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Conserved domains on  [gi|399830|sp|P30971|]
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RecName: Full=Gonadotropin subunit beta-1; AltName: Full=GTH-I-beta; AltName: Full=Gonadotropin beta-I chain; Flags: Precursor

Protein Classification

GHB_like domain-containing protein( domain architecture ID 11251631)

GHB_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GHB smart00068
Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones ...
 16-114 3.22e-36

Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology.


:

Pssm-ID: 214502  Cd Length: 107  Bit Score: 118.93  E-value: 3.22e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399830       16 GCFGCHLKNVSIPMER--CGQRVCIHTTICEGLCFSEDAVFESPDEAPEHRVCN-GDWSYEVKHIQGCP----ESITYPV 88
Cdd:smart00068   1 LRPGCRPTNATIAVEKeeCPVCITINTTICAGYCYTRDPVYKSPLPPLPQRVCTyRELRYETVRLPGCPpgvdPVVTYPV 80

                           90       100
                   ....*....|....*....|....*.
gi 399830       89 ATNCYCSACNTKDTYCTRLYAHIPSC 114
Cdd:smart00068  81 ALSCHCGKCNTDTTDCTVESLGPDSC 106
 
Name Accession Description Interval E-value
GHB smart00068
Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones ...
 16-114 3.22e-36

Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology.


Pssm-ID: 214502  Cd Length: 107  Bit Score: 118.93  E-value: 3.22e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399830       16 GCFGCHLKNVSIPMER--CGQRVCIHTTICEGLCFSEDAVFESPDEAPEHRVCN-GDWSYEVKHIQGCP----ESITYPV 88
Cdd:smart00068   1 LRPGCRPTNATIAVEKeeCPVCITINTTICAGYCYTRDPVYKSPLPPLPQRVCTyRELRYETVRLPGCPpgvdPVVTYPV 80

                           90       100
                   ....*....|....*....|....*.
gi 399830       89 ATNCYCSACNTKDTYCTRLYAHIPSC 114
Cdd:smart00068  81 ALSCHCGKCNTDTTDCTVESLGPDSC 106
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 17-114 3.05e-29

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 101.33  E-value: 3.05e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399830      17 CFGCHLKNVSIPMER--CGQRVCIHTTICEGLCFSEDAVFESPDEAPEHRVCNG-DWSYEVKHIQGCPE----SITYPVA 89
Cdd:pfam00007   1 RKKCIPTNYTISVEKegCTSCKTINTTICAGYCYTRDPVYKDGRRAVSQRVCTYrDVTYETVVLPGCPPgvdpTVTYPVA 80

                          90       100
                  ....*....|....*....|....*
gi 399830      90 TNCYCSACNTKDTYCTRLYAHIPSC 114
Cdd:pfam00007  81 LSCHCGNCPTDNSDCTRLSLQPDSC 105
GHB_like cd00069
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 20-107 2.04e-25

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


Pssm-ID: 200450  Cd Length: 96  Bit Score: 91.19  E-value: 2.04e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399830    20 CHLKNVSIPMER--CGQRVCIHTTICEGLCFSEDAVFESPDE-APEHRVCNGD-WSYEVKHIQGCP----ESITYPVATN 91
Cdd:cd00069   1 CHPRNYTIAVEKegCGVCLAINTTICAGRCDTRDPVYKSPPYkPSHQPVCTYDeWRYETVRLPGCPpgvdPTYTYPVALS 80

                        90
                ....*....|....*.
gi 399830    92 CYCSACNTKDTYCTRL 107
Cdd:cd00069  81 CRCGLCNTDTTDCTRL 96
 
Name Accession Description Interval E-value
GHB smart00068
Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones ...
 16-114 3.22e-36

Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology.


Pssm-ID: 214502  Cd Length: 107  Bit Score: 118.93  E-value: 3.22e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399830       16 GCFGCHLKNVSIPMER--CGQRVCIHTTICEGLCFSEDAVFESPDEAPEHRVCN-GDWSYEVKHIQGCP----ESITYPV 88
Cdd:smart00068   1 LRPGCRPTNATIAVEKeeCPVCITINTTICAGYCYTRDPVYKSPLPPLPQRVCTyRELRYETVRLPGCPpgvdPVVTYPV 80

                           90       100
                   ....*....|....*....|....*.
gi 399830       89 ATNCYCSACNTKDTYCTRLYAHIPSC 114
Cdd:smart00068  81 ALSCHCGKCNTDTTDCTVESLGPDSC 106
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 17-114 3.05e-29

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 101.33  E-value: 3.05e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399830      17 CFGCHLKNVSIPMER--CGQRVCIHTTICEGLCFSEDAVFESPDEAPEHRVCNG-DWSYEVKHIQGCPE----SITYPVA 89
Cdd:pfam00007   1 RKKCIPTNYTISVEKegCTSCKTINTTICAGYCYTRDPVYKDGRRAVSQRVCTYrDVTYETVVLPGCPPgvdpTVTYPVA 80

                          90       100
                  ....*....|....*....|....*
gi 399830      90 TNCYCSACNTKDTYCTRLYAHIPSC 114
Cdd:pfam00007  81 LSCHCGNCPTDNSDCTRLSLQPDSC 105
GHB_like cd00069
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 20-107 2.04e-25

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


Pssm-ID: 200450  Cd Length: 96  Bit Score: 91.19  E-value: 2.04e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399830    20 CHLKNVSIPMER--CGQRVCIHTTICEGLCFSEDAVFESPDE-APEHRVCNGD-WSYEVKHIQGCP----ESITYPVATN 91
Cdd:cd00069   1 CHPRNYTIAVEKegCGVCLAINTTICAGRCDTRDPVYKSPPYkPSHQPVCTYDeWRYETVRLPGCPpgvdPTYTYPVALS 80

                        90
                ....*....|....*.
gi 399830    92 CYCSACNTKDTYCTRL 107
Cdd:cd00069  81 CRCGLCNTDTTDCTRL 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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