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Conserved domains on  [gi|41055044|ref|NP_956661|]
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protein ABHD14B [Danio rerio]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 17-212 2.17e-23

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 93.14  E-value: 2.17e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044  17 GDQPLFYRQAvpssGSGGLCVLLLHGIRFSSKNWQKIgtLETLAAaGYRALAIDLPGLGQSKAAVAPAAVGELapAVFLR 96
Cdd:COG0596  10 DGVRLHYREA----GPDGPPVVLLHGLPGSSYEWRPL--IPALAA-GYRVIAPDLRGHGRSDKPAGGYTLDDL--ADDLA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044  97 QVCEGLQTGPVVIISPSLSGMYSLPFLFQHSELLKAYIPVAPI------------------------CTEKFTAEQYGSI 152
Cdd:COG0596  81 ALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVlaalaeplrrpglapealaallraLARTDLRERLARI 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41055044 153 QTPALIVYGDQDTQLGEVSLNNL-SQLPNHRVVVMKGAGHPCYLDDPETWHKAVLDFLQQL 212
Cdd:COG0596 161 TVPTLVIWGEKDPIVPPALARRLaELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 17-212 2.17e-23

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 93.14  E-value: 2.17e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044  17 GDQPLFYRQAvpssGSGGLCVLLLHGIRFSSKNWQKIgtLETLAAaGYRALAIDLPGLGQSKAAVAPAAVGELapAVFLR 96
Cdd:COG0596  10 DGVRLHYREA----GPDGPPVVLLHGLPGSSYEWRPL--IPALAA-GYRVIAPDLRGHGRSDKPAGGYTLDDL--ADDLA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044  97 QVCEGLQTGPVVIISPSLSGMYSLPFLFQHSELLKAYIPVAPI------------------------CTEKFTAEQYGSI 152
Cdd:COG0596  81 ALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVlaalaeplrrpglapealaallraLARTDLRERLARI 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41055044 153 QTPALIVYGDQDTQLGEVSLNNL-SQLPNHRVVVMKGAGHPCYLDDPETWHKAVLDFLQQL 212
Cdd:COG0596 161 TVPTLVIWGEKDPIVPPALARRLaELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 37-183 3.50e-09

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 54.82  E-value: 3.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044    37 VLLLHGIRFSSKNWQKIgtLETLAAAGYRALAIDLPGLGQSKAAVAPAAVGELAPAVFLRQVCEGLQTGPVVIISPSLSG 116
Cdd:pfam00561   3 VLLLHGLPGSSDLWRKL--APALARDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41055044   117 MYSLPFLFQHSELLKAYIPVAPICTEKFTAEQYGSIqtpALIVYGDQDTQLGEVSLNNLSQLPNHRV 183
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDPPHELDEADRFI---LALFPGFFDGFVADFAPNPLGRLVAKLL 144
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 33-93 4.70e-06

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 46.48  E-value: 4.70e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41055044   33 GGLCVLLLHGirFSS--KNWqkIGTLETLAAaGYRALAIDLPGLGQSKAAVAPAAVGELAPAV 93
Cdd:PRK14875 130 DGTPVVLIHG--FGGdlNNW--LFNHAALAA-GRPVIALDLPGHGASSKAVGAGSLDELAAAV 187
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 17-212 2.17e-23

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 93.14  E-value: 2.17e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044  17 GDQPLFYRQAvpssGSGGLCVLLLHGIRFSSKNWQKIgtLETLAAaGYRALAIDLPGLGQSKAAVAPAAVGELapAVFLR 96
Cdd:COG0596  10 DGVRLHYREA----GPDGPPVVLLHGLPGSSYEWRPL--IPALAA-GYRVIAPDLRGHGRSDKPAGGYTLDDL--ADDLA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044  97 QVCEGLQTGPVVIISPSLSGMYSLPFLFQHSELLKAYIPVAPI------------------------CTEKFTAEQYGSI 152
Cdd:COG0596  81 ALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVlaalaeplrrpglapealaallraLARTDLRERLARI 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41055044 153 QTPALIVYGDQDTQLGEVSLNNL-SQLPNHRVVVMKGAGHPCYLDDPETWHKAVLDFLQQL 212
Cdd:COG0596 161 TVPTLVIWGEKDPIVPPALARRLaELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
18-211 3.07e-16

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 74.27  E-value: 3.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044  18 DQPLFYRQAVPSSGSGGLcVLLLHGIRFSSKNWQKIGtlETLAAAGYRALAIDLPGLGQSKAAVA-----PAAVGELAPA 92
Cdd:COG2267  13 GLRLRGRRWRPAGSPRGT-VVLVHGLGEHSGRYAELA--EALAAAGYAVLAFDLRGHGRSDGPRGhvdsfDDYVDDLRAA 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044  93 V-FLRQvcegLQTGPVVIISPSLSGMYSLPFLFQHSELLKAYIPVAPICTEK-------------FTAEQYGSIQTPALI 158
Cdd:COG2267  90 LdALRA----RPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYRADpllgpsarwlralRLAEALARIDVPVLV 165

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 41055044 159 VYGDQDTQL-GEVSLNNLSQL-PNHRVVVMKGAGHPCYLD-DPETWHKAVLDFLQQ 211
Cdd:COG2267 166 LHGGADRVVpPEAARRLAARLsPDVELVLLPGARHELLNEpAREEVLAAILAWLER 221
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
26-209 1.33e-10

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 58.82  E-value: 1.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044  26 AVPSSGSGGLCVLLLHGIrFSSKNWQKiGTLETLAAAGYRALAIDLPGLGQ--SKAAVAPAAVGELAPAV---------- 93
Cdd:COG0412  21 ARPAGGGPRPGVVVLHEI-FGLNPHIR-DVARRLAAAGYVVLAPDLYGRGGpgDDPDEARALMGALDPELlaadlraald 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044  94 FLRQVcEGLQTGPVVIISPSLSGMYSLpFLFQHSELLKAYIPVAPICTEKFTAEQYGSIQTPALIVYGDQDTQLGEVSLN 173
Cdd:COG0412  99 WLKAQ-PEVDAGRVGVVGFCFGGGLAL-LAAARGPDLAAAVSFYGGLPADDLLDLAARIKAPVLLLYGEKDPLVPPEQVA 176

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 41055044 174 NLSQ-----LPNHRVVVMKGAGH-------PCYldDPET---WHKAVLDFL 209
Cdd:COG0412 177 ALEAalaaaGVDVELHVYPGAGHgftnpgrPRY--DPAAaedAWQRTLAFL 225
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
37-211 2.13e-10

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 58.10  E-value: 2.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044  37 VLLLHGiRFSSKNWQKIGTLETLAAAGYRALAIDLPGLGQSKAAVAPAAVGELAPAVflRQVCE--GLQTGPVVIISPSL 114
Cdd:COG1506  26 VVYVHG-GPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVLAAI--DYLAArpYVDPDRIGIYGHSY 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044 115 SGMYSLPFLFQHSELLKAYIPVAPIC--------TEKFTAEQYG-------------------SIQTPALIVYGDQDTQl 167
Cdd:COG1506 103 GGYMALLAAARHPDRFKAAVALAGVSdlrsyygtTREYTERLMGgpwedpeayaarsplayadKLKTPLLLIHGEADDR- 181

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 41055044 168 geVSLNNLSQL--------PNHRVVVMKGAGHPCYLDDPETWHKAVLDFLQQ 211
Cdd:COG1506 182 --VPPEQAERLyealkkagKPVELLVYPGEGHGFSGAGAPDYLERILDFLDR 231
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
37-212 3.08e-09

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 54.95  E-value: 3.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044  37 VLLLHGirFSSkNWQKIGTL-ETLAAAGYRALAIDLPGLGQSKAAVAP--------AAVGELApavFLRQVCE-----GL 102
Cdd:COG1647  18 VLLLHG--FTG-SPAEMRPLaEALAKAGYTVYAPRLPGHGTSPEDLLKttwedwleDVEEAYE---ILKAGYDkviviGL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044 103 QTG-----------P----VVIISPSLS----GMYSLPFLFQHSELLKA----------------YIPVAPICT----EK 143
Cdd:COG1647  92 SMGgllalllaaryPdvagLVLLSPALKiddpSAPLLPLLKYLARSLRGigsdiedpevaeyaydRTPLRALAElqrlIR 171

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41055044 144 FTAEQYGSIQTPALIVYGDQDTQlgeVSLNNLSQL------PNHRVVVMKGAGHPCYLD-DPETWHKAVLDFLQQL 212
Cdd:COG1647 172 EVRRDLPKITAPTLIIQSRKDEV---VPPESARYIyerlgsPDKELVWLEDSGHVITLDkDREEVAEEILDFLERL 244
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 37-183 3.50e-09

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 54.82  E-value: 3.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044    37 VLLLHGIRFSSKNWQKIgtLETLAAAGYRALAIDLPGLGQSKAAVAPAAVGELAPAVFLRQVCEGLQTGPVVIISPSLSG 116
Cdd:pfam00561   3 VLLLHGLPGSSDLWRKL--APALARDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41055044   117 MYSLPFLFQHSELLKAYIPVAPICTEKFTAEQYGSIqtpALIVYGDQDTQLGEVSLNNLSQLPNHRV 183
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDPPHELDEADRFI---LALFPGFFDGFVADFAPNPLGRLVAKLL 144
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 33-93 4.70e-06

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 46.48  E-value: 4.70e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41055044   33 GGLCVLLLHGirFSS--KNWqkIGTLETLAAaGYRALAIDLPGLGQSKAAVAPAAVGELAPAV 93
Cdd:PRK14875 130 DGTPVVLIHG--FGGdlNNW--LFNHAALAA-GRPVIALDLPGHGASSKAVGAGSLDELAAAV 187
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 36-110 3.85e-05

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 41.35  E-value: 3.85e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41055044  36 CVLLLHGIRFSSKNWQKIGtlETLAAAGYRALAIDLPGLGQSKAAVApaavGELAPavFLRQVCEGLQTGPVVII 110
Cdd:COG1075   7 PVVLVHGLGGSAASWAPLA--PRLRAAGYPVYALNYPSTNGSIEDSA----EQLAA--FVDAVLAATGAEKVDLV 73
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 37-120 4.55e-05

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 42.85  E-value: 4.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055044    37 VLLLHGIrfssknWQKIGTLETLAAAGYRALAIDLPGLGQSKAavAPAAVGELAPavFLRQVCEGLQTGPVVIISPSLSG 116
Cdd:pfam12697   1 VVLVHGA------GLSAAPLAALLAAGVAVLAPDLPGHGSSSP--PPLDLADLAD--LAALLDELGAARPVVLVGHSLGG 70


                  ....
gi 41055044   117 MYSL 120
Cdd:pfam12697  71 AVAL 74
PRK11126 PRK11126
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
 33-79 1.40e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional


Pssm-ID: 236855 [Multi-domain]  Cd Length: 242  Bit Score: 38.67  E-value: 1.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 41055044   33 GGLCVLLLHGIRFSSKNWQKIGTletlAAAGYRALAIDLPGLGQSKA 79
Cdd:PRK11126   1 GLPWLVFLHGLLGSGQDWQPVGE----ALPDYPRLYIDLPGHGGSAA 43
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 37-77 2.16e-03

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 38.03  E-value: 2.16e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 41055044   37 VLLLHGIRFSSKNWQKIgtLETLAAAGYRALAIDLPGLGQS 77
Cdd:PRK00870  49 VLLLHGEPSWSYLYRKM--IPILAAAGHRVIAPDLIGFGRS 87
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 152-212 3.49e-03

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 37.51  E-value: 3.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41055044  152 IQTPALIVYGDQD--TQL----GEVSLNNLSQLPNHRVVVMKGAGHPCYLDDPETWHKAVLDFLQQL 212
Cdd:PLN02679 291 ISLPILVLWGDQDpfTPLdgpvGKYFSSLPSQLPNVTLYVLEGVGHCPHDDRPDLVHEKLLPWLAQL 357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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