTCCRP 88
Cdd:pfam13885   4 PSCCQPSCCQPSCC----------QPSCCQPSCCQPSCCRPSCCRSSCCQP 44
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
40-88 5.67e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.90  E-value: 5.67e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 14210534    40 CCVSSCCRPQCCQttccrttcchPSCCVSSCCRPQCCQSVCCQPTCCRP 88
Cdd:pfam13885   1 CCQPSCCQPSCCQ----------PSCCQPSCCQPSCCQPSCCRPSCCRS 39
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
20-84 1.41e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.05  E-value: 1.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14210534    20 CCRPSYCQTTCCRTTCCRPSCCVSSCCRPqccqttccrttcchpsccvsSCCRPQCCQSVCCQPT 84
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQP--------------------SCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
5-48 3.48e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 33.89  E-value: 3.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 14210534     5 CCGSVCSDQGCGLENCCRPSYCQTTCCRTTCCRPSCCVSSCCRP 48
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQP 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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