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Conserved domains on  [gi|21704250|ref|NP_663597|]
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zinc finger protein 71, related sequence isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-62 1.20e-29

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 108.83  E-value: 1.20e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 21704250      5 LSFRDVAIDFSEEEWECLGPAQWNLYRDVMLENYSHLVFLGLALSKPYLVTCLEKIQE 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-363 4.44e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 4.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 106 MNPYKCEECAKSFHSPSLSSKESRIHTGGKPYKCEV--CGKAFCIPLLLSKHKIIHTVEKPYKCDI-------------- 169
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskassssl 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 170 --CGKAFQYPSKLS--------RHKQIHSEEKPYK----------------------------CEVCGMAFHFPSLLLVH 211
Cdd:COG5048 111 ssSSSNSNDNNLLSshslppssRDPQLPDLLSISNlrnnplpgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 212 KRIHTGEKPYKCEECGKAFRNSSFLSKHKIIHRgEKPYKCEVCGKDFHY----PSRLYNHKKIHSGEKPYKCELC-GKAF 286
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKsllsQSPSSLSSSDSSSSASESPRSSlPTAS 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 287 C-----FPSSLSKHKRIHTgekPYKCKECEKPFCYLSSLSKHK--IIHTGE--KPYKCD--LCGKAFRYPSLLSEHKVIH 355
Cdd:COG5048 270 SqssspNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLH 346


                ....*...
gi 21704250 356 TGNKPYKC 363
Cdd:COG5048 347 TSISPAKE 354
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-62 1.20e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 108.83  E-value: 1.20e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 21704250      5 LSFRDVAIDFSEEEWECLGPAQWNLYRDVMLENYSHLVFLGLALSKPYLVTCLEKIQE 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-45 5.64e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.22  E-value: 5.64e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21704250     4 MLSFRDVAIDFSEEEWECLGPAQWNLYRDVMLENYSHLVFLG 45
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-44 4.85e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.52  E-value: 4.85e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21704250   5 LSFRDVAIDFSEEEWECLGPAQWNLYRDVMLENYSHLVFL 44
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-363 4.44e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 4.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 106 MNPYKCEECAKSFHSPSLSSKESRIHTGGKPYKCEV--CGKAFCIPLLLSKHKIIHTVEKPYKCDI-------------- 169
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskassssl 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 170 --CGKAFQYPSKLS--------RHKQIHSEEKPYK----------------------------CEVCGMAFHFPSLLLVH 211
Cdd:COG5048 111 ssSSSNSNDNNLLSshslppssRDPQLPDLLSISNlrnnplpgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 212 KRIHTGEKPYKCEECGKAFRNSSFLSKHKIIHRgEKPYKCEVCGKDFHY----PSRLYNHKKIHSGEKPYKCELC-GKAF 286
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKsllsQSPSSLSSSDSSSSASESPRSSlPTAS 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 287 C-----FPSSLSKHKRIHTgekPYKCKECEKPFCYLSSLSKHK--IIHTGE--KPYKCD--LCGKAFRYPSLLSEHKVIH 355
Cdd:COG5048 270 SqssspNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLH 346


                ....*...
gi 21704250 356 TGNKPYKC 363
Cdd:COG5048 347 TSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
208-232 4.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 4.84e-04
                          10        20
                  ....*....|....*....|....*
gi 21704250   208 LLVHKRIHTGEKPYKCEECGKAFRN 232
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-62 1.20e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 108.83  E-value: 1.20e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 21704250      5 LSFRDVAIDFSEEEWECLGPAQWNLYRDVMLENYSHLVFLGLALSKPYLVTCLEKIQE 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-45 5.64e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.22  E-value: 5.64e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21704250     4 MLSFRDVAIDFSEEEWECLGPAQWNLYRDVMLENYSHLVFLG 45
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-44 4.85e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.52  E-value: 4.85e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21704250   5 LSFRDVAIDFSEEEWECLGPAQWNLYRDVMLENYSHLVFL 44
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-363 4.44e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 4.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 106 MNPYKCEECAKSFHSPSLSSKESRIHTGGKPYKCEV--CGKAFCIPLLLSKHKIIHTVEKPYKCDI-------------- 169
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskassssl 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 170 --CGKAFQYPSKLS--------RHKQIHSEEKPYK----------------------------CEVCGMAFHFPSLLLVH 211
Cdd:COG5048 111 ssSSSNSNDNNLLSshslppssRDPQLPDLLSISNlrnnplpgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 212 KRIHTGEKPYKCEECGKAFRNSSFLSKHKIIHRgEKPYKCEVCGKDFHY----PSRLYNHKKIHSGEKPYKCELC-GKAF 286
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKsllsQSPSSLSSSDSSSSASESPRSSlPTAS 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 287 C-----FPSSLSKHKRIHTgekPYKCKECEKPFCYLSSLSKHK--IIHTGE--KPYKCD--LCGKAFRYPSLLSEHKVIH 355
Cdd:COG5048 270 SqssspNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLH 346


                ....*...
gi 21704250 356 TGNKPYKC 363
Cdd:COG5048 347 TSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
116-381 5.18e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 5.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 116 KSFHSPSLSSKESRIHTGGKPYKCEVCGKAFCIPLLLSKHKIIHTVEKPYKCDICGKAFQYPSKLSRH-KQIHSEEKPYK 194
Cdd:COG5048 178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSA 257

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 195 CEVCGMAF---------HFPSLLLVHKRIHTgekPYKCEECGKAFRNSSFLSKHK--IIHRGE--KPYKC--EVCGKDFH 259
Cdd:COG5048 258 SESPRSSLptassqsssPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFS 334

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 260 YPSRLYNHKKIHSGEKPYKCEL--CGKAF------CFPSSLSKHKRIHTGEKpykcKECEKPFC-------YLSSLSKHK 324
Cdd:COG5048 335 RNDALKRHILLHTSISPAKEKLlnSSSKFspllnnEPPQSLQQYKDLKNDKK----SETLSNSCirnfkrdSNLSLHIIT 410

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 21704250 325 IIHTGEKPYKCDLCGKAFRYPSLLSEHKVIHTGNKPYKCEVCGKaFHFSSQLKKHKK 381
Cdd:COG5048 411 HLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 217-272 4.52e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 4.52e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21704250 217 GEKPYKCE--ECGKAFRNSSFLSKHK-------------------IIHRGEKPYKCEVCGKDFHYPSRLYNHKKiHS 272
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYHRK-HS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 301-381 4.73e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 4.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 301 GEKPYKCK--ECEKPFCYLSSLSKHKIiHTGEKPykcdlcgKAFRYPSLLSeHKVIHTGNKPYKCEVCGKAFHFSSQLKK 378
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ...
gi 21704250 379 HKK 381
Cdd:COG5189 417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 91-188 7.87e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 7.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250  91 EWKKVFQNHQMLDLRMNPykceeCAKSFHSPSLS-SKESRIHT--------GGKPYKCEV--CGKAF------------- 146
Cdd:COG5189 300 EIRGGISTGEMIDVRKLP-----CTNSSSNGKLAhGGERNIDTpsrmlkvkDGKPYKCPVegCNKKYknqnglkyhmlhg 374

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 21704250 147 -CIPLLLS-----KHKIIHTVEKPYKCDICGKAFQYPSKLSRHKQiHS 188
Cdd:COG5189 375 hQNQKLHEnpspeKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK-HS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-282 1.78e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 1.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 176 YPSKLSRHKQIHSEEKPYKCEVCGMAFHFPSLLLVHKRIHTGEKPYKC--EECGKAFRNSSFLSKHKIIHRGEKPYKCEV 253
Cdd:COG5048  17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96

                        90       100
                ....*....|....*....|....*....
gi 21704250 254 CGKDFHYPSRlyNHKKIHSGEKPYKCELC 282
Cdd:COG5048  97 SLPLSNSKAS--SSSLSSSSSNSNDNNLL 123
zf-H2C2_2 pfam13465
Zinc-finger double domain;
208-232 4.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 4.84e-04
                          10        20
                  ....*....|....*....|....*
gi 21704250   208 LLVHKRIHTGEKPYKCEECGKAFRN 232
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-376 6.78e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 6.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21704250 275 KPYKCELCGKAFCFPSSLSKHKRIHTGEKPYKC--KECEKPFCYLSSLSKHKIIHTGEKPYKC-DLCGKAFRYPSLLSEH 351
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                        90       100
                ....*....|....*....|....*
gi 21704250 352 KVIHTGNKPYKCEVCGKAFHFSSQL 376
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQ 136
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-344 8.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 21704250   319 SLSKHKIIHTGEKPYKCDLCGKAFRY 344
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
263-286 2.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.47e-03
                          10        20
                  ....*....|....*....|....
gi 21704250   263 RLYNHKKIHSGEKPYKCELCGKAF 286
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-312 3.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.62e-03
                          10        20
                  ....*....|....*....|..
gi 21704250   291 SLSKHKRIHTGEKPYKCKECEK 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGK 22
zf-H2C2_2 pfam13465
Zinc-finger double domain;
152-174 3.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.66e-03
                          10        20
                  ....*....|....*....|...
gi 21704250   152 LSKHKIIHTVEKPYKCDICGKAF 174
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
236-258 7.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.13e-03
                          10        20
                  ....*....|....*....|...
gi 21704250   236 LSKHKIIHRGEKPYKCEVCGKDF 258
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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