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Conserved domains on  [gi|17555642|ref|NP_499668|]
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Putative phospholipase B-like 1 [Caenorhabditis elegans]

Protein Classification

phospholipase B family protein( domain architecture ID 10522720)

phospholipase B family protein may catalyze the hydrolytic cleavage of acylester bonds in glycerophospholipids

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Phospholip_B pfam04916
Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester ...
53-548 0e+00

Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.


:

Pssm-ID: 461479  Cd Length: 483  Bit Score: 711.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642    53 ATAYFHDEVNQTGWAFLEVDViSPKIPHYLQGYAAGFAEGRATRHLIDLHIINTVNGYCDGAKHFCDE-LGEFMVDNLKW 131
Cdd:pfam04916   1 ARAYFNDSVNTTGWGFLEIET-NSVYSDTLQAYAAGFLEGYLTAELIYDHYSNTFPAYCKNSTEFCDPkLRAFLEENLKW 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   132 MEQEIRENPEDEYWQQVNLTVNQLFGLIHGYENQlGAEIDFKQIAVHPIFMIQIAGDLEDLAMKFKKPENP---KKVFSG 208
Cdd:pfam04916  80 MRKQVKENPDDPYWRQVGLVYAQLDGLVAGYNAR-AASDKRKPLTFFQILLLNLAGDLEDLVPALTPPKNSsaaKFKMKE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   209 PGHCSALVKLLPKNEDILFSHVTWSSYGTMLRINKKYSFKTGD----PGQIYSFSSYPASITSTDDFVLTSAKLAILETT 284
Cdd:pfam04916 159 PGHCSALIKLLPGFEDLLFGHTTWSSYSAMLRIYKHYTFPVSDravvPGTTVSFSSYPGLLSSLDDFYITSSGLAVMETT 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   285 IGNYNEKSLDLITPNTVLTWIRAEIAHRTASSGLQWAEAFGRHNSGTYNNEWVVVDYKQFHRGKEVQPetGIIHVVEQMP 364
Cdd:pfam04916 239 NGIFNQTLYKLIKPSSVLTWQRVMVANRLAHSGREWAEIFSRYNSGTYNNQWMVLDYKLFTPGQELPD--GTFWVVEQIP 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   365 GHIVHSDKTAHLFRETYWPGYNQPYYKQIIRFSDTDKMVEKFGDWYSYDKTPRALIFKRDHNTVTDMSSMIALMRSNNYT 444
Cdd:pfam04916 317 GYIEASDVTAVLNRTGYWPSYNIPYFPEIYNISGYPAMVEKYGDWFSYDLTPRAKIFRRDQGNVTDLESMKALMRYNNYK 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   445 KDPLSKCdcnppySAENAIACRSDLNPLNgtypfkslGFRDHGAIDVKVTNSKLINSLQFTAVSGPPggvTKDVPIFDWK 524
Cdd:pfam04916 397 KDPLSKG------SPENAISARGDLNPAG--------GHRAFGAIDTKVTNYALVLSLQARAISGPT---TDTQPPFDWS 459
                         490       500
                  ....*....|....*....|....
gi 17555642   525 TSPLREKVPHFGQPDRWNFAPVTY 548
Cdd:pfam04916 460 SSPFFNVTRHQGHPDVWNFDFVTM 483
 
Name Accession Description Interval E-value
Phospholip_B pfam04916
Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester ...
53-548 0e+00

Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.


Pssm-ID: 461479  Cd Length: 483  Bit Score: 711.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642    53 ATAYFHDEVNQTGWAFLEVDViSPKIPHYLQGYAAGFAEGRATRHLIDLHIINTVNGYCDGAKHFCDE-LGEFMVDNLKW 131
Cdd:pfam04916   1 ARAYFNDSVNTTGWGFLEIET-NSVYSDTLQAYAAGFLEGYLTAELIYDHYSNTFPAYCKNSTEFCDPkLRAFLEENLKW 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   132 MEQEIRENPEDEYWQQVNLTVNQLFGLIHGYENQlGAEIDFKQIAVHPIFMIQIAGDLEDLAMKFKKPENP---KKVFSG 208
Cdd:pfam04916  80 MRKQVKENPDDPYWRQVGLVYAQLDGLVAGYNAR-AASDKRKPLTFFQILLLNLAGDLEDLVPALTPPKNSsaaKFKMKE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   209 PGHCSALVKLLPKNEDILFSHVTWSSYGTMLRINKKYSFKTGD----PGQIYSFSSYPASITSTDDFVLTSAKLAILETT 284
Cdd:pfam04916 159 PGHCSALIKLLPGFEDLLFGHTTWSSYSAMLRIYKHYTFPVSDravvPGTTVSFSSYPGLLSSLDDFYITSSGLAVMETT 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   285 IGNYNEKSLDLITPNTVLTWIRAEIAHRTASSGLQWAEAFGRHNSGTYNNEWVVVDYKQFHRGKEVQPetGIIHVVEQMP 364
Cdd:pfam04916 239 NGIFNQTLYKLIKPSSVLTWQRVMVANRLAHSGREWAEIFSRYNSGTYNNQWMVLDYKLFTPGQELPD--GTFWVVEQIP 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   365 GHIVHSDKTAHLFRETYWPGYNQPYYKQIIRFSDTDKMVEKFGDWYSYDKTPRALIFKRDHNTVTDMSSMIALMRSNNYT 444
Cdd:pfam04916 317 GYIEASDVTAVLNRTGYWPSYNIPYFPEIYNISGYPAMVEKYGDWFSYDLTPRAKIFRRDQGNVTDLESMKALMRYNNYK 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   445 KDPLSKCdcnppySAENAIACRSDLNPLNgtypfkslGFRDHGAIDVKVTNSKLINSLQFTAVSGPPggvTKDVPIFDWK 524
Cdd:pfam04916 397 KDPLSKG------SPENAISARGDLNPAG--------GHRAFGAIDTKVTNYALVLSLQARAISGPT---TDTQPPFDWS 459
                         490       500
                  ....*....|....*....|....
gi 17555642   525 TSPLREKVPHFGQPDRWNFAPVTY 548
Cdd:pfam04916 460 SSPFFNVTRHQGHPDVWNFDFVTM 483
 
Name Accession Description Interval E-value
Phospholip_B pfam04916
Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester ...
53-548 0e+00

Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.


Pssm-ID: 461479  Cd Length: 483  Bit Score: 711.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642    53 ATAYFHDEVNQTGWAFLEVDViSPKIPHYLQGYAAGFAEGRATRHLIDLHIINTVNGYCDGAKHFCDE-LGEFMVDNLKW 131
Cdd:pfam04916   1 ARAYFNDSVNTTGWGFLEIET-NSVYSDTLQAYAAGFLEGYLTAELIYDHYSNTFPAYCKNSTEFCDPkLRAFLEENLKW 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   132 MEQEIRENPEDEYWQQVNLTVNQLFGLIHGYENQlGAEIDFKQIAVHPIFMIQIAGDLEDLAMKFKKPENP---KKVFSG 208
Cdd:pfam04916  80 MRKQVKENPDDPYWRQVGLVYAQLDGLVAGYNAR-AASDKRKPLTFFQILLLNLAGDLEDLVPALTPPKNSsaaKFKMKE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   209 PGHCSALVKLLPKNEDILFSHVTWSSYGTMLRINKKYSFKTGD----PGQIYSFSSYPASITSTDDFVLTSAKLAILETT 284
Cdd:pfam04916 159 PGHCSALIKLLPGFEDLLFGHTTWSSYSAMLRIYKHYTFPVSDravvPGTTVSFSSYPGLLSSLDDFYITSSGLAVMETT 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   285 IGNYNEKSLDLITPNTVLTWIRAEIAHRTASSGLQWAEAFGRHNSGTYNNEWVVVDYKQFHRGKEVQPetGIIHVVEQMP 364
Cdd:pfam04916 239 NGIFNQTLYKLIKPSSVLTWQRVMVANRLAHSGREWAEIFSRYNSGTYNNQWMVLDYKLFTPGQELPD--GTFWVVEQIP 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   365 GHIVHSDKTAHLFRETYWPGYNQPYYKQIIRFSDTDKMVEKFGDWYSYDKTPRALIFKRDHNTVTDMSSMIALMRSNNYT 444
Cdd:pfam04916 317 GYIEASDVTAVLNRTGYWPSYNIPYFPEIYNISGYPAMVEKYGDWFSYDLTPRAKIFRRDQGNVTDLESMKALMRYNNYK 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555642   445 KDPLSKCdcnppySAENAIACRSDLNPLNgtypfkslGFRDHGAIDVKVTNSKLINSLQFTAVSGPPggvTKDVPIFDWK 524
Cdd:pfam04916 397 KDPLSKG------SPENAISARGDLNPAG--------GHRAFGAIDTKVTNYALVLSLQARAISGPT---TDTQPPFDWS 459
                         490       500
                  ....*....|....*....|....
gi 17555642   525 TSPLREKVPHFGQPDRWNFAPVTY 548
Cdd:pfam04916 460 SSPFFNVTRHQGHPDVWNFDFVTM 483
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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