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Conserved domains on  [gi|218512156|sp|P07589|]
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RecName: Full=Fibronectin; Short=FN; Contains: RecName: Full=Anastellin; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 354-402 1.27e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 98.14  E-value: 1.27e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 218512156    354 GNSNGEPCVLPFTYNGKTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 402
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 414-462 1.35e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 95.44  E-value: 1.35e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 218512156    414 GNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 462
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
fn3 pfam00041
Fibronectin type III domain;
1541-1622 1.26e-20

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 88.24  E-value: 1.26e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1541 DVPRDLEVIAATPTSLLISWDAPAV---TVRYYRITYGETGGSSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1617
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 218512156  1618 DSPAS 1622
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1635-1715 6.57e-19

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 83.23  E-value: 6.57e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1635 DKPSQMQVTDVQDNSISVRWLPS---SSPVTGYRVTTAPKNGPGPSKTKTVGPDQTEMTIEGLQPTVEYVVSVYAQNQNG 1711
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1712 ESQP 1715
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
702-1027 1.01e-18

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 92.76  E-value: 1.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  702 STSPAVTSNTVTGETTPLSPVVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGdepqYLDLPSTATSVNIPDL 781
Cdd:COG3401   124 TATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT----SLTVTSTTLVDGGGDI 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  782 LPGRKYTVNVYEISEEGEQNL---ILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPRAP-ITGYRIVYSPSVEGSSTEL 857
Cdd:COG3401   200 EPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKV 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  858 NlPETANSVTLSDLQPGVQYNITIYAV-EENQESTPvfiQQETTGVPRSDKVPPPRDLQFVEVTDVKITIMWTPPESP-V 935
Cdd:COG3401   280 A-TVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAP---SNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAdV 355

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  936 TGYRVDVIPVNlPGEHGQRLPVSRNTFAEVTGLSPGVTYHFKVFAVN-QGRESKPLTAQQATKLDAPTNLQFINETDTTV 1014
Cdd:COG3401   356 TGYNVYRSTSG-GGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDaAGNESAPSEEVSATTASAASGESLTASVDAVP 434

                         330
                  ....*....|...
gi 218512156 1015 IVTWTPPRARIVG 1027
Cdd:COG3401   435 LTDVAGATAAASA 447
fn3 pfam00041
Fibronectin type III domain;
1451-1531 6.23e-18

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.54  E-value: 6.23e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1451 DSPSGIDFSDITANSFTVHWIAPR---ATITGYRIRHHPENMGGRPREDRVPPSRNSITLTNLNPGTEYVVSIVALNSKE 1527
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1528 ESLP 1531
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1996-2076 6.36e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 80.62  E-value: 6.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1996 DAPSNLRFLATTPNSLLVSWQPPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIQVIALKNNQ 2072
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 218512156 2073 KSEP 2076
Cdd:cd00063    82 ESPP 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1132-1482 3.22e-17

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 88.14  E-value: 3.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1132 VTSESGSIVVSGLTPGVEYVYTISVLRDGQERDAP---IVKKVVTPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYR 1208
Cdd:COG3401   187 VTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYR 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1209 ITTTPTNGQqgySLEEVVHADQSSCTFENLSPGLEYNVSVYTV-KDDKESVP------ISDTIIPEVPQltDLSFVDITD 1281
Cdd:COG3401   266 VYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAPsnvvsvTTDLTPPAAPS--GLTATAVGS 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1282 SSIGLRWTPLNSSTIIGYRITVVAAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTA 1358
Cdd:COG3401   341 SSITLSWTASSDADVTGYNVYRSTSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1359 VPPPTDLRFTNVgPDTMRVTWAPPSSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQhe 1438
Cdd:COG3401   418 ASAASGESLTAS-VDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTG-- 494

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 218512156 1439 SIPLRGRQKTALDSPSGIDFSDITANSFTVHWIAPRATITGYRI 1482
Cdd:COG3401   495 SLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTV 538
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1493-1949 2.02e-15

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.36  E-value: 2.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1493 PREDRVPPSRNSITLTNLNPGTEYVVSIVALNSKEESLPLVGQQSTVSDVPRDLEVIAATPTSLLISWDAPAVTVRYYRI 1572
Cdd:COG3401    92 TGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVS 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1573 TYGETGGSSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPVSINYRTEIDKPSQMQVTDVQDNSISV 1652
Cdd:COG3401   172 PDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTL 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1653 RWLPSSSP-VTGYRVTTAPKNGPGPSKTKTVgpDQTEMTIEGLQPTVEYVVSVYAQNQNGESQPLVQTAVTNIDR----- 1726
Cdd:COG3401   252 SWDPVTESdATGYRVYRSNSGDGPFTKVATV--TTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLtppaa 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1727 PKGLAFTDVDVDSIKIAWE-SPQGQVSRYRVTYSSPEDGIHELFpAPDGEEETAELQGLRPGSEYTVSVVALHDD-MESQ 1804
Cdd:COG3401   330 PSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYTKI-AETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESA 408

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1805 PLIGTQSTTIPAPTNLKFTQVTPTSLTAQWTAPNVQLTGYRVRVTPKEKTGPMKEINLAP---DSSSVVVSGLMVATKYE 1881
Cdd:COG3401   409 PSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVpftTTSSTVTATTTDTTTAN 488

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218512156 1882 VSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAIPANGQTPI 1949
Cdd:COG3401   489 LSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTS 556
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 2.13e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 72.00  E-value: 2.13e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156    187 CFDQAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2298-2342 2.67e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.61  E-value: 2.67e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156   2298 CFDPYTVSHYAIGEEWERLSDSGFKLSCQCLGFGSGHFRCDSSKW 2342
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2343-2384 3.25e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.61  E-value: 3.25e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 218512156   2343 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHE 2384
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 471-514 5.71e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.84  E-value: 5.71e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156    471 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCVAYSQ 514
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
232-271 9.41e-15

Fibronectin type I domain;


:

Pssm-ID: 459644  Cd Length: 40  Bit Score: 70.04  E-value: 9.41e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 523-561 2.15e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 2.15e-14
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 218512156    523 GITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQ 561
Cdd:smart00058    7 GTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 562-605 3.25e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.25e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156    562 CQDSETRTFYQIGDSWEK-YLQGVRYQCYCYGRGIGEWACQPLQT 605
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
999-1078 4.54e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 4.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   999 DAPTNLQFINETDTTVIVTWTPPRAR---IVGYRLTVGLTRGGQPKQ-YNVGPAASQYPLRNLQPGSEYAVSLVAVKGNQ 1074
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1075 QSPR 1078
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
620-692 9.70e-13

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 9.70e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218512156   620 TPSQPNSHPIQWSAPE--SSHISKYILRWKPKNSPDRWKEATIPGHLNSYTIKGLRPGVVYEGQLISVQHYGQRE 692
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 1.63e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 63.91  E-value: 1.63e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156     98 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 2.29e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 63.52  E-value: 2.29e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 218512156    142 CHEG--GQSYKIGDTWRRPHEtGGYMLECVCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2386-2425 7.37e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.96  E-value: 7.37e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 218512156 2386 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2425
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 1.02e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.50  E-value: 1.02e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 218512156   53 CYDN--GKHYQINQQWERTYLGSALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 308-346 5.06e-06

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 45.40  E-value: 5.06e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 218512156  308 HCVTDS-GVVYSVGMQWLKTQGNKQMLCTCLGN--GVSCQET 346
Cdd:cd00061     2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
1097-1154 1.51e-05

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.48  E-value: 1.51e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218512156  1097 TEVTETTIVITWTPAPR-----IGFKLGVRPSQGGEAPREVT--SESGSIVVSGLTPGVEYVYTI 1154
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgngpiTGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRV 73
fn3 pfam00041
Fibronectin type III domain;
2212-2270 2.44e-05

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 2.44e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218512156  2212 TISWT-PFQESSE---YIISCHPVGIDEEPLQFRVPGTSASATLTGLTRGATYNIIVEAVKDQ 2270
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 354-402 1.27e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 98.14  E-value: 1.27e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 218512156    354 GNSNGEPCVLPFTYNGKTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 402
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 414-462 1.35e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 95.44  E-value: 1.35e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 218512156    414 GNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 462
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 355-402 6.74e-23

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 93.52  E-value: 6.74e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 218512156  355 NSNGEPCVLPFTYNGKTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 402
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 415-462 1.36e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 92.37  E-value: 1.36e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 218512156  415 NSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 462
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
361-402 5.30e-21

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 87.63  E-value: 5.30e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 218512156   361 CVLPFTYNGKTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 402
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1541-1622 1.26e-20

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 88.24  E-value: 1.26e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1541 DVPRDLEVIAATPTSLLISWDAPAV---TVRYYRITYGETGGSSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1617
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 218512156  1618 DSPAS 1622
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1635-1715 6.57e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 83.23  E-value: 6.57e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1635 DKPSQMQVTDVQDNSISVRWLPS---SSPVTGYRVTTAPKNGPGPSKTKTVGPDQTEMTIEGLQPTVEYVVSVYAQNQNG 1711
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1712 ESQP 1715
Cdd:pfam00041   81 EGPP 84
fn2 pfam00040
Fibronectin type II domain;
421-462 8.99e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 81.46  E-value: 8.99e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 218512156   421 CHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 462
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
702-1027 1.01e-18

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 92.76  E-value: 1.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  702 STSPAVTSNTVTGETTPLSPVVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGdepqYLDLPSTATSVNIPDL 781
Cdd:COG3401   124 TATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT----SLTVTSTTLVDGGGDI 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  782 LPGRKYTVNVYEISEEGEQNL---ILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPRAP-ITGYRIVYSPSVEGSSTEL 857
Cdd:COG3401   200 EPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKV 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  858 NlPETANSVTLSDLQPGVQYNITIYAV-EENQESTPvfiQQETTGVPRSDKVPPPRDLQFVEVTDVKITIMWTPPESP-V 935
Cdd:COG3401   280 A-TVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAP---SNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAdV 355

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  936 TGYRVDVIPVNlPGEHGQRLPVSRNTFAEVTGLSPGVTYHFKVFAVN-QGRESKPLTAQQATKLDAPTNLQFINETDTTV 1014
Cdd:COG3401   356 TGYNVYRSTSG-GGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDaAGNESAPSEEVSATTASAASGESLTASVDAVP 434

                         330
                  ....*....|...
gi 218512156 1015 IVTWTPPRARIVG 1027
Cdd:COG3401   435 LTDVAGATAAASA 447
fn3 pfam00041
Fibronectin type III domain;
1451-1531 6.23e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.54  E-value: 6.23e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1451 DSPSGIDFSDITANSFTVHWIAPR---ATITGYRIRHHPENMGGRPREDRVPPSRNSITLTNLNPGTEYVVSIVALNSKE 1527
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1528 ESLP 1531
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1996-2076 6.36e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 80.62  E-value: 6.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1996 DAPSNLRFLATTPNSLLVSWQPPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIQVIALKNNQ 2072
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 218512156 2073 KSEP 2076
Cdd:cd00063    82 ESPP 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1132-1482 3.22e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 88.14  E-value: 3.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1132 VTSESGSIVVSGLTPGVEYVYTISVLRDGQERDAP---IVKKVVTPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYR 1208
Cdd:COG3401   187 VTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYR 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1209 ITTTPTNGQqgySLEEVVHADQSSCTFENLSPGLEYNVSVYTV-KDDKESVP------ISDTIIPEVPQltDLSFVDITD 1281
Cdd:COG3401   266 VYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAPsnvvsvTTDLTPPAAPS--GLTATAVGS 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1282 SSIGLRWTPLNSSTIIGYRITVVAAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTA 1358
Cdd:COG3401   341 SSITLSWTASSDADVTGYNVYRSTSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1359 VPPPTDLRFTNVgPDTMRVTWAPPSSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQhe 1438
Cdd:COG3401   418 ASAASGESLTAS-VDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTG-- 494

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 218512156 1439 SIPLRGRQKTALDSPSGIDFSDITANSFTVHWIAPRATITGYRI 1482
Cdd:COG3401   495 SLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTV 538
fn3 pfam00041
Fibronectin type III domain;
1996-2076 5.04e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 75.14  E-value: 5.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1996 DAPSNLRFLATTPNSLLVSWQPPRAR---ITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIQVIALKNNQ 2072
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  2073 KSEP 2076
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
909-989 9.96e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 9.96e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   909 PPPRDLQFVEVTDVKITIMWTPPE---SPVTGYRVDVIPVNLpGEHGQRLPVSRNTF-AEVTGLSPGVTYHFKVFAVNQG 984
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNS-GEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 218512156   985 RESKP 989
Cdd:pfam00041   80 GEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1541-1623 1.50e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 74.07  E-value: 1.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1541 DVPRDLEVIAATPTSLLISWDAPAVT---VRYYRITYGETGGSSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1617
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*.
gi 218512156 1618 DSPASS 1623
Cdd:cd00063    82 ESPPSE 87
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1493-1949 2.02e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.36  E-value: 2.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1493 PREDRVPPSRNSITLTNLNPGTEYVVSIVALNSKEESLPLVGQQSTVSDVPRDLEVIAATPTSLLISWDAPAVTVRYYRI 1572
Cdd:COG3401    92 TGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVS 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1573 TYGETGGSSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPVSINYRTEIDKPSQMQVTDVQDNSISV 1652
Cdd:COG3401   172 PDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTL 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1653 RWLPSSSP-VTGYRVTTAPKNGPGPSKTKTVgpDQTEMTIEGLQPTVEYVVSVYAQNQNGESQPLVQTAVTNIDR----- 1726
Cdd:COG3401   252 SWDPVTESdATGYRVYRSNSGDGPFTKVATV--TTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLtppaa 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1727 PKGLAFTDVDVDSIKIAWE-SPQGQVSRYRVTYSSPEDGIHELFpAPDGEEETAELQGLRPGSEYTVSVVALHDD-MESQ 1804
Cdd:COG3401   330 PSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYTKI-AETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESA 408

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1805 PLIGTQSTTIPAPTNLKFTQVTPTSLTAQWTAPNVQLTGYRVRVTPKEKTGPMKEINLAP---DSSSVVVSGLMVATKYE 1881
Cdd:COG3401   409 PSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVpftTTSSTVTATTTDTTTAN 488

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218512156 1882 VSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAIPANGQTPI 1949
Cdd:COG3401   489 LSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTS 556
fn3 pfam00041
Fibronectin type III domain;
1815-1895 2.05e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1815 PAPTNLKFTQVTPTSLTAQWTAP---NVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTL 1891
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1892 TSRP 1895
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 2.13e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 72.00  E-value: 2.13e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156    187 CFDQAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2298-2342 2.67e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.61  E-value: 2.67e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156   2298 CFDPYTVSHYAIGEEWERLSDSGFKLSCQCLGFGSGHFRCDSSKW 2342
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 812-900 2.76e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 2.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  812 PDAPPDPTVDQVDDTSIVVRWSRPR---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIYAVEEN 887
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 218512156  888 QESTPVFIQQETT 900
Cdd:cd00063    81 GESPPSESVTVTT 93
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2343-2384 3.25e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.61  E-value: 3.25e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 218512156   2343 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHE 2384
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
fn3 pfam00041
Fibronectin type III domain;
1360-1441 4.13e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.45  E-value: 4.13e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1360 PPPTDLRFTNVGPDTMRVTWAPPS--SIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1437
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1438 ESIP 1441
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 471-514 5.71e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.84  E-value: 5.71e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156    471 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCVAYSQ 514
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
232-271 9.41e-15

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 70.04  E-value: 9.41e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 232-276 1.03e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.07  E-value: 1.03e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156    232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS 276
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 523-561 2.15e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 2.15e-14
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 218512156    523 GITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQ 561
Cdd:smart00058    7 GTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 562-605 3.25e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.25e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156    562 CQDSETRTFYQIGDSWEK-YLQGVRYQCYCYGRGIGEWACQPLQT 605
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
999-1078 4.54e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 4.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   999 DAPTNLQFINETDTTVIVTWTPPRAR---IVGYRLTVGLTRGGQPKQ-YNVGPAASQYPLRNLQPGSEYAVSLVAVKGNQ 1074
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1075 QSPR 1078
Cdd:pfam00041   81 EGPP 84
fn1 pfam00039
Fibronectin type I domain;
187-226 9.14e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 67.34  E-value: 9.14e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156   187 CFDQAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITC 226
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
471-509 9.23e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 67.34  E-value: 9.23e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156   471 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC 509
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1635-1722 1.03e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.68  E-value: 1.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1635 DKPSQMQVTDVQDNSISVRWLPSS---SPVTGYRVTTAPKNGPGPSKTKTVGPDQTEMTIEGLQPTVEYVVSVYAQNQNG 1711
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 218512156 1712 ESQPLVQTAVT 1722
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1451-1531 2.74e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 2.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1451 DSPSGIDFSDITANSFTVHWIAPRAT---ITGYRIRHHPENMGGRPREDRVPPSRNSITLTNLNPGTEYVVSIVALNSKE 1527
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 218512156 1528 ESLP 1531
Cdd:cd00063    82 ESPP 85
fn1 pfam00039
Fibronectin type I domain;
2298-2337 2.84e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.80  E-value: 2.84e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156  2298 CFDPYTVSHYAIGEEWERLSDSGFKLSCQCLGFGSGHFRC 2337
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
562-600 2.86e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.80  E-value: 2.86e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156   562 CQDSETRTFYQIGDSWEK-YLQGVRYQCYCYGRGIGEWAC 600
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERpSQRGHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1996-2074 3.59e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 66.87  E-value: 3.59e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   1996 DAPSNLRFLATTPNSLLVSWQPP-RARITGYIIKY--EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIQVIALKNNQ 2072
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 218512156   2073 KS 2074
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 560-603 6.93e-13

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 64.66  E-value: 6.93e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 218512156  560 DQCQDSETRTFYQIGDSWEKYLQGVRYQCYCYGrGIGEWACQPL 603
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
620-692 9.70e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 9.70e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218512156   620 TPSQPNSHPIQWSAPE--SSHISKYILRWKPKNSPDRWKEATIPGHLNSYTIKGLRPGVVYEGQLISVQHYGQRE 692
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 1.63e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 63.91  E-value: 1.63e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156     98 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1543-1619 1.64e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.64e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   1543 PRDLEVIAATPTSLLISWDAPAVT-----VRYYRITYGETGGSspVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1617
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 218512156   1618 DS 1619
Cdd:smart00060   82 EG 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 2.29e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 63.52  E-value: 2.29e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 218512156    142 CHEG--GQSYKIGDTWRRPHEtGGYMLECVCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
98-136 2.29e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 63.10  E-value: 2.29e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156    98 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISC 136
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 812-890 2.50e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.56  E-value: 2.50e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156    812 PDAPPDPTVDQVDDTSIVVRWSRP-----RAPITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEE 886
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 218512156    887 NQES 890
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1360-1439 3.28e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.17  E-value: 3.28e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   1360 PPPTDLRFTNVGPDTMRVTWAPPSSIELTNLLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1437
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 218512156   1438 ES 1439
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2386-2425 7.37e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.96  E-value: 7.37e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 218512156 2386 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2425
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 96-137 7.74e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.96  E-value: 7.74e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 218512156   96 ETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGaGRGRISCT 137
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 999-1085 7.75e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 7.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  999 DAPTNLQFINETDTTVIVTWTPPR---ARIVGYRLTVGLTRGGQPKQYNVGPA-ASQYPLRNLQPGSEYAVSLVAVKGNQ 1074
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGsETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 218512156 1075 QSPRVTGV-FTT 1085
Cdd:cd00063    82 ESPPSESVtVTT 93
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 185-228 8.53e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 8.53e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 218512156  185 EKCFDQAAGTSYVVGETWEKPYQGwMMVDCTCLGeGSGRITCTS 228
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
2343-2380 1.55e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 60.79  E-value: 1.55e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156  2343 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKC 2380
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2296-2340 1.58e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.81  E-value: 1.58e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 218512156 2296 DSCFDPYTVSHYAIGEEWERLSDsGFKLSCQCLGfGSGHFRCDSS 2340
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1360-1441 1.98e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 1.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1360 PPPTDLRFTNVGPDTMRVTWAPPSSI--ELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1437
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 218512156 1438 ESIP 1441
Cdd:cd00063    82 ESPP 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1451-1529 3.80e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.09  E-value: 3.80e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   1451 DSPSGIDFSDITANSFTVHWIAP-RATITGYRIRHHPENMGGRPREDRV--PPSRNSITLTNLNPGTEYVVSIVALNSKE 1527
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 218512156   1528 ES 1529
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1815-1902 4.57e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 4.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1815 PAPTNLKFTQVTPTSLTAQWTAP---NVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTL 1891
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 218512156 1892 TSRPAQGVVTT 1902
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1635-1713 5.35e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 5.35e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   1635 DKPSQMQVTDVQDNSISVRWLPSS-----SPVTGYRVTTAPKNGPGpsKTKTVGPDQTEMTIEGLQPTVEYVVSVYAQNQ 1709
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEW--KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 218512156   1710 NGES 1713
Cdd:smart00060   80 AGEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 1.02e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.50  E-value: 1.02e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 218512156   53 CYDN--GKHYQINQQWERTYLGSALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
142-180 1.12e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.48  E-value: 1.12e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 218512156   142 CHE--GGQSYKIGDTWRRPHETGgYMLECVCLGNGKGEWTC 180
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2387-2427 1.81e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 58.13  E-value: 1.81e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156   2387 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2427
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 469-509 2.08e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 57.73  E-value: 2.08e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 218512156  469 EICTTNE-GVMYRIGDQWDKQHDmGHMMRCTCVGNgRGEWTC 509
Cdd:cd00061     1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARC 40
fn1 pfam00039
Fibronectin type I domain;
525-556 3.28e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.94  E-value: 3.28e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 218512156   525 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 556
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2342-2383 5.71e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.57  E-value: 5.71e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 218512156 2342 WCHDN--GVNYKIGEKWDRQGEnGQMMSCTCLGNgKGEFKCDPH 2383
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 999-1076 8.56e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 8.56e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156    999 DAPTNLQFINETDTTVIVTWTPP-----RARIVGYRLtVGLTRGGQPKQYNVGPAASQYPLRNLQPGSEYAVSLVAVKGN 1073
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRV-EYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 218512156   1074 QQS 1076
Cdd:smart00060   81 GEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 230-274 1.05e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.80  E-value: 1.05e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 218512156  230 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCICTGNgRGEWKCERH 274
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 517-559 2.76e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 54.65  E-value: 2.76e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 218512156  517 DQCIVD--GITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDPV 559
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 53-93 3.79e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 54.28  E-value: 3.79e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156     53 CYDN--GKHYQINQQWERTYL-GSALVCTCYGGSRG-FNCESKPE 93
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 140-182 8.33e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 53.10  E-value: 8.33e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 218512156  140 NRCHEG--GQSYKIGDTWRRPHEtgGYMLECVCLGNgKGEWTCKP 182
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1815-1886 1.20e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 1.20e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218512156   1815 PAPTNLKFTQVTPTSLTAQWTAPNV-QLTGYRV--RVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYA 1886
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn1 pfam00039
Fibronectin type I domain;
2387-2422 4.29e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 51.16  E-value: 4.29e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156  2387 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2422
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
fn1 pfam00039
Fibronectin type I domain;
53-88 3.13e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 48.85  E-value: 3.13e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156    53 CYDN--GKHYQINQQWERTYL-GSALVCTCYGGSRG-FNC 88
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 617-690 2.99e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 2.99e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 218512156    617 ITETPSQPNSHPIQWSAPESSHISKYILRWKPKNSP--DRWKEATIPGHLNSYTIKGLRPGVVYEGQLISVQHYGQ 690
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREegSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 308-346 5.06e-06

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 45.40  E-value: 5.06e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 218512156  308 HCVTDS-GVVYSVGMQWLKTQGNKQMLCTCLGN--GVSCQET 346
Cdd:cd00061     2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 309-348 8.82e-06

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 44.65  E-value: 8.82e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156    309 CVTD-SGVVYSVGMQWLKTQGNKQML-CTCLGNG---VSCQETAV 348
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1097-1154 1.51e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.48  E-value: 1.51e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218512156  1097 TEVTETTIVITWTPAPR-----IGFKLGVRPSQGGEAPREVT--SESGSIVVSGLTPGVEYVYTI 1154
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgngpiTGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRV 73
fn3 pfam00041
Fibronectin type III domain;
2212-2270 2.44e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 2.44e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218512156  2212 TISWT-PFQESSE---YIISCHPVGIDEEPLQFRVPGTSASATLTGLTRGATYNIIVEAVKDQ 2270
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 610-700 2.99e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.79  E-value: 2.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  610 SGPVQVIITETpsQPNSHPIQWSAPES--SHISKYILRWKPKNSPDRWKEATIPGHLNSYTIKGLRPGVVYEGQLISVQH 687
Cdd:cd00063     2 SPPTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 218512156  688 YGQ-REVTRFDFTT 700
Cdd:cd00063    80 GGEsPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1097-1162 1.07e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 1.07e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218512156   1097 TEVTETTIVITWTP-------APRIGFKLGVRPSQGGEAPREVTSESGSIVVSGLTPGVEYVYTISVLRDGQE 1162
Cdd:smart00060   10 TDVTSTSVTLSWEPppddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1097-1162 8.27e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.56  E-value: 8.27e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 218512156 1097 TEVTETTIVITWTP-----APRIGFKLGVRPSQGGEaPREVTSESG---SIVVSGLTPGVEYVYTISVLRDGQE 1162
Cdd:cd00063    10 TDVTSTSVTLSWTPpeddgGPITGYVVEYREKGSGD-WKEVEVTPGsetSYTLTGLKPGTEYEFRVRAVNGGGE 82
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 354-402 1.27e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 98.14  E-value: 1.27e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 218512156    354 GNSNGEPCVLPFTYNGKTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 402
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 414-462 1.35e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 95.44  E-value: 1.35e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 218512156    414 GNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 462
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 355-402 6.74e-23

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 93.52  E-value: 6.74e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 218512156  355 NSNGEPCVLPFTYNGKTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 402
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 415-462 1.36e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 92.37  E-value: 1.36e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 218512156  415 NSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 462
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
361-402 5.30e-21

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 87.63  E-value: 5.30e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 218512156   361 CVLPFTYNGKTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 402
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1541-1622 1.26e-20

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 88.24  E-value: 1.26e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1541 DVPRDLEVIAATPTSLLISWDAPAV---TVRYYRITYGETGGSSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1617
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 218512156  1618 DSPAS 1622
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1635-1715 6.57e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 83.23  E-value: 6.57e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1635 DKPSQMQVTDVQDNSISVRWLPS---SSPVTGYRVTTAPKNGPGPSKTKTVGPDQTEMTIEGLQPTVEYVVSVYAQNQNG 1711
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1712 ESQP 1715
Cdd:pfam00041   81 EGPP 84
fn2 pfam00040
Fibronectin type II domain;
421-462 8.99e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 81.46  E-value: 8.99e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 218512156   421 CHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 462
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
702-1027 1.01e-18

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 92.76  E-value: 1.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  702 STSPAVTSNTVTGETTPLSPVVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGdepqYLDLPSTATSVNIPDL 781
Cdd:COG3401   124 TATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT----SLTVTSTTLVDGGGDI 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  782 LPGRKYTVNVYEISEEGEQNL---ILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPRAP-ITGYRIVYSPSVEGSSTEL 857
Cdd:COG3401   200 EPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKV 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  858 NlPETANSVTLSDLQPGVQYNITIYAV-EENQESTPvfiQQETTGVPRSDKVPPPRDLQFVEVTDVKITIMWTPPESP-V 935
Cdd:COG3401   280 A-TVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAP---SNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAdV 355

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  936 TGYRVDVIPVNlPGEHGQRLPVSRNTFAEVTGLSPGVTYHFKVFAVN-QGRESKPLTAQQATKLDAPTNLQFINETDTTV 1014
Cdd:COG3401   356 TGYNVYRSTSG-GGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDaAGNESAPSEEVSATTASAASGESLTASVDAVP 434

                         330
                  ....*....|...
gi 218512156 1015 IVTWTPPRARIVG 1027
Cdd:COG3401   435 LTDVAGATAAASA 447
fn3 pfam00041
Fibronectin type III domain;
1451-1531 6.23e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.54  E-value: 6.23e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1451 DSPSGIDFSDITANSFTVHWIAPR---ATITGYRIRHHPENMGGRPREDRVPPSRNSITLTNLNPGTEYVVSIVALNSKE 1527
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1528 ESLP 1531
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1996-2076 6.36e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 80.62  E-value: 6.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1996 DAPSNLRFLATTPNSLLVSWQPPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIQVIALKNNQ 2072
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 218512156 2073 KSEP 2076
Cdd:cd00063    82 ESPP 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1132-1482 3.22e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 88.14  E-value: 3.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1132 VTSESGSIVVSGLTPGVEYVYTISVLRDGQERDAP---IVKKVVTPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYR 1208
Cdd:COG3401   187 VTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYR 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1209 ITTTPTNGQqgySLEEVVHADQSSCTFENLSPGLEYNVSVYTV-KDDKESVP------ISDTIIPEVPQltDLSFVDITD 1281
Cdd:COG3401   266 VYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAPsnvvsvTTDLTPPAAPS--GLTATAVGS 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1282 SSIGLRWTPLNSSTIIGYRITVVAAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTA 1358
Cdd:COG3401   341 SSITLSWTASSDADVTGYNVYRSTSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1359 VPPPTDLRFTNVgPDTMRVTWAPPSSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQhe 1438
Cdd:COG3401   418 ASAASGESLTAS-VDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTG-- 494

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 218512156 1439 SIPLRGRQKTALDSPSGIDFSDITANSFTVHWIAPRATITGYRI 1482
Cdd:COG3401   495 SLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTV 538
fn3 pfam00041
Fibronectin type III domain;
1996-2076 5.04e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 75.14  E-value: 5.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1996 DAPSNLRFLATTPNSLLVSWQPPRAR---ITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIQVIALKNNQ 2072
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  2073 KSEP 2076
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
909-989 9.96e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 9.96e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   909 PPPRDLQFVEVTDVKITIMWTPPE---SPVTGYRVDVIPVNLpGEHGQRLPVSRNTF-AEVTGLSPGVTYHFKVFAVNQG 984
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNS-GEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 218512156   985 RESKP 989
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
813-884 1.22e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.99  E-value: 1.22e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 218512156   813 DAPPDPTVDQVDDTSIVVRWSRPR---APITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 884
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1541-1623 1.50e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 74.07  E-value: 1.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1541 DVPRDLEVIAATPTSLLISWDAPAVT---VRYYRITYGETGGSSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1617
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*.
gi 218512156 1618 DSPASS 1623
Cdd:cd00063    82 ESPPSE 87
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1242-1760 1.85e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.36  E-value: 1.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1242 LEYNVSVYTVKDDKESVPISDTIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSV 1321
Cdd:COG3401    22 AVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1322 GYYTVTGlePGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNVGPDTMRVTWAPPSSIE-LTNLLVRYSPVKNE 1400
Cdd:COG3401   102 SVGGATN--TGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAgAGVVVSPDTSATAA 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1401 EDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQ----KTALDSPSGIDFSDITANSFTVHWIA-PRA 1475
Cdd:COG3401   180 VATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPvTES 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1476 TITGYRIRHHPENMGGRPREDRVppSRNSITLTNLNPGTEYVVSIVALNSKEEslplVGQQSTVSDV---------PRDL 1546
Cdd:COG3401   260 DATGYRVYRSNSGDGPFTKVATV--TTTSYTDTGLTNGTTYYYRVTAVDAAGN----ESAPSNVVSVttdltppaaPSGL 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1547 EVIAATPTSLLISWDAPA-VTVRYYRItYGETGGSSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKP 1625
Cdd:COG3401   334 TATAVGSSSITLSWTASSdADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEE 412

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1626 VSINYRTEIDKPSQMQVTDVQDNSISVRWLPSSSPVTGYRVTTA-------PKNGPGPSKTKTVGPDQTEMTIEGLQPTV 1698
Cdd:COG3401   413 VSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAvladggdTGNAVPFTTTSSTVTATTTDTTTANLSVT 492

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 218512156 1699 EYVVSVYAQNQNGESQPLVQTAVT----NIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSS 1760
Cdd:COG3401   493 TGSLVGGSGASSVTNSVSVIGASAaaavGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSAS 558
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1493-1949 2.02e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.36  E-value: 2.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1493 PREDRVPPSRNSITLTNLNPGTEYVVSIVALNSKEESLPLVGQQSTVSDVPRDLEVIAATPTSLLISWDAPAVTVRYYRI 1572
Cdd:COG3401    92 TGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVS 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1573 TYGETGGSSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPVSINYRTEIDKPSQMQVTDVQDNSISV 1652
Cdd:COG3401   172 PDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTL 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1653 RWLPSSSP-VTGYRVTTAPKNGPGPSKTKTVgpDQTEMTIEGLQPTVEYVVSVYAQNQNGESQPLVQTAVTNIDR----- 1726
Cdd:COG3401   252 SWDPVTESdATGYRVYRSNSGDGPFTKVATV--TTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLtppaa 329

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1727 PKGLAFTDVDVDSIKIAWE-SPQGQVSRYRVTYSSPEDGIHELFpAPDGEEETAELQGLRPGSEYTVSVVALHDD-MESQ 1804
Cdd:COG3401   330 PSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYTKI-AETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESA 408

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1805 PLIGTQSTTIPAPTNLKFTQVTPTSLTAQWTAPNVQLTGYRVRVTPKEKTGPMKEINLAP---DSSSVVVSGLMVATKYE 1881
Cdd:COG3401   409 PSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVpftTTSSTVTATTTDTTTAN 488

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218512156 1882 VSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAIPANGQTPI 1949
Cdd:COG3401   489 LSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTS 556
fn3 pfam00041
Fibronectin type III domain;
1815-1895 2.05e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1815 PAPTNLKFTQVTPTSLTAQWTAP---NVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTL 1891
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1892 TSRP 1895
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 2.13e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 72.00  E-value: 2.13e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156    187 CFDQAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2298-2342 2.67e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.61  E-value: 2.67e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156   2298 CFDPYTVSHYAIGEEWERLSDSGFKLSCQCLGFGSGHFRCDSSKW 2342
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 812-900 2.76e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.30  E-value: 2.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  812 PDAPPDPTVDQVDDTSIVVRWSRPR---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIYAVEEN 887
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 218512156  888 QESTPVFIQQETT 900
Cdd:cd00063    81 GESPPSESVTVTT 93
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2343-2384 3.25e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.61  E-value: 3.25e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 218512156   2343 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHE 2384
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
fn3 pfam00041
Fibronectin type III domain;
1360-1441 4.13e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.45  E-value: 4.13e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1360 PPPTDLRFTNVGPDTMRVTWAPPS--SIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1437
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1438 ESIP 1441
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 471-514 5.71e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.84  E-value: 5.71e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156    471 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCVAYSQ 514
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
232-271 9.41e-15

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 70.04  E-value: 9.41e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 232-276 1.03e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.07  E-value: 1.03e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156    232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS 276
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 523-561 2.15e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 2.15e-14
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 218512156    523 GITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQ 561
Cdd:smart00058    7 GTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 562-605 3.25e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.25e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156    562 CQDSETRTFYQIGDSWEK-YLQGVRYQCYCYGRGIGEWACQPLQT 605
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
999-1078 4.54e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 4.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   999 DAPTNLQFINETDTTVIVTWTPPRAR---IVGYRLTVGLTRGGQPKQ-YNVGPAASQYPLRNLQPGSEYAVSLVAVKGNQ 1074
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1075 QSPR 1078
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 909-996 6.61e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 6.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  909 PPPRDLQFVEVTDVKITIMWTPPE---SPVTGYRVDVIPVNLPGEHGQRLPVSRNTFAEVTGLSPGVTYHFKVFAVNQGR 985
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 218512156  986 ESKPLTAQQAT 996
Cdd:cd00063    82 ESPPSESVTVT 92
fn1 pfam00039
Fibronectin type I domain;
187-226 9.14e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 67.34  E-value: 9.14e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156   187 CFDQAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITC 226
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
471-509 9.23e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 67.34  E-value: 9.23e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156   471 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC 509
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1635-1722 1.03e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.68  E-value: 1.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1635 DKPSQMQVTDVQDNSISVRWLPSS---SPVTGYRVTTAPKNGPGPSKTKTVGPDQTEMTIEGLQPTVEYVVSVYAQNQNG 1711
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 218512156 1712 ESQPLVQTAVT 1722
Cdd:cd00063    82 ESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
1907-1986 2.41e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 2.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1907 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTP-IQRTIRPDVRSYTITGLQPGTDYKIHLYTLNDNA 1982
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 218512156  1983 RSSP 1986
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1269-1351 2.55e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 2.55e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1269 PQLTDLSFVDITDSSIGLRWTPL--NSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGG 1346
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 218512156  1347 ESAPT 1351
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1451-1531 2.74e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 2.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1451 DSPSGIDFSDITANSFTVHWIAPRAT---ITGYRIRHHPENMGGRPREDRVPPSRNSITLTNLNPGTEYVVSIVALNSKE 1527
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 218512156 1528 ESLP 1531
Cdd:cd00063    82 ESPP 85
fn1 pfam00039
Fibronectin type I domain;
2298-2337 2.84e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.80  E-value: 2.84e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156  2298 CFDPYTVSHYAIGEEWERLSDSGFKLSCQCLGFGSGHFRC 2337
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
562-600 2.86e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.80  E-value: 2.86e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156   562 CQDSETRTFYQIGDSWEK-YLQGVRYQCYCYGRGIGEWAC 600
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERpSQRGHVLQCTCLGNGGGEIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1697-2067 3.02e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.42  E-value: 3.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1697 TVEYVVSVYAQNQNGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSS-PEDGIHELFPAPDGE 1775
Cdd:COG3401    21 TAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVaAAPPTATGLTTLTGS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1776 EETAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTTIPAPTNLKFTQVTPTSLTAQWTAPNVQLTGYRVRVTPKEKTG 1855
Cdd:COG3401   101 GSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAV 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1856 PMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGV--VTTLENVSPPRRARVTDATETTITISWRTKTET- 1932
Cdd:COG3401   181 ATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESd 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1933 ITGFQV--DAIPANGQTPIQRTirpDVRSYTITGLQPGTDYKIHLYTLNDNARSSP--VVIDASTAI---DAPSNLRFLA 2005
Cdd:COG3401   261 ATGYRVyrSNSGDGPFTKVATV---TTTSYTDTGLTNGTTYYYRVTAVDAAGNESApsNVVSVTTDLtppAAPSGLTATA 337

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218512156 2006 TTPNSLLVSWQPPR-ARITGYIIKYEKPGSPPREVVPRPRPGvTEATITGLEPGTEYTIQVIA 2067
Cdd:COG3401   338 VGSSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAETVTT-TSYTDTGLTPGTTYYYKVTA 399
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1996-2074 3.59e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 66.87  E-value: 3.59e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   1996 DAPSNLRFLATTPNSLLVSWQPP-RARITGYIIKY--EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIQVIALKNNQ 2072
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 218512156   2073 KS 2074
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 560-603 6.93e-13

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 64.66  E-value: 6.93e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 218512156  560 DQCQDSETRTFYQIGDSWEKYLQGVRYQCYCYGrGIGEWACQPL 603
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
698-1035 7.95e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 73.88  E-value: 7.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  698 FTTTSTSPAVTSNTVTGETTPLSPVvaTSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSV 776
Cdd:COG3401   212 TDTGGESAPSNEVSVTTPTTPPSAP--TGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSY 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  777 NIPDLLPGRKYTVNVYEISEEGEQ----NLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPRAPITGYRIVYSPSVE 851
Cdd:COG3401   288 TDTGLTNGTTYYYRVTAVDAAGNEsapsNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGG 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  852 GSSTELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGVPRSDKVPPPRDLQFVEVTDVKITIM 927
Cdd:COG3401   368 GTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASA 447

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  928 WTPPESPVTGYRVDVIPVNLPgehgqrlPVSRNTFAEVTGLSPGVTYHFKVFAVNQGRESKPLTAQQATKLDAPTNLQFI 1007
Cdd:COG3401   448 ASNPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAV 520

                         330       340
                  ....*....|....*....|....*...
gi 218512156 1008 NETDTTVIVTWTPPRARIVGYRLTVGLT 1035
Cdd:COG3401   521 GGAPDGTPNVTGASPVTVGASTGDVLIT 548
fn3 pfam00041
Fibronectin type III domain;
728-799 8.22e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 8.22e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218512156   728 SVTEITASSFVVSW---VSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYTVNVYEISEEGE 799
Cdd:pfam00041    7 TVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
fn3 pfam00041
Fibronectin type III domain;
620-692 9.70e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 9.70e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218512156   620 TPSQPNSHPIQWSAPE--SSHISKYILRWKPKNSPDRWKEATIPGHLNSYTIKGLRPGVVYEGQLISVQHYGQRE 692
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 1.63e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 63.91  E-value: 1.63e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156     98 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1543-1619 1.64e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.64e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   1543 PRDLEVIAATPTSLLISWDAPAVT-----VRYYRITYGETGGSspVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1617
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 218512156   1618 DS 1619
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
771-1299 1.91e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 72.73  E-value: 1.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  771 STATSVNIPDLLPGRKYTVNVYEISEEGEQNLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPRAPITGYriVYSPSV 850
Cdd:COG3401     4 SYLTSLDAGIAASAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGT--TSGVAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  851 EGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETTGVPRSDKVPPPRDLQFVEVTDVKITIMWTP 930
Cdd:COG3401    82 VAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTAS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  931 PESPVTGYRVDVIPVNLPGEHGQRLPVSRNTFAEVTGLSPGVTYHFKVFAVNQGRESKPLTAQQATKL----DAPTNLQF 1006
Cdd:COG3401   162 SVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1007 INETDTTVIVTWTP-PRARIVGYRLTVGLTRGGQPKQYNVGPAASqYPLRNLQPGS--EYAVSLVAVKGNQQSPRVTGVF 1083
Cdd:COG3401   242 TADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKVATVTTTS-YTDTGLTNGTtyYYRVTAVDAAGNESAPSNVVSV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1084 TTLQPLGSIPHY--NTEVTETTIVITWTPAP---RIGFKLGVRPSQGGEAPREVTSESG-SIVVSGLTPGVEYVYTISVL 1157
Cdd:COG3401   321 TTDLTPPAAPSGltATAVGSSSITLSWTASSdadVTGYNVYRSTSGGGTYTKIAETVTTtSYTDTGLTPGTTYYYKVTAV 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1158 RDGQERDAPIVKKVVTPLSPPTNLHLEA-------NPDTGVLTVSWERSTTPD---------ITGYRITTTPTNGQQGYS 1221
Cdd:COG3401   401 DAAGNESAPSEEVSATTASAASGESLTAsvdavplTDVAGATAAASAASNPGVsaavladggDTGNAVPFTTTSSTVTAT 480

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218512156 1222 LEEVVHADQSSCTFENLSPGLEYNVSVYTVKDDKESVPISDTIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGY 1299
Cdd:COG3401   481 TTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSAS 558
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 2.29e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 63.52  E-value: 2.29e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 218512156    142 CHEG--GQSYKIGDTWRRPHEtGGYMLECVCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
98-136 2.29e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 63.10  E-value: 2.29e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156    98 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISC 136
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 812-890 2.50e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.56  E-value: 2.50e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156    812 PDAPPDPTVDQVDDTSIVVRWSRP-----RAPITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEE 886
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 218512156    887 NQES 890
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
1176-1259 2.98e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 2.98e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1176 SPPTNLHL-EANPDTgvLTVSWERSTTP--DITGYRITTTPTNGQQgYSLEEVVHADQSSCTFENLSPGLEYNVSVYTVK 1252
Cdd:pfam00041    1 SAPSNLTVtDVTSTS--LTVSWTPPPDGngPITGYEVEYRPKNSGE-PWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 218512156  1253 DDKESVP 1259
Cdd:pfam00041   78 GGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1360-1439 3.28e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.17  E-value: 3.28e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   1360 PPPTDLRFTNVGPDTMRVTWAPPSSIELTNLLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1437
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 218512156   1438 ES 1439
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2386-2425 7.37e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.96  E-value: 7.37e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 218512156 2386 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2425
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 96-137 7.74e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.96  E-value: 7.74e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 218512156   96 ETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGaGRGRISCT 137
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 999-1085 7.75e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 7.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  999 DAPTNLQFINETDTTVIVTWTPPR---ARIVGYRLTVGLTRGGQPKQYNVGPA-ASQYPLRNLQPGSEYAVSLVAVKGNQ 1074
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGsETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 218512156 1075 QSPRVTGV-FTT 1085
Cdd:cd00063    82 ESPPSESVtVTT 93
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 185-228 8.53e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 8.53e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 218512156  185 EKCFDQAAGTSYVVGETWEKPYQGwMMVDCTCLGeGSGRITCTS 228
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
2343-2380 1.55e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 60.79  E-value: 1.55e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156  2343 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKC 2380
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2296-2340 1.58e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.81  E-value: 1.58e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 218512156 2296 DSCFDPYTVSHYAIGEEWERLSDsGFKLSCQCLGfGSGHFRCDSS 2340
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1360-1441 1.98e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 1.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1360 PPPTDLRFTNVGPDTMRVTWAPPSSI--ELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1437
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 218512156 1438 ESIP 1441
Cdd:cd00063    82 ESPP 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1451-1529 3.80e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.09  E-value: 3.80e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   1451 DSPSGIDFSDITANSFTVHWIAP-RATITGYRIRHHPENMGGRPREDRV--PPSRNSITLTNLNPGTEYVVSIVALNSKE 1527
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 218512156   1528 ES 1529
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1815-1902 4.57e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 4.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1815 PAPTNLKFTQVTPTSLTAQWTAP---NVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTL 1891
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 218512156 1892 TSRPAQGVVTT 1902
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1635-1713 5.35e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 5.35e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   1635 DKPSQMQVTDVQDNSISVRWLPSS-----SPVTGYRVTTAPKNGPGpsKTKTVGPDQTEMTIEGLQPTVEYVVSVYAQNQ 1709
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEW--KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 218512156   1710 NGES 1713
Cdd:smart00060   80 AGEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 1.02e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.50  E-value: 1.02e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 218512156   53 CYDN--GKHYQINQQWERTYLGSALVCTCYGGSRGFNCES 90
Cdd:cd00061     3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
fn1 pfam00039
Fibronectin type I domain;
142-180 1.12e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.48  E-value: 1.12e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 218512156   142 CHE--GGQSYKIGDTWRRPHETGgYMLECVCLGNGKGEWTC 180
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1725-1813 1.16e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 1.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1725 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIHELFPAPDGEEETAELQGLRPGSEYTVSVVALHDDM 1801
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 218512156 1802 ESQPLIGTQSTT 1813
Cdd:cd00063    82 ESPPSESVTVTT 93
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2387-2427 1.81e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 58.13  E-value: 1.81e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156   2387 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2427
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 469-509 2.08e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 57.73  E-value: 2.08e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 218512156  469 EICTTNE-GVMYRIGDQWDKQHDmGHMMRCTCVGNgRGEWTC 509
Cdd:cd00061     1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARC 40
fn1 pfam00039
Fibronectin type I domain;
525-556 3.28e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.94  E-value: 3.28e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 218512156   525 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 556
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 909-987 4.36e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.01  E-value: 4.36e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156    909 PPPRDLQFVEVTDVKITIMWTPPESPV-TGYRVDVIPVNLPGEHGQR--LPVSRNTFAEVTGLSPGVTYHFKVFAVNQGR 985
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGiTGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 218512156    986 ES 987
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1266-1357 5.65e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 5.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1266 PEVPQltDLSFVDITDSSIGLRWTP--LNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLI 1343
Cdd:cd00063     1 PSPPT--NLRVTDVTSTSVTLSWTPpeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....
gi 218512156 1344 NGGESAPTTLTQQT 1357
Cdd:cd00063    79 GGGESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2342-2383 5.71e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.57  E-value: 5.71e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 218512156 2342 WCHDN--GVNYKIGEKWDRQGEnGQMMSCTCLGNgKGEFKCDPH 2383
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 999-1076 8.56e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 8.56e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156    999 DAPTNLQFINETDTTVIVTWTPP-----RARIVGYRLtVGLTRGGQPKQYNVGPAASQYPLRNLQPGSEYAVSLVAVKGN 1073
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRV-EYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 218512156   1074 QQS 1076
Cdd:smart00060   81 GEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 230-274 1.05e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.80  E-value: 1.05e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 218512156  230 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCICTGNgRGEWKCERH 274
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1176-1265 1.44e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1176 SPPTNLHLEANPDTGVlTVSWERSTTP--DITGYRITTTPTNGQQGYSLEeVVHADQSSCTFENLSPGLEYNVSVYTVKD 1253
Cdd:cd00063     2 SPPTNLRVTDVTSTSV-TLSWTPPEDDggPITGYVVEYREKGSGDWKEVE-VTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|..
gi 218512156 1254 DKESVPISDTII 1265
Cdd:cd00063    80 GGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
1725-1805 1.96e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.27  E-value: 1.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  1725 DRPKGLAFTDVDVDSIKIAWESP---QGQVSRYRVTYSSPEDGIHEL-FPAPdGEEETAELQGLRPGSEYTVSVVALHDD 1800
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNeITVP-GTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 218512156  1801 MESQP 1805
Cdd:pfam00041   80 GEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1907-1987 2.39e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 2.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1907 SPPRRARVTDATETTITISW---RTKTETITGFQVDAIPANGQTPIQ-RTIRPDVRSYTITGLQPGTDYKIHLYTLNDNA 1982
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*
gi 218512156 1983 RSSPV 1987
Cdd:cd00063    82 ESPPS 86
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 517-559 2.76e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 54.65  E-value: 2.76e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 218512156  517 DQCIVD--GITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDPV 559
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 53-93 3.79e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 54.28  E-value: 3.79e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156     53 CYDN--GKHYQINQQWERTYL-GSALVCTCYGGSRG-FNCESKPE 93
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1811-2068 4.34e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.94  E-value: 4.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1811 STTIPAPTNLKFTQVTPTSLTAQWTA-PNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKD 1889
Cdd:COG3401    46 VTTKESPGTLLVAAGLSSGGGLGTGGrAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTA 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1890 TLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAIPANGQTpiQRTIRPDVRSYTITGLQPGT 1969
Cdd:COG3401   126 TTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT--SLTVTSTTLVDGGGDIEPGT 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1970 DYKIHLYTLNDNARSSPV----VIDASTAIDAPSNLRFLATTPNSLLVSWQP-PRARITGYIIKYEKPGSPPREVVPRPR 2044
Cdd:COG3401   204 TYYYRVAATDTGGESAPSnevsVTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKVATVT 283

                         250       260
                  ....*....|....*....|....
gi 218512156 2045 pgVTEATITGLEPGTEYTIQVIAL 2068
Cdd:COG3401   284 --TTSYTDTGLTNGTTYYYRVTAV 305
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 140-182 8.33e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 53.10  E-value: 8.33e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 218512156  140 NRCHEG--GQSYKIGDTWRRPHEtgGYMLECVCLGNgKGEWTCKP 182
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1815-1886 1.20e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 1.20e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218512156   1815 PAPTNLKFTQVTPTSLTAQWTAPNV-QLTGYRV--RVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYA 1886
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
712-900 4.20e-08

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 58.80  E-value: 4.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  712 VTGETTPLSPVVATSESVTE--ITASSFVVSWVSASDTVSgfrveYELSEEGDEPQYLDLPST-ATSVNIPDLLPGRkYT 788
Cdd:COG4733   527 VPPQWPPVNVTTSESLSVVAqgTAVTTLTVSWDAPAGAVA-----YEVEWRRDDGNWVSVPRTsGTSFEVPGIYAGD-YE 600

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  789 VNVYEISEEGEQNLILSTSQTTA---PDAPPDPTVDQV--DDTSIVVRWSRP-RAPITGYRIVYSPSVEGSSTELNLPE- 861
Cdd:COG4733   601 VRVRAINALGVSSAWAASSETTVtgkTAPPPAPTGLTAtgGLGGITLSWSFPvDADTLRTEIRYSTTGDWASATVAQALy 680

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 218512156  862 TANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETT 900
Cdd:COG4733   681 PGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQAS 719
fn1 pfam00039
Fibronectin type I domain;
2387-2422 4.29e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 51.16  E-value: 4.29e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156  2387 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2422
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1176-1257 4.69e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 4.69e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   1176 SPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGYSLEEV-VHADQSSCTFENLSPGLEYNVSVYTVKDD 1254
Cdd:smart00060    2 SPPSNLRVTDVTSTSV-TLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 218512156   1255 KES 1257
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 728-810 5.58e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 5.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  728 SVTEITASSFVVSWVSASDT---VSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYTVNVYEISEEGEQNLIL 804
Cdd:cd00063     8 RVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                  ....*.
gi 218512156  805 STSQTT 810
Cdd:cd00063    88 SVTVTT 93
fn1 pfam00039
Fibronectin type I domain;
53-88 3.13e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 48.85  E-value: 3.13e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 218512156    53 CYDN--GKHYQINQQWERTYL-GSALVCTCYGGSRG-FNC 88
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1907-1981 5.90e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 5.90e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   1907 SPPRRARVTDATETTITISWRTKTET-----ITGFQVDAIPANGQTpIQRTIRPDVRSYTITGLQPGTDYKIHLYTLNDN 1981
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 728-799 5.96e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 5.96e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218512156    728 SVTEITASSFVVSW-VSASDTVSGFRVEYELSEEGDEPQYLDLPSTA--TSVNIPDLLPGRKYTVNVYEISEEGE 799
Cdd:smart00060    8 RVTDVTSTSVTLSWePPPDDGITGYIVGYRVEYREEGSEWKEVNVTPssTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1272-1348 2.06e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 2.06e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 218512156   1272 TDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGY--YTVTGLEPGIDYDISVITLINGGES 1348
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 617-690 2.99e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 2.99e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 218512156    617 ITETPSQPNSHPIQWSAPESSHISKYILRWKPKNSP--DRWKEATIPGHLNSYTIKGLRPGVVYEGQLISVQHYGQ 690
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREegSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 308-346 5.06e-06

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 45.40  E-value: 5.06e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 218512156  308 HCVTDS-GVVYSVGMQWLKTQGNKQMLCTCLGN--GVSCQET 346
Cdd:cd00061     2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 309-348 8.82e-06

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 44.65  E-value: 8.82e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 218512156    309 CVTD-SGVVYSVGMQWLKTQGNKQML-CTCLGNG---VSCQETAV 348
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
826-1176 1.29e-05

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 50.71  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  826 TSIVVRWSRPRAPITgYRIVYSPsveGSSTELNLPET-ANSVTLSDLQPGvQYNITIYAV-EENQESTPVFIQQETTGVp 903
Cdd:COG4733   552 TTLTVSWDAPAGAVA-YEVEWRR---DDGNWVSVPRTsGTSFEVPGIYAG-DYEVRVRAInALGVSSAWAASSETTVTG- 625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  904 rsdKVPPPRDLQFVEVTDV--KITIMWT-PPESPVTGYRVDVIPVNLPGEHGQRLPVSRNTFAEVTGLSPGVTYHFKVFA 980
Cdd:COG4733   626 ---KTAPPPAPTGLTATGGlgGITLSWSfPVDADTLRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARA 702

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  981 VNQ-GRESKPLTAQQATKlDAPTNLQF----INETDTTVIVTWTPPRARIVGY-RLTVGLTRGGQPKQYNVGPAASQYPL 1054
Cdd:COG4733   703 VDRsGNVSAWWVSGQASA-DAAGILDAitgqILETELGQELDAIIQNATVAEVvAATVTDVTAQIDTAVLFAGVATAAAI 781

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1055 RNlqpgseYAVSLVAVKGNQQSPRVTGVFTTLQPLGSIPHynTEVTETTIVITWTPAPRIGFKLGVRPSqGGEAPREVTS 1134
Cdd:COG4733   782 GA------EARVAATVAESATAAAATGTAADAAGDASGGV--TAGTSGTTGAGDTAASTTRVAAAVVLA-GVVVYGDAII 852

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 218512156 1135 ESGSIVVSGLTPGVEYVYTISVLRDGQERDAPIVKKVVTPLS 1176
Cdd:COG4733   853 ESGNTGDIVATGDIASAAAGAVATTVSGTTAADVSAVADSTA 894
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1810-2065 1.30e-05

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 50.71  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1810 QSTTIPAPTNLKFTQVTPTSLTAQ----WTAPNVQLTGYRVRVTPKEKTGPMkeinlapdssSVVVSglmvATKYEVSVY 1885
Cdd:COG4733   451 VARTVQSVAGRTLTVSTAYSETPEagavWAFGPDELETQLFRVVSIEENEDG----------TYTIT----AVQHAPEKY 516

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1886 ALKDT--LTSRPAQGVVTTLEnVSPPRRARVTDATETTITISWRTKTETITgFQVDAIPANGQtpIQRTIRPDVRSYTIT 1963
Cdd:COG4733   517 AAIDAgaFDDVPPQWPPVNVT-TSESLSVVAQGTAVTTLTVSWDAPAGAVA-YEVEWRRDDGN--WVSVPRTSGTSFEVP 592

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1964 GLQPGtDYKIHLYTLNDNARSSPVVIDASTAI----DAPSNLRFLATTPNSLLV--SW-QPPRARITGYIIKYEKPGSPP 2036
Cdd:COG4733   593 GIYAG-DYEVRVRAINALGVSSAWAASSETTVtgktAPPPAPTGLTATGGLGGItlSWsFPVDADTLRTEIRYSTTGDWA 671

                         250       260
                  ....*....|....*....|....*....
gi 218512156 2037 REVVPRPRPGVTEATITGLEPGTEYTIQV 2065
Cdd:COG4733   672 SATVAQALYPGNTYTLAGLKAGQTYYYRA 700
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
617-883 1.44e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.39  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  617 ITETPSQPNSHPIQWSAPESSHISKYILRWKpKNSPDRWKE-ATIPGhlNSYTIKGLRPGVVYegqlisvqHYGqreVTR 695
Cdd:COG3401   239 LTATADTPGSVTLSWDPVTESDATGYRVYRS-NSGDGPFTKvATVTT--TSYTDTGLTNGTTY--------YYR---VTA 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  696 FDFTTTSTSPavtSNTVTGETTPLSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDLPSTAT 774
Cdd:COG3401   305 VDAAGNESAP---SNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAdVTGYNVYRSTSGGG-TYTKIAETVTTT 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  775 SVNIPDLLPGRKYTVNVYEISEEGEQ----NLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPRAPITGYRIVYSPSV 850
Cdd:COG3401   381 SYTDTGLTPGTTYYYKVTAVDAAGNEsapsEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLAD 460

                         250       260       270
                  ....*....|....*....|....*....|...
gi 218512156  851 EGSSTELNLPETANSVTLSDLQPGVQYNITIYA 883
Cdd:COG3401   461 GGDTGNAVPFTTTSSTVTATTTDTTTANLSVTT 493
fn3 pfam00041
Fibronectin type III domain;
1097-1154 1.51e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.48  E-value: 1.51e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218512156  1097 TEVTETTIVITWTPAPR-----IGFKLGVRPSQGGEAPREVT--SESGSIVVSGLTPGVEYVYTI 1154
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgngpiTGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRV 73
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1727-1803 1.66e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 1.66e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156   1727 PKGLAFTDVDVDSIKIAWESPQ-----GQVSRYRVTYSSPEDGIHELFPAPDgeEETAELQGLRPGSEYTVSVVALHDDM 1801
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPS--STSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 218512156   1802 ES 1803
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
2212-2270 2.44e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 2.44e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218512156  2212 TISWT-PFQESSE---YIISCHPVGIDEEPLQFRVPGTSASATLTGLTRGATYNIIVEAVKDQ 2270
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 610-700 2.99e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.79  E-value: 2.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  610 SGPVQVIITETpsQPNSHPIQWSAPES--SHISKYILRWKPKNSPDRWKEATIPGHLNSYTIKGLRPGVVYEGQLISVQH 687
Cdd:cd00063     2 SPPTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 218512156  688 YGQ-REVTRFDFTT 700
Cdd:cd00063    80 GGEsPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1097-1162 1.07e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 1.07e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218512156   1097 TEVTETTIVITWTP-------APRIGFKLGVRPSQGGEAPREVTSESGSIVVSGLTPGVEYVYTISVLRDGQE 1162
Cdd:smart00060   10 TDVTSTSVTLSWEPppddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1368-1848 2.41e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 46.48  E-value: 2.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1368 TNVGPDTMRVTWAPPSSIELTNLLVRYSPVKNEEDVAELSISP-SDNAVVLTnllpGTEYlvsVSSVYE--QHESIPLRG 1444
Cdd:COG4733   456 QSVAGRTLTVSTAYSETPEAGAVWAFGPDELETQLFRVVSIEEnEDGTYTIT----AVQH---APEKYAaiDAGAFDDVP 528

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1445 RQKTALDSPSGIDFSDITANS----FTVHWIAPRATITgYRIRHHPENMGGRPREDRvppSRNSITLTNLNPGTeYVVSI 1520
Cdd:COG4733   529 PQWPPVNVTTSESLSVVAQGTavttLTVSWDAPAGAVA-YEVEWRRDDGNWVSVPRT---SGTSFEVPGIYAGD-YEVRV 603

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1521 VALNSKEESLPLVGQQSTV----SDVPRDLEVIAATP--TSLLISWDAPA-VTVRYYRITYGETG--GSSPVQEFTVPGS 1591
Cdd:COG4733   604 RAINALGVSSAWAASSETTvtgkTAPPPAPTGLTATGglGGITLSWSFPVdADTLRTEIRYSTTGdwASATVAQALYPGN 683

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1592 ksTATISGLKPGVDYTITVYAVTGRGDSpaSSKPVSINYRTEIDKPSQMQVTDVQDNSISVRWLPSSSPVTGYRVTTAPK 1671
Cdd:COG4733   684 --TYTLAGLKAGQTYYYRARAVDRSGNV--SAWWVSGQASADAAGILDAITGQILETELGQELDAIIQNATVAEVVAATV 759

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1672 NGPGPSKTKTVGPDQtemTIEGLQPTVEYVVSVYAQNQNGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQV 1751
Cdd:COG4733   760 TDVTAQIDTAVLFAG---VATAAAIGAEARVAATVAESATAAAATGTAADAAGDASGGVTAGTSGTTGAGDTAASTTRVA 836

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156 1752 SRYRV-TYSSPEDGIHELFPAPDGEEETAELQGLRpGSEYTVSVVALHDDMESQPLIGTQSTTIPAPTNLKFTQVTPTSL 1830
Cdd:COG4733   837 AAVVLaGVVVYGDAIIESGNTGDIVATGDIASAAA-GAVATTVSGTTAADVSAVADSTAASLTAIVIAATTIIDAIGDGT 915

                         490
                  ....*....|....*...
gi 218512156 1831 TAQWTAPNVQLTGYRVRV 1848
Cdd:COG4733   916 TREPAGDIGASGGAQGFA 933
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1097-1162 8.27e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.56  E-value: 8.27e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 218512156 1097 TEVTETTIVITWTP-----APRIGFKLGVRPSQGGEaPREVTSESG---SIVVSGLTPGVEYVYTISVLRDGQE 1162
Cdd:cd00063    10 TDVTSTSVTLSWTPpeddgGPITGYVVEYREKGSGD-WKEVEVTPGsetSYTLTGLKPGTEYEFRVRAVNGGGE 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
592-867 8.81e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.53  E-value: 8.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  592 GRGIGEWACQPLQTYPDTSGPVQ-VIITETPSQPNSHPIQWSAPESSHISKY-ILRWKPKNSPDRWKEATIPGhlNSYTI 669
Cdd:COG3401   307 AAGNESAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSWTASSDADVTGYnVYRSTSGGGTYTKIAETVTT--TSYTD 384

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  670 KGLRPGVVYEGQLISVQHYGqrevtrfdfTTTSTSPAVTSNTVTGETTPLSPVVATSESVTEITASSFVVSWVSASDTVS 749
Cdd:COG3401   385 TGLTPGTTYYYKVTAVDAAG---------NESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSA 455

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218512156  750 GFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYTVNVYEISEEGEQNLILSTSQTTAPDAPPDPTVDQVDDTSIV 829
Cdd:COG3401   456 AVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASP 535

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 218512156  830 VRWSRPRAPITGYRIVYSPSVEGSSTELNLPETANSVT 867
Cdd:COG3401   536 VTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYL 573
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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