|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
33-402 |
7.81e-122 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 357.64 E-value: 7.81e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 33 ISFSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAF 112
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 113 ANTFPMLLLAAGLVGTGSSVFHPESSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYgkGNVGWFSLAALL 192
Cdd:cd17478 81 APNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALF--GGLGLLILLIIP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 193 AIVVLLQVSRWYKIQQEAQKKQSKGlnNKIRLPRKTLLGSLAILLILIFSKYFYLASISSYYTFYLIHKfGVSVQNAQIH 272
Cdd:cd17478 159 GLAVALLLLRLRPLKKPEAKKAAAK--SSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 273 LFVFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYASLYWTGVLTVFIGVILASAFSAILVYAQELIPGKT 352
Cdd:cd17478 236 LSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNV 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1063068299 353 GMVSGLFFGLAFGMGGIGAAVLGYIADLKSIEYVYHICAYLPLLGIFTLF 402
Cdd:cd17478 316 GLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
29-403 |
1.16e-36 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 136.92 E-value: 1.16e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 29 ILTAISFSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLI 108
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 109 LLAFANTFPMLLLAAGLVGTGSSVFHPESSR-VARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIApygkgNVGWFS 187
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKlIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA-----AFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 188 LAALLAIVVLLqvsrwykiqqeaqkkqskglnnkirlprkTLLGSLAILLILIFSKYFYLASISSYYTFYLIHKFGVSVQ 267
Cdd:COG2271 166 AFLILGLPGLL-----------------------------LALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 268 NAQIHLFVFLFAVAAGTMIGGPLGDKIGR--KYVIWGSILGVAPFTLILPYA-SLYWTGVLTVFIGVILASAFSAILVYA 344
Cdd:COG2271 217 QAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLpSPALAIALLFLAGFGLGGAFGLLWALA 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 345 QELIPGK-TGMVSGLFFGLAFGMGGIGAAVLGYIADLKSIEYVYHICAYLPLLGIFTLFL 403
Cdd:COG2271 297 AELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
29-367 |
1.74e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 136.26 E-value: 1.74e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 29 ILTAISFSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLI 108
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 109 LLAFANTFPMLLLAAGLVGTGSSVFHPES-SRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVgwFS 187
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAAlALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV--FL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 188 LAALLAIVVLLQVSRWYKIQQEAQKKQSKGLNNKIRLPRKTLLGSLAILLIlifskYFYLASISSYYTFYLIHKFGVSVQ 267
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLL-----GFGFFALFTYLPLYLQEVLGLSAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 268 NAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYASLYWT-GVLTVFIGVILASAFSAILVYAQE 346
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLlLLALFLLGFGFGLLFPLLQALVAE 323
|
330 340
....*....|....*....|..
gi 1063068299 347 LIPGK-TGMVSGLFFGLAFGMG 367
Cdd:COG2814 324 LAPPEaRGRASGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
33-402 |
6.87e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 119.07 E-value: 6.87e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 33 ISFSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAF 112
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 113 ANTFPMLLLAAGLVGTGSSVFHPESSR-VARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFSLAAL 191
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLAlIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 192 LAIVVLLQVSRWYKIQQEAQKKQSKGLNNKIRL-PRKTLLGS--LAILLILIFSKYFYLASISSYYTFYLIHKFGVSVQN 268
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLkLLKRVLKNpgLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 269 AQIHLFVFLFAVAAGTMIGGPLGDK-IGRKYVIWGSILGVAPFTLILPYA-SLYWTGVLTVFIGVILASAFSAILVYAQE 346
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLApSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1063068299 347 LIP-GKTGMVSGLFFGLAFGMGGIGAAVLGYIADLK-SIEYVYHICAYLPLLGIFTLF 402
Cdd:cd06174 321 LFPpEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATfGLTGAFLVLAVLLLLAAILLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
29-403 |
1.63e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 118.06 E-value: 1.63e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 29 ILTAISFSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLI 108
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 109 LLAFANTFPMLLLAAGLVGTGSSVFHPESSR-VARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFS 187
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIAlVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 188 LAALLAIVVLLqvsrWYKIqqeaqKKQSKGLNNKIRLPRKTLLGSLA-----ILLILIFSKYFYLASISSYYTFYLIHKF 262
Cdd:COG2223 166 GILLLVVAVLA----WLFL-----RDPPAGAAAAAKASLRDQLEALRdprfwLLSLLYFGTFGSFIGFSSWLPPYLVDQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 263 GVSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYASLYWTGVLTVFIGVILASAFSAILV 342
Cdd:COG2223 237 GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAV 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063068299 343 YAQ--ELIPGK-TGMVSGLFFGLAFGMGGIGAAVLGYIADL-KSIEYVYHICAYLPLLGIFTLFL 403
Cdd:COG2223 317 FALvpDIFPTKnAGAVYGLVGAAGGLGGFLGPLLFGALLDAtGSYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
33-371 |
1.17e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 109.43 E-value: 1.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 33 ISFSHLLNDMIQSLILAIYPM-LQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLA 111
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 112 FANTFPMLLLAAGLVGTGSSVFHPESSR-VARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVgwFSLAA 190
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALAlIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAA--FLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 191 LLAIVVLLQVSRWYKIQQEAQKKQSKGLNNKIRLPRKTLLGSLAILLILIFSKYFYLASISSYYTFYLIHKFGVSVQNAQ 270
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 271 IHLFVFLFAVAAGTMIGGPLGDKIGRKYVIW----GSILGVAPFTLILPYASLYWTGVLTVFIGVILASAFSAILVYAQE 346
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLlallLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....*.
gi 1063068299 347 LIP-GKTGMVSGLFFGLAFGMGGIGA 371
Cdd:pfam07690 319 LAPkEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
33-403 |
8.66e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 104.58 E-value: 8.66e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 33 ISFSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAF 112
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 113 ANTFPMLLLAAGLVGTGSSVFHPES-SRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFSLA-A 190
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAlA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 191 LLAIVVLLQVSRWYKIQQEAQKKQSKGLNNKIRLPRKTllGSLAILLILIFSKYFYLASISSYYTFYLIHKFGVSVQNAQ 270
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRD--RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 271 IHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYASLYWT-GVLTVFIGVILASAFSAILVYAQELIP 349
Cdd:cd17325 239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLlLLLLALLGLGLGLVFPATLALLADIVP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1063068299 350 -GKTGMVSGLfFGLAFGMGG-IGAAVLGYIADLKSIEYVYHICAYLPLLGIFTLFL 403
Cdd:cd17325 319 pEGRGTAMGL-FNTAFSLGMvLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
23-387 |
1.09e-23 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 101.47 E-value: 1.09e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 23 RNTVFSILTAISFSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGF 102
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 103 TLTGLILLAFANTFPMLLLAAGLVGTGSSVF----HPESSRVARMASGGRHGFAQSLFqvggNLGSSLGPLLAALLIAPY 178
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLdvaaNPYVAALGPETAASRLNLLHAFF----SLGALLGPLLGGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 179 GKGNVG---WFSLAALLAIVVLLQVSRWYKIQQEAQKKQSKGLNNKIRLPRKTLLgslaILLILIFSKYFYLASISSYYT 255
Cdd:COG0738 159 LSLSWHlpyLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLL----LGGLAIFLYVGAEGAIGDWLP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 256 FYLIHKFGVSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIG-RKYVIWGSILGVAPFTLILPYASLYWTGVLTVFIGVILA 334
Cdd:COG0738 235 LYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGpVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLS 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1063068299 335 SAFSAILVYAQELIPGKTGMVSGLFFGLAFGMGGIGAAVLGYIADLKSIEYVY 387
Cdd:COG0738 315 LMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAF 367
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
46-402 |
3.34e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 97.23 E-value: 3.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 46 LILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGL 125
Cdd:cd17324 17 VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 126 VGTGSSVFHPESSRVA-RMASGGRHGFAQSLFQVGGNLGSSLGPLLAAlLIAPYgkgnVGW---FSLAALLAIVVLLQVS 201
Cdd:cd17324 97 AGLAHGGFWAIAAAYAaDLVPPEKRGRAIGLVFSGLTLGLVLGRPLGG-LLGQL----LGWraaFLAIAVLALLAALLLW 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 202 RWYKIQQEAQKKQSKGLNNKIRLPRKTLLGSLAILLILIFSKYFylaSISSYYTFYLIHKFGVSVQNAQIHLFVFLFAVA 281
Cdd:cd17324 172 RLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFF---ALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 282 AGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYASLYWTGVLTVFI-GVILASAFSAILVYAQELIPGKTGMVSGLFF 360
Cdd:cd17324 249 VGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTRVLRLAPEARGLASSLYL 328
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1063068299 361 GLAFGMGGIGAAVLGYIADLKSIEYVYHICAYLPLLGIFTLF 402
Cdd:cd17324 329 AAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
52-380 |
2.79e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 88.78 E-value: 2.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 52 PMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGLVGTGSS 131
Cdd:COG2807 42 PEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 132 VFHPESSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYG-KGNVGWFSLAALLAIVVLLQVSRwykiQQEA 210
Cdd:COG2807 122 VGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGwRGALAVWALLALLALLLWLPLLR----RRPA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 211 QKKQSKGLNNKIRLPRKTLLGSLAILLILI-FSKYFYLASISSYYtfyliHKFGVSVQNAQIHLFVFLFAVAAGTMIGGP 289
Cdd:COG2807 198 AAAAAPAAASLRSLWRSPLAWLLTLFFGLQsLLYYAVVAWLPPIL-----RDAGLSAATAGLLLSLFQLAGIPGSLLVPL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 290 LGDKIG-RKYVIWGSILGVAPFTLILPYASLYWTGVLTVFIGVILASAFSAILVYAQEL--IPGKTGMVSGLFFGLAFGM 366
Cdd:COG2807 273 LADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRarTPAEAAALSGMAQSVGYLL 352
|
330
....*....|....
gi 1063068299 367 GGIGAAVLGYIADL 380
Cdd:COG2807 353 AALGPLLVGALHDA 366
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
30-403 |
3.47e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 88.40 E-value: 3.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 30 LTAISFSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLIL 109
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 110 LAFANTFPMLLLAAGLVGTGSSVFHPES-SRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLiapygkGNVGWFSL 188
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLAlTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL------AAISWRYP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 189 AALLAIVVLLQVSRWYKIQQEAQKKQSKGLNNKIRLPRKTLLGSLAILLILIFSKYFYL-ASISSYYTFYLIHKFGVSVQ 267
Cdd:cd17474 155 FFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLyFAFLTYLPFLLELLYGISPI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 268 NAQIHLFVFLFAVAAGTMIGGP-LGDKIGRKYVIWGSILGVAPFTLILPYA-SLYWTGVLTVFIGVILASAFSAILVYAQ 345
Cdd:cd17474 235 IIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVpSLALLLIAIVLFGLGLGLNLPLLTTLVT 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1063068299 346 ELIP-GKTGMVSGLFFGLAFGMGGIGAAVLGYIADLKSIEYVYHICAYLPLLGIFTLFL 403
Cdd:cd17474 315 ELAPeEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
30-403 |
1.94e-17 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 83.44 E-value: 1.94e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 30 LTAISFSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLIL 109
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 110 LAFANTFPMLLLAAGLVGTGSSVFHPES-SRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGkgnvGW--- 185
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIApTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG----GWrwa 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 186 FSLAALLAIVVLLQVSRWYKIQQEAQKKQSKGLNN---------KIRLPRKTLLGSLAILLILIFSKYFYLASISSYYTF 256
Cdd:cd17328 157 FRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKStatsfladlKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 257 YLIHKFGVSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWG------SILGVAPFTLILPYASLY--WTGVLTVF 328
Cdd:cd17328 237 AFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADplvcavGLLAAAPFLFLALVLALSnlLLAWVLLF 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 329 IGVILASAFSAILVYA-QELIPGK---TGMVSGLFFGLAFGmGGIGAAVLGYIADL-----KSIEYVYHICAYLPLLGIF 399
Cdd:cd17328 317 LGEFLLSLNWAPVFAIlLYVVIPTrrsTASAIQILLSHLLG-DAGSPYLIGLISDLlrqnkDSPLAEAASLQYALLLCSF 395
|
....
gi 1063068299 400 TLFL 403
Cdd:cd17328 396 VLVL 399
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
35-379 |
3.62e-16 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 79.59 E-value: 3.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 35 FSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFAN 114
Cdd:cd17475 3 LAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 115 TFPMLLLAAGLVGTGSSVFHPESSR-VARMASGGRHGFAQSLFQVGGNLGSSLGpllAALLiaPYGKGNVGW---FSLAA 190
Cdd:cd17475 83 SYPVLLVLLFLVGAGYGSVQPGGGRaIMRWFPPRERGLAMGIRQTGVPLGGALA---AALL--PPLALHYGWraaFVVAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 191 LLAIVVLLQVSRWYKIQQEAqkKQSKGLNNKIRLPRKTLLGSLAILLILIFSKYFYLA--SISSYYTFYLIHKFGVSVQN 268
Cdd:cd17475 158 LVSILAAVLFWLFYREPPAA--SAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPqfALLTFLLLFLHDHLGLSVVA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 269 AQIHLFVFLFAVAAGTMIGGPLGDKIG----RKYVIWGSILGVAPFTLI--LPYASLYWTGVLTVFIGVILASAFSAI-L 341
Cdd:cd17475 236 AGALLAVAQLGGALGRIGLGRVSDRVFggrrRPVLVITAAIAAAALLVLslLSPGTPLWLLVLLLILLGLFAIGWNGLyL 315
|
330 340 350
....*....|....*....|....*....|....*....
gi 1063068299 342 VYAQELIP-GKTGMVSGLFFGLAFGMGGIGAAVLGYIAD 379
Cdd:cd17475 316 TLVAESAGpEQAGTALGLANTINFIGIAIGPPLFGLLVD 354
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
32-402 |
9.71e-16 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 77.97 E-value: 9.71e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 32 AISFSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKpYSLPIGMGFTLTGLI--L 109
Cdd:cd17370 3 LLGLVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGK-RKPLVILGYGLSALAkpL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 110 LAFANTFPMLLLAAGLVGTGSSVFHPesSR---VARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKG--NVG 184
Cdd:cd17370 82 LALAGSWQLVLLLRILERLGKGIRTP--PRdalLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNyrTIF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 185 WFSLA-ALLAIVVLLQVSRWYKIQQEAQKKQSKGLNNKIRLPRKTLLGSLAILLILIFSKYFYLasissyytfYLIHKFG 263
Cdd:cd17370 160 LLAAIpALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLI---------LRAQELG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 264 VSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWGSIL--GVAPFTLILPyASLYWTGVLTVFIGVILASAFSAIL 341
Cdd:cd17370 231 LSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLslALAYLGFALG-SSLWLLLLGFILWGLYMGAQESIER 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063068299 342 VYAQELIP-GKTGMVSGLfFGLAFGMGG-IGAAVLGYIADLKSIEYVYHICAYLPLLGIFTLF 402
Cdd:cd17370 310 AAVADLVPaELRGTAYGL-FNTVVGIGWlLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
46-399 |
2.40e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 76.86 E-value: 2.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 46 LILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGL 125
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 126 VGTGSSVFHPESSR-VARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFSLAALLAIVVLLQVsRWY 204
Cdd:cd17489 94 HGIGWGAFTTAAATlVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFL-VKD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 205 KIQQEAQKKQSKGLNNKIRLPRKTLLGSLAILLIlifskYFYLASISSYYTFYLIHKFgvsvqnaqIHLFVFLFAVAAGT 284
Cdd:cd17489 173 PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLA-----SIAYGAISTFLPLYAAERG--------ISNAGLFFTVYAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 285 MIG-----GPLGDKIGRKYVIWGSILGVAPFTLILPYASLYWTGVLT-VFIGVILASAFSAILVYA-QELIPGKTGMVSG 357
Cdd:cd17489 240 LLLsrpfsGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAaVLYGLGFGLLFPALQALAvDLVPPHRRGAANG 319
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1063068299 358 LFFGLAFGMGGIGAAVLGYIADLKSIEYVYHICAYLPLLGIF 399
Cdd:cd17489 320 TFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
38-403 |
1.51e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 74.57 E-value: 1.51e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 38 LLNDMIQSLILAIYpMLQSEFSLSFVqiGMITLTYQITASLLQPFIGLYTDKYPKPYSL---PIGMGFTLTGLILLAFAN 114
Cdd:cd06173 12 ALGDWIFTVALPWL-VLQLTGSALLV--GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLilaDLLRALLAAVLALLALLG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 115 --TFPMLLLAAGLVGTGSSVFHP-ESSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVgwFSLAAL 191
Cdd:cd06173 89 slSLWLLLVLAFLLGIASAFFGPaRQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA--FAINAL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 192 LAIVVLLQVSRWYKIQQEAQKKQSKGLNNKIRLPRKTLLGS--LAILLILIFSKYFYLASISSYYTFYLIHKFGVSVQNA 269
Cdd:cd06173 167 SFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSplLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGY 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 270 QIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYASLYW-TGVLTVFIGVILASAFSAILVYAQELI 348
Cdd:cd06173 247 GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWlLLAALFLLGLAGGLFNVPLNTLLQLRV 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1063068299 349 PGKT-GMVSGLFFGLAFGMGGIGAAVLGYIADLKSIEYVYHICAYLPLLGIFTLFL 403
Cdd:cd06173 327 PDELrGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
35-378 |
6.72e-14 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 72.35 E-value: 6.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 35 FSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMItLTYQITASLLQPFI-GLYTDKYPKPYSLPIGMGFTLTGLILLAFA 113
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVI-FSSQNAGYLIGSLLaGFLMKRLGRRRTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 114 NTFPMLLLAAGLVGTGSSVFHPESSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIApyGKGNVGWFSLAALLA 193
Cdd:cd17333 82 PSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLT--SELSWSWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 194 IVVLLQVSRWYKIQQEAQKKQSKGLNNKIRLPRKTLLGSLAILLILIFSKYFYLA--SISSYYTFYLIHKFGVSVQNAQI 271
Cdd:cd17333 160 YLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAetAFSSWVPSYLVEKKHVSDGLAGY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 272 HLFVFLFAVAAGTMIGGPLGDKIG-RKYVIWGSILGVAPFTLILPYASLYWTGVLTVFIGVILASAFSAILVYAQELIPG 350
Cdd:cd17333 240 LLSGFWVGITIGRLLGGPISRRIKpHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPY 319
|
330 340
....*....|....*....|....*...
gi 1063068299 351 KTGMVSGLFfglaFGMGGIGAAVLGYIA 378
Cdd:cd17333 320 AKGKGTSVL----LAAGSIGGAIIPFIM 343
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
42-380 |
7.87e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 72.63 E-value: 7.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 42 MIQSLILAIYpmLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYP------KPY----SLPIGMGFTLTGLI-LL 110
Cdd:COG2211 27 GLLSAYLLYF--YTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrrRPWiligAIPLALSFVLLFTApDL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 111 AFANTFPMLLLAAGLVGTGSSVFH-PESSRVARMASGGR-HGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNV-GWFS 187
Cdd:COG2211 105 SPTGKLIYALVTYLLLGLAYTLVNiPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAAlGYRL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 188 LAALLAIV--VLLQVSRWYKIQQEAQKKQSKGLNNKIRLPRKTllGSLAILLILIFSKYFYLASISSYYTFYLIHKFGVS 265
Cdd:COG2211 185 TALIFAVLglLAFLLTFFGTKERPVPEEEKVSLKESLKALLKN--RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLS 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 266 VQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYV-IWGSILGVAPFTLI--LPYASLYWTGVLTVFIGVILASAFSAILV 342
Cdd:COG2211 263 AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAfIIGLLLAALGLLLLffLGPGNLWLLLVLAALAGIGLGAILVLPWA 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1063068299 343 Y------AQELIPGK--TGMVSGLF-FGLAFGMgGIGAAVLGYIADL 380
Cdd:COG2211 343 MladvvdYDEWKTGRrrEGLYFGIFtFAIKLGQ-ALAGALAGLLLAL 388
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
48-401 |
2.25e-13 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 71.10 E-value: 2.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 48 LAIYpmLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGLVG 127
Cdd:cd17329 22 MAIY--LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 128 TGSSVFHPESSR-VARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLiapYGKGNVGWFSLAALLAIVVLLQVSRWYKI 206
Cdd:cd17329 100 FGGGLFEPASEAmIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL---LLYSFRLLFLAAAVLFLLAALVLLFLLPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 207 QQeAQKKQSKGLNNKIRLPRKTLLGSLAILLILIFSKYFYLASISSYYTFYLIHKFGVSVQnaqihLFVFLFAVAAGTMI 286
Cdd:cd17329 177 TR-PKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES-----LLGLLLALNALLIV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 287 GG-----PLGDKIGRKYVIWGSILGVAPFTLILPYASLYWTGVLTVF---IGVILASAFSAILVYAqeLIP-GKTGMVSG 357
Cdd:cd17329 251 LLqfpvaRLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIvltLGEMLVFPAVQTLVAA--LAPpDKRGSYMG 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1063068299 358 lFFGLAFGMGG-IGAAVLGYIADLKSIEYVYHICAYLPLLGIFTL 401
Cdd:cd17329 329 -FYALAWGLGRaIGPLVGGLLLDLLGPGLPWLILAALGLIAAALL 372
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
52-380 |
1.33e-12 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 68.56 E-value: 1.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 52 PMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGLVGTGSS 131
Cdd:TIGR00881 19 PYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 132 VFHPESSR-VARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGwFSLAALLAIVVLLQVSRWYK----- 205
Cdd:TIGR00881 99 MGWPPCGRtVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWV-FIVPGIIAIIVSLICFLLLRdspqs 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 206 ------------IQQEAQKKQSKGLNNKIRLPRKTLLGSLAILLILI-FSKYFYLASISSYYTFYLIHKFGVSVQNAQIH 272
Cdd:TIGR00881 178 cglppaeempneEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGyVFVYVVRTGILDWSPLYLTQEKGFSKEKASWA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 273 LFVFLFAVAAGTMIGGPLGDKI--GRKYVI-----WGSILGVAPFTLIlPYASLYWTGVLTVFIGVILASAFSAILVYAQ 345
Cdd:TIGR00881 258 FTLYELGGLVGTLLAGWLSDKLfnGRRGPLavffmALIIVSLLVYWLN-PAANPLMDLICLFALGFLVYGPQMLIGVIAS 336
|
330 340 350
....*....|....*....|....*....|....*.
gi 1063068299 346 ELIPGKTGMVSGLFFGLAFGMGGIGA-AVLGYIADL 380
Cdd:TIGR00881 337 ELAPKKAAGTAAGFVGFFAYLGGILAgLPLGYLADG 372
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
98-402 |
6.36e-12 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 66.42 E-value: 6.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 98 IGMGFTLTGLILLAFANTFPMLLLAAGLVGTGSSVFHPESSRVAR----MASGGRHGFAQSLFQVGGNLGSSLGPLLAAL 173
Cdd:cd17471 68 LALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAReyadRSSGRDATLFNSVLRAAFSLAWVIGPPLAFL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 174 LIAPYGKGnvGWFSLAALLAIVVLLQVSRWYK-IQQEAQKKQSKGLNNKIRLPRKTLLGSLAILLILIFSKyFYLASISs 252
Cdd:cd17471 148 LLDVLGFT--GLFLLAALLYLVVALLVLFLLPsVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANS-MYIIAMP- 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 253 yytFYLIHKFGVSVQNAQIhlfvfLFAVAAG----TMIG-GPLGDKIG-RKYVIWGSILGVAPFTLILPYASLYWTGVLT 326
Cdd:cd17471 224 ---LYVTNELGGSESWVGL-----LFGLAAAleipIMLLaGLLAKRFGkRRLLLAGFLAGVLFYLGLALATSLWQLIALQ 295
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063068299 327 VFIGVILASAFSAILVYAQELIPGKTGMVSGLFFGlAFGMGGI-GAAVLGYIADLKSIEYVYHICAYLPLLGIFTLF 402
Cdd:cd17471 296 LLNAIFIGITAGLGISYFQDLMPGQPGLATTLYSN-ASRIGSLlGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
32-198 |
1.53e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 65.29 E-value: 1.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 32 AISFSHLLNDMIQSLILAIYPM-LQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILL 110
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 111 AFANTFPMLLLAAGLVGTGSSVFHP-ESSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFSLA 189
Cdd:cd17325 283 PLATSFWLLLLLLALLGLGLGLVFPaTLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAA 362
|
....*....
gi 1063068299 190 ALLAIVVLL 198
Cdd:cd17325 363 LLLLAAVLF 371
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
30-378 |
1.57e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 65.32 E-value: 1.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 30 LTAISFSHLLNDMIQSLILAIYPMLQSEFS--LSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGL 107
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 108 ILLAFANTFPMLLLAAGLVGTGSSVFHP-ESSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIaPYGKGNVGW- 185
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPgASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLI-PLLSGDWGWr 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 186 --FSLAALLAIVVLLQvsrwykiqqeaqkkqskglnnkirlpRKTLLgsLAILLILIFSKYFYLasISSYYTFYLIHKFG 263
Cdd:cd17316 160 ilFLIGALPALLALLL--------------------------RRRTL--LLILLWFFISFGYYG--LTTFLPTYLQTVLG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 264 VSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYA---SLYWTGVLTVFIGVILASAFSAI 340
Cdd:cd17316 210 LSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsgSPTLLLLLLFILSFFVGGVWGAL 289
|
330 340 350
....*....|....*....|....*....|....*....
gi 1063068299 341 LVYAQELIPGKT-GMVSGLFFGLAFGMGGIGAAVLGYIA 378
Cdd:cd17316 290 YAYLAELFPTEVrATGVGLSYNLGRLGGGGAPPLIALLL 328
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
109-383 |
1.67e-11 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 65.40 E-value: 1.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 109 LLAFANTFPMLLLAAGLVGTGSSVFHPESSRVARMASGGRH-GFAQSLFQVGGNLGSSLGPLLAALLIaPYGKGNVGW-- 185
Cdd:cd17371 80 LCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHrGKALGYVQSGWAVGWLLATLLAALLF-PLLPPEIAWrv 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 186 -FSLAALLAIVVLLqVSRWYKIQQEAQKKQSKGLNNKIR------LPRKTLLGSLAILLILIFSkYFYLASISSYYTFYL 258
Cdd:cd17371 159 lFLLGALPALLVLF-IRRFVKEPPQWQAARAARRHFADRpslrelFSPPLLRTTLLASLLATGA-LGGYYGITTWLPSYL 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 259 IHKFGVSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIW-GSILGVAPFTLILPY-ASLYWTGVLTVFIGVILASA 336
Cdd:cd17371 237 TGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFAlFALGSAISILLYFFLpLSPTLILILGFPLGFFASGP 316
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1063068299 337 FSAILVYAQELIPGKTGmVSGLFFGLAFG--MGGIGAAVLGYIADLKSI 383
Cdd:cd17371 317 FSGMGAYLTELFPTAVR-ATAQGFCYNVGriIGALFPFLVGFLATSGSL 364
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
52-379 |
6.75e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 63.36 E-value: 6.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 52 PMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGLVGTGSS 131
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 132 VFHPESSR-VARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIapygkGNVGWFSLAALLAIVVLLQVSRWYKiqqea 210
Cdd:cd17319 107 GFFPGAIKaLAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL-----LLFGWRWAFIIEGLLGLLLAVLWWF----- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 211 qkkqskglnnkirlprktLLGSLAILLILIFSKYFYLASISSYYTFYLIHKFGVSVQNAQIHLFVFLFAVAAGTMIGGPL 290
Cdd:cd17319 177 ------------------YLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 291 GDKI---GRKYVIWGSILGVAPFTLILPYA-SLYWTGVLTVFIGVILASAFSAILVYAQELIPGKTGMVSGLFFGLAFGM 366
Cdd:cd17319 239 SDRLlrgARRLVIIIGLLLAAVGLLLAYLTtSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNL 318
|
330
....*....|....
gi 1063068299 367 GGIGAAVL-GYIAD 379
Cdd:cd17319 319 GGFVAPLLiGYLVD 332
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
45-375 |
8.93e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 62.96 E-value: 8.93e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 45 SLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMG-FTLTGLiLLAFANTFPMLLLAA 123
Cdd:cd17321 13 TIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLAlFGLASL-LCALAPSLAFLIAAR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 124 GLVGTGSSVFHPES-SRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIApygkgNVGW---FSLAALLAIVVLLq 199
Cdd:cd17321 92 ALQGIGAAAIMPASlALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE-----LFGWrwiFLINVPIGLVALL- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 200 vsrwykiqqeaqkkqskglnnkirLPRKTLLGSLAILLIlifskYFYLASISSYYTFYLIHKFGVSVQNAQIHLFVFLFA 279
Cdd:cd17321 166 ------------------------LARTFSGAVLAAFLL-----GAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 280 VAAGTMIGGPLGDKIG-RKYVIWGSIL---GVAPFTLILPYASLYWTGVLTVFIGVILASAFSAILVYA-QELIPGKTGM 354
Cdd:cd17321 217 MLVAAPLAGRLADRFGpRLVLVAGLLLtavGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAAlSSVPKEKAGA 296
|
330 340
....*....|....*....|..
gi 1063068299 355 VSGLfFGLAFGMGG-IGAAVLG 375
Cdd:cd17321 297 ASGI-LNTARQLGGaLGVALLG 317
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
223-403 |
5.71e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 57.29 E-value: 5.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 223 RLPRKTLLGSLAILLILIFSKYFYLASISsyytfYLIHKFGVSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWG 302
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALP-----LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 303 SILGVAPFTLILPYA-SLYWTGVLTVFIGVILASAFSAILVYAQELIPGKT-GMVSGLFFGLAFGMGGIGAAVLGYIADL 380
Cdd:COG2814 81 GLLLFALGSLLCALApSLWLLLAARFLQGLGAGALFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180
....*....|....*....|...
gi 1063068299 381 KSIEYVYHICAYLPLLGIFTLFL 403
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
275-404 |
9.90e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 56.43 E-value: 9.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 275 VFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYASLYWT-GVLTVFIGVILASAFSAILVYAQELIPGKTG 353
Cdd:cd17317 33 IFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELfLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYR 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1063068299 354 MVSGLFFGLAFGMGGIGAAVLGYIADLKSIeyvYHICAYLPLLGIFTLFLP 404
Cdd:cd17317 113 SFVGILFGLFWALGYMLLALLAYLIRDWRW---LQLAISLPGLLFLLLLWW 160
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
53-371 |
1.47e-08 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 56.16 E-value: 1.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 53 MLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFAN-TFPMLLLAAGLVGTGSS 131
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVqSYSVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 132 VFHPESSRVARMASGGRHGFAQSLFQVGGNLGSSL----GPLLAALLIAPYGKGNV---GW------FSLAALLAIVVLL 198
Cdd:TIGR00886 107 SFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVaqfvMPPIIGSLIFGGGQPAHlawGWafvivpAGILLLPALLIFF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 199 QVSRWYkiqqeaqKKQSKGLNNKIRLPRKTLLGSLAILLILIFSKYF--YLAsISSYYTFYLIHKFGVSVQNAQIHLFVF 276
Cdd:TIGR00886 187 VGADTP-------PGKPATGKLSFKEALKVFGNRHTWILALLYSVTFgsFLG-VSSIFAMLFKDQFGLSKVQAGAYASLG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 277 LFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILpYASLYWTGVLTVFIGVILASAFSAIL----VYAqeLIPGKT 352
Cdd:TIGR00886 259 GFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLV-VLGLVSDGSLAAFIVLFVALFFFAGAgngsTFA--LVPHIF 335
|
330
....*....|....*....
gi 1063068299 353 GMVSGLFFGLAFGMGGIGA 371
Cdd:TIGR00886 336 RRATGAVSGLIGAIGNLGG 354
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
143-349 |
1.50e-08 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 56.15 E-value: 1.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 143 MASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNV---GW---FSLAALLAIVVL-----LQVSRWYKIQQEAQ 211
Cdd:cd17367 129 VAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLGEDQMaawGWripFLLGGVLAVVVLwlrrgLEETESFEAIAESN 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 212 KKQSKGLNNKIRLPRKTLLgslAILLILIFSKYFYlaSISSYYTFYLIHKFGVSVQNAQIHLFVFLFAVAAGTMIGGPLG 291
Cdd:cd17367 209 EASAGTLRELRRHPRELLL---VVGLTAGGTLAFY--TWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLS 283
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063068299 292 DKIGRKYVIWGSILGVAPFTLILPYASLYWTGVLTVFIGVILA----SAFSAIL-VYAQELIP 349
Cdd:cd17367 284 DRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAFALVLVGlvflSGYTSINaVVKAELFP 346
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
30-403 |
2.75e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 55.28 E-value: 2.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 30 LTAISFSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLIL 109
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 110 LAFANTFPMLLLAAGLVGTGSSVFHPESSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFslA 189
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV--A 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 190 ALLAIVVLLQVSRWykiqqeaqkkqskglnnkirlprktlLGSLAILLILIFSKYFYLASISSYYTFYLIHKFGVSVQNA 269
Cdd:cd17330 159 AALALLNLVLVLFF--------------------------LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 270 QIHLFVF-LFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYAS-LYWTGVLTVFIGVILASAFSAI-LVYAQE 346
Cdd:cd17330 213 GLLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPALsALLSKS 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1063068299 347 LIPGKTGMVSGLFFGLAFGMGGIGAAVLGYIADLKSIEYVYHICAYLPLLGIFTLFL 403
Cdd:cd17330 293 VPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
51-383 |
3.60e-08 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 54.96 E-value: 3.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 51 YPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGLVGTGS 130
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 131 SV----FHPESSRVARmaSGGR------HGFaqslFQVGGNLGSSLGPLLAALLIAPYGKgnvgwFSLAALLAIVVLLQV 200
Cdd:cd17393 102 GAldvaMNAQGVAVER--AYGRpimsslHAM----WSLGGLAGALLGAAAIGAGVSPGVH-----LLAAAVLLLLAALVA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 201 SRWYkiQQEAQKKQSKGLNNKIRLPRKTLLGSLAILLILIFSKYFYLASISSYYTFYLIHKFGVSVQNAQIHLFVFLFAV 280
Cdd:cd17393 171 IRAL--LPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAM 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 281 AAGTMIGGPLGDKIGRKYVI-WGSILGVAPFTLILPYASLYWTGVLTVFIGVILASAFSAILVYAQELIPGKTGmvSGLF 359
Cdd:cd17393 249 TVGRLFGDRLVDRFGDVAVLrAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLAAG--IAVA 326
|
330 340
....*....|....*....|....*.
gi 1063068299 360 FGLAFGMGG--IGAAVLGYIADLKSI 383
Cdd:cd17393 327 RVATLGYLGflVGPPLIGFLADATGL 352
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
52-403 |
1.05e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 53.38 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 52 PMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAG-LVGTGS 130
Cdd:cd17353 27 PPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGvLGGIGA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 131 SVFHPESSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGN------VGWFSLAALLAIVVLLQVSRWY 204
Cdd:cd17353 107 GIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTtflilgIIFLIIIVIGAFLIRDPPKGWV 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 205 KIQQEAQKKQSKGLNNKIRLPRKTLLGSLAILLILIFSKYFYLASISSYYTFYLIHKFGVSVQNAQIHLFVFLFAVAAGT 284
Cdd:cd17353 187 PPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 285 MIGGPLGDKIGRKYV--IWGSILGVAPFTLILpYASLYWTGVLTVFI-GVILASAFSAILVYAQELIPGKT-GMVSGLFF 360
Cdd:cd17353 267 PFWGWLSDKIGRKNTlsIAFLIQGVAMFLLPF-IGSVAVLFVLGVALiGFCYGGGFALFPALTADFFGTKNaGTNYGLLY 345
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1063068299 361 gLAFGMGG-IGAAVLGYIADLKSIEYVYHICAYLPLLGIFTLFL 403
Cdd:cd17353 346 -TAKGVGGlIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALL 388
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
35-374 |
1.11e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 53.41 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 35 FSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFA- 113
Cdd:cd17341 6 LSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAv 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 114 NTFPMLLLAAGLVGTGSSVFHPESSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIA--PYGKGNVGW---FSL 188
Cdd:cd17341 86 SSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGaiVFDGGFVGWrnaFFV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 189 AALLAIVVLLQVSRWYKIQQEAqkkqskglNNKIRLPRKTLLGSLAILLILIFSkYFYLAS------ISSYYTFYLIHKF 262
Cdd:cd17341 166 PGILLAIAAVLVLLFGDDLPTG--------KASALEFLKVQLAVLKNYRTWILS-LLYGVTfgsfvgFSNVLPTYFKTRF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 263 GVSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYASLYWTGVLTVFIGVILASAFSAILV 342
Cdd:cd17341 237 GLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAG 316
|
330 340 350
....*....|....*....|....*....|....
gi 1063068299 343 YAQ--ELIPGKTGMVSGLFFGLAFGMGGIGAAVL 374
Cdd:cd17341 317 NGSvfRMVPFIFRRELGAVTGLVGAIGGLGGFFL 350
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
29-291 |
1.39e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.51 E-value: 1.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 29 ILTAISFSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLI 108
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 109 LLAFANTFPMLLLAAGLVGTGSSVFHPES-SRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFS 187
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGAlALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 188 L---AALLAIVVLLQVSRWYKIQQEAQKKQSKGLNNKIRLPRKTLLGSLAILLILIFSKYFYLASISSYYTFYLIHKFGV 264
Cdd:COG0477 175 AplgLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
250 260
....*....|....*....|....*..
gi 1063068299 265 SVQNAQIHLFVFLFAVAAGTMIGGPLG 291
Cdd:COG0477 255 ALLLLAALLLLLLLLLLLALLLALLLL 281
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
52-380 |
1.46e-07 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 53.01 E-value: 1.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 52 PMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFAN----TFPMLLLAAGLVG 127
Cdd:cd17345 27 PYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPsatsSVGLMFILLFLNG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 128 TGSSVFHPESSR-VARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGW-FSLAALLAIVVLLQV----- 200
Cdd:cd17345 107 WFQGMGWPPSGRtMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGWWRGaFIFPAIIAIIVAVIVlflgk 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 201 -------------SRWYKIQQEAQKKQSKGLNNKiRLPRKTLLGSLAILLILIFSKYFYLA--SISSYYTFYLIHKFGVS 265
Cdd:cd17345 187 dtpeseglppieeYKGDYPEEADGEEEEQELSAW-EIFVKYVLKNKLLWYIAIANVFVYLVryGILDWAPTYLSEVKGFS 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 266 VQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILpyaSLYW--TGVLTVFIGVILASAF-----S 338
Cdd:cd17345 266 KAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVAL---IVYWlaPNVLVDLIALIALGFLiygpvM 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1063068299 339 AILVYAQELIPGK-TGMVSGL--FFGLAFGMGGiGAAVLGYIADL 380
Cdd:cd17345 343 LIGLQALELVPKKaAGTAAGLtgLFGYLGGSVL-ATALIGIIVDH 386
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
54-380 |
1.71e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 53.04 E-value: 1.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 54 LQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKY-PKPYSLPIGMGFTLtGLILLAFANTFPMLLLAAGLVGTGSSV 132
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFgPRRVMLLGLLLLAA-GLVLLALATSLWQLYLLWGLLGGGGAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 133 FHPES--SRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYG-KGNVGWFSLAALLAIVVLLQVSRwykiQQE 209
Cdd:cd17355 108 TLAAVafATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGwRTALLVLALLALLVLVPVLLLLR----RRP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 210 AQKKQSKGLNNKIRLPRKTLL-----GSLAILLILIFSKYFYLASISSYYTFYLIHkFGVSVQNAQIHLFVFLFAVAAGT 284
Cdd:cd17355 184 ADLALRAYDDASPASPGSTLKealrsASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 285 MIGGPLGDKIGRKYVIWGSILGVAPFTLILPYAslywTGVLTVFIGVILASAFSAILV-------YAQELIPGKTGMVSG 357
Cdd:cd17355 263 LLSGWLGDRYSPRRLLAASYALRALGLALLLLL----PFPPLALLLFAALFGLGWGATvpltaalAARYFGARSYGTLFG 338
|
330 340
....*....|....*....|...
gi 1063068299 358 LFFGLAFGMGGIGAAVLGYIADL 380
Cdd:cd17355 339 LVFAPHQLGSALGPWLGGLLYDR 361
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
23-166 |
1.80e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 52.67 E-value: 1.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 23 RNTVFSILTAISFshLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGF 102
Cdd:COG2814 205 RRPRLLLLLLLAF--LLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063068299 103 TLTGLILLAFANTFPMLLLAAGLVGTGSSVFHP-ESSRVARMASGGRHGFAQSLFQVGGNLGSSL 166
Cdd:COG2814 283 LALGLLLLALAGSLWLLLLALFLLGFGFGLLFPlLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
42-377 |
2.06e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 52.58 E-value: 2.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 42 MIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLL 121
Cdd:cd17504 10 LVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 122 AAGLVGTGSSVFhPESSRVARMA-SGGRHGFAQSLFQVGGNLGSSLGPLLAALLIApygkgNVGW---FSLAALLAIVVL 197
Cdd:cd17504 90 GRALQGIGGAVF-PLAFALVREEfPPERVPVAQGILSATFGIGAGIGLPLGGWIVQ-----HLGWrwiFWTAAPVAVLLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 198 LQVSrwykiqqeaqkkqskgLNNKIRLPRKTLLGSLAILLILIFSKYFYLASISSYYTFYLIHKFGVSVQNAqihlFVFL 277
Cdd:cd17504 164 ALVP----------------LIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEA----GLLL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 278 FAVAAGTMIGGPLGDKIGRKY-----VIWGSILGVAPFTLILPY-ASLYWTGVLTVFIGVILASAFSAIL-VYAQELIPG 350
Cdd:cd17504 224 LPGALVMLIAGPLAGRLIARVgprrvLLIGLVISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFASLPnIVVESVPPD 303
|
330 340
....*....|....*....|....*..
gi 1063068299 351 KTGMVSGLFFGLAFGMGGIGAAVLGYI 377
Cdd:cd17504 304 RTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
42-375 |
4.49e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 51.42 E-value: 4.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 42 MIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLL 121
Cdd:cd17503 10 LDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLII 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 122 AAGLVGTGSSVFHPES-SRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFSLAALLAIVVLLQV 200
Cdd:cd17503 90 FRILQGFGGGVLIPLAqTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 201 srwykiqqeaqkkqskgLNNKIRLPRKTLLGSLAILLIlifskYFYLASISSYYTFYLIHKFGVSVQNAQIHLFVFLFAV 280
Cdd:cd17503 170 -----------------LDLRLFKDRNFTLGLLLSFLL-----GLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLAS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 281 AAGTMIGGPLGDKIG-RKYVIWGSIL---GVAPFTLILPYASLYWTGVLTVFIGVILASAFSAILVYA-QELIPGKTGMV 355
Cdd:cd17503 228 AILSPLVGRLLDKFGpRLLLLAGLLLlalGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLAlNSLPPEQIGDA 307
|
330 340
....*....|....*....|
gi 1063068299 356 SGLFFGLAFGMGGIGAAVLG 375
Cdd:cd17503 308 TALFNTIRQLGGSIGTALLA 327
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
65-403 |
4.69e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.45 E-value: 4.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 65 IGMITLTYQITASLLQPFIGLYTDKYPKpYSLPIGMGFTLTGL--ILLAFANTFPMLLLAAGLVGTGSSVFHPESSRVAR 142
Cdd:cd17490 33 IGIILGAYGISQMLLRIPLGILSDRIGK-RKLFIIIGLLFTVLasLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 143 MASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFS-LAALLAIVVLLQVsrwyKIQQEAQKKQSKGLNNK 221
Cdd:cd17490 112 YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAaLAGVLGFILSLFI----KEERREKKPVLTELKEL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 222 IRLPRKTLLGSLAILLILIFskyfyLASISSYYTFYLIHKFGVSVQNAQIHL--FVFLFAVAAGTMIGGPL-GDKIGRKY 298
Cdd:cd17490 188 LSVLKDKKLLFFSLLAILQQ-----MITFSTTFGFTPLIAKQLGASSFQLGLlsIIYLLPNALASLLSGTLfYKKLGERN 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 299 VIWGSILGVAPFTLILPYAS-LYWTGVLTVFIGVILASAFSAILVYAQELIP-GKTGMVSGLFFGL-AFGMgGIGAAVLG 375
Cdd:cd17490 263 TIIIGFLLLGAYCFLIPFAPnLTLLYLLQALNGFGTGILFPLLMSLSIEGVPaEQRSTAMGFFQAIyALGM-FLGPVLVG 341
|
330 340
....*....|....*....|....*....
gi 1063068299 376 YIADLKSIEYVYHICAYLPLLG-IFTLFL 403
Cdd:cd17490 342 IISEAFGLQTGFFVIGVIALLAaILSLAY 370
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
32-202 |
7.24e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 50.64 E-value: 7.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 32 AISFSHLLNDMIQSLILA-IYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLP--IGMGFTLTGLI 108
Cdd:COG2271 184 LLALAYFLVYFALYGFLTwLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVlaIGLLLAALALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 109 LLAFANTFPMLLLAAGLVGTGSSVFHP-ESSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNV-GWF 186
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGlLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAfLLL 343
|
170
....*....|....*.
gi 1063068299 187 SLAALLAIVVLLQVSR 202
Cdd:COG2271 344 AALALLAALLALLLLR 359
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
29-403 |
1.19e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.96 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 29 ILTAISFSHLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLI 108
Cdd:cd17312 4 IFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 109 LLAFANTFPMLLLAAGLVGTGSSVFHPESSR-VARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVgwFS 187
Cdd:cd17312 84 FMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKlLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAA--FL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 188 LAALLAIVVLLQVSRWYkiqqeaqkkqskglnnkIRLPRKTLLGSLAILLIlifskYFYLASISSYYTFYLIHKFGVSVQ 267
Cdd:cd17312 162 VPGIVGLVVAIILFFFL-----------------RDSPPYVWVLSLAYAFV-----YIVRYACLDWGPLYLYEVKGYSLI 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 268 NAQIHLFVFLFAVAAGTMIGGPLGDKI--GRKYVIWGSILGVAPFTLILPY---ASLYWTGVLTVFIGVILASAFSAILV 342
Cdd:cd17312 220 DAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWffpHNKLLSIVLLFLIGFFVGGPINLIGG 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063068299 343 YAQELIPGK--TGMVSGLFFGLAFGMGGIGAAVLGYIADLKSIEYVYHICAYLPLLGIFTLFL 403
Cdd:cd17312 300 AAAQDIGRKeaAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLS 362
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
49-403 |
2.88e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 48.74 E-value: 2.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 49 AIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGLVGT 128
Cdd:cd17365 20 FVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 129 GSSVFHPES-SRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFSLAALLAIVVLLqvsrwykiq 207
Cdd:cd17365 100 GLGAAMPNAiTLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLL--------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 208 qeaqkkqskglnnkirlpRKTLLGSLAILLILiFSKYFYLAsissyYTFYLIHKFGVSVQNAQIHLFVFLFAVAAGTMIG 287
Cdd:cd17365 171 ------------------RGTLLLWVTFFMGL-LLVYLLNS-----WLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 288 GPLGDKIGRKYVIWGSILGVAPFTLILPY--ASLYWTGVLTVFIGVILASAFSAILVYAQELIPGK---TGMVSGLFFGL 362
Cdd:cd17365 227 GWLADRFGPKRVLALFFALGAVSLALLGVspASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEvraTGVGWALGVGR 306
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1063068299 363 afgMGGIGAAVLG--YIADLKSIEYVYHICAYLPLLGIFTLFL 403
Cdd:cd17365 307 ---LGAILGPLLGglLLAAGLGPESVFLALAIPAALGALAVLL 346
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
153-380 |
3.46e-06 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 48.76 E-value: 3.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 153 QSLFQVGGNLGSSLGPLLAALLIAPYGKGNV--GWFSLAALLAIV-VLLQVSRWYKIQQEAQKKQSKGLNNKIRLPRKTL 229
Cdd:cd17332 138 TSWRMFFATIGGLLVTVLPPPLVAYFGGGNAsrGYFLTALIIGIIgIILLLICFFGTRERVVPPEEEKSKLPLLKSLKAL 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 230 LGSLAILLILIFSKYFYLA--SISSYYTFYLIHKFGvSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGV 307
Cdd:cd17332 218 LKNRPFLILLLAYLLYFLAfnIVNTVLVYYFKYVLG-GRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLA 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 308 APFTL---ILPYASLYWTGVLTVFIGVILASAFS------AILVYAQELIPGK--TGMVSGLF-FGLAFGMgGIGAAVLG 375
Cdd:cd17332 297 ILGLLllfFLPPGNLVLILVLAVLAGIGYGGANLlpwamlADVIDYGELKTGKrrEGIFYSVMtFFRKLGL-ALAGALVG 375
|
....*
gi 1063068299 376 YIADL 380
Cdd:cd17332 376 LILSL 380
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
74-402 |
2.31e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.10 E-value: 2.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 74 ITASLLQPFIGLYTDKYP-KPYSLPIGMGFTLTgLILLAFANTFPMLLLAAGLVGTGSSVFHPESSRVARMASGGRHGFA 152
Cdd:cd17391 47 LVSAIFSPIWGRLADRYGrKPMLLRASLGMAIV-IGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 153 QSLFQVGGNLGSSLGPLLAALLIAPYGKGNVgwFSLAALL----AIVVLLQVSRWYKIQQEAQKKQSKGLNNKIrlPRKT 228
Cdd:cd17391 126 LGTLSTGVVAGTLIGPLLGGFLADLFGIRNV--FFITGGLlflaFLLTLFFVKEDFKPVEKKKMVSTKEVWNSV--PNPS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 229 LLGSLAILLILIfskYFYLASISSYYTFYlIHKFGVSVQNAQIHLFVFLFAVAAGTMIGGP----LGDKIGRKYVIWGSI 304
Cdd:cd17391 202 LLISLFVTTFII---QLANQSIEPILTLY-IRQLMGDASNLAFISGLVFSATGVSSLLSAPrlgkLGDRIGHHRILLGAL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 305 LGVAPFTLILPYASLYWT-GVLTVFIGVILASAFSAILVYAQELIP-GKTGMVSGLFFGLAFGMGGIGAAVLGYIADLKS 382
Cdd:cd17391 278 LASALLYIPQAFVQTPWQlGILRFLLGLATGGLLPAINSLLAKITPkEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFG 357
|
330 340
....*....|....*....|
gi 1063068299 383 IEYVYHICAYLPLLGIFTLF 402
Cdd:cd17391 358 YRAVFVVTALLVLLNAIWSF 377
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
277-375 |
2.35e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 46.20 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 277 LFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYASLYWT-GVLTVFIGVILASAFSAILVYAQELIPGK-TGM 354
Cdd:TIGR00895 62 LIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQlLILRFLAGLGLGGLMPNLNALVSEYAPKRfRGT 141
|
90 100
....*....|....*....|.
gi 1063068299 355 VSGLFFgLAFGMGGIGAAVLG 375
Cdd:TIGR00895 142 AVGLMF-CGYPIGAAVGGFLA 161
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
30-359 |
2.45e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.03 E-value: 2.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 30 LTAISFSHLLNDMIQSLILAIYPMLQSEFSL-SFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLI 108
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQHFVPnSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 109 LLAFANTFPMLLLAAGLVGTGSSVFHPES-SRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLiapygkGNVGWFS 187
Cdd:cd17473 81 AGLFLDSLYALLASRALLGIGVAGIMTLAtALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL------AEIGWRA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 188 --LAALLAIVVLLQVsrWYKIQQEAQKKQSKGLNNKIRLPRKtLLGSLAILLILIFSKYFYLASISSYYTFYLIHKFGVS 265
Cdd:cd17473 155 pfLVYLLALPVLILV--LLFLPEPARKSKSAASPGAATAAAL-PWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 266 VQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVI-WGSILGVAPFTLILPYASLYWTGVLTVFIGVILASAFSAILVYA 344
Cdd:cd17473 232 AALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLaIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWA 311
|
330
....*....|....*.
gi 1063068299 345 QELIP-GKTGMVSGLF 359
Cdd:cd17473 312 MSLVPpELRGRAMGIV 327
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
94-205 |
3.85e-05 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 45.64 E-value: 3.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 94 YSLPIGMGFTLTGLILLAFA-NTFPMLLLAAGLVGTGSSVFHPE-SSRVARMASGG--RHGFAQSLFQVGGNLGSSLGPL 169
Cdd:cd17346 72 RTVFIGGILMALGYLLLALSpFSVSMLYLGLALIIVGNGLFKPNiSSLVGKLYDENdpRRDSGFSIFYMGINLGAFLAPL 151
|
90 100 110
....*....|....*....|....*....|....*....
gi 1063068299 170 LAALLIAPYGKGNVgwFSLAA---LLAIVVLLQVSRWYK 205
Cdd:cd17346 152 LCGTLGDNYGYHYG--FGLAAvgmLLGLLIFLLGRKKLL 188
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
64-375 |
3.97e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.24 E-value: 3.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 64 QIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGLVGTGSSVFHPES-SRVAR 142
Cdd:cd17477 32 LIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 143 MASGGRHGFAQSLFQVGGNLGSSLGPLLAALlIAPYGKGNVGWFSLAALLAIVVLLQVSRWYKIQQEAQKkqskglnnkI 222
Cdd:cd17477 112 LATNENRGRVLGLYSTVLGLGFALGPLLLAL-VGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAES---------I 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 223 RLPRKTLLGSLAILLILIFSkyFYLASISSYYTFYLIHKfGVSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWG 302
Cdd:cd17477 182 SLRRLLRIAPLALLGAFVAG--FLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLG 258
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063068299 303 SILGVAPFTLILPYAS--LYWTGVLTVFIGVILASAFSAILVYAQELIPGKTGMVSGLFFGLAFGMGGIGAAVLG 375
Cdd:cd17477 259 CALLGALAALLLPLVPglPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLA 333
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
5-198 |
4.71e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.26 E-value: 4.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 5 DPTHPQEETDVLQRKANKRNTVFSILtAISFSHLLNDMIQSLILAIYPM-LQSEFSLSFVQIGMITLTYQITASLLQPFI 83
Cdd:cd17473 175 EPARKSKSAASPGAATAAALPWKRVL-PIYFLAFLAMLLFYVIPIQLPFlLQERGGGSAALIGLALAIASLAGAIGALLF 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 84 GLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGLVGTGSSVFHPE-SSRVARMASGGRHGFAQSLFQVGGNL 162
Cdd:cd17473 254 GRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTlNSWAMSLVPPELRGRAMGIVTSAFFL 333
|
170 180 190
....*....|....*....|....*....|....*.
gi 1063068299 163 GSSLGPLLAALLIAPYGkGNVGWFSLAALLAIVVLL 198
Cdd:cd17473 334 GQFLSPLVLGPLVNLTG-GLSGAFLILGVLALVLAI 368
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
80-202 |
5.68e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.95 E-value: 5.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 80 QPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFA-NTFPMLLLAAGLVGTGSSVFHPESSR-VARMASGGRHGFAQSLFQ 157
Cdd:cd17355 262 RLLSGWLGDRYSPRRLLAASYALRALGLALLLLLpFPPLALLLFAALFGLGWGATVPLTAAlAARYFGARSYGTLFGLVF 341
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1063068299 158 VGGNLGSSLGPLLAALLIAPYGKGNVGWFSLAALLAIVVLLQVSR 202
Cdd:cd17355 342 APHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
2-168 |
1.20e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.95 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 2 SNADPTHPQEETDVLQRKANKRNTVFSILTAIsfshLLNDMIQSLILAIYPMLQSEFSLSFVQIGMITLTYQITASLLQP 81
Cdd:pfam07690 178 KRPKPAEEARLSLIVAWKALLRDPVLWLLLAL----LLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRL 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 82 FIGLYTDKYPKPYSLPIGMGFTLT---GLILLAFANTFPMLLLAAGLVGTGSSVFHP-ESSRVARMASGGRHGFAQSLFQ 157
Cdd:pfam07690 254 LLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGFGLVFPaLNALVSDLAPKEERGTASGLYN 333
|
170
....*....|.
gi 1063068299 158 VGGNLGSSLGP 168
Cdd:pfam07690 334 TAGSLGGALGP 344
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
49-294 |
1.91e-04 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 43.55 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 49 AIYPMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLpiGMGFTLTGLILLAFAntFPMLLLAAGLVGT 128
Cdd:PRK11663 44 AAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFM--GIGLIATGIINILFG--FSSSLWAFALLWV 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 129 GSSVFH----PESSRV-ARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYgkgnvGW---FSLAALLAIVV---- 196
Cdd:PRK11663 120 LNAFFQgwgwPVCAKLlTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHY-----GWrygMMIAGIIAIVVglfl 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 197 ------------LLQVSRWYKIQQE-AQKKQSKGLNNKIRLPRKTLLGSLAILLILIFS-KYFYLASISSYYTFYLIHKF 262
Cdd:PRK11663 195 cwrlrdkpqamgLPSVGEWRHDALElAQQQEGAGLSRKEILTKYVLLNPYIWLLSFSYVlVYVVRAAINDWGNLYMSETL 274
|
250 260 270
....*....|....*....|....*....|..
gi 1063068299 263 GVSVQNAQIHLFVFLFAVAAGTMIGGPLGDKI 294
Cdd:PRK11663 275 GVDLVTANSAVSMFELGGFIGALVAGWGSDKL 306
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
52-379 |
3.08e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.56 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 52 PMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGLVGTGSS 131
Cdd:cd17320 23 PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 132 VFHPESSRVARMASGGRHgfAQSLF-QVGGNLGSS--LGPLLAALLIAPYgkgnvGW---FSLAALLAIVVLLQVSRWYK 205
Cdd:cd17320 103 AGSVVARAIVRDLYSGAE--LAKIFsLLMMILAIApaLAPLLGGLLLLFF-----GWraiFVFLALLGLLLLLLVLLFLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 206 IQQEAQkKQSKGLNNKIRLPRKTLLGSLAILLILIFSkyFYLASISSYYT---FYLIHKFGVSvqnaqIHLFVFLFAVAA 282
Cdd:cd17320 176 ETLPEE-KRKPLLSSLLRAYKRVLKNRRFLGYALALG--LSFAGLFAYLAaapFIYIEQLGLS-----PAQFGLLFALNA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 283 GTMIGGP-----LGDKIG-RKYVIWGSILGVAPFTLILPYASLYWTGVLTVFIGVILAS-----AFSAILVYAQELIPGK 351
Cdd:cd17320 248 IALILGSllngrLVRRFGpRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFfgfglIFPNATSLALEPFPHV 327
|
330 340
....*....|....*....|....*...
gi 1063068299 352 TGMVSGLFFGLAFGMGGIGAAVLGYIAD 379
Cdd:cd17320 328 AGTASALLGFLQFLIGALAGALVGLLPN 355
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
6-202 |
3.50e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 3.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 6 PTHPQEETDVLQRKANK-RNTVFSILTAISFSHLLNDMIQSLILAIYpmLQSEFSLSFVQIGMITLTYQITASLLQPFIG 84
Cdd:cd17329 180 KRRAAEKTEILRGYKIVlRDRAFLLFLLASFLISLIYFQLESTLPVY--VVEILGLGESLLGLLLALNALLIVLLQFPVA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 85 LYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGLVGTGSSVFHPESSR-VARMAS----GGRHGFAQSLFQVG 159
Cdd:cd17329 258 RLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTlVAALAPpdkrGSYMGFYALAWGLG 337
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1063068299 160 GnlgsSLGPLLAALLIAPYGkGNVGWFSLAALLAIVVLLQVSR 202
Cdd:cd17329 338 R----AIGPLVGGLLLDLLG-PGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
54-198 |
3.61e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.17 E-value: 3.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 54 LQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDK-YPKPYSLPIGMGFTLTGLILLAFANTFP------MLLLAAGLV 126
Cdd:cd17319 206 LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRlLRGARRLVIIIGLLLAAVGLLLAYLTTSpvvaviLLSLAGFGI 285
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063068299 127 GTGSSVFhpeSSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFSLAALLAIVVLL 198
Cdd:cd17319 286 GAASPVF---WSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALL 354
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
50-198 |
3.69e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 42.29 E-value: 3.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 50 IYPMLQSEFSLSFVQIGMI-TLTY------QITASLLQPFIGLytdkypkPYSLPIGMGFTLTGLILLAFANTFPMLLLA 122
Cdd:cd06180 21 LLPLMLAELGLSYAQAGWIaTANYagylvgALLASFLRRRGRA-------RRLIRGGLLLTVLLLAAMALTSGFAALLAL 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063068299 123 AGLVGTGSS-VFHPESSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFSLAALLAIVVLL 198
Cdd:cd06180 94 RFLAGAASAfVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLL 170
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
52-338 |
4.50e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.23 E-value: 4.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 52 PMLQsEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYP------KPYSLpIGMGFTLTGLILLAFANTF--------- 116
Cdd:cd17313 24 PILQ-TLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNsrigrrRPFIL-VGAPLAALGLILIPNAADIglalgdgpr 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 117 --PMLLLAAGLVG---TGSSVFHPESSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALL-----IAPYGKGNVGW- 185
Cdd:cd17313 102 twALVLFVLGIVLldfAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILwdhnwFGFALGGNLKVp 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 186 FSLAALL----AIVVLLQVS--RWYKIQQEAQKKQSKGLNNK-IRLPRKTLLGSLAILLILIFSKYFYLASISSYYTFYL 258
Cdd:cd17313 182 FYIGAIIllvcVLVTLFFVKepPLSPEAGEHSENPSLGEVLKsLLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYM 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 259 -----------IHKFGVSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGVA-PFTLILPYASLYWTGVLT 326
Cdd:cd17313 262 geevyhgtsaaSSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAvGMALMALVHNVTVALVLF 341
|
330
....*....|..
gi 1063068299 327 VFIGVILASAFS 338
Cdd:cd17313 342 ALGGIGWATINI 353
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
292-404 |
6.36e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.93 E-value: 6.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 292 DKIGRKYVIWGSIL--GVAPFTLILPYASLYWTGVLTVFIGVI-LASAFSAILVYAQELIPGktgMVSGLFFGLAFGMGG 368
Cdd:TIGR00898 380 DRLGRRYTMAASLLlaGVALLLLLFVPVDLYFLRTALAVLGKFgITSAFQMVYLYTAELYPT---VVRNLGVGVCSTMAR 456
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1063068299 369 IGAAVLGYIADLKSIEY-----VYHICAYLplLGIFTLFLP 404
Cdd:TIGR00898 457 VGSIISPFLVYLGEKWLflplvLFGGLALL--AGILTLFLP 495
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
144-378 |
6.73e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.74 E-value: 6.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 144 ASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKG---NVGW---FSLAALLAIVVL-----LQVSRWYKIQQEAQK 212
Cdd:cd17369 134 APPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLSDEaflSWGWripFLLSAVLVAVGLyirlrLEETPVFRRAKEAGQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 213 KQSKGLNNKIRLPRKTLLgsLAILLILIFSKYFYLasISSYYTFYLIHKFGVSVQnaqihlfVFLFAVAAGTMIG----- 287
Cdd:cd17369 214 VVRAPLVEVLRRHWRALL--LAIGLRLAENVLFYL--FTTFALSYATQTLGVDRS-------TVLLAVLIASVVAaitip 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 288 --GPLGDKIGRKYV-IWGSILGVA---PFTLILPYASLYWTGVLTVFI-GVILASAFSAILVYAQELIPGKTgMVSGLFF 360
Cdd:cd17369 283 lfGWLSDRVGRRPVyLAGALLAALfafPFFWLLDTGSTWLIVLAAVVVlGVLHGMMYGPQAAFLAELFPTRV-RYTGASL 361
|
250
....*....|....*...
gi 1063068299 361 GLAFGmGGIGAAVLGYIA 378
Cdd:cd17369 362 GYQLG-AILGGGFAPLIA 378
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
258-403 |
7.80e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.95 E-value: 7.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 258 LIHKFGVSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYA-SLYWTGVLTVFIGVILASA 336
Cdd:COG0477 40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLApSPELLIAARALQGIGAGGL 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063068299 337 FSAILVYAQELIPGKtgmVSGLFFGLAFGMGGIGAA----VLGYIADLKSIEYVYHICAYLPLLGIFTLFL 403
Cdd:COG0477 120 MPGALALIAELFPAR---ERGRALGLWGAAIGLGLAlgplLGGLLVAALGWRWIFLINAPLGLLALVLRLR 187
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
275-404 |
9.47e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.46 E-value: 9.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 275 VFLFAVAAGTMIGGPLGDKIGRKYV-IWGSILGVAPFTLILPYASLYWTGVLTVFIGVILASAFSAILVyAQELIPGK-- 351
Cdd:cd06179 40 AWSLAQAVLGPIVGRLSDLFGRRWFfIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAV-ASELVPNKyr 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1063068299 352 ----TGMVSGLFFGLAFGMGGIGAAVLGYIADLKSIEYVYHICAYLPLLGIFTLFLP 404
Cdd:cd06179 119 glvqGVVNLVASPGSALGPLIAGALVEANAAGWRWIFYINAIFNALALILLFFFYHP 175
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
22-198 |
9.48e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.04 E-value: 9.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 22 KRNTVFSILTAISFSHLLNDMIQSLILAIYpmLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMG 101
Cdd:COG2211 225 LKNRPFLLLLLAYLLFFLALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 102 FTLTGLILLAFA--NTFPMLLLAAGLVGTGSSVFH-------PESSRVARMASGGRH-GFAQSLFQVGGNLGSSLGPLLA 171
Cdd:COG2211 303 LAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILvlpwamlADVVDYDEWKTGRRReGLYFGIFTFAIKLGQALAGALA 382
|
170 180
....*....|....*....|....*..
gi 1063068299 172 ALLIAPYGKGNVGWFSLAALLAIVVLL 198
Cdd:COG2211 383 GLLLALFGYVAGAAQSPSALTGIRLLF 409
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
81-404 |
1.28e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.64 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 81 PFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGLVGTGSS-VFHPESSRVARMASGGRHGFAQSLFQVG 159
Cdd:cd17317 43 LLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAgIFTVGFVLGMEIVGPKYRSFVGILFGLF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 160 GNLGSSLGPLLAALLiapygkgnVGWFSLAALLAIVVLLQVSRWYKIqqeaqkkqskglnnkirlPRKTllgslaILLIL 239
Cdd:cd17317 123 WALGYMLLALLAYLI--------RDWRWLQLAISLPGLLFLLLLWWL------------------PRRT------IIVGL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 240 IFskyfyLASISSYYTFYLihkfGVSVQNAQIHLFVFLFAVAA--GTMIGGPLGDKIGRKYVIWGSIL--GVAPFTLILP 315
Cdd:cd17317 171 IW-----FVTSLVYYGLSL----NSSNLGGNLYLNFFLSGLVEipAYFLALLLLDRLGRRWTLSGSLLlaGLACLVTALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 316 YASLYWTGVLTVFIGVILAS-AFSAILVYAQELIPgktGMVSGLFFGLAFGMGGIGAAVLGYIADLKSIEYV--YHICAY 392
Cdd:cd17317 242 PDDENTLALTLALVGKFAISaAFSVIYLYTAELYP---TVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLlpLIIFGV 318
|
330
....*....|...
gi 1063068299 393 LPLLGIF-TLFLP 404
Cdd:cd17317 319 LALLGGLlTLLLP 331
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
262-339 |
1.29e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 40.67 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 262 FGVSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIwgsILGVAPFTLilpyASLYWTGVLTV--FIGVILASAFSA 339
Cdd:PRK11102 21 FGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVI---LGGTLVFAL----AAVACALAQTIdqLIYMRFLHGLAA 93
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
44-404 |
1.36e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 40.62 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 44 QSLILAIYPMLQSEFSlSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAA 123
Cdd:cd17502 12 QTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 124 GLVGTGSSVFHPESSRV-ARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFSLA-ALLAIVVLLQVs 201
Cdd:cd17502 91 AIQGIGGGGLMSLAFIIiADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPiGGLALALLRTI- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 202 rwykiqqeaqkkqskglnnkirlprktllgslAILLILIFSKYFYLASISSYYTFYLIHKFGVSVQNAQIHLFVFLFAVA 281
Cdd:cd17502 170 --------------------------------LLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 282 AGTMIGGPLGDKIGR-KYVIWGS----ILGVAPFTLILPYASLYWTGVLTVFIGVILASAFSAILVYAQELIP-GKTGMV 355
Cdd:cd17502 218 IGSIISGALISKTGRyKPLIVIGtilmSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPpADVGVA 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1063068299 356 SGlFFGLAFGMGG-IGAAvlgyiadlksIEYVYHICAYLPLLG-IFTLFLP 404
Cdd:cd17502 298 TA-TNTFFRSLGGtLGVA----------ITDVFLVALALAALAfLLSLFLP 337
|
|
| MFS_SLC22A16_CT2 |
cd17375 |
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ... |
275-377 |
1.72e-03 |
|
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 40.12 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 275 VFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYASLYWTGVLTVFIGVILASA-FSAILVYAQELIPGKTG 353
Cdd:cd17375 43 IFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSGyLVVVFVYVTEFTGIKAR 122
|
90 100
....*....|....*....|....
gi 1063068299 354 MVSGLFFGLAFGMGGIGAAVLGYI 377
Cdd:cd17375 123 TWASMHVHAFFAVGIMVVALVGYL 146
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
60-369 |
2.87e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.49 E-value: 2.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 60 LSFVQIGMITLTYQITASLLQPFIGLYTDKYPKpYSLPIGMGFTLTGLILLAFA---NTFPMLLLAAGLVGTGSSVFHPE 136
Cdd:cd17335 29 LSPTQIGILIGIRPFVRFLSAPLWGALADRFGK-RKALLLLSLLAAVLFFLSLFfvaQIFWLLLLLVILGAFFSAPVVPL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 137 SSRVArMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLI--APYGKGNVGWFSLAALLAIVVLLqVSRWYKIQQEAQKKQ 214
Cdd:cd17335 108 VDSIT-LQYLGEERERYGKQRLWGSIGFGIAALLVGILIdrSSTYKNYTIAFYVFAVLMLLALL-LALKFPFRPKHPEPN 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 215 SKGLNnkirlpRKTLLGSLAILlILIFSKYFYLASISSYYTFYLIHKFGVSVQNAQIHLfVFLFAVAAGTMI---GGPLG 291
Cdd:cd17335 186 ENTGG------LLALLRNPRVL-AFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGL-LWTVGVVSEIPFfffSSRLI 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 292 DKIGRKYVIW-GSILGVAPFTLILPYASLYWTGVLTVFIGVILASAFSAILVYAQELIPGKT-----GMVSGLFFGLAFG 365
Cdd:cd17335 258 QRFGHVGLLYlGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLrataqGLLQGLYFGLGGG 337
|
....
gi 1063068299 366 MGGI 369
Cdd:cd17335 338 LGSL 341
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
42-196 |
2.87e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 2.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 42 MIQSLILAIYpmLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAF---ANTFPM 118
Cdd:cd17321 185 GGLLFLLPLY--LQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALlgaDSSVWL 262
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063068299 119 LLLAAGLVGTGSSVFHPESSRVARMASG-GRHGFAQSLFQVGGNLGSSLGPLLAALLIAPYGKGNVGWFSLAALLAIVV 196
Cdd:cd17321 263 LLPGLVLLGLGLGLFATPLTNAALSSVPkEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAA 341
|
|
| cynX |
PRK09705 |
putative cyanate transporter; Provisional |
52-405 |
3.51e-03 |
|
putative cyanate transporter; Provisional
Pssm-ID: 236614 [Multi-domain] Cd Length: 393 Bit Score: 39.41 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 52 PMLQSEFSLSFVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTFPMLLLAAGLVGTGSS 131
Cdd:PRK09705 33 PQLRQASGMSFSVAALLTALPVVTMGGLALAGSWLHQHVSERRSVAISLLLIAVGALMRELYPQSALLLSSALLGGVGIG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 132 VFHPESSRVARMASGGRHGFAQSLFQV----GGNLGSSLGPLLAALLIAPYGKgnVGWFSLAALLAIVVLLQVSRWykiQ 207
Cdd:PRK09705 113 IIQAVMPSVIKRRFQQRTPLVMGLWSAalmgGGGLGAAITPWLVQHSETWYQT--LAWWALPAVVALFAWWWQSAR---E 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 208 QEAQKKQSKGLNNKIRLPRKTLLGslaILLILIFSKYFYL-ASISSYYTfylihKFGVSVQNAQIHLFVFLFAVAAGTMI 286
Cdd:PRK09705 188 VASSHKTTTTPVRVVFTPRAWTLG---VYFGLINGGYASLiAWLPAFYI-----EIGASAQYSGSLLALMTLGQAAGALL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 287 GGPLGDKIGRKYVIWGSIL----GVAPFTLILPYASLYWTGVltvfIGVILASAFSAILVYAQELI--PGKTGMVSGLFF 360
Cdd:PRK09705 260 MPAMARHQDRRKLLMLALVlqlvGFCGFIWLPLQLPVLWAMV----CGLGLGGAFPLCLLLALDHSvqPAIAGKLVAFMQ 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1063068299 361 GLAFGMGGIGAAVLGYIADLK---SIEYVYHICAYLPLLGIFTLFLPN 405
Cdd:PRK09705 336 GIGFIIAGLAPWFSGVLRSISgnyLMDWAFHALCVVGLMIITLRFAPA 383
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
83-367 |
3.52e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 39.28 E-value: 3.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 83 IGLYTDKYPKPYSLPIGMGFTLTGLILLAFANTF-------PMLLLAAGLVgTGSSV---FHPESSRVARMASGGRHGFA 152
Cdd:cd17368 60 LGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYatigiaaPLLVLLARLL-QGFAAggeVGGVTAYLVEAAPPGRRGFY 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 153 QSLFQVGGNLGSSLGPLLAALLIAPYGKGNV---GW-FSLAALLAIVVLLQVSRWYKIQQEA-----QKKQSKGLNNKIR 223
Cdd:cd17368 139 TSWQSASQQVAIVAGALVGYLLSLTLTAEALaewGWrIPFFIGLLIIPLGLWLRRSLEETEAflerkARPTRRELFALLA 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 224 LPRKTLLGSLAILLILIFSKYFylasISSYYTFYLIHKFGVSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWGS 303
Cdd:cd17368 219 NNRRIILLGMLLVAGSTVTFYF----TTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVI 294
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063068299 304 ILGVapftLILPYASLYW----------TGVLTVFiGVILASAFSAILVYAQELIPGKtgmVSGLFFGLAFGMG 367
Cdd:cd17368 295 TLAA----LVTLYPVFAWltaapsfgrlLLVLLVL-SFFFGMYGGAMVVALVELFPVR---VRSTGFSLVYALA 360
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
258-378 |
3.94e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.21 E-value: 3.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 258 LIHKFGVSVQNAQIHLFVFLFAVAAGTMIGGPLGDKIGRKYVIWGSILGVAPFTLILPYASLYWT-GVLTVFIGVILASA 336
Cdd:cd17371 25 LIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQlLILRALAGLGFGGE 104
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1063068299 337 FSAILVYAQELIPGKTGMVSGLFFGLAFGMGGIGAAVLGYIA 378
Cdd:cd17371 105 WAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALL 146
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
32-198 |
6.32e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.76 E-value: 6.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 32 AISFSHLLNDMIQSLILAIYPMLQSEFSLSfVQIGMITLTYQITASLLQPFIGLYTDKYPKPYSLPIGMGFTLTGLILLA 111
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063068299 112 FANTFPMLLLAAGLVGTGSSVFHPESSRVARMASGGRHGFAQSLFQVGGNLGSSLGPLLAALLIApygKGNVGW---FSL 188
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVE---ANAAGWrwiFYI 157
|
170
....*....|
gi 1063068299 189 AALLAIVVLL 198
Cdd:cd06179 158 NAIFNALALI 167
|
|
| |
