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Conserved domains on  [gi|188497661|ref|NP_598678|]
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MLX-interacting protein isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NES2-NLS_MLXIP cd21772
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 121-237 4.62e-90

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in MLX-interacting protein (MLXIP), and similar proteins; MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. It binds DNA by forming a heterodimer with Max-like protein (MLX) and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. MLXIP may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


:

Pssm-ID: 439288  Cd Length: 117  Bit Score: 281.18  E-value: 4.62e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 121 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRR 200
Cdd:cd21772    1 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRR 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 188497661 201 PEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHK 237
Cdd:cd21772   81 PEAIATEGKYWKRRIEIVIREYHKWRTYFKKRLQKHK 117
bHLH_SF super family cl00081
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 717-785 6.31e-38

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


The actual alignment was detected with superfamily member cd19688:

Pssm-ID: 469605  Cd Length: 72  Bit Score: 135.85  E-value: 6.31e-38
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 188497661 717 KNRQ-KHISAEQKRRFNIRMGFNTLNSLISNN--SKQTSHAITLQKTMEYITKLQQERMQMQEEARRLREEI 785
Cdd:cd19688    1 KNRRmKHISAEQKRRFNIKICFDTLNSLVSTLknSKPISNAITLQKTVEYIAKLQQERTQMQEETKRLREEI 72
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 348-699 1.40e-13

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 75.36  E-value: 1.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  348 PPPSSLPAADPSSPPSqgnilPNTALPPASLPNSLITSSAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEPPLSVPQP 427
Cdd:PHA03247 2612 APPSPLPPDTHAPDPP-----PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  428 FLPVFTMTLLSPGPAPAPVPTalplvPSPAPTLNPPTPPAFLQPQKFAGVSKSTPVITHTASATLTHDASATtfsqnqgl 507
Cdd:PHA03247 2687 AARPTVGSLTSLADPPPPPPT-----PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG-------- 2753

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  508 vitahhPTPSSSPCALALSPVPQPPA--VGPPQPHLTFIHPKPVSLTGVRHKQPPKIVPAPKPEPVSLVLKNACIAPAAF 585
Cdd:PHA03247 2754 ------PARPARPPTTAGPPAPAPPAapAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP 2827

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  586 SGQPQKVIMTsAPLKREGILASTVSPSNVVIASAAITRASGVTEFLSHSTSSQPSPVSRLFSPSTVQDSlvkgEQVSLHG 665
Cdd:PHA03247 2828 LPPPTSAQPT-APPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST----ESFALPP 2902

                         330       340       350
                  ....*....|....*....|....*....|....
gi 188497661  666 GSPQVPATGSSRDCPNSGQASPCPSEQSPSPQSP 699
Cdd:PHA03247 2903 DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP 2936
 
Name Accession Description Interval E-value
NES2-NLS_MLXIP cd21772
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 121-237 4.62e-90

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in MLX-interacting protein (MLXIP), and similar proteins; MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. It binds DNA by forming a heterodimer with Max-like protein (MLX) and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. MLXIP may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439288  Cd Length: 117  Bit Score: 281.18  E-value: 4.62e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 121 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRR 200
Cdd:cd21772    1 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRR 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 188497661 201 PEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHK 237
Cdd:cd21772   81 PEAIATEGKYWKRRIEIVIREYHKWRTYFKKRLQKHK 117
bHLHzip_MLXIP cd19688
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and ...
 717-785 6.31e-38

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and similar proteins; MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm.


Pssm-ID: 381531  Cd Length: 72  Bit Score: 135.85  E-value: 6.31e-38
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 188497661 717 KNRQ-KHISAEQKRRFNIRMGFNTLNSLISNN--SKQTSHAITLQKTMEYITKLQQERMQMQEEARRLREEI 785
Cdd:cd19688    1 KNRRmKHISAEQKRRFNIKICFDTLNSLVSTLknSKPISNAITLQKTVEYIAKLQQERTQMQEETKRLREEI 72
PHA03247 PHA03247
large tegument protein UL36; Provisional
 348-699 1.40e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 75.36  E-value: 1.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  348 PPPSSLPAADPSSPPSqgnilPNTALPPASLPNSLITSSAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEPPLSVPQP 427
Cdd:PHA03247 2612 APPSPLPPDTHAPDPP-----PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  428 FLPVFTMTLLSPGPAPAPVPTalplvPSPAPTLNPPTPPAFLQPQKFAGVSKSTPVITHTASATLTHDASATtfsqnqgl 507
Cdd:PHA03247 2687 AARPTVGSLTSLADPPPPPPT-----PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG-------- 2753

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  508 vitahhPTPSSSPCALALSPVPQPPA--VGPPQPHLTFIHPKPVSLTGVRHKQPPKIVPAPKPEPVSLVLKNACIAPAAF 585
Cdd:PHA03247 2754 ------PARPARPPTTAGPPAPAPPAapAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP 2827

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  586 SGQPQKVIMTsAPLKREGILASTVSPSNVVIASAAITRASGVTEFLSHSTSSQPSPVSRLFSPSTVQDSlvkgEQVSLHG 665
Cdd:PHA03247 2828 LPPPTSAQPT-APPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST----ESFALPP 2902

                         330       340       350
                  ....*....|....*....|....*....|....
gi 188497661  666 GSPQVPATGSSRDCPNSGQASPCPSEQSPSPQSP 699
Cdd:PHA03247 2903 DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP 2936
HLH pfam00010
Helix-loop-helix DNA-binding domain;
719-768 8.37e-09

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 52.08  E-value: 8.37e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 188497661  719 RQKHISAEQKRRFNIRMGFNTLNSLI--SNNSKQTSHAITLQKTMEYITKLQ 768
Cdd:pfam00010   2 REAHNERERRRRDRINDAFDELRELLptLPPDKKLSKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
725-770 1.30e-08

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 51.84  E-value: 1.30e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 188497661   725 AEQKRRFNIRMGFNTLNSLI--SNNSKQTSHAITLQKTMEYITKLQQE 770
Cdd:smart00353   3 RERRRRRKINEAFDELRSLLptLPKNKKLSKAEILRLAIEYIKSLQEE 50
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 369-699 2.35e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.22  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  369 PNTALPPASLPNSLITSSAAPSLDPTegqgcertSQTVDPFIQPADFGPSEPPLSVPQPFLPVFTMTLLSPGPAPAPVPT 448
Cdd:pfam03154 177 QSGAASPPSPPPPGTTQAATAGPTPS--------APSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPP 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  449 ALPLVPSPAPTLNPPTPpafLQPQKFAGVSKSTPVITHTASATLTHDASATTFSqnqglvitahhPTPSSSPCALALSPV 528
Cdd:pfam03154 249 LQPMTQPPPPSQVSPQP---LPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFP-----------LTPQSSQSQVPPGPS 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  529 PQPPAVGPPQPHLtfihpkPVSLTGVRHKQPPKIVPAPkPEPVSLvlknACIAPAAFSGQPQKVIMTSAPLKREGILAST 608
Cdd:pfam03154 315 PAAPGQSQQRIHT------PPSQSQLQSQQPPREQPLP-PAPLSM----PHIKPPPTTPIPQLPNPQSHKHPPHLSGPSP 383

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  609 VS-PSNVVIASAAITRASGVTEflsHSTSSQPSPVSRLFSPSTVQDSLVkgeQVSLHGGSPQVPATGSSRdcPNSGQASP 687
Cdd:pfam03154 384 FQmNSNLPPPPALKPLSSLSTH---HPPSAHPPPLQLMPQSQQLPPPPA---QPPVLTQSQSLPPPAASH--PPTSGLHQ 455

                         330
                  ....*....|..
gi 188497661  688 CPSeQSPSPQSP 699
Cdd:pfam03154 456 VPS-QSPFPQHP 466
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 349-542 2.13e-03

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 41.39  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 349 PPSSLPAADPSSPPSQGNILPNTALPPASLPNSLITS---SAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEP-PLSV 424
Cdd:cd23959   56 PLYGAVSPEGENPFDGPGLVTASTVSDCYVGNANFYEvdmSDAFAMAPDESLGPFRAARVPNPFSASSSTQRETHkTAQV 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 425 PQPFlpvftmtllsPGPAPAPVPTA--LPLVPSPAPTLNPPTPPAFLQPQKFAGVSKSTPVITHTASATLTHDASATTFS 502
Cdd:cd23959  136 APPK----------AEPQTAPVTPFgqLPMFGQHPPPAKPLPAAAAAQQSSASPGEVASPFASGTVSASPFATATDTAPS 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 188497661 503 QNQGLVITAHHPTPSSSPCALALSPVPQPPAVGPPQPHLT 542
Cdd:cd23959  206 SGAPDGFPAEASAPSPFAAPASAASFPAAPVANGEAATPT 245
 
Name Accession Description Interval E-value
NES2-NLS_MLXIP cd21772
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 121-237 4.62e-90

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in MLX-interacting protein (MLXIP), and similar proteins; MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. It binds DNA by forming a heterodimer with Max-like protein (MLX) and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. MLXIP may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439288  Cd Length: 117  Bit Score: 281.18  E-value: 4.62e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 121 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRR 200
Cdd:cd21772    1 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRR 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 188497661 201 PEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHK 237
Cdd:cd21772   81 PEAIATEGKYWKRRIEIVIREYHKWRTYFKKRLQKHK 117
NES2-NLS_ChREBP cd21771
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 121-237 5.29e-73

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), and similar proteins; ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a large transcription factor that functions at two levels, nuclear localization and DNA binding. It binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. ChREBP contains functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439287  Cd Length: 116  Bit Score: 235.25  E-value: 5.29e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 121 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSvDVDEHRR 200
Cdd:cd21771    1 SIDPTLTRLFECMSLAYSGKLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYIQYVEKRKNPVCGFVTPLEGS-EADEHRK 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 188497661 201 PEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHK 237
Cdd:cd21771   80 PEAVVLEGNYWKRRIEVVMKEYHKWRIYYKKRLRKSS 116
NES2-NLS_ChREBP-like cd21739
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 121-233 3.43e-67

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), MLX-interacting protein (MLXIP), and similar proteins; This family includes two transcription factors: ChREBP and MLXIP. ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), functions at two levels; nuclear localization and DNA binding. ChREBP binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. MLXIP binds DNA by forming a heterodimer with Max-like protein (MLX), and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. Members in this family may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439286  Cd Length: 113  Bit Score: 219.44  E-value: 3.43e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 121 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLdgsvDVDEHRR 200
Cdd:cd21739    1 AIDESLTKLFKCLTLAYSGKLTSPKWKNFKGLKLRWKDKIRLNNAIWREWHMQFVKKKKPPVCQFAVPL----DDDTHKK 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 188497661 201 PEAITTEGKYWKSRIEIVIREYHKWRTYFKKRL 233
Cdd:cd21739   77 PEAVVLEGKYWKRRLETVVREYKKWRLFYKDKL 109
bHLHzip_MLXIP cd19688
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and ...
 717-785 6.31e-38

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and similar proteins; MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm.


Pssm-ID: 381531  Cd Length: 72  Bit Score: 135.85  E-value: 6.31e-38
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 188497661 717 KNRQ-KHISAEQKRRFNIRMGFNTLNSLISNN--SKQTSHAITLQKTMEYITKLQQERMQMQEEARRLREEI 785
Cdd:cd19688    1 KNRRmKHISAEQKRRFNIKICFDTLNSLVSTLknSKPISNAITLQKTVEYIAKLQQERTQMQEETKRLREEI 72
bHLHzip_MLXIP_like cd11405
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), ...
 718-785 5.32e-29

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381411 [Multi-domain]  Cd Length: 74  Bit Score: 110.44  E-value: 5.32e-29
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 188497661 718 NRQKHISAEQKRRFNIRMGFNTLNSLI----SNNSKQTSHAITLQKTMEYITKLQQERMQMQEEARRLREEI 785
Cdd:cd11405    3 RRLSHISAEQKRRFNIKSGFDTLQSLIpslgQNPNQKVSKAAMLQKAAEYIKSLKRERQQMQEEAEQLRQEI 74
bHLHzip_MLXIPL cd19689
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) ...
 719-785 1.97e-26

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins; MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381532  Cd Length: 76  Bit Score: 103.12  E-value: 1.97e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 188497661 719 RQKHISAEQKRRFNIRMGFNTLNSLISNNSKQ----TSHAITLQKTMEYITKLQQERMQMQEEARRLREEI 785
Cdd:cd19689    6 RITHISAEQKRRFNIKLGFDTLHSLVTTLSSQpsikISKATTLQKTAEYISKLQQERAQLQEEAQRLRDQI 76
PHA03247 PHA03247
large tegument protein UL36; Provisional
 348-699 1.40e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 75.36  E-value: 1.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  348 PPPSSLPAADPSSPPSqgnilPNTALPPASLPNSLITSSAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEPPLSVPQP 427
Cdd:PHA03247 2612 APPSPLPPDTHAPDPP-----PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  428 FLPVFTMTLLSPGPAPAPVPTalplvPSPAPTLNPPTPPAFLQPQKFAGVSKSTPVITHTASATLTHDASATtfsqnqgl 507
Cdd:PHA03247 2687 AARPTVGSLTSLADPPPPPPT-----PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG-------- 2753

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  508 vitahhPTPSSSPCALALSPVPQPPA--VGPPQPHLTFIHPKPVSLTGVRHKQPPKIVPAPKPEPVSLVLKNACIAPAAF 585
Cdd:PHA03247 2754 ------PARPARPPTTAGPPAPAPPAapAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP 2827

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  586 SGQPQKVIMTsAPLKREGILASTVSPSNVVIASAAITRASGVTEFLSHSTSSQPSPVSRLFSPSTVQDSlvkgEQVSLHG 665
Cdd:PHA03247 2828 LPPPTSAQPT-APPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST----ESFALPP 2902

                         330       340       350
                  ....*....|....*....|....*....|....
gi 188497661  666 GSPQVPATGSSRDCPNSGQASPCPSEQSPSPQSP 699
Cdd:PHA03247 2903 DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP 2936
bHLHzip_Mlx cd19687
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar ...
 719-785 1.61e-12

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription.


Pssm-ID: 381530 [Multi-domain]  Cd Length: 76  Bit Score: 63.59  E-value: 1.61e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 188497661 719 RQKHISAEQKRRFNIRMGFNTLNSLI-------SNNSKQTSHAITLQKTMEYITKLQQERMQMQEEARRLREEI 785
Cdd:cd19687    3 REAHTQAEQKRRDAIKKGYDDLQDIVptcqqqdDIGSQKLSKATILQRSIDYIQFLHQQKKKQEEELSALRKEV 76
HLH pfam00010
Helix-loop-helix DNA-binding domain;
719-768 8.37e-09

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 52.08  E-value: 8.37e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 188497661  719 RQKHISAEQKRRFNIRMGFNTLNSLI--SNNSKQTSHAITLQKTMEYITKLQ 768
Cdd:pfam00010   2 REAHNERERRRRDRINDAFDELRELLptLPPDKKLSKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
725-770 1.30e-08

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 51.84  E-value: 1.30e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 188497661   725 AEQKRRFNIRMGFNTLNSLI--SNNSKQTSHAITLQKTMEYITKLQQE 770
Cdd:smart00353   3 RERRRRRKINEAFDELRSLLptLPKNKKLSKAEILRLAIEYIKSLQEE 50
bHLHzip_scCBP1 cd11398
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae ...
 719-779 2.43e-08

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae centromere-binding protein 1 (CBP-1) and similar proteins; CBP-1, also termed centromere promoter factor 1 (CPF1), or centromere-binding factor 1 (CBF1), is a bHLHzip protein that is required for chromosome stability and methionine prototrophy. It binds as a homodimer to the centromere DNA elements I (CDEI, GTCACATG) region of the centromere that is required for optimal centromere function.


Pssm-ID: 381404 [Multi-domain]  Cd Length: 89  Bit Score: 51.96  E-value: 2.43e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 188497661 719 RQKHISAEQKRRFNIRMGFNTLNSLISNNSKQTSHAITLQKTMEYITKLQQERMQMQEEAR 779
Cdd:cd11398    8 RDNHKEVERRRRENINEGINELAALVPGNAREKNKGAILARAVEYIQELQETEAKNIEKWT 68
bHLH_ScINO2_like cd11388
basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and ...
 719-779 2.56e-08

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins; INO2 is a positive regulatory factor required for depression of the co-regulated phospholipid biosynthetic enzymes in Saccharomyces cerevisiae. It is also involved in the expression of ITR1.


Pssm-ID: 381394  Cd Length: 68  Bit Score: 51.20  E-value: 2.56e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 188497661 719 RQKHISAEQKRRFNIRMGFNTLNSLI----SNNSKQTSHAITLQKTMEYITKLQQERMQMQEEAR 779
Cdd:cd11388    4 KWKHVEAEKKRRNQIKKGFEDLINLInyprNNNEKRISKSELLNKAVDDIRGLLKANEQLQEEIN 68
bHLHzip_Mlx_like cd11404
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, ...
 718-789 4.98e-08

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription. The family also includes Saccharomyces cerevisiae INO4, which is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast.


Pssm-ID: 381410 [Multi-domain]  Cd Length: 70  Bit Score: 50.76  E-value: 4.98e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 188497661 718 NRQKHISAEQKRRFNIRMGFNTLNSLISNNSKQ-TSHAITLQKTMEYITKLqqermqmQEEARRLREEIEELN 789
Cdd:cd11404    2 RRLNHVRSEKKRRELIKKGYDELCALVPGLDPQkRTKADILQKAADWIQEL-------KEENEKLEEQLDELK 67
bHLH_scINO4_like cd11403
basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar ...
 719-785 5.13e-08

basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar proteins; INO4 is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast. INO4 dimerizes with INO2 and binds to an UAS DNA element to control expression of the genes whose expression is inositol-responsive.


Pssm-ID: 381409  Cd Length: 71  Bit Score: 50.54  E-value: 5.13e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 188497661 719 RQKHISAEQKRRFNIRMGFNTLNSLISNNSKQT--SHAITLQKTMEYITKLQQERMQMQEEARRLREEI 785
Cdd:cd11403    3 KENHISSEHKRREAIREGFDRLCAIVPALSSSQsrSEAVVYVKTVEYLKELYERRAKLRSQLRSKGVEI 71
PHA03247 PHA03247
large tegument protein UL36; Provisional
 344-772 1.54e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 1.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  344 GSMLPPPSSLPAADPssppsqgnilPNTALPPASLPNSLITSSAAPSLDPTegqgcertsqtvDPFIQPADFGPSEPPLS 423
Cdd:PHA03247 2765 GPPAPAPPAAPAAGP----------PRRLTRPAVASLSESRESLPSPWDPA------------DPPAAVLAPAAALPPAA 2822

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  424 VPQPFLPVFTMTL-LSPGPAPAPVPTALPLVPSPAP----TLNPPTPPAFLQPqkfagVSKSTPVITHTASATLthdaSA 498
Cdd:PHA03247 2823 SPAGPLPPPTSAQpTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKP-----AAPARPPVRRLARPAV----SR 2893

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  499 TTFSQNQGLVITAHHPTPSSSPCALALSPVPQPPAVGPPQPHLTFIHPKPvsltgvrhkqPPKIVPAPKPEPVSLV--LK 576
Cdd:PHA03247 2894 STESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL----------APTTDPAGAGEPSGAVpqPW 2963

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  577 NACIAPAAFSgQPQKVIMTSAPlKREGILASTVSPSnvviaSAAITRASGVTEFLSHSTSSQPSPVS---RLFSPSTVQD 653
Cdd:PHA03247 2964 LGALVPGRVA-VPRFRVPQPAP-SREAPASSTPPLT-----GHSLSRVSSWASSLALHEETDPPPVSlkqTLWPPDDTED 3036

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  654 SlvkgEQVSLHGGSPQVPATGSSRDCPNSGQASPCPSEQSPSPQSPQNNCSGKSTDPKNVAAlknrqkhiSAEQKRRFNI 733
Cdd:PHA03247 3037 S----DADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSA--------NAALSRRYVR 3104

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 188497661  734 RMGFNTLNSLIS------NNSKQTSHAItLQKTMEYITKLQQERM 772
Cdd:PHA03247 3105 STGRSALAVLIEacrrirRQLRRTRHAL-LDRSGAVLTGLYHVRM 3148
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 726-769 1.65e-07

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 48.29  E-value: 1.65e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 188497661 726 EQKRRFNIRMGFNTLNSLISN--NSKQTSHAITLQKTMEYITKLQQ 769
Cdd:cd00083    1 ERRRRDKINDAFEELKRLLPElpDSKKLSKASILQKAVEYIRELQS 46
PHA03247 PHA03247
large tegument protein UL36; Provisional
 339-573 1.75e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 1.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  339 SRSIFGSMLPPPSSLPAADPSSPPSQGNILPNTALPPASLPNSLI---TSS--AAPSLDPTEGQGCERTSQTVDPFIQPA 413
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLpppTSAqpTAPPPPPGPPPPSLPLGGSVAPGGDVR 2863

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  414 DFGPSEPPLSVP--QPFLPVFTMtllsPGPAPAPVPTALPLVPSPAPTLNPPTPPAFLQPQKFAGVSKSTpvithtasat 491
Cdd:PHA03247 2864 RRPPSRSPAAKPaaPARPPVRRL----ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQP---------- 2929

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  492 lthdasattfsqnqglviTAHHPTPSSSPCALALSPVPQP---PAVGPPQPHLTFIHPKPVSLTGVRHKQPPKIVPAPKP 568
Cdd:PHA03247 2930 ------------------QPPPPPPPRPQPPLAPTTDPAGagePSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS 2991


                  ....*
gi 188497661  569 EPVSL 573
Cdd:PHA03247 2992 STPPL 2996
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 348-708 5.01e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.02  E-value: 5.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  348 PPPSSLPAADPSSPPSQGnilPNTALPPASLPNSLITSSAAPSLDPTEGQGCERTSQTvdpfiqPADFGPSEPPLSVPQP 427
Cdd:PHA03307   53 VTVVAGAAACDRFEPPTG---PPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPT------PPGPSSPDPPPPTPPP 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  428 flpvftmtlLSPGPAPAP-VPTALPLVPSPAPTLNPPTPPAFLQPqkfagvsksTPVITHTASATLTHDASATTfsqnqg 506
Cdd:PHA03307  124 ---------ASPPPSPAPdLSEMLRPVGSPGPPPAASPPAAGASP---------AAVASDAASSRQAALPLSSP------ 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  507 lviTAHHPTPSSSPCALALSPVPQPPAVGPPQPHLTFIH----PKPVSLTGVRHKQPPKIVPAPKPEPVSLVL--KNACI 580
Cdd:PHA03307  180 ---EETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISAsassPAPAPGRSAADDAGASSSDSSSSESSGCGWgpENECP 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  581 APAAFSGQPQKVIMTSAPLKREGILASTVSPSnvviasAAITRASGVTEFLSHSTSSQPSPVSRLFSPSTVQDSLVKGEQ 660
Cdd:PHA03307  257 LPRPAPITLPTRIWEASGWNGPSSRPGPASSS------SSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTS 330

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 188497661  661 VSLHGGSPQVPATGSSRDCPNSGQASPCPSEQSPSPQSPQNNCSGKST 708
Cdd:PHA03307  331 SSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSP 378
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 348-699 5.14e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.02  E-value: 5.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  348 PPPSSLPAADPSSPPSQGNILPNTALPPASLPNSLitSSAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEPPLSVPQP 427
Cdd:PHA03307  100 PAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDL--SEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLS 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  428 flpvftmtlLSPGPAPAPVPTALPLVPSPAPTLNPPTPPAfLQPQKFAGVSKSTPVITHTASATLTHDASATTFSQNQGL 507
Cdd:PHA03307  178 ---------SPEETARAPSSPPAEPPPSTPPAAASPRPPR-RSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGC 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  508 VITAHHPTPSSSPcalalSPVPQPPAVGPPQPHltfIHPKPVSLTGVRHKQPPKivPAPKPEPvslvlknacIAPAAFSG 587
Cdd:PHA03307  248 GWGPENECPLPRP-----APITLPTRIWEASGW---NGPSSRPGPASSSSSPRE--RSPSPSP---------SSPGSGPA 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  588 QPQKVIMTSAPLKREGILASTvSPSNVVIASAAITRASGVTeflSHSTSSQPSPVSRLFSPSTVQDSLVKGEQVSLHGGS 667
Cdd:PHA03307  309 PSSPRASSSSSSSRESSSSST-SSSSESSRGAAVSPGPSPS---RSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGR 384

                         330       340       350
                  ....*....|....*....|....*....|..
gi 188497661  668 PQVPATGSSRDCPNSGQASPCPSEQSPSPQSP 699
Cdd:PHA03307  385 PTRRRARAAVAGRARRRDATGRFPAGRPRPSP 416
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
 719-789 3.15e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 46.00  E-value: 3.15e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 188497661 719 RQKHISAEQKRRFNIRMGFNTLNSLI---SNNSKqTSHAITLQKTMEYITKLQQERMQMQEEARRLREEIEELN 789
Cdd:cd11400    2 RRLHNVLERQRRNDLKNSFEKLRDLVpelADNEK-ASKVVILKKATEYIKQLQQEEKKLEKEKDKLKARNEQLR 74
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
402-674 6.91e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 49.87  E-value: 6.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 402 TSQTVDPFIQPADFGPSEPPLSvPQPFLPvFTMTLLS---------------PGPAPAPVPTALP-----LVPSPAPTLN 461
Cdd:PRK12323 325 DAQEVQLFYQIANLGRSELALA-PDEYAG-FTMTLLRmlafrpgqsgggagpATAAAAPVAQPAPaaaapAAAAPAPAAP 402

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 462 PPTPPAFLQPQKFAGVSKSTPVITHTASATLthdASATTFSQNQGLVITAHHPTPSSSPCALALSPVPQPPAVGPPQPhl 541
Cdd:PRK12323 403 PAAPAAAPAAAAAARAVAAAPARRSPAPEAL---AAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAA-- 477

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 542 tfihpkpvsltgvrhKQPPKIVPAPKPEPVSLVLKNACIAPAAFsgqPQKVIMTSAPLKREGILASTVSPSNVVIASAAI 621
Cdd:PRK12323 478 ---------------AAPARAAPAAAPAPADDDPPPWEELPPEF---ASPAPAQPDAAPAGWVAESIPDPATADPDDAFE 539

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 188497661 622 TRASGVTEFLSHSTSSQPSPVSRLFSPSTVQDSLVKGEQVSLHGGSPQVPATG 674
Cdd:PRK12323 540 TLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLPVRG 592
bHLHzip_MGA_like cd19682
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) ...
 719-782 1.39e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) family; The MGA family includes MGA, Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins. MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites. spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381525 [Multi-domain]  Cd Length: 65  Bit Score: 43.42  E-value: 1.39e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 188497661 719 RQKHISAEQKRRFNIRMGFNTLNSLI-SNNSKQTSHAITLQKTMEYITKLQQERMQMQEEARRLR 782
Cdd:cd19682    1 RLRHKKRERERRSELRELFDKLKQLLgLDSDEKASKLAVLTEAIEEIQQLKREEDELQKEKARLT 65
bHLHzip_TFE3 cd18928
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and ...
 714-793 1.44e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins; TFE3, also termed Class E basic helix-loop-helix protein 33 (bHLHe33), is a bHLHzip transcription factor that is involved in B cell function. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF.


Pssm-ID: 381498 [Multi-domain]  Cd Length: 91  Bit Score: 44.27  E-value: 1.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 714 AALKNRQK---HISAEQKRRFNIRMGFNTLNSLISNNSK---QTSHAITLQKTMEYITKLQQERMQMQEEARRLReEIEE 787
Cdd:cd18928    4 AFLKERQKkdnHNLIERRRRFNINDRIKELGTLIPKSTDpemRWNKGTILKASVDYIRKLQKEQQRSKEIEMRQR-KLEQ 82


                 ....*.
gi 188497661 788 LNTTII 793
Cdd:cd18928   83 ANRSLQ 88
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 369-699 2.35e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.22  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  369 PNTALPPASLPNSLITSSAAPSLDPTegqgcertSQTVDPFIQPADFGPSEPPLSVPQPFLPVFTMTLLSPGPAPAPVPT 448
Cdd:pfam03154 177 QSGAASPPSPPPPGTTQAATAGPTPS--------APSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPP 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  449 ALPLVPSPAPTLNPPTPpafLQPQKFAGVSKSTPVITHTASATLTHDASATTFSqnqglvitahhPTPSSSPCALALSPV 528
Cdd:pfam03154 249 LQPMTQPPPPSQVSPQP---LPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFP-----------LTPQSSQSQVPPGPS 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  529 PQPPAVGPPQPHLtfihpkPVSLTGVRHKQPPKIVPAPkPEPVSLvlknACIAPAAFSGQPQKVIMTSAPLKREGILAST 608
Cdd:pfam03154 315 PAAPGQSQQRIHT------PPSQSQLQSQQPPREQPLP-PAPLSM----PHIKPPPTTPIPQLPNPQSHKHPPHLSGPSP 383

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  609 VS-PSNVVIASAAITRASGVTEflsHSTSSQPSPVSRLFSPSTVQDSLVkgeQVSLHGGSPQVPATGSSRdcPNSGQASP 687
Cdd:pfam03154 384 FQmNSNLPPPPALKPLSSLSTH---HPPSAHPPPLQLMPQSQQLPPPPA---QPPVLTQSQSLPPPAASH--PPTSGLHQ 455

                         330
                  ....*....|..
gi 188497661  688 CPSeQSPSPQSP 699
Cdd:pfam03154 456 VPS-QSPFPQHP 466
PHA03378 PHA03378
EBNA-3B; Provisional
 263-568 3.19e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.75  E-value: 3.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 263 PVPMEEDSLLDTDMLMSEFSDTLFSTlsSHQPvawpnPREIAHLGNADMIQPGLIPLQPNLDFMDTFEPFQdlfsssrSI 342
Cdd:PHA03378 625 PMPLRPIPMRPLRMQPITFNVLVFPT--PHQP-----PQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQ-------WA 690

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 343 FGSMLPPPSSL-PAADPSSPPSQGN---ILPNTALPPASLPNSLITSSAAPS-LDPTEGQGCERTSQTVDPFIQPADFGP 417
Cdd:PHA03378 691 PGTMQPPPRAPtPMRPPAAPPGRAQrpaAATGRARPPAAAPGRARPPAAAPGrARPPAAAPGRARPPAAAPGRARPPAAA 770

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 418 SEPPLSVPQPFLPVFTMTLLSPGPAPAPVPTALP---LVPSPAPTLNPPTPPAFLQPQKFAGVSKSTPVI------THTA 488
Cdd:PHA03378 771 PGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPtsmQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLkkpaalERQA 850

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 489 SATLTHD-ASATTFSQNQGLVITAHHPTPSS------SPCALALSPVPQPPA-------VGPPQPHLTFIHPKPVSLTGV 554
Cdd:PHA03378 851 AAGPTPSpGSGTSDKIVQAPVFYPPVLQPIQvmrqlgSVRAAAASTVTQAPTeytgerrGVGPMHPTDIPPSKRAKTDAY 930

                        330
                 ....*....|....
gi 188497661 555 RHKQPPKIVPAPKP 568
Cdd:PHA03378 931 VESQPPHGGQSHSF 944
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 348-697 3.62e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.84  E-value: 3.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  348 PPPSSLPAADPSSPPSQGNILPNTALPPASLPNSLITSSAAP-SLDPTEGQGCERTSQTVDPFIQPADfGPSEPPLSVPQ 426
Cdd:pfam03154 186 PPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhTLIQQTPTLHPQRLPSPHPPLQPMT-QPPPPSQVSPQ 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  427 PFLPVFTMTLLSPGPAPapVPTALPLVPSPAPTLNPPTPPAFLQPQkfaGVSKSTPVITHTASATLTHDASATTFSQNQG 506
Cdd:pfam03154 265 PLPQPSLHGQMPPMPHS--LQTGPSHMQHPVPPQPFPLTPQSSQSQ---VPPGPSPAAPGQSQQRIHTPPSQSQLQSQQP 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  507 lviTAHHPTPsssPCALALSPVPQPPAVGPPQPHLTFIHPKPVSLTGVRHKQ-PPKIVPAPKPEPVSLVLKN--ACIAPA 583
Cdd:pfam03154 340 ---PREQPLP---PAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQmNSNLPPPPALKPLSSLSTHhpPSAHPP 413

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  584 AFSGQPQKVIMTSAPLKREGILASTVSPSNVVIA--SAAITRASGVTEFLSHS-TSSQPSPVSRLFSPSTVQDSLVKGEQ 660
Cdd:pfam03154 414 PLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHppTSGLHQVPSQSPFPQHPfVPGGPPPITPPSGPPTSTSSAMPGIQ 493

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 188497661  661 ------VSLHGGSPQ-----VPATGSSRDCPNSGQA--SPCPSEQSPSPQ 697
Cdd:pfam03154 494 ppssasVSSSGPVPAavscpLPPVQIKEEALDEAEEpeSPPPPPRSPSPE 543
bHLH_AtBIM_like cd11453
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like ...
 719-777 4.35e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like proteins (BIMs) and similar proteins; The family includes Arabidopsis thaliana BIM1 and its homologs (BIM2 and BIM3), which are bHLH transcription factors that interact with BES1 to regulate transcription of Brassinosteroid (BR)-induced gene. BR regulates many growth and developmental processes such as cell elongation, vascular development, senescence stress responses, and photomorphogenesis. BIM1 heterodimerize with BES1 and bind to E-box sequences present in many BR-induced promoters to regulated BR-induced genes.


Pssm-ID: 381459  Cd Length: 77  Bit Score: 42.46  E-value: 4.35e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 188497661 719 RQKHISAEQKRRFNIRMGFNTLNSLISNNSKQTSHAITLQKTMEYITKLqQERMQMQEE 777
Cdd:cd11453    4 RSKHSATEQRRRSKINERLQALRDLIPHSDQKRDKASFLLEVIEYIQAL-QEKVAKLEE 61
PHA03378 PHA03378
EBNA-3B; Provisional
 348-570 4.71e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.37  E-value: 4.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 348 PPPSSLPAADPSSPPSQGNIlPNTALPPASLPNSLITSSAAP-SLDPTEGQGCERTSQTVDPFIQPADFG------PSEP 420
Cdd:PHA03378 576 PLTSPTTSQLASSAPSYAQT-PWPVPHPSQTPEPPTTQSHIPeTSAPRQWPMPLRPIPMRPLRMQPITFNvlvfptPHQP 654

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 421 PLSVPQPFLPVFTMTLLSP-GPAPAPVPTALPLVPSPAPTLNPPTPPAFLQP--------QKFAGVSKSTPVITHTASAT 491
Cdd:PHA03378 655 PQVEITPYKPTWTQIGHIPyQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPpaappgraQRPAAATGRARPPAAAPGRA 734

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 492 LTHDASATTFSQNQGLVITAHHP----TPSSSPCALALSPVPQPPAVGPPQPhltfihpkpvsltgvrhKQPPKIVPAPK 567
Cdd:PHA03378 735 RPPAAAPGRARPPAAAPGRARPPaaapGRARPPAAAPGAPTPQPPPQAPPAP-----------------QQRPRGAPTPQ 797


                 ...
gi 188497661 568 PEP 570
Cdd:PHA03378 798 PPP 800
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
 724-774 9.42e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 41.14  E-value: 9.42e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 188497661 724 SAEQKRRFNIRMGFNTLNSLISN-NSKQTSHAITLQKTMEYITKLQQERMQM 774
Cdd:cd11419   10 SNERRRMQSINAGFQSLRTLLPHcDGEKLSKAAILQQTAEYIFSLEQEKTRL 61
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
 722-769 1.16e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 40.63  E-value: 1.16e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 188497661 722 HISAEQKRRFNIRMGFNTLNSLISNnSKQTSHAITLQKTMEYITKLQQ 769
Cdd:cd11393    1 HSIAERKRREKINERIRALRSLVPN-GGKTDKASILDEAIEYIKFLQE 47
bHLHzip_SREBP_like cd11395
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 719-785 1.48e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.


Pssm-ID: 381401 [Multi-domain]  Cd Length: 87  Bit Score: 41.16  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 719 RQKHISAEQKRRFNIRMGFNTLNSLI-----------------SNNSKQTSHAITLQKTMEYITKLQQERMQMQEEARRL 781
Cdd:cd11395    4 RLPHNAIEKRYRSNLNTKIERLRDAIpslrspegksddgglggLAPTTKLSKATILTKAIEYIRHLEQENERLEEENEEL 83


                 ....
gi 188497661 782 REEI 785
Cdd:cd11395   84 RQQV 87
bHLHzip_MITF_like cd11397
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated ...
 717-777 1.65e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated transcription factor family (MITF) family; The MITF (also known as microphthalmia-TFE, or MiT) family is a small family that contain a basic helix loop helix domain associated with a leucine zipper (bHLHZip). The MITF family comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF family can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381403  Cd Length: 69  Bit Score: 40.74  E-value: 1.65e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 717 KNRQK---HISAEQKRRFNIRMGFNTLNSLISNNS----KQTSHAItLQKTMEYITKLQ--QERMQMQEE 777
Cdd:cd11397    1 KDRQKkdnHNMIERRRRFNINDRIKELGTLLPKSNdpdmRWNKGTI-LKASVDYIRKLQkeQERLRQLEE 69
bHLH_AtAIG1_like cd11455
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar ...
 709-770 1.67e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar proteins; AIG1, also termed AtbHLH32, or EN 54, or protein target of MOOPTEROS 5, is a transcription factor required for MONOPTEROS-dependent root initiation in embryo.


Pssm-ID: 381461  Cd Length: 80  Bit Score: 41.13  E-value: 1.67e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 188497661 709 DPKNVAALKnrqKHISAEQKRRFNIRMGFNTLNSLISNNSKqTSHAITLQKTMEYITKLQQE 770
Cdd:cd11455    1 EDKALAASK---SHSEAERRRRERINSHLATLRTLLPNLSK-TDKASLLAEVVQHVKELKRQ 58
bHLHzip_spESC1_like cd19690
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) ...
 719-782 1.71e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins; spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381533  Cd Length: 65  Bit Score: 40.52  E-value: 1.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 188497661 719 RQKHISAEQKRRFNIRMGFNTLNSLI--SNNSKQTSHAItLQKTMEYITKLQQERMQMQEEARRLR 782
Cdd:cd19690    1 RVSHKLAERKRRKEMKELFEDLRDALpqERGTKASKWEI-LTKAISYIQQLKRHIRELRSEVNDLR 65
CiPC pfam15800
Clock interacting protein circadian; CiPC is a family of proteins found in eukaryotes. The ...
 534-785 2.49e-04

Clock interacting protein circadian; CiPC is a family of proteins found in eukaryotes. The protein was identified in sheep as a gene-orthologue involved in regulation of the circadian clock. Proteins in this family are typically between 220 and 400 amino acids in length.


Pssm-ID: 464879  Cd Length: 338  Bit Score: 44.38  E-value: 2.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  534 VGPPQPHLTFIHP---KPVSLTGVRHKQP------------PKIVPAPKPEPVSLVLKNaciapaafSGQPQKVimtsap 598
Cdd:pfam15800  83 VIPAQPQLLFLQPpvpPPISPSPSGDKKKdsrnylpilnsyPKIAPHPGKRGLSLTPEE--------RGEPSVS------ 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  599 lKREGILASTVSPSNVVIASAAITRASGVTEFLSHSTSSQPSPVSRLFSPSTVQDSlvKGEQVSLHGGSPQVPA-TGSSR 677
Cdd:pfam15800 149 -KRVCTERHRVSLSSAGRTSRHVPSSSPSRNFPPSAQDSNSQSSSSLLASGSPSTL--EEIHHTSSDTHKKESPlTPSSP 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  678 DCPNSGQASPCPSEQSPSPQSPQNNCSGKSTDPKNVAALKNRQKHISAEQKRRFNirmgfNTLNSLisnnSKQTSHAITL 757
Cdd:pfam15800 226 SPPLSTSSPSPSSTESFLPPSPPSAPISSPADPGQKPESPGSVLEQRQSKHKRFQ-----NTLVIL----HKSGLLGITL 296

                         250       260       270
                  ....*....|....*....|....*....|.
gi 188497661  758 qKTMEYI---TKLQQERMQMQEEARRLREEI 785
Cdd:pfam15800 297 -KTKELIrqnQATQRELDRLKEQTQLFVEAI 326
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 337-710 2.71e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 44.57  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  337 SSSRSIFGSMLPPPSslpaadpSSPPSQGNILPNTALPPASLPNSLITSSAAPSlDPTEGQGCERTSQTVDPFIQPADFG 416
Cdd:pfam17823 120 SSSPSSAAQSLPAAI-------AALPSEAFSAPRAAACRANASAAPRAAIAAAS-APHAASPAPRTAASSTTAASSTTAA 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  417 PSEPPLSVPQpflpvftmtllspgpAPAPVPTALPLVPSPAPTLNPPTPPAflqpqkFAGVSKSTPVI-THTASATLTHD 495
Cdd:pfam17823 192 SSAPTTAASS---------------APATLTPARGISTAATATGHPAAGTA------LAAVGNSSPAAgTVTAAVGTVTP 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  496 ASATTFSQNQGLVITAHHPTPSSSPCALALSPVPQPPAVGPPQPHLTFIHPKPVSLTGVRHKQPPKIVPAPKPEPVSLVL 575
Cdd:pfam17823 251 AALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEPTPSPSNT 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  576 KNACIAPAAFSGQPQKVIMTSAPLKREGIlASTVspsnvviasaAITRASGVTEFLSHSTSSQPSPV---SRLFSPSTVQ 652
Cdd:pfam17823 331 TLEPNTPKSVASTNLAVVTTTKAQAKEPS-ASPV----------PVLHTSMIPEVEATSPTTQPSPLlptQGAAGPGILL 399

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 188497661  653 DSlvkgEQVslhgGSPQVPATGSSRDCPNSGQASPCPSEQSPSPqSPQNNCSGKSTDP 710
Cdd:pfam17823 400 AP----EQV----ATEATAGTASAGPTPRSSGDPKTLAMASCQL-STQGQYLVVTTDP 448
bHLH_SOHLH_like cd19683
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ...
 717-768 3.05e-04

basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family and similar proteins; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation. The family also includes transcription factor-like 5 protein (TCFL5) and similar proteins. TCFL5, also termed Cha transcription factor, or HPV-16 E2-binding protein 1 (E2BP-1), is a bHLH transcription factor that plays a crucial role in spermatogenesis. It regulates cell proliferation or differentiation of cells through binding to a specific DNA sequence like other bHLH molecules.


Pssm-ID: 381526  Cd Length: 58  Bit Score: 39.64  E-value: 3.05e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 188497661 717 KNRQKHISAEQKRRFNIRMGFNTLNSLISNNSKQTSHAITLQKTMEYITKLQ 768
Cdd:cd19683    1 KSRERHNAKERQRRERIKIACDQLRKLVPGCSRKTDKATVFEFTVAYIKFLR 52
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 338-708 3.53e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.52  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  338 SSRSIFGSMLPPPSSLPA---ADPSSPPSQGNILPNTALPPASLPNSLITSSAAPSLDPTegqgcerTSQTVDPfiQPAD 414
Cdd:pfam05109 450 SSTHVPTNLTAPASTGPTvstADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSP-------TSAVTTP--TPNA 520

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  415 FGPSePPLSVPQPFLPVFTMTLLSPGPApapVPTALPLVPSPAPTLNPPTPPAFLQPqkfagVSKSTPVithTASATLTH 494
Cdd:pfam05109 521 TSPT-PAVTTPTPNATSPTLGKTSPTSA---VTTPTPNATSPTPAVTTPTPNATIPT-----LGKTSPT---SAVTTPTP 588

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  495 DASATTFSQNQGLVITAHHPTPSSSPCALALSPVPQP-PAVGPPQPHLTFIHPKPVSLtgvrhkqppkivpapKPEPVSL 573
Cdd:pfam05109 589 NATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNAtSAVTTGQHNITSSSTSSMSL---------------RPSSISE 653

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  574 VLkNACIAPAAFSGQPqkvIMTSA-PLKREGIlastvspsnvviasAAITRASGVTEFLSHST-SSQPSPVSRLFSPSTV 651
Cdd:pfam05109 654 TL-SPSTSDNSTSHMP---LLTSAhPTGGENI--------------TQVTPASTSTHHVSTSSpAPRPGTTSQASGPGNS 715

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 188497661  652 QDSLVKGEqVSLHGGSPqvPATGSSRDCPnSGQASPCPSEQSPSPQSpQNNCSGKST 708
Cdd:pfam05109 716 STSTKPGE-VNVTKGTP--PKNATSPQAP-SGQKTAVPTVTSTGGKA-NSTTGGKHT 767
bHLHzip_N-Myc_like cd11456
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, ...
 719-788 4.33e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, also termed Class E basic helix-loop-helix protein 37 (bHLHe37), is a bHLHZip proto-oncogene protein that positively regulates the transcription of MYCNOS in neuroblastoma cells. It is also essential during embryonic development. N-Myc has a critical role in regulating the switch between proliferation and differentiation of progenitor cells. It binds DNA as a heterodimer with MAX. The family also includes S-Myc, encoded by rat or mouse intronless myc gene, which has apoptosis-inducing activity.


Pssm-ID: 381462 [Multi-domain]  Cd Length: 87  Bit Score: 39.89  E-value: 4.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 188497661 719 RQKHISAEQKRRFNIRMGFNTLNSLISNNSKQTSHA--ITLQKTMEYITKLQQERMQMQEEARRLREEIEEL 788
Cdd:cd11456    6 RRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAkvVILKKATEYVHSLQAEEQKLLLEKEKLQARQQQL 77
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
 722-770 4.83e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 39.16  E-value: 4.83e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 188497661 722 HISAEQKRRFNIRMGFNTLNSLISNNSKQT-----SHAITLQKTMEYITKLQQE 770
Cdd:cd11387    2 HNAVERRRRDNINEKIQELGSLVPPSRLETkdlkpNKGSILSKAVEYIRELQNQ 55
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 416-596 5.49e-04

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 44.11  E-value: 5.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661   416 GPSEPPLSVPQPFLPVFTmtllspgPAPAPVPTALPLVP-SPAPTLNPPTP-----------PAFLQPQKFAGVSKS--- 480
Cdd:pfam15324  965 REPPVAASVPGDLPTKET-------LLPTPVPTPQPTPPcSPPSPLKEPSPvktpdsspcvsEHDFFPVKEIPPEKGadt 1037

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661   481 ----TPVITHTASATLTHDASATtfsqnqglvitahhPTPSSSPCALALSPVPQPPAVGP------------PQPHLTFI 544
Cdd:pfam15324 1038 gpavSLVITPTVTPIATPPPAAT--------------PTPPLSENSIDKLKSPSPELPKPwedsdlpleeenPNSEQEEL 1103

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 188497661   545 HPKPVSLTGVRHKQPPKIV-PAPKPEPVSLVLKNACIAPAAFSGQPQKVIMTS 596
Cdd:pfam15324 1104 HPRAVVMSVARDEEPESVVlPASPPEPKPLAPPPLGAAPPSPPQSPSSSSSTL 1156
PHA03379 PHA03379
EBNA-3A; Provisional
 396-627 6.36e-04

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 43.51  E-value: 6.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 396 GQGCERTSQTVDPFIQPADFGPsEPPLSVPQPFLPVFTMTLLSPGPA------------PAPVPTALPLVPSPAPTlNPP 463
Cdd:PHA03379 395 GKLTERAREALEKASEPTYGTP-RPPVEKPRPEVPQSLETATSHGSAqvpepppvhdlePGPLHDQHSMAPCPVAQ-LPP 472

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 464 TPPAFLQP-QKFAGVSKS-----TPVITHTASATLTHDASattFSQNQGLVITAHHPTPssspcaLALSPVPQP-----P 532
Cdd:PHA03379 473 GPLQDLEPgDQLPGVVQDgrpacAPVPAPAGPIVRPWEAS---LSQVPGVAFAPVMPQP------MPVEPVPVPtvaleR 543

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 533 AVGPPQPHLTFIHP-KPVSLTGVRHK-QPPKIVPAPKPEPVSLVLKN--------ACIAPAAFSGQPQKVIMTS--APLK 600
Cdd:PHA03379 544 PVCPAPPLIAMQGPgETSGIVRVRERwRPAPWTPNPPRSPSQMSVRDrlarlraeAQPYQASVEVQPPQLTQVSpqQPME 623

                        250       260
                 ....*....|....*....|....*..
gi 188497661 601 REGILASTVSPSNVVIASAAITRASGV 627
Cdd:PHA03379 624 YPLEPEQQMFPGSPFSQVADVMRAGGV 650
bHLHzip_Mnt cd11402
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar ...
 717-799 6.44e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins; Mnt, also termed Class D basic helix-loop-helix protein 3 (bHLHd3), or Myc antagonist MNT, or protein ROX, is a bHLHZip transcriptional repressor that binds DNA as a heterodimer with MAX. It binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. Mnt has an important role as an antagonist and regulator of Myc activities and it is a potential tumor suppressor. Mnt is ubiquitously expressed. Mnt-deficient mice shown to exhibit early postnatal lethality.


Pssm-ID: 381408 [Multi-domain]  Cd Length: 77  Bit Score: 39.23  E-value: 6.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 717 KNRQKHISAEQKRRFNIRMGFNTLNSLISN-NSKQTSHAITLQKTMEYITKLQQERMQMQEEARRLREEieelnttIISC 795
Cdd:cd11402    1 GTREVHNKLEKNRRAHLKECFETLKRQIPNlDDKKTSNLNILRSALRYIQILKRKEKEYEHEMERLARE-------KIAL 73


                 ....
gi 188497661 796 QQLL 799
Cdd:cd11402   74 QQRL 77
PHA03247 PHA03247
large tegument protein UL36; Provisional
 348-699 6.82e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  348 PPPSSLPAADPSSPPSQGNilpntaLPPASLPNSLITSSAAPSLdPTEGQGCERTSQTvdpfiqpaDFGPSEPPLsvpqp 427
Cdd:PHA03247 2496 PDPGGGGPPDPDAPPAPSR------LAPAILPDEPVGEPVHPRM-LTWIRGLEELASD--------DAGDPPPPL----- 2555

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  428 flpvftmtllspgPAPAPVPTALPLVPSPAPTLNPP------------TPPAFLQPQ-------KFAGVSKSTPV--ITH 486
Cdd:PHA03247 2556 -------------PPAAPPAAPDRSVPPPRPAPRPSepavtsrarrpdAPPQSARPRapvddrgDPRGPAPPSPLppDTH 2622

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  487 TASATLTHDASATTFSQNQGLVITAHHPTPSSSPCA-------LALSPVPQPPAVGPPQ-PHLTFIHPKPVSLTGVRHKQ 558
Cdd:PHA03247 2623 APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprRARRLGRAAQASSPPQrPRRRAARPTVGSLTSLADPP 2702

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  559 PPKIVPAPKPEPVSLVLKNACIAPAAFSGQPqkvimtsaplkregilASTVSPSNVVIASAAITRASGVTEFLSHSTSSQ 638
Cdd:PHA03247 2703 PPPPTPEPAPHALVSATPLPPGPAAARQASP----------------ALPAAPAPPAVPAGPATPGGPARPARPPTTAGP 2766

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 188497661  639 PSPVSRLFSPSTVQDSLVKGEQVSLHGGSPQVPATGSSRDCPN--SGQASPCPSEQSPSPQSP 699
Cdd:PHA03247 2767 PAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAavLAPAAALPPAASPAGPLP 2829
PHA01929 PHA01929
putative scaffolding protein
 369-476 7.24e-04

putative scaffolding protein


Pssm-ID: 177328  Cd Length: 306  Bit Score: 42.73  E-value: 7.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 369 PNTALPPASLPNslITSSAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEPPLSVPQPfLPVFTMTLLSPGPAPA-PVP 447
Cdd:PHA01929   3 QNEQQLPPGLAG--LVANVPPAAAPTPQPNPVIQPQAPVQPGQPGAPQQLAIPTQQPQP-VPTSAMTPHVVQQAPAqPAP 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 188497661 448 TALPL-VPSPAPTLNPPTPPAFLQPQKFAG 476
Cdd:PHA01929  80 AAPPAaGAALPEALEVPPPPAFTPNGEIVG 109
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
348-569 7.72e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.30  E-value: 7.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 348 PPPSSLPAADPSSPPSQGNILPNTALPPASLPNSLITSSAAPSLDPTEGQGCERTS---QTVDPFIQPADfGPSEPPLSV 424
Cdd:PRK07003 375 RVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPappATADRGDDAAD-GDAPVPAKA 453

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 425 PQPFLPVFTMTLLSPGPAPAPVPTALPLVPSPAPTLNPPTPPAFLQPQKFAGVSK----------------STPVITHTA 488
Cdd:PRK07003 454 NARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPdarapaaasredapaaAAPPAPEAR 533

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 489 SATLTHD---------ASATTFSQNQGLVITAHHptpSSSPCALALSPVPQPPAVGPPQPHLTFIHPKPVSLTGVRHKQP 559
Cdd:PRK07003 534 PPTPAAAapaaraggaAAALDVLRNAGMRVSSDR---GARAAAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPP 610

                        250
                 ....*....|
gi 188497661 560 PKIVPAPKPE 569
Cdd:PRK07003 611 NGAARAEQAA 620
bHLHzip_Max cd11406
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, ...
 719-788 7.94e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, also termed Class D basic helix-loop-helix protein 4 (bHLHd4), or Myc-associated factor X, is a bHLHZip transcription regulator that forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a transcriptional repressor. Max homodimer bind DNA but is transcriptionally inactive. Targeted deletion of max results in early embryonic lethality in mice.


Pssm-ID: 381412  Cd Length: 69  Bit Score: 38.87  E-value: 7.94e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 188497661 719 RQKHISAEQKRRFNIRMGFNTL-NSLISNNSKQTSHAITLQKTMEYITklqqermQMQEEARRLREEIEEL 788
Cdd:cd11406    2 RAHHNALERKRRDHIKDSFHSLrDSVPSLQGEKASRAQILKKATEYIQ-------YMRRKNHTHQQDIDDL 65
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 349-542 2.13e-03

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 41.39  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 349 PPSSLPAADPSSPPSQGNILPNTALPPASLPNSLITS---SAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEP-PLSV 424
Cdd:cd23959   56 PLYGAVSPEGENPFDGPGLVTASTVSDCYVGNANFYEvdmSDAFAMAPDESLGPFRAARVPNPFSASSSTQRETHkTAQV 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 425 PQPFlpvftmtllsPGPAPAPVPTA--LPLVPSPAPTLNPPTPPAFLQPQKFAGVSKSTPVITHTASATLTHDASATTFS 502
Cdd:cd23959  136 APPK----------AEPQTAPVTPFgqLPMFGQHPPPAKPLPAAAAAQQSSASPGEVASPFASGTVSASPFATATDTAPS 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 188497661 503 QNQGLVITAHHPTPSSSPCALALSPVPQPPAVGPPQPHLT 542
Cdd:cd23959  206 SGAPDGFPAEASAPSPFAAPASAASFPAAPVANGEAATPT 245
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 348-699 2.96e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 2.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 348 PPPSSLPAADPSSPPSQGNILPNTALPPASLPNSLITSSAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEPPLSVPQP 427
Cdd:PRK07764 404 AAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPA 483

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 428 FLPVFTmtllSPGPAPAPVPTALPLVPSPAPTL--------------NPPTPPAFLQPQKFAGVSKSTPVITHTASAtlt 493
Cdd:PRK07764 484 PPAAPA----PAAAPAAPAAPAAPAGADDAATLrerwpeilaavpkrSRKTWAILLPEATVLGVRGDTLVLGFSTGG--- 556

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 494 hDASATTFSQNQGLVITAHH---------------------------PTPSSSPCALAlSPVPQPPAVGPPQPHltfiHP 546
Cdd:PRK07764 557 -LARRFASPGNAEVLVTALAeelggdwqveavvgpapgaaggegppaPASSGPPEEAA-RPAAPAAPAAPAAPA----PA 630

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 547 KPVSLTGVRHKQPPKIVPAPKPEPvslvlKNACIAPAAFSGQPQKVIMTS-APLKREGILASTVSPSNVVIASAAITRAS 625
Cdd:PRK07764 631 GAAAAPAEASAAPAPGVAAPEHHP-----KHVAVPDASDGGDGWPAKAGGaAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 188497661 626 GVTEFLSHSTSSQPSPVSRLFSPSTVQDSlvKGEQVSLHGGSPQVPAT----GSSRDCPNSGQASPCPSEQSPSPQSP 699
Cdd:PRK07764 706 AATPPAGQADDPAAQPPQAAQGASAPSPA--ADDPVPLPPEPDDPPDPagapAQPPPPPAPAPAAAPAAAPPPSPPSE 781
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 452-584 3.24e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 41.33  E-value: 3.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 452 LVPSPAPTLNPPTPPAflqpqkfagvskSTPVITHTASATLTHDASATTFSQNQGLVITAHHPTPSSSPCAlalSPVPQP 531
Cdd:PRK14950 360 LVPVPAPQPAKPTAAA------------PSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVA---PPVPHT 424

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 188497661 532 PAVGPPQphltfihPKPVSLTGVRHKQPPkivPAPKPEPVSlvlknACIAPAA 584
Cdd:PRK14950 425 PESAPKL-------TRAAIPVDEKPKYTP---PAPPKEEEK-----ALIADGD 462
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
348-539 4.49e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 4.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 348 PPPSSLPAADPSSPPSQGNILPNTALPPASLPNSLITSSAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEPPLSVPQP 427
Cdd:PRK12323 396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAA 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 428 flpvftmtllspgPAPAPVPTALPLVPSPAPTLNPP---TPPAFLQPqkfaGVSKSTPVITHTASATLTHDASATTfsqn 504
Cdd:PRK12323 476 -------------AAAAPARAAPAAAPAPADDDPPPweeLPPEFASP----APAQPDAAPAGWVAESIPDPATADP---- 534

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 188497661 505 qglviTAHHPTPSSSPCAlalSPVPQPPAVGPPQP 539
Cdd:PRK12323 535 -----DDAFETLAPAPAA---APAPRAAAATEPVV 561
BRLZ smart00338
basic region leucin zipper;
758-799 4.75e-03

basic region leucin zipper;


Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 36.39  E-value: 4.75e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 188497661   758 QKTMEYITKLQQERMQMQEEARRLREEIEELNTTIISCQQLL 799
Cdd:smart00338  22 ERKKAEIEELERKVEQLEAENERLKKEIERLRRELEKLKSEL 63
bHLH_AtNAI1_like cd11452
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein NAI1 and similar ...
 718-784 5.10e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein NAI1 and similar proteins; NAI1, also termed AtbHLH20, or EN 27, is a bHLH transcription activator that regulates the expression of at least NAI2, PYK10 and PBP1. It is required for and mediates the formation of endoplasmic reticulum bodies (ER bodies). It plays a role in the symbiotic interactions with the endophytes of the Sebacinaceae fungus family, such as Piriformospora indica and Sebacina.


Pssm-ID: 381458 [Multi-domain]  Cd Length: 75  Bit Score: 36.67  E-value: 5.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 188497661 718 NRQKHISAEQKRRFNIRMGFNTLNSLISnNSKQTSHAITLQKTMEYITKLQQERMQMQEEARRLREE 784
Cdd:cd11452    2 LAQDHILAERKRREKLSQRFIALSALVP-GLKKMDKASVLGDAIKHIKQLQERVKELEEEKKEKRLM 67
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 435-539 6.94e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.18  E-value: 6.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 435 TLLSPGPAPAPVPTALPL----VPSPAPTLNPPTPPAFLQPQKFAGVSKSTPvithtasATLTHDASATTFSqnqglvit 510
Cdd:PRK14950 358 ALLVPVPAPQPAKPTAAApspvRPTPAPSTRPKAAAAANIPPKEPVRETATP-------PPVPPRPVAPPVP-------- 422

                         90       100
                 ....*....|....*....|....*....
gi 188497661 511 ahHPTPSSSPCALALSPVPQPPAVGPPQP 539
Cdd:PRK14950 423 --HTPESAPKLTRAAIPVDEKPKYTPPAP 449
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 346-641 7.13e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  346 MLPPPSSLPAADPSSPPSQGNILPNTALPPASLpnslitsSAAPSLDPTEGQGCERTSQTVDPFIQPAdfgpsepplsvp 425
Cdd:PRK10263  341 TQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVI-------APAPEGYPQQSQYAQPAVQYNEPLQQPV------------ 401

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  426 QPFLPVFTMTLLSPGPAPAPVPTALPLVPSPAPTLNPPTPPAFLQPQKFAGVSKSTPVITHTASATLTHDASATTFsqnq 505
Cdd:PRK10263  402 QPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPL---- 477

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  506 glvitaHHPTPSSSPcALALSPVPQPPAVGPPQPHLTFIhpKPVSLTGVRHKQPPKIVPAPKPEPVS--LVLKNACIAPA 583
Cdd:PRK10263  478 ------YQQPQPVEQ-QPVVEPEPVVEETKPARPPLYYF--EEVEEKRAREREQLAAWYQPIPEPVKepEPIKSSLKAPS 548

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 188497661  584 AFSGQPQKVIMTSAPLKrEGILASTVSpsnvviASAAITRASGVtefLSHSTSSQPSP 641
Cdd:PRK10263  549 VAAVPPVEAAAAVSPLA-SGVKKATLA------TGAAATVAAPV---FSLANSGGPRP 596
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
359-568 8.66e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.86  E-value: 8.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 359 SSPPSQGNILPNTALPPASLPNSlitSSAAPSLDPTEGQGCERTSQTVDPFIQpADFGPSEPPLSVPqpflPVFTMTLLS 438
Cdd:PRK12323 372 AGPATAAAAPVAQPAPAAAAPAA---AAPAPAAPPAAPAAAPAAAAAARAVAA-APARRSPAPEALA----AARQASARG 443

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661 439 PGPAPAPVPTalplvPSPAPTlnPPTPPAFLQPQKFAGVSKSTPVITHTASATLTHDASATTFSQNQGLVITAHHPTPSS 518
Cdd:PRK12323 444 PGGAPAPAPA-----PAAAPA--AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDA 516

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 188497661 519 SPCALALSPVPQPPAVGPPQPHLTFIHPKPVSLTGVRHKQPPKIVPAPKP 568
Cdd:PRK12323 517 APAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPP 566
PHA03247 PHA03247
large tegument protein UL36; Provisional
 348-561 8.73e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 8.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  348 PPPSSLPAADPSSPPSQ--GNILPNTalpPASLPNSLITSSAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEPPLSVP 425
Cdd:PHA03247  280 PPPEAAAPNGAAAPPDGvwGAALAGA---PLALPAPPDPPPPAPAGDAEEEDDEDGAMEVVSPLPRPRQHYPLGFPKRRR 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188497661  426 QPFLPVFTMTLLSPG---PAPAPVPTALPLVPSPAPTLNPPTPPAFLQPQKFAGVSKSTPVITHTASATLTHDASATtfs 502
Cdd:PHA03247  357 PTWTPPSSLEDLSAGrhhPKRASLPTRKRRSARHAATPFARGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPAT--- 433

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 188497661  503 qnqglvitahhPTPSSSPC---ALALSPVPQPPAVGPPQPHLTFIHPKPVSLTGVRHKQPPK 561
Cdd:PHA03247  434 -----------PLPSAEPGsddGPAPPPERQPPAPATEPAPDDPDDATRKALDALRERRPPE 484
bHLHzip_SREBP cd11394
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 718-784 9.80e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box.


Pssm-ID: 381400 [Multi-domain]  Cd Length: 73  Bit Score: 35.71  E-value: 9.80e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 188497661 718 NRQKHISAEQKRRFNIRMGFNTLNSLISNNSKQTSHAITLQKTMEYITKLQQERMQMQEEARRLREE 784
Cdd:cd11394    6 KRSAHNAIEKRYRSSINDRIIELKDLVVGPDAKMNKSAVLRKAIDYIRYLQKVNQKLKQENMALKKA 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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