|
Name |
Accession |
Description |
Interval |
E-value |
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
29-458 |
0e+00 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 531.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 29 EFLSQQGATVIVSEIKTEDLLgdYPRRLRSLNVALEMGQHSAQTFDSAALIVLSPGVDPAALPLAQAQAKGIPIVSEVEL 108
Cdd:COG0771 21 RLLAKLGAEVTVSDDRPAPEL--AAAELEAPGVEVVLGEHPEELLDGADLVVKSPGIPPDHPLLKAARAAGIPVIGEIEL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 109 ASWFLTPPLIAITGTNGKSTTTALIGHLLLSWGKKVFVGGNIGTPLTTYLLRDDDADYIVAEISSFQLEAIATFRPFISL 188
Cdd:COG0771 99 AYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLEPEPPDVYVLELSSFQLETTPSLRPDVAV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 189 LLNVGEDHLSRHPTLAAYAAAKARIFQNQGVQDWAVLNHDDMIVRSLIPPIKAQLLLFSREQQGGDlGVWFEApGTVVYK 268
Cdd:COG0771 179 ILNITPDHLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKARVVPFSLKEPLEG-GAGLED-GKLVDR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 269 GKGQgskkERFSLARVKIKGMHNVENIMAAVGAARICGMPSAVIQDALDTFAGLEHRLELVGEWHGVSVYNDSKATNVAS 348
Cdd:COG0771 257 ASGE----ELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGVRFINDSKATNPDA 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 349 ALTALQSLDSPIILLAGGRDKGGSYAPLRGVMKERVKALILMGEAKEKMRAAFQDL-LPVYLVAGMEEGVRLAWNIAQGG 427
Cdd:COG0771 333 TLAALESFDGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAgVPVVIVETMEEAVAAAAELARPG 412
|
410 420 430
....*....|....*....|....*....|.
gi 1084753147 428 EAILLSPACSSFDMFHDYEDRGRTFKEIVRR 458
Cdd:COG0771 413 DVVLLSPACASFDQFKNYEERGDVFKEAVRE 443
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
9-458 |
1.84e-147 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 428.24 E-value: 1.84e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 9 ELRDKRAVVAGMAATGMAAAEFLSQQGATVIVSEIKTEDLLGDYPRRLRSLNVALEMGQHSAQTFDSAALIVLSPGVDPA 88
Cdd:PRK14106 2 ELKGKKVLVVGAGVSGLALAKFLKKLGAKVILTDEKEEDQLKEALEELGELGIELVLGEYPEEFLEGVDLVVVSPGVPLD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 89 ALPLAQAQAKGIPIVSEVELASWFLTPPLIAITGTNGKSTTTALIGHLLLSWGKKVFVGGNIGTPLTTYLLRDDDADYIV 168
Cdd:PRK14106 82 SPPVVQAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYPLIDAVEEYGEDDIIV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 169 AEISSFQLEAIATFRPFISLLLNVGEDHLSRHPTLAAYAAAKARIFQNQGVQDWAVLNHDDMIVRSLIPPIKAQLLLFSR 248
Cdd:PRK14106 162 AEVSSFQLETIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRTRSLAKKAKARVIFFSR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 249 EQQgGDLGVWFEApGTVVYKGKGQgsKKERFSLARVKIKGMHNVENIMAAVGAARICGMPSAVIQDALDTFAGLEHRLEL 328
Cdd:PRK14106 242 KSL-LEEGVFVKN-GKIVISLGGK--EEEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEF 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 329 VGEWHGVSVYNDSKATNVASALTALQSLDSPIILLAGGRDKGGSYAPLRGVMKERVKALILMGEAKEKMRAAFQD--LLP 406
Cdd:PRK14106 318 VAEINGVKFINDSKGTNPDAAIKALEAYETPIVLIAGGYDKGSDFDEFAKAFKEKVKKLILLGETAQEIAEAARKygFDN 397
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1084753147 407 VYLVAGMEEGVRLAWNIAQGGEAILLSPACSSFDMFHDYEDRGRTFKEIVRR 458
Cdd:PRK14106 398 ILFAETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLFKELVLE 449
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
29-458 |
1.09e-136 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 400.18 E-value: 1.09e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 29 EFLSQQGATVIVSEIKTEDLLGDYPRRLR-SLNVALEMGQHSAQtFDSAALIVLSPGVDPAALPLAQAQAKGIPIVSEVE 107
Cdd:TIGR01087 16 RFLHKKGAEVTVTDLKPNEELEPSMGQLRlNEGSVLHTGLHLED-LNNADLVVKSPGIPPDHPLVQAAAKRGIPVVGDIE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 108 LASWFLTPPLIAITGTNGKSTTTALIGHLLLSWGKKVFVGGNIGTPLTTyLLRDDDADYIVAEISSFQLEAIATFRPFIS 187
Cdd:TIGR01087 95 LFLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALE-VLDQEGAELYVLELSSFQLETTESLRPEIA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 188 LLLNVGEDHLSRHPTLAAYAAAKARIFQNQGVQDWAVLNHDDMIVRSLIPPIKAQLLLFSREqqgGDLGVWFEAP-GTVV 266
Cdd:TIGR01087 174 LILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKSKAQVIWFSVE---KDAERGLCIRdGGLY 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 267 YKGKGqgskkerfslARVKIKGMHNVENIMAAVGAARICGMPSAVIQDALDTFAGLEHRLELVGEWHGVSVYNDSKATNV 346
Cdd:TIGR01087 251 LKPND----------LEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYNDSKATNV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 347 ASALTALQSLDSPIILLAGGRDKGGSYAPLRGVMKERVKALILMGEAKEKMRAAFQDL-LPVYLVAGMEEGVRLAWNIAQ 425
Cdd:TIGR01087 321 HATLAALSAFDNPVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAgLSVYLVESLEEAVQAAREVAS 400
|
410 420 430
....*....|....*....|....*....|...
gi 1084753147 426 GGEAILLSPACSSFDMFHDYEDRGRTFKEIVRR 458
Cdd:TIGR01087 401 PGDVVLLSPACASFDQFKSYEERGEKFKELVRA 433
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
29-340 |
8.34e-32 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 126.33 E-value: 8.34e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 29 EFLSQQGATVIVSEIKtedllgDYP--RRLRSLNVALEMGqHSAQTFDSAALIVLSPGVDPAALPLAQAQAKGIPIVS-- 104
Cdd:COG0773 22 EILLALGYKVSGSDLA------ESPmtERLEALGIPVFIG-HDAENIDDADLVVVSSAIPRDNPELVAARERGIPVLSra 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 105 EVeLASWFLTPPLIAITGTNGKSTTTALIGHLLLSWGKK--VFVGG---NIGTPLttyllRDDDADYIVAEI----SSFQ 175
Cdd:COG0773 95 EM-LAELMRGKRSIAVAGTHGKTTTTSMLAHILEEAGLDptFLIGGilnNFGTNA-----RLGDGDYFVAEAdesdGSFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 176 LeaiatFRPFISLLLNVGEDHLSRHPTLAayaaakaRIFQ----------NQGVqdwAVLNHDDMIVRSLIPPIKAQLLL 245
Cdd:COG0773 169 H-----YSPDIAVVTNIEADHLDIYGDLE-------AIKEafhefarnvpFYGL---LVLCADDPGLRELLPRCGRPVIT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 246 FSREQQG---------GDLGVWFeapgTVVYKGKGQGskkeRFSLarvKIKGMHNVENIMAAVGAARICGMPSAVIQDAL 316
Cdd:COG0773 234 YGFSEDAdyraeniriDGGGSTF----DVLRRGEELG----EVEL---NLPGRHNVLNALAAIAVALELGVDPEAIAEAL 302
|
330 340
....*....|....*....|....
gi 1084753147 317 DTFAGLEHRLELVGEWHGVSVYND 340
Cdd:COG0773 303 ASFKGVKRRFELKGEVGGVTVIDD 326
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
120-302 |
1.41e-29 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 114.32 E-value: 1.41e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 120 ITGTNGKSTTTALIGHLLLSWGKKVFVGGN------------IGTPLTTYLLRDDDADYIVAEISSFQLE---AIATFRP 184
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTyigksgnttnnaIGLPLTLAEMVEAGAEYAVLEVSSHGLGegrLSGLLKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 185 FISLLLNVGEDHLSRHPTLAAYAAAKARIFQNQGVQDWAVLNHDD---MIVRSLIPPIKAQLLLFSREQqggdlGVWFEA 261
Cdd:pfam08245 81 DIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDpygAFLIAKLKKAGVRVITYGIEG-----EADLRA 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1084753147 262 pGTVVYKGKGQGSKKERFSLARVKIK----GMHNVENIMAAVGAA 302
Cdd:pfam08245 156 -ANIELSSDGTSFDLFTVPGGELEIEipllGRHNVYNALAAIAAA 199
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
107-356 |
7.88e-29 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 117.90 E-value: 7.88e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 107 ELASWF---LTPPLIAITGTNGKSTTTALIGHLLLSWGKKVFVGGN----IGTPLTtyLLR-DDDADYIVAE--ISSF-- 174
Cdd:COG0770 89 QLAAAHrarFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNfnneIGVPLT--LLRlPEDHEFAVLEmgMNHPge 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 175 --QLEAIAtfRPFISLLLNVGEDHLSRHPTLAAYAAAKARIFQNQGVQDWAVLNHDDMIVRSLIPPIKAQLLLFSREQqG 252
Cdd:COG0770 167 iaYLARIA--RPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKARVLTFGLSE-D 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 253 GDL---GVWFEAPGT---VVYKGKGqgskkERFSLARVkikGMHNVENIMAAVGAARICGMPSAVIQDALDTFAGLEHRL 326
Cdd:COG0770 244 ADVraeDIELDEDGTrftLHTPGGE-----LEVTLPLP---GRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRL 315
|
250 260 270
....*....|....*....|....*....|.
gi 1084753147 327 ELVGEWHGVSVYNDS-KAtNVASALTALQSL 356
Cdd:COG0770 316 EVIEGAGGVTLIDDSyNA-NPDSMKAALDVL 345
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
107-370 |
4.13e-28 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 115.95 E-value: 4.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 107 ELASWFLTPP-----LIAITGTNGKSTTTALIGHLLLSWGKKVfvgGNIGT------------PLTT--------YL--L 159
Cdd:COG0769 67 LLAAAFYGHPsqklkLIGVTGTNGKTTTTYLLAQILRALGKKT---GLIGTvgngiggelipsSLTTpealdlqrLLaeM 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 160 RDDDADYIVAEISSfqlEAIATFR----PF-ISLLLNVGEDHLSRHPTLAAYAAAKARIFQNQGVQDWAVLNHDDMIVRS 234
Cdd:COG0769 144 VDAGVTHVVMEVSS---HALDQGRvdgvRFdVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGRR 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 235 LIPPIKAQLLLFSREQQGgdlgvWFEAPGtVVYKGKGQgskkeRFSLA--------RVKIKGMHNVENIMAAVGAARICG 306
Cdd:COG0769 221 LAAAAPARVITYGLKADA-----DLRATD-IELSADGT-----RFTLVtpggevevRLPLIGRFNVYNALAAIAAALALG 289
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 307 MPSAVIQDALDTFAGLEHRLELVGEWHGVSVYNDSKAT--NVASALTALQSLDSP-IILL--AGG-RDKG 370
Cdd:COG0769 290 IDLEEILAALEKLKGVPGRMERVDGGQGPTVIVDYAHTpdALENVLEALRPHTKGrLIVVfgCGGdRDRG 359
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
107-370 |
4.19e-23 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 101.36 E-value: 4.19e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 107 ELASWFLTPP-----LIAITGTNGKSTTTALIGHLLLSWGKKVfvgGNIGT------------PLTT----------YLL 159
Cdd:PRK00139 82 LLAAAFYGHPsdklkLIGVTGTNGKTTTAYLLAQILRLLGEKT---ALIGTlgngiggelipsGLTTpdaldlqrllAEL 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 160 RDDDADYIVAEISSfqlEAIATFR----PF-ISLLLNVGEDHLSRHPTLAAYAAAKARIFQNQGVQdwAVLNHDDMIVRS 234
Cdd:PRK00139 159 VDAGVTYAAMEVSS---HALDQGRvdglKFdVAVFTNLSRDHLDYHGTMEDYLAAKARLFSELGLA--AVINADDEVGRR 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 235 LIPPIKAqlllFSREQQGGDLgvWFEApgtVVYKGKGQgskkeRFSLA---RVKIKGMHNVENIMAAVGAARICGMPSAV 311
Cdd:PRK00139 234 LLALPDA----YAVSMAGADL--RATD---VEYTDSGQ-----TFTLVtevESPLIGRFNVSNLLAALAALLALGVPLED 299
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1084753147 312 IQDALDTFAGLEHRLELVGEWHGVSVY------NDSkatnVASALTALQSLDSP-IILL--AGG-RDKG 370
Cdd:PRK00139 300 ALAALAKLQGVPGRMERVDAGQGPLVIvdyahtPDA----LEKVLEALRPHAKGrLICVfgCGGdRDKG 364
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
107-359 |
2.44e-20 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 92.71 E-value: 2.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 107 ELASWF---LTPPLIAITGTNGKSTTTALIGHLLLSWGKKVFVGGN----IGTPLTtyLLR-DDDADYIVAEISSFQLEA 178
Cdd:TIGR01143 63 ALARAKrakFSGKVIGITGSSGKTTTKEMLAAILSHKYKVFATPGNfnneIGLPLT--LLRaPGDHDYAVLEMGASHPGE 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 179 IATF----RPFISLLLNVGEDHLSRHPTLAAYAAAKARIFQNQGVQDWAVLNHDD---MIVRSLIPPIKaqllLFSREQQ 251
Cdd:TIGR01143 141 IAYLaeiaKPDIAVITNIGPAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDpafADLAKRLPNRN----ILSFGFE 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 252 GGDL---GVWFEAPGTVVYKGKGQGSKKErfslARVKIKGMHNVENIMAAVGAARICGMPSAVIQDALDTFAGLEHRLEL 328
Cdd:TIGR01143 217 GGDFvakDISYSALGSTSFTLVAPGGEFE----VSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEV 292
|
250 260 270
....*....|....*....|....*....|.
gi 1084753147 329 VGEwHGVSVYNDSKATNVASALTALQSLDSP 359
Cdd:TIGR01143 293 QTK-NGLTLIDDTYNANPDSMRAALDALARF 322
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
116-319 |
2.26e-18 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 87.90 E-value: 2.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 116 PLIAITGTNGKSTTTALIGHLLLSWGKKV--------FVGGN-IGTPLTT------YLLRDDDADYIVAEISSFQL--EA 178
Cdd:PRK14016 481 PIVAVTGTNGKTTTTRLIAHILKLSGKRVgmtttdgvYIDGRlIDKGDCTgpksarRVLMNPDVEAAVLETARGGIlrEG 560
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 179 IATFRPFISLLLNVGEDHLSRH--PTLAAYAAAKARIFQNQGVQDWAVLNHDDMIVRSLIPPIKAQLLLFSRE------- 249
Cdd:PRK14016 561 LAYDRCDVGVVTNIGEDHLGLGgiNTLEDLAKVKRVVVEAVKPDGYAVLNADDPMVAAMAERCKGKVIFFSMDpdnpvia 640
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1084753147 250 ---QQGGdLGVWFEApGTVVYKgkgQGSKKER-FSLARVKI--KGM--HNVENIMAAVGAARICGMPSAVIQDALDTF 319
Cdd:PRK14016 641 ehrAQGG-RAVYVEG-DYIVLA---EGGWEIRiISLADIPLtlGGKagFNIENALAAIAAAWALGIDIELIRAGLRTF 713
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
117-370 |
5.43e-18 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 86.22 E-value: 5.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 117 LIAITGTNGKSTTTALIGHLLLSWGKKVFVGGNIG----------------TP----LTTYL--LRDDDADYIVAEISSF 174
Cdd:TIGR01085 87 VIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGyrlggndliknpaaltTPealtLQSTLaeMVEAGAQYAVMEVSSH 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 175 QLEA--IATFRPFISLLLNVGEDHLSRHPTLAAYAAAKARIFQNQGVQDWAVLNHDDMIVRSLippiKAQLLL---FSRE 249
Cdd:TIGR01085 167 ALAQgrVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQF----VKRLPKditVSAI 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 250 QQGGDLGVWFEAPGTVVYKGKGQG----SKKERFSLaRVKIKGMHNVENIMAAV-GAARICGMPSAVIQDALDTFAGLEH 324
Cdd:TIGR01085 243 TQPADGRAQDIKITDSGYSFEGQQftfeTPAGEGHL-HTPLIGRFNVYNLLAALaTLLHLGGIDLEDIVAALEKFRGVPG 321
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1084753147 325 RLELVGEWHGVSVYNDSKATNVA--SALTALQSL-DSPIILL--AGG-RDKG 370
Cdd:TIGR01085 322 RMELVDGGQKFLVIVDYAHTPDAleKALRTLRKHkDGRLIVVfgCGGdRDRG 373
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
107-402 |
1.74e-16 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 82.44 E-value: 1.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 107 ELASWF---LTPPLIAITGTNGKSTTTALIGHLLLSWGKKVFV---GGN----IGTPLTTYLLRDDDADYIV-------A 169
Cdd:PRK11929 592 RLATAWrarFSLPVVAITGSNGKTTTKEMIAAILAAWQGEDRVlatEGNfnneIGVPLTLLRLRAQHRAAVFelgmnhpG 671
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 170 EISsfQLEAIAtfRPFISLLLNVGEDHLSRHPTLAAYAAAKARIFQNQGVQDWAVLNHDDMIVRSLIPPIKAQLLLFSRE 249
Cdd:PRK11929 672 EIA--YLAAIA--APTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFGL 747
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 250 QQGGDLGVWFEAPGTVVYKGKG------QGSKKERFSLARVkikGMHNVENIMAAVGAARICGMPSAVIQDALDTFAGLE 323
Cdd:PRK11929 748 QPGADVYAEKIAKDISVGEAGGtrcqvvTPAGSAEVYLPLI---GEHNLRNALAAIACALAAGASLKQIRAGLERFQPVA 824
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 324 HRLELVGEWHGVSVYNDSKATNVASALTALQSLD----SPIILLAGgrDKG-------------GSYAPLRGvmkerVKA 386
Cdd:PRK11929 825 GRMQRRRLSCGTRIIDDTYNANPDSMRAAIDVLAelpnGPRALVLG--DMLelgdngpamhrevGKYARQLG-----IDA 897
|
330
....*....|....*.
gi 1084753147 387 LILMGEAKEKMRAAFQ 402
Cdd:PRK11929 898 LITLGEAARDAAAAFG 913
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
107-430 |
4.28e-16 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 81.29 E-value: 4.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 107 ELASWFLTPP-----LIAITGTNGKSTTTALIGHLLLSWGKKVFVGGN---------IGTPLTT----------YLLRDD 162
Cdd:PRK11929 99 ELAARWYGRPseqlsLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTlgarldgrlIPGSLTTpdaiilhrilARMRAA 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 163 DADYIVAEISSFQLEA--IATFRPFISLLLNVGEDHLSRHPTLAAYAAAKARIFQNQGVQDWAVLNHDDMIVRSLIppik 240
Cdd:PRK11929 179 GADAVAMEASSHGLEQgrLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAAARLL---- 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 241 aqlllfsREQQGGDLGVWF--EAPGTVVYKGKGQGSKKERFSLA--------RVKIKGMHNVENIMAAVGAARICGMPSA 310
Cdd:PRK11929 255 -------AALPRGLKVGYSpqNAGADVQARDLRATAHGQVFTLAtpdgsyqlVTRLLGRFNVSNLLLVAAALKKLGLPLA 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 311 VIQDALDTFAGLEHRLELVGEW---HGVSVYNDSKAT--NVASALTAL----QSLDSPIILL--AGG-RDKGGSyaPLRG 378
Cdd:PRK11929 328 QIARALAAVSPVPGRMERVGPTagaQGPLVVVDYAHTpdALAKALTALrpvaQARNGRLVCVfgCGGdRDKGKR--PEMG 405
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1084753147 379 VMKERVKALILM------GEAKEKMRAAfqdllpvyLVAGMEEGVRLAwNIAQGGEAI 430
Cdd:PRK11929 406 RIAAELADRVVVtsdnprSEAPEAIIDQ--------ILAGIPAGARVF-VISDRAEAI 454
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
116-358 |
4.04e-08 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 55.73 E-value: 4.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 116 PLIAITGTNGKSTTTALIGHLLLSwgKKVFV------GGNIGTPLTTYLLRDDDADYIV-AEISSFQ----LEAIatFRP 184
Cdd:PRK11930 108 PVIGITGSNGKTIVKEWLYQLLSP--DYNIVrsprsyNSQIGVPLSVWQLNEEHELGIFeAGISQPGemeaLQKI--IKP 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 185 FISLLLNVGEDHLSRHPTLAAYAAAKARIFQNQGVqdwAVLNHDDMIVRSLIPPI--KAQLLLFSREQQGGDLGVWFEAP 262
Cdd:PRK11930 184 TIGILTNIGGAHQENFRSIKQKIMEKLKLFKDCDV---IIYNGDNELISSCITKSnlTLKLISWSRKDPEAPLYIPFVEK 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 263 G------TVVYKGkGQGSKKERFSlarvkikGMHNVENIMAAVGAARICGMPSAVIQDALDTFAGLEHRLELVGEWHGVS 336
Cdd:PRK11930 261 KedhtviSYTYKG-EDFHFEIPFI-------DDASIENLIHCIAVLLYLGYSADQIQERMARLEPVAMRLEVKEGINNCT 332
|
250 260
....*....|....*....|..
gi 1084753147 337 VYNDSKATNVASALTALQSLDS 358
Cdd:PRK11930 333 LINDSYNSDLQSLDIALDFLNR 354
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
77-327 |
4.76e-08 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 55.59 E-value: 4.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 77 ALIVLSPGVDPAALPLAQAQAKGIPIVSEVELASwFLTPPLIAI--TGTNGKSTTTALIGHLLLSWGK--KVFVGGNIGT 152
Cdd:PRK14573 65 AVVVYSSSISKDNVEYLSAKSRGNRLVHRAELLA-ELMQEQISIlvSGSHGKTTVSSLITAIFQEAKKdpSYAIGGLNQE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 153 PLTTYllrDDDADYIVAEISSFQlEAIATFRPFISLLLNVGEDHLSRHPTLAAYAAAKARIFQNQGVQDWAVL-NHDDMI 231
Cdd:PRK14573 144 GLNGY---SGSSEYFVAEADESD-GSLKHYTPEFSVITNIDNEHLSNFEGDRELLLASIQDFARKVQQINKCFyNGDCPR 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 232 VRSLIPPI------KAQLLLFSREQQGgdlgvWfEAPGTVVYKGKgqgskkeRFSLARVKIKGMHNVENIMAAVGAARIC 305
Cdd:PRK14573 220 LKGCLQGHsygfssSCDLHILSYYQEG-----W-RSYFSAKFLGV-------VYQDIELNLVGMHNVANAAAAMGIALTL 286
|
250 260
....*....|....*....|..
gi 1084753147 306 GMPSAVIQDALDTFAGLEHRLE 327
Cdd:PRK14573 287 GIDEGAIRNALKGFSGVQRRLE 308
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
323-389 |
5.15e-06 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 44.64 E-value: 5.15e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084753147 323 EHRLELVGEWHGVSVYNDsKATNVASALTALQSL----DSPIILLAGG-RDKGGSYAPLRGVMKERVKALIL 389
Cdd:pfam02875 2 PGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALrnlfPGRLILVFGGmGDRDAEFHALLGRLAAALADVVI 72
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
117-432 |
5.67e-04 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 42.33 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 117 LIAITGTNGKSTTTALIGHLLLSWGK-------------KVFVGGNIGTPLTTYLLR------DDDADYIVAEISSfqlE 177
Cdd:PRK14022 112 LLAFTGTKGKTTAAYFAYHILKQLHKpamlstmnttldgETFFKSALTTPESLDLFKmmaeavDNGMTHLIMEVSS---Q 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 178 AIATFRPF-----ISLLLNVGEDHLS--RHPTLAAYAAAKARIFQNQGVqdwAVLNHDdmivRSLIPPIKAQLLLFSREQ 250
Cdd:PRK14022 189 AYLVGRVYgltfdVGVFLNITPDHIGpiEHPTFEDYFYHKRLLMENSKA---VVVNSD----MDHFSELLEQVTPQEHDF 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 251 QGGDLGVWFEAPGTVVYKGKGQgskkerfsLA---RVKIKGMHNVENIMAAVGAARICGMPSAVIQDALDTfAGLEHRLE 327
Cdd:PRK14022 262 YGIDSENQIMASNAFSFEATGK--------LAgtyDIQLIGKFNQENAMAAGLACLRLGASLEDIQKGIAQ-TPVPGRME 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084753147 328 LVGEWHGVSVYNDSKATnvASALTALQSLDSP-----IILLAGGR-DKGGSYAPLRGVMKERV--KALILMGE--AKEKM 397
Cdd:PRK14022 333 VLTQSNGAKVFIDYAHN--GDSLNKLIDVVEEhqkgkLILLLGAAgNKGESRRPDFGRVANRHpyLQVILTADdpNNEDP 410
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1084753147 398 RAAFQDLL-----PVYLVAGMEEGVRLAWNIAQG-GEAILL 432
Cdd:PRK14022 411 KMITQEIAshithPVEIIDDRAEAIKHAMSITEGpGDAVII 451
|
|
| |
