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Conserved domains on  [gi|1159235350|gb|OPH30821|]
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protein vanZ [Enterococcus faecium]

Protein Classification

VanZ family protein( domain architecture ID 10008822)

VanZ family protein; VanZ family protein is an integral membrane protein similar to Enterococcus faecium protein VanZ, which confers low-level resistance to the glycopeptide antibiotic teicoplanin (Te)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VanZ COG4767
Glycopeptide antibiotics resistance protein [Defense mechanisms];
40-125 8.83e-17

Glycopeptide antibiotics resistance protein [Defense mechanisms];


:

Pssm-ID: 443799  Cd Length: 91  Bit Score: 71.01  E-value: 8.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159235350  40 NLVPFST----FSFENTTVLRETTYNLIVFFPFGVLLNVNFKRL-SFSKKLGIIFLVSFLAELIQFLFGIGVADITDLIT 114
Cdd:COG4767     1 NLVPFKSiledLALGGSIAVIQILGNILLFVPLGFLLPLLFKRLrSFKRVLLLGFLLSLLIEVLQLILPGRVFDIDDLIL 80

                          90
                  ....*....|.
gi 1159235350 115 NTTGGLIGLWA 125
Cdd:COG4767    81 NTLGALLGYLL 91
 
Name Accession Description Interval E-value
VanZ COG4767
Glycopeptide antibiotics resistance protein [Defense mechanisms];
40-125 8.83e-17

Glycopeptide antibiotics resistance protein [Defense mechanisms];


Pssm-ID: 443799  Cd Length: 91  Bit Score: 71.01  E-value: 8.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159235350  40 NLVPFST----FSFENTTVLRETTYNLIVFFPFGVLLNVNFKRL-SFSKKLGIIFLVSFLAELIQFLFGIGVADITDLIT 114
Cdd:COG4767     1 NLVPFKSiledLALGGSIAVIQILGNILLFVPLGFLLPLLFKRLrSFKRVLLLGFLLSLLIEVLQLILPGRVFDIDDLIL 80

                          90
                  ....*....|.
gi 1159235350 115 NTTGGLIGLWA 125
Cdd:COG4767    81 NTLGALLGYLL 91
VanZ pfam04892
VanZ like family; This family contains several examples of the VanZ protein, but also contains ...
 61-128 2.24e-09

VanZ like family; This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.


Pssm-ID: 461467  Cd Length: 79  Bit Score: 51.32  E-value: 2.24e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1159235350  61 NLIVFFPFGVLLNVNFKRlSFSKKLGIIFLVSFLAELIQFLFGIGVADITDLITNTTGGLIGLWAYQL 128
Cdd:pfam04892  13 NIAHFVPFGFLLPLLFKR-RFLKTLLLGFLYSLSDELHQLFVPGRSFDVDDVILNTLGALIGILLYLL 79
 
Name Accession Description Interval E-value
VanZ COG4767
Glycopeptide antibiotics resistance protein [Defense mechanisms];
40-125 8.83e-17

Glycopeptide antibiotics resistance protein [Defense mechanisms];


Pssm-ID: 443799  Cd Length: 91  Bit Score: 71.01  E-value: 8.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159235350  40 NLVPFST----FSFENTTVLRETTYNLIVFFPFGVLLNVNFKRL-SFSKKLGIIFLVSFLAELIQFLFGIGVADITDLIT 114
Cdd:COG4767     1 NLVPFKSiledLALGGSIAVIQILGNILLFVPLGFLLPLLFKRLrSFKRVLLLGFLLSLLIEVLQLILPGRVFDIDDLIL 80

                          90
                  ....*....|.
gi 1159235350 115 NTTGGLIGLWA 125
Cdd:COG4767    81 NTLGALLGYLL 91
VanZ pfam04892
VanZ like family; This family contains several examples of the VanZ protein, but also contains ...
 61-128 2.24e-09

VanZ like family; This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.


Pssm-ID: 461467  Cd Length: 79  Bit Score: 51.32  E-value: 2.24e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1159235350  61 NLIVFFPFGVLLNVNFKRlSFSKKLGIIFLVSFLAELIQFLFGIGVADITDLITNTTGGLIGLWAYQL 128
Cdd:pfam04892  13 NIAHFVPFGFLLPLLFKR-RFLKTLLLGFLYSLSDELHQLFVPGRSFDVDDVILNTLGALIGILLYLL 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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