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Conserved domains on  [gi|26986605|ref|NP_758495|]
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FAD-dependent oxidoreductase domain-containing protein 1 isoform 1 [Mus musculus]

Protein Classification

FAD-binding oxidoreductase( domain architecture ID 11429741)

FAD-binding oxidoreductase catalyzes the oxidation or reduction of a specific substrate using flavin adenine dinucleotide (FAD) as a cofactor

CATH:  3.50.50.60
EC:  1.-.-.-
Gene Ontology:  GO:0016491

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
62-480 4.20e-65

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


:

Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 214.77  E-value: 4.20e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605  62 EQADVVIIGGGILGLSVAFWLkkleSRRGAiRVLVVEQDHTYSRASSTgpSVGGIWQQFS---VPENVQLSLFSINFLRn 138
Cdd:COG0665   1 ATADVVVIGGGIAGLSTAYHL----ARRGL-DVTVLERGRPGSGASGR--NAGQLRPGLAalaDRALVRLAREALDLWR- 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 139 ineylAVVDAPPVELQFNPSGCLLLA-SEKDAATLENNVKMQRQEGAKVCLMSPEQLQTKFPWINVEGVALASYgLEDEG 217
Cdd:COG0665  73 -----ELAAELGIDCDFRRTGVLYLArTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLY-DPDDG 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 218 WFDAWSLLQGLRRKVQSMGV-FFCQGEVTRFitsstpmkTPTGEHVVlrrinnvHVKMDKsleyQPVECAVVINAAGAWS 296
Cdd:COG0665 147 HVDPAKLVRALARAARAAGVrIREGTPVTGL--------EREGGRVT-------GVRTER----GTVRADAVVLAAGAWS 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 297 GKIAELAGVgkglpgtlqgtKLPVEPRKRYVhLWHCPQGPGLETPLVADiSGVYFRREGLGSNYLGGcspteEEEPDPTN 376
Cdd:COG0665 208 ARLLPMLGL-----------RLPLRPVRGYV-LVTEPLPDLPLRPVLDD-TGVYLRPTADGRLLVGG-----TAEPAGFD 269

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 377 LNVDHDFFQnKVWPHLVQRVPSFKTLEhllhlqVQSAWAGYYDYnTFDQNGVVGPHPLVVNMYFATGFSGRGLQHAPGIG 456
Cdd:COG0665 270 RAPTPERLE-ALLRRLRRLFPALADAE------IVRAWAGLRPM-TPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAG 341

                       410       420
                ....*....|....*....|....
gi 26986605 457 RAVAEIMLEGHfKTIDMSPFLFTR 480
Cdd:COG0665 342 RLLADLILGGE-PPLDLAPFSPDR 364
 
Name Accession Description Interval E-value
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
62-480 4.20e-65

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 214.77  E-value: 4.20e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605  62 EQADVVIIGGGILGLSVAFWLkkleSRRGAiRVLVVEQDHTYSRASSTgpSVGGIWQQFS---VPENVQLSLFSINFLRn 138
Cdd:COG0665   1 ATADVVVIGGGIAGLSTAYHL----ARRGL-DVTVLERGRPGSGASGR--NAGQLRPGLAalaDRALVRLAREALDLWR- 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 139 ineylAVVDAPPVELQFNPSGCLLLA-SEKDAATLENNVKMQRQEGAKVCLMSPEQLQTKFPWINVEGVALASYgLEDEG 217
Cdd:COG0665  73 -----ELAAELGIDCDFRRTGVLYLArTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLY-DPDDG 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 218 WFDAWSLLQGLRRKVQSMGV-FFCQGEVTRFitsstpmkTPTGEHVVlrrinnvHVKMDKsleyQPVECAVVINAAGAWS 296
Cdd:COG0665 147 HVDPAKLVRALARAARAAGVrIREGTPVTGL--------EREGGRVT-------GVRTER----GTVRADAVVLAAGAWS 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 297 GKIAELAGVgkglpgtlqgtKLPVEPRKRYVhLWHCPQGPGLETPLVADiSGVYFRREGLGSNYLGGcspteEEEPDPTN 376
Cdd:COG0665 208 ARLLPMLGL-----------RLPLRPVRGYV-LVTEPLPDLPLRPVLDD-TGVYLRPTADGRLLVGG-----TAEPAGFD 269

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 377 LNVDHDFFQnKVWPHLVQRVPSFKTLEhllhlqVQSAWAGYYDYnTFDQNGVVGPHPLVVNMYFATGFSGRGLQHAPGIG 456
Cdd:COG0665 270 RAPTPERLE-ALLRRLRRLFPALADAE------IVRAWAGLRPM-TPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAG 341

                       410       420
                ....*....|....*....|....
gi 26986605 457 RAVAEIMLEGHfKTIDMSPFLFTR 480
Cdd:COG0665 342 RLLADLILGGE-PPLDLAPFSPDR 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 65-462 9.55e-44

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 157.56  E-value: 9.55e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605    65 DVVIIGGGILGLSVAFWLkkleSRRGaIRVLVVEQDHTYSRASSTGPSvGGIWQQFSVPEN---VQLSLFSINFLRNINE 141
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYEL----ARRG-LSVTLLERGDDPGSGASGRNA-GLIHPGLRYLEPselARLALEALDLWEELEE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   142 YLAVvdappvELQFNPSGCLLLASEKDAATLENNVKMQRQEGAKVCLMSPEQLQTKFPWINVEGVALASYgleDEGWFDA 221
Cdd:pfam01266  75 ELGI------DCGFRRCGVLVLARDEEEEALEKLLAALRRLGVPAELLDAEELRELEPLLPGLRGGLFYP---DGGHVDP 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   222 WSLLQGLRRKVQSMGV-FFCQGEVTRfitsstpmktptgehvvLRRINNVHVkmdkslEYQPVECAVVINAAGAWSGKIA 300
Cdd:pfam01266 146 ARLLRALARAAEALGVrIIEGTEVTG-----------------IEEEGGVWG------VVTTGEADAVVNAAGAWADLLA 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   301 elagvgkglpgtLQGTKLPVEPRKRYV-HLWHCPQGPGL--ETPLVADISGVYFRREGLGSNYLGGcsptEEEEPDPTNL 377
Cdd:pfam01266 203 ------------LPGLRLPVRPVRGQVlVLEPLPEALLIlpVPITVDPGRGVYLRPRADGRLLLGG----TDEEDGFDDP 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   378 NVDHDFFQnKVWPHLVQRVPSFKTLEHllhlqvqsAWAGYYDynTFDQNGVVGPhPLVVNMYFATGFSGRGLQHAPGIGR 457
Cdd:pfam01266 267 TPDPEEIE-ELLEAARRLFPALADIER--------AWAGLRP--LPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGK 334


                  ....*
gi 26986605   458 AVAEI 462
Cdd:pfam01266 335 LLAEL 339
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 65-481 1.37e-11

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 66.01  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605    65 DVVIIGGGILGLSVAFWLKKlesrRGaIRVLVVEQ-DHTYSRASSTGPSvgGIWQQfSVPENvqlslFSINFLRNINEYL 143
Cdd:TIGR01377   2 DVIVVGAGIMGCFAAYHLAK----HG-KKTLLLEQfDLPHSRGSSHGQS--RIIRK-AYPED-----FYTPMMLECYQLW 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   144 AVVDAPPVELQFNPSGCLLLASEKDAATLENNVKMQRQEGAKVClMSPEQLQTKFPWINV-EGvalaSYGLEDE--GWFD 220
Cdd:TIGR01377  69 AQLEKEAGTKLHRQTGLLLLGPKENQFLKTIQATLSRHGLEHEL-LSSKQLKQRFPNIRVpRN----EVGLLDPngGVLY 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   221 AWSLLQGLRRKVQSMGVFFCQGEVTRFITsstpmktPTGEHVVlrrinnVHVKMDKsleYQPVECAVvinAAGAWSGKIA 300
Cdd:TIGR01377 144 AEKALRALQELAEAHGATVRDGTKVVEIE-------PTELLVT------VKTTKGS---YQANKLVV---TAGAWTSKLL 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   301 ELAGVgkglpgtlqgtKLPVEPRKRYVHLWHCPQ----GPGLETP--LVADISGVY-----FRREGLGSNYLGG---CSP 366
Cdd:TIGR01377 205 SPLGI-----------EIPLQPLRINVCYWREKEpgsyGVSQAFPcfLVLGLNPHIyglpsFEYPGLMKVYYHHgqqIDP 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   367 TEEEEPdPTNLNVDHDFFQNKVWPHLVQRVPSFKTLEHLLHLqvqsawagyydyNTFDQNGVVGPHPLVVNMYFATGFSG 446
Cdd:TIGR01377 274 DERDCP-FGADIEDVQILRKFVRDHLPGLNGEPKKGEVCMYT------------NTPDEHFVIDLHPKYDNVVIGAGFSG 340

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 26986605   447 RGLQHAPGIGRAVAEIMLEGHfKTIDMSPFLFTRF 481
Cdd:TIGR01377 341 HGFKLAPVVGKILAELAMKLK-PSYDLAIFSLNRF 374
solA PRK11259
N-methyl-L-tryptophan oxidase;
418-481 2.33e-06

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 49.83  E-value: 2.33e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26986605  418 YDyNTFDQNGVVGPHPLVVNMYFATGFSGRGLQHAPGIGRAVAEIMLEGHFKtIDMSPFLFTRF 481
Cdd:PRK11259 313 YT-NTPDEHFIIDTLPGHPNVLVASGCSGHGFKFASVLGEILADLAQDGTSD-FDLSPFSLSRF 374
 
Name Accession Description Interval E-value
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
62-480 4.20e-65

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 214.77  E-value: 4.20e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605  62 EQADVVIIGGGILGLSVAFWLkkleSRRGAiRVLVVEQDHTYSRASSTgpSVGGIWQQFS---VPENVQLSLFSINFLRn 138
Cdd:COG0665   1 ATADVVVIGGGIAGLSTAYHL----ARRGL-DVTVLERGRPGSGASGR--NAGQLRPGLAalaDRALVRLAREALDLWR- 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 139 ineylAVVDAPPVELQFNPSGCLLLA-SEKDAATLENNVKMQRQEGAKVCLMSPEQLQTKFPWINVEGVALASYgLEDEG 217
Cdd:COG0665  73 -----ELAAELGIDCDFRRTGVLYLArTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLY-DPDDG 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 218 WFDAWSLLQGLRRKVQSMGV-FFCQGEVTRFitsstpmkTPTGEHVVlrrinnvHVKMDKsleyQPVECAVVINAAGAWS 296
Cdd:COG0665 147 HVDPAKLVRALARAARAAGVrIREGTPVTGL--------EREGGRVT-------GVRTER----GTVRADAVVLAAGAWS 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 297 GKIAELAGVgkglpgtlqgtKLPVEPRKRYVhLWHCPQGPGLETPLVADiSGVYFRREGLGSNYLGGcspteEEEPDPTN 376
Cdd:COG0665 208 ARLLPMLGL-----------RLPLRPVRGYV-LVTEPLPDLPLRPVLDD-TGVYLRPTADGRLLVGG-----TAEPAGFD 269

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 377 LNVDHDFFQnKVWPHLVQRVPSFKTLEhllhlqVQSAWAGYYDYnTFDQNGVVGPHPLVVNMYFATGFSGRGLQHAPGIG 456
Cdd:COG0665 270 RAPTPERLE-ALLRRLRRLFPALADAE------IVRAWAGLRPM-TPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAG 341

                       410       420
                ....*....|....*....|....
gi 26986605 457 RAVAEIMLEGHfKTIDMSPFLFTR 480
Cdd:COG0665 342 RLLADLILGGE-PPLDLAPFSPDR 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 65-462 9.55e-44

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 157.56  E-value: 9.55e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605    65 DVVIIGGGILGLSVAFWLkkleSRRGaIRVLVVEQDHTYSRASSTGPSvGGIWQQFSVPEN---VQLSLFSINFLRNINE 141
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYEL----ARRG-LSVTLLERGDDPGSGASGRNA-GLIHPGLRYLEPselARLALEALDLWEELEE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   142 YLAVvdappvELQFNPSGCLLLASEKDAATLENNVKMQRQEGAKVCLMSPEQLQTKFPWINVEGVALASYgleDEGWFDA 221
Cdd:pfam01266  75 ELGI------DCGFRRCGVLVLARDEEEEALEKLLAALRRLGVPAELLDAEELRELEPLLPGLRGGLFYP---DGGHVDP 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   222 WSLLQGLRRKVQSMGV-FFCQGEVTRfitsstpmktptgehvvLRRINNVHVkmdkslEYQPVECAVVINAAGAWSGKIA 300
Cdd:pfam01266 146 ARLLRALARAAEALGVrIIEGTEVTG-----------------IEEEGGVWG------VVTTGEADAVVNAAGAWADLLA 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   301 elagvgkglpgtLQGTKLPVEPRKRYV-HLWHCPQGPGL--ETPLVADISGVYFRREGLGSNYLGGcsptEEEEPDPTNL 377
Cdd:pfam01266 203 ------------LPGLRLPVRPVRGQVlVLEPLPEALLIlpVPITVDPGRGVYLRPRADGRLLLGG----TDEEDGFDDP 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   378 NVDHDFFQnKVWPHLVQRVPSFKTLEHllhlqvqsAWAGYYDynTFDQNGVVGPhPLVVNMYFATGFSGRGLQHAPGIGR 457
Cdd:pfam01266 267 TPDPEEIE-ELLEAARRLFPALADIER--------AWAGLRP--LPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGK 334


                  ....*
gi 26986605   458 AVAEI 462
Cdd:pfam01266 335 LLAEL 339
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
62-308 1.01e-12

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 69.79  E-value: 1.01e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605  62 EQADVVIIGGGILGLSVAFWLKKLESRrgaiRVLVVEQ-----DHTYSRASSTG-----PSVGgiwqqfsvpenvqlSLf 131
Cdd:COG0579   3 EMYDVVIIGAGIVGLALARELSRYEDL----KVLVLEKeddvaQESSGNNSGVIhaglyYTPG--------------SL- 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 132 SINFLRNINE-YLAVVDAppVELQFNPSGCLLLA-SEKDAATLEnnvkmQRQEGAK------VCLMSPEQLQTKFPWINV 203
Cdd:COG0579  64 KARLCVEGNElFYELCRE--LGIPFKRCGKLVVAtGEEEVAFLE-----KLYERGKangvpgLEILDREELRELEPLLSD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605 204 EGVAlASYgLEDEGWFDAWSLLQGLRRKVQSMGV-FFCQGEVTRFItsstpmktptgehvvlRRINNVHVKMDKSleyqP 282
Cdd:COG0579 137 EGVA-ALY-SPSTGIVDPGALTRALAENAEANGVeLLLNTEVTGIE----------------REGDGWEVTTNGG----T 194

                       250       260
                ....*....|....*....|....*.
gi 26986605 283 VECAVVINAAGAWSGKIAELAGVGKG 308
Cdd:COG0579 195 IRARFVINAAGLYADRLAQMAGIGKD 220
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 65-481 1.37e-11

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 66.01  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605    65 DVVIIGGGILGLSVAFWLKKlesrRGaIRVLVVEQ-DHTYSRASSTGPSvgGIWQQfSVPENvqlslFSINFLRNINEYL 143
Cdd:TIGR01377   2 DVIVVGAGIMGCFAAYHLAK----HG-KKTLLLEQfDLPHSRGSSHGQS--RIIRK-AYPED-----FYTPMMLECYQLW 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   144 AVVDAPPVELQFNPSGCLLLASEKDAATLENNVKMQRQEGAKVClMSPEQLQTKFPWINV-EGvalaSYGLEDE--GWFD 220
Cdd:TIGR01377  69 AQLEKEAGTKLHRQTGLLLLGPKENQFLKTIQATLSRHGLEHEL-LSSKQLKQRFPNIRVpRN----EVGLLDPngGVLY 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   221 AWSLLQGLRRKVQSMGVFFCQGEVTRFITsstpmktPTGEHVVlrrinnVHVKMDKsleYQPVECAVvinAAGAWSGKIA 300
Cdd:TIGR01377 144 AEKALRALQELAEAHGATVRDGTKVVEIE-------PTELLVT------VKTTKGS---YQANKLVV---TAGAWTSKLL 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   301 ELAGVgkglpgtlqgtKLPVEPRKRYVHLWHCPQ----GPGLETP--LVADISGVY-----FRREGLGSNYLGG---CSP 366
Cdd:TIGR01377 205 SPLGI-----------EIPLQPLRINVCYWREKEpgsyGVSQAFPcfLVLGLNPHIyglpsFEYPGLMKVYYHHgqqIDP 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   367 TEEEEPdPTNLNVDHDFFQNKVWPHLVQRVPSFKTLEHLLHLqvqsawagyydyNTFDQNGVVGPHPLVVNMYFATGFSG 446
Cdd:TIGR01377 274 DERDCP-FGADIEDVQILRKFVRDHLPGLNGEPKKGEVCMYT------------NTPDEHFVIDLHPKYDNVVIGAGFSG 340

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 26986605   447 RGLQHAPGIGRAVAEIMLEGHfKTIDMSPFLFTRF 481
Cdd:TIGR01377 341 HGFKLAPVVGKILAELAMKLK-PSYDLAIFSLNRF 374
solA PRK11259
N-methyl-L-tryptophan oxidase;
418-481 2.33e-06

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 49.83  E-value: 2.33e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26986605  418 YDyNTFDQNGVVGPHPLVVNMYFATGFSGRGLQHAPGIGRAVAEIMLEGHFKtIDMSPFLFTRF 481
Cdd:PRK11259 313 YT-NTPDEHFIIDTLPGHPNVLVASGCSGHGFKFASVLGEILADLAQDGTSD-FDLSPFSLSRF 374
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 63-116 4.68e-05

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 45.59  E-value: 4.68e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 26986605  63 QADVVIIGGGILGLSVAFWLKKLesrrgAIRVLVVEQDhtysrasstgPSVGGI 116
Cdd:COG1232   1 MKRVAVIGGGIAGLTAAYRLAKA-----GHEVTVLEAS----------DRVGGL 39
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 60-120 7.15e-05

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 45.24  E-value: 7.15e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26986605  60 PPEQADVVIIGGGILGLSVAFWLKklesRRGaIRVLVVEQdhtysrasstGPSVGGIWQQF 120
Cdd:COG2072   3 ATEHVDVVVIGAGQAGLAAAYHLR----RAG-IDFVVLEK----------ADDVGGTWRDN 48
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 61-120 1.50e-04

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 43.77  E-value: 1.50e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26986605  61 PEQADVVIIGGGILGLSVAFWLKklesRRGaIRVLVVEQD---HTYSRASSTGPSVG------GIWQQF 120
Cdd:COG0654   1 MMRTDVLIVGGGPAGLALALALA----RAG-IRVTVVERApppRPDGRGIALSPRSLellrrlGLWDRL 64
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 17-218 1.64e-04

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 44.07  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   17 RGLRtrKGGFTLdwdAKVSDFKKKVDsILPGKKYEVLYDTSHLP-------PEQADVVIIGGGILGLSVAFWLkkleSRR 89
Cdd:PRK01747 213 RGLQ--EAGFTV---RKVKGFGRKRE-MLVGELEQTLPAPLAAPwfarpgsPKARDAAIIGGGIAGAALALAL----ARR 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26986605   90 GAiRVLVVEQDHTYSRASStGPSVGGIWQQFSVPENVqLSLFSIN-FLRNINEYLAVVDApPVELQFNPSGCLLLA-SEK 167
Cdd:PRK01747 283 GW-QVTLYEADEAPAQGAS-GNRQGALYPLLSKDDNA-LSRFFRAaFLFARRFYDALPAA-GVAFDHDWCGVLQLAwDEK 358

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 26986605  168 DAATLEnnvKMQRQEGAK--VCLMSPEQLQTKfpwinvEGVALASYGL--EDEGW 218
Cdd:PRK01747 359 SAEKIA---KMLALGLPAelARALDAEEAEEL------AGLPVPCGGIfyPQGGW 404
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
65-98 3.71e-04

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 42.89  E-value: 3.71e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 26986605   65 DVVIIGGGILGLSVAFWLkkLESRRGAiRVLVVE 98
Cdd:PRK11728   4 DFVIIGGGIVGLSTAMQL--QERYPGA-RIAVLE 34
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 65-117 7.11e-04

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 41.89  E-value: 7.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 26986605    65 DVVIIGGGILGLSVAfwlkkLESRRGAIRVLVVEQdhTYSRASSTGPSVGGIW 117
Cdd:pfam00890   1 DVLVIGGGLAGLAAA-----LAAAEAGLKVAVVEK--GQPFGGATAWSSGGID 46
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 62-117 1.01e-03

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 41.36  E-value: 1.01e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 26986605  62 EQADVVIIGGGILGLSVAfwlkkLESRRGAIRVLVVEQDHTY---SRASStgpsvGGIW 117
Cdd:COG1053   2 HEYDVVVVGSGGAGLRAA-----LEAAEAGLKVLVLEKVPPRgghTAAAQ-----GGIN 50
PRK07804 PRK07804
L-aspartate oxidase; Provisional
 62-116 1.11e-03

L-aspartate oxidase; Provisional


Pssm-ID: 236102 [Multi-domain]  Cd Length: 541  Bit Score: 41.49  E-value: 1.11e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 26986605   62 EQADVVIIGGGILGLSVAfwlkkLESRRGAIRVLVVEQDHTysRASSTGPSVGGI 116
Cdd:PRK07804  15 DAADVVVVGSGVAGLTAA-----LAARRAGRRVLVVTKAAL--DDGSTRWAQGGI 62
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 66-101 1.14e-03

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 41.37  E-value: 1.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 26986605   66 VVIIGGGILGLSVAFWLKKLESrrgAIRVLVVEQDH 101
Cdd:PRK11883   3 VAIIGGGITGLSAAYRLHKKGP---DADITLLEASD 35
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 64-100 2.62e-03

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 40.20  E-value: 2.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 26986605    64 ADVVIIGGGILGLSVAFWLKKlESRRGAIRVLVVEQD 100
Cdd:TIGR00562   3 KHVVIIGGGISGLCAAYYLEK-EIPELPVELTLVEAS 38
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
56-106 9.14e-03

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 38.35  E-value: 9.14e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 26986605   56 TSHLPPEQADVVIIGGGILGLSVAFWLkkleSRRGaIRVLVVEQDHT---YSRA 106
Cdd:PRK06183   3 AQHPDAHDTDVVIVGAGPVGLTLANLL----GQYG-VRVLVLERWPTlydLPRA 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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