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Conserved domains on  [gi|3025122|sp|P73594|]
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RecName: Full=WD repeat-containing protein slr1409

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
41-325 3.84e-73

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 231.34  E-value: 3.84e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   41 LERQFTGSDVAINRIHFSPDGQFLLTAAADGVGTLW-TKEGEMLGQLQGQKPPMFNARLSPDRQILITTGYDGTIRLWNL 119
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWdLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  120 Q-GELLEEQQPHRAAVADAIFSPDSQIIVTCSDDGQTKIFTRQGQEIASVLK--SGTARNLAYHPQGLLIASVSDSGSLH 196
Cdd:COG2319 192 AtGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADGTVR 271

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  197 LINPN-GKIEREISTGQGRINNVNFSPNGEQLLTSGINGSAKLWNLA-GELIHEYKVvPTGWVNSAQFYPKGEWLATASD 274
Cdd:COG2319 272 LWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSD 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 3025122  275 DGTIRFWQ-KDGQLIYELPLVNARLTSLSFSPDGKQLAATSSQGQVWVFNLS 325
Cdd:COG2319 351 DGTVRLWDlATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
41-325 3.84e-73

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 231.34  E-value: 3.84e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   41 LERQFTGSDVAINRIHFSPDGQFLLTAAADGVGTLW-TKEGEMLGQLQGQKPPMFNARLSPDRQILITTGYDGTIRLWNL 119
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWdLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  120 Q-GELLEEQQPHRAAVADAIFSPDSQIIVTCSDDGQTKIFTRQGQEIASVLK--SGTARNLAYHPQGLLIASVSDSGSLH 196
Cdd:COG2319 192 AtGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADGTVR 271

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  197 LINPN-GKIEREISTGQGRINNVNFSPNGEQLLTSGINGSAKLWNLA-GELIHEYKVvPTGWVNSAQFYPKGEWLATASD 274
Cdd:COG2319 272 LWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSD 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 3025122  275 DGTIRFWQ-KDGQLIYELPLVNARLTSLSFSPDGKQLAATSSQGQVWVFNLS 325
Cdd:COG2319 351 DGTVRLWDlATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-323 1.44e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 215.66  E-value: 1.44e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   41 LERQFTGSDVAINRIHFSPDGQFLLTAAADGVGTLW-TKEGEMLGQLQGQKPPMFNARLSPDRQILITTGYDGTIRLWNL 119
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWdLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  120 Q-GELLEEQQPHRAAVADAIFSPDSQIIVTCSDDGQTKIF-TRQGQEIASVL-KSGTARNLAYHPQGLLIASVSDSGSLH 196
Cdd:cd00200  81 EtGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  197 LINP-NGKIEREISTGQGRINNVNFSPNGEQLLTSGINGSAKLWNL-AGELIHEYkVVPTGWVNSAQFYPKGEWLATASD 274
Cdd:cd00200 161 LWDLrTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLsTGKCLGTL-RGHENGVNSVAFSPDGYLLASGSE 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 3025122  275 DGTIRFWQ-KDGQLIYELPLVNARLTSLSFSPDGKQLAATSSQGQVWVFN 323
Cdd:cd00200 240 DGTIRVWDlRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 243-281 2.74e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 2.74e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 3025122     243 GELIHEYKVvPTGWVNSAQFYPKGEWLATASDDGTIRFW 281
Cdd:smart00320   2 GELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
254-281 3.54e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.54e-06
                          10        20
                  ....*....|....*....|....*...
gi 3025122    254 TGWVNSAQFYPKGEWLATASDDGTIRFW 281
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
41-325 3.84e-73

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 231.34  E-value: 3.84e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   41 LERQFTGSDVAINRIHFSPDGQFLLTAAADGVGTLW-TKEGEMLGQLQGQKPPMFNARLSPDRQILITTGYDGTIRLWNL 119
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWdLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  120 Q-GELLEEQQPHRAAVADAIFSPDSQIIVTCSDDGQTKIFTRQGQEIASVLK--SGTARNLAYHPQGLLIASVSDSGSLH 196
Cdd:COG2319 192 AtGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADGTVR 271

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  197 LINPN-GKIEREISTGQGRINNVNFSPNGEQLLTSGINGSAKLWNLA-GELIHEYKVvPTGWVNSAQFYPKGEWLATASD 274
Cdd:COG2319 272 LWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSD 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 3025122  275 DGTIRFWQ-KDGQLIYELPLVNARLTSLSFSPDGKQLAATSSQGQVWVFNLS 325
Cdd:COG2319 351 DGTVRLWDlATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
41-325 2.50e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 221.32  E-value: 2.50e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   41 LERQFTGSDVAINRIHFSPDGQFLLTAAADGVGTLW-TKEGEMLGQLQGQKPPMFNARLSPDRQILITTGYDGTIRLWNL 119
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWdLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  120 Q-GELLEEQQPHRAAVADAIFSPDSQIIVTCSDDGQTKIFTRQGQEIASVLK--SGTARNLAYHPQGLLIASVSDSGSLH 196
Cdd:COG2319 150 AtGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTghTGAVRSVAFSPDGKLLASGSADGTVR 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  197 LINPN-GKIEREISTGQGRINNVNFSPNGEQLLTSGINGSAKLWNLA-GELIHEYKVvPTGWVNSAQFYPKGEWLATASD 274
Cdd:COG2319 230 LWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAtGELLRTLTG-HSGGVNSVAFSPDGKLLASGSD 308

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 3025122  275 DGTIRFWQ-KDGQLIYELPLVNARLTSLSFSPDGKQLAATSSQGQVWVFNLS 325
Cdd:COG2319 309 DGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-323 1.44e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 215.66  E-value: 1.44e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   41 LERQFTGSDVAINRIHFSPDGQFLLTAAADGVGTLW-TKEGEMLGQLQGQKPPMFNARLSPDRQILITTGYDGTIRLWNL 119
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWdLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  120 Q-GELLEEQQPHRAAVADAIFSPDSQIIVTCSDDGQTKIF-TRQGQEIASVL-KSGTARNLAYHPQGLLIASVSDSGSLH 196
Cdd:cd00200  81 EtGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  197 LINP-NGKIEREISTGQGRINNVNFSPNGEQLLTSGINGSAKLWNL-AGELIHEYkVVPTGWVNSAQFYPKGEWLATASD 274
Cdd:cd00200 161 LWDLrTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLsTGKCLGTL-RGHENGVNSVAFSPDGYLLASGSE 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 3025122  275 DGTIRFWQ-KDGQLIYELPLVNARLTSLSFSPDGKQLAATSSQGQVWVFN 323
Cdd:cd00200 240 DGTIRVWDlRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
41-285 2.40e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.52  E-value: 2.40e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   41 LERQFTGSDVAINRIHFSPDGQFLLTAAADGVGTLW-TKEGEMLGQLQGQKPPMFNARLSPDRQILITTGYDGTIRLWNL 119
Cdd:COG2319 154 LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWdLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  120 Q-GELLEEQQPHRAAVADAIFSPDSQIIVTCSDDGQTKIFTRQGQEIASVLK--SGTARNLAYHPQGLLIASVSDSGSLH 196
Cdd:COG2319 234 AtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTghSGGVNSVAFSPDGKLLASGSDDGTVR 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  197 LINPN-GKIEREISTGQGRINNVNFSPNGEQLLTSGINGSAKLWNLA-GELIHEYKVvPTGWVNSAQFYPKGEWLATASD 274
Cdd:COG2319 314 LWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTG-HTGAVTSVAFSPDGRTLASGSA 392

                       250
                ....*....|.
gi 3025122  275 DGTIRFWQKDG 285
Cdd:COG2319 393 DGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
41-325 2.88e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.82  E-value: 2.88e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   41 LERQFTGSDVAINRIHFSPDGQFLLTAAADGVGTLWTKEGEMLGQLQGQKPPMFNARLSPDRQILITTGYDGTIRLWNLQ 120
Cdd:COG2319  29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  121 -GELLEEQQPHRAAVADAIFSPDSQIIVTCSDDGQTKIFTRQGQEIASVLK--SGTARNLAYHPQGLLIASVSDSGSLHL 197
Cdd:COG2319 109 tGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTghSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  198 INP-NGKIEREISTGQGRINNVNFSPNGEQLLTSGINGSAKLWNLA-GELIHEYKvVPTGWVNSAQFYPKGEWLATASDD 275
Cdd:COG2319 189 WDLaTGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSAD 267

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 3025122  276 GTIRFWQ-KDGQLIYELPLVNARLTSLSFSPDGKQLAATSSQGQVWVFNLS 325
Cdd:COG2319 268 GTVRLWDlATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
57-325 2.65e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.71  E-value: 2.65e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   57 FSPDGQFLLTAAADGVGTLWT-KEGEMLGQLQGQKPPMFNARLSPDRQILITTGYDGTIRLWNL-QGELLEEQQPHRAAV 134
Cdd:COG2319   2 LSADGAALAAASADLALALLAaALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAaAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  135 ADAIFSPDSQIIVTCSDDGQTKIFTRQGQEIASVLK--SGTARNLAYHPQGLLIASVSDSGSLHLINP-NGKIEREISTG 211
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTghTGAVRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  212 QGRINNVNFSPNGEQLLTSGINGSAKLWNLA-GELIHEYKvVPTGWVNSAQFYPKGEWLATASDDGTIRFWQ-KDGQLIY 289
Cdd:COG2319 162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLWDlATGKLLR 240

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 3025122  290 ELPLVNARLTSLSFSPDGKQLAATSSQGQVWVFNLS 325
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-326 1.26e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 1.26e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  128 QPHRAAVADAIFSPDSQIIVTCSDDGQTKIFTRQGQEIASVLKSgtarnlayHPQGlliasvsdsgslhlinpngkiere 207
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG--------HTGP------------------------ 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  208 istgqgrINNVNFSPNGEQLLTSGINGSAKLWNL-AGELIHEYKVVpTGWVNSAQFYPKGEWLATASDDGTIRFWQ-KDG 285
Cdd:cd00200  54 -------VRDVAASADGTYLASGSSDKTIRLWDLeTGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDvETG 125

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 3025122  286 QLIYELPLVNARLTSLSFSPDGKQLAATSSQGQVWVFNLSY 326
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 206-324 6.49e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.78  E-value: 6.49e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  206 REISTGQGRINNVNFSPNGEQLLTSGINGSAKLWNLAGELIHEYKVVPTGWVNSAQFYPKGEWLATASDDGTIRFWQ-KD 284
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDlET 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 3025122  285 GQLIYELPLVNARLTSLSFSPDGKQLAATSSQGQVWVFNL 324
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122
WD40 COG2319
WD40 repeat [General function prediction only];
177-325 1.39e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 1.39e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  177 LAYHPQGLLIASVSDSGSLHLINPNGKIEREISTGQGRINNVNFSPNGEQLLTSGINGSAKLWNLAGELIHEYKVVPTGW 256
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  257 VNSAQFYPKGEWLATASDDGTIRFWQ-KDGQLIYELPLVNARLTSLSFSPDGKQLAATSSQGQVWVFNLS 325
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA 150
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 145-276 3.17e-08

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 52.37  E-value: 3.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  145 IIVTCSDDGQTKIFTRQgqeiasvLKSGTARNL----------AYHPQGLLIASVSDSGS---LHLINPNGKIEREISTG 211
Cdd:COG0823   1 LAFTLSRDGNSDIYVVD-------LDGGEPRRLtnspgidtspAWSPDGRRIAFTSDRGGgpqIYVVDADGGEPRRLTFG 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3025122  212 QGRINNVNFSPNGEQLL-TSGINGSAKLW--NLAGeliHEYKVVPTGWvNSAQFYPKGEWLATASDDG 276
Cdd:COG0823  74 GGYNASPSWSPDGKRLAfVSRSDGRFDIYvlDLDG---GAPRRLTDGP-GSPSWSPDGRRIVFSSDRG 137
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 243-281 2.74e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 2.74e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 3025122     243 GELIHEYKVvPTGWVNSAQFYPKGEWLATASDDGTIRFW 281
Cdd:smart00320   2 GELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 104-239 3.30e-07

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 49.29  E-value: 3.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  104 ILITTGYDGTIRLW--NLQGELLEEQQPHRAAVADAIFSPDSQIIVTCSD-DGQTKIFT--RQGQEIASVLKSGTA-RNL 177
Cdd:COG0823   1 LAFTLSRDGNSDIYvvDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDrGGGPQIYVvdADGGEPRRLTFGGGYnASP 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3025122  178 AYHPQGLLIASVSDSGS---LHLINPNGKIEREISTGQGrinNVNFSPNGEQLL-TSGINGSAKLW 239
Cdd:COG0823  81 SWSPDGKRLAFVSRSDGrfdIYVLDLDGGAPRRLTDGPG---SPSWSPDGRRIVfSSDRGGRPDLY 143
WD40 pfam00400
WD domain, G-beta repeat;
254-281 3.54e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.54e-06
                          10        20
                  ....*....|....*....|....*...
gi 3025122    254 TGWVNSAQFYPKGEWLATASDDGTIRFW 281
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 57-325 3.11e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 45.80  E-value: 3.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122    57 FSPDGQFLLTAAADGVGT-----LWT--KEGEMLGQLQGqkPPMFNARLSPD-RQILITT-------------GYDGTIR 115
Cdd:COG4946  112 WTPDGKSVLFASNRGSPPsrsnqLYTvpVDGGLPERLPL--PPAGDGSFSPDgKKLAYTRigrefrtwkryrgGTAGDIW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   116 LWNLQGELLEEQQPHRAAVADAIFSPDSqiIVTCSD-DGQTKIF--TRQGQEIASVLK---------SGTARNLAYHpQG 183
Cdd:COG4946  190 IYDLGTGEFTRLTDFGGNDRNPMWIGDR--IYFLSDrDGTFNLYsyDPDGKDLRQLTHfkdfdvrfpSTDGGRIVYE-QG 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   184 lliasvsdsGSLHLINPNG----KIE-----------REISTGQGRINNVNFSPNGEQLLTSgingsaklwnlA-GELIh 247
Cdd:COG4946  267 ---------GDLYLLDLASgeprKLNitlagdfpqrrPRWVDVSGYLTSFALSPDGKRVAFE-----------ArGEVF- 325

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   248 eykVVPTG---WVN----------SAQFYPKGEWLATASDdgtirfwqKDGQliYELPLVNA-------RLT-------- 299
Cdd:COG4946  326 ---TVPAEkgpTRNltntpgvrerLPAWSPDGKSIAYFSD--------ASGE--YELYIAPAdgsgepkQLTlgdlgrvf 392

                        330       340
                 ....*....|....*....|....*.
gi 3025122   300 SLSFSPDGKQLAATSSQGQVWVFNLS 325
Cdd:COG4946  393 NPVWSPDGKKIAFTDNRGRLWVVDLA 418
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 120-158 3.41e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.41e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 3025122     120 QGELLEEQQPHRAAVADAIFSPDSQIIVTCSDDGQTKIF 158
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 136-326 1.13e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.87  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   136 DAIFSPDSQIIVTCSD-DGQTKIFTR----QGQEIASVL-KSGTARNLAYHPQGLLIASVSDSGSLHLINPNGKIEREIS 209
Cdd:COG4946  347 LPAWSPDGKSIAYFSDaSGEYELYIApadgSGEPKQLTLgDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRKVD 426

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   210 TGQ--GRINNVNFSPNGEqlltsgingsaklwnlageliheykvvptgwvnsaqfypkgeWLATASDDGT----IRFWQK 283
Cdd:COG4946  427 TDGygDGISDLAWSPDSK------------------------------------------WLAYSKPGPNqlsqIFLYDV 464

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 3025122   284 DGQLIYEL--PLVNArlTSLSFSPDGKQLAATSSQgqvwVFNLSY 326
Cdd:COG4946  465 ETGKTVQLtdGRYDD--GSPAFSPDGKYLYFLSSR----DFNPTY 503
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 137-223 2.11e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122    137 AIFSPDSQIIVTCSDDGQTKIFTRQGQEIASVL---KSGTARNLAYHPQGLLIASVSDSGSLHLINP-NGKIEREISTGQ 212
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSpdkEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAeNGKIVHHFSAGS 80

                          90
                  ....*....|.
gi 3025122    213 GRINNVNFSPN 223
Cdd:pfam12894  81 DLITCLGWGEN 91
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 264-319 2.22e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 2.22e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 3025122    264 PKGEWLATASDDGTIRFWQKDGQLIYELPLVN--ARLTSLSFSPDGKQLAATSSQGQV 319
Cdd:pfam12894   5 PTMDLIALATEDGELLLHRLNWQRVWTLSPDKedLEVTSLAWRPDGKLLAVGYSDGTV 62
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 110-325 2.83e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 42.72  E-value: 2.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   110 YDGTIRLWNL---QGELLE--------EQQPHRAAVADAI--FSPdsqiivtcSDDGQTKIFTRQGqEIASV-LKSGTAR 175
Cdd:COG4946  265 QGGDLYLLDLasgEPRKLNitlagdfpQRRPRWVDVSGYLtsFAL--------SPDGKRVAFEARG-EVFTVpAEKGPTR 335

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   176 NLAyhpqglliasvsdsgslhliNPNGKIEREIStgqgrinnvnFSPNGEQLL-TSGINGSAKLW--NLAGE-----LIH 247
Cdd:COG4946  336 NLT--------------------NTPGVRERLPA----------WSPDGKSIAyFSDASGEYELYiaPADGSgepkqLTL 385

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   248 EykvvPTGWVNSAQFYPKGEWLATASDDGTIRfwqkdgqlIYEL----------PLVNARLTSLSFSPDGKQLAATSS-- 315
Cdd:COG4946  386 G----DLGRVFNPVWSPDGKKIAFTDNRGRLW--------VVDLasgkvrkvdtDGYGDGISDLAWSPDSKWLAYSKPgp 453

                        250
                 ....*....|..
gi 3025122   316 --QGQVWVFNLS 325
Cdd:COG4946  454 nqLSQIFLYDVE 465
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-240 2.85e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 2.85e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 3025122     201 NGKIEREISTGQGRINNVNFSPNGEQLLTSGINGSAKLWN 240
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
121-158 2.95e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 2.95e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 3025122    121 GELLEEQQPHRAAVADAIFSPDSQIIVTCSDDGQTKIF 158
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 42-177 4.32e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 40.04  E-value: 4.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   42 ERQFTGSDVAINRIHFSPDGQFLL-TAAADGVGTLWTK--EGEMLGQLQGQKPPMFNARLSPD-RQILITTGYDGTIRLW 117
Cdd:COG0823  23 PRRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYVVdaDGGEPRRLTFGGGYNASPSWSPDgKRLAFVSRSDGRFDIY 102

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3025122  118 --NLQGellEEQQPHRAAVADAIFSPDSQIIVTCSDDGqtkiftrQGQEIASVLKSGTARNL 177
Cdd:COG0823 103 vlDLDG---GAPRRLTDGPGSPSWSPDGRRIVFSSDRG-------GRPDLYVVDLDGRKRRL 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-118 4.75e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.75e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 3025122      80 GEMLGQLQGQKPPMFNARLSPDRQILITTGYDGTIRLWN 118
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 98-322 5.04e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.15  E-value: 5.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   98 LSPDRQILITTGYDGTIRLWNLQGELL--------EEQQPHR-AAVAdaiFSPDSQIIVTCSDDGQTKIFTRQGQEIASV 168
Cdd:cd05819  15 VDSSGNIYVADTGNNRIQVFDPDGNFItsfgsfgsGDGQFNEpAGVA---VDSDGNLYVADTGNHRIQKFDPDGNFLASF 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  169 LKSGTARNLAYHPQGLLIAS-----VSDSG--SLHLINPNGKIEREI---STGQGRINN---VNFSPNGEQLLTSGINGS 235
Cdd:cd05819  92 GGSGDGDGEFNGPRGIAVDSsgniyVADTGnhRIQKFDPDGEFLTTFgsgGSGPGQFNGptgVAVDSDGNIYVADTGNHR 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  236 AKLWNLAGELIheyKVVPTGWVNSAQF-YPKGewLATASD----------------DGTIRFWQKDGQLIYELPLVNaRL 298
Cdd:cd05819 172 IQVFDPDGNFL---TTFGSTGTGPGQFnYPTG--IAVDSDgniyvadsgnnrvqvfDPDGAGFGGNGNFLGSDGQFN-RP 245

                       250       260
                ....*....|....*....|....
gi 3025122  299 TSLSFSPDGKQLAATSSQGQVWVF 322
Cdd:cd05819 246 SGLAVDSDGNLYVADTGNNRIQVF 269
WD40 pfam00400
WD domain, G-beta repeat;
80-118 5.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3025122     80 GEMLGQLQGQKPPMFNARLSPDRQILITTGYDGTIRLWN 118
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 38-76 6.84e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 6.84e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 3025122      38 KLNLERQFTGSDVAINRIHFSPDGQFLLTAAADGVGTLW 76
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 284-323 8.57e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 8.57e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 3025122     284 DGQLIYELPLVNARLTSLSFSPDGKQLAATSSQGQVWVFN 323
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 130-322 1.39e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.41  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   130 HRAAVADAIFSPD-SQIIVTCSDDGQTKIFtrqgqeIASVlKSGTARNLAYHP------------QGLLIASVSDSGS-- 194
Cdd:COG4946   59 HPGYESFPRFSPDgKWIAFTSDYDGNTDVY------VMPA-EGGEPKRLTYHPandrvvgwtpdgKSVLFASNRGSPPsr 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   195 ---LHLINPNGKIEREISTGQGriNNVNFSPNGEQLL--------------TSGINGsaKLW--NLAGeliHEYKVVPTG 255
Cdd:COG4946  132 snqLYTVPVDGGLPERLPLPPA--GDGSFSPDGKKLAytrigrefrtwkryRGGTAG--DIWiyDLGT---GEFTRLTDF 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   256 --------WVNSAQFY--------------PKGE--------------WLATasDDGTIRFwQKDGQLiYEL-------- 291
Cdd:COG4946  205 ggndrnpmWIGDRIYFlsdrdgtfnlysydPDGKdlrqlthfkdfdvrFPST--DGGRIVY-EQGGDL-YLLdlasgepr 280

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 3025122   292 PL-----------------VNARLTSLSFSPDGKQLAATsSQGQVWVF 322
Cdd:COG4946  281 KLnitlagdfpqrrprwvdVSGYLTSFALSPDGKRVAFE-ARGEVFTV 327
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 247-324 1.48e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.41  E-value: 1.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   247 HEYKVVPTGWvnsaqfYPKGEWL--ATASDDGTIRFWQ-----KDGQLIYELPLVNArlTSLSFSPDGKQLAAT------ 313
Cdd:COG4946  103 HPANDRVVGW------TPDGKSVlfASNRGSPPSRSNQlytvpVDGGLPERLPLPPA--GDGSFSPDGKKLAYTrigref 174

                         90
                 ....*....|....*....
gi 3025122   314 --------SSQGQVWVFNL 324
Cdd:COG4946  175 rtwkryrgGTAGDIWIYDL 193
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 87-234 1.50e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 39.58  E-value: 1.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   87 QGQKPPMFNA----RLSPDRQILITTGYDGTIRLWNLQGELL---EEQQPHRAAVADA-IFSPDSQIIVTCSDDGQTKIF 158
Cdd:cd14963  48 PGTGPGEFKYpygiAVDSDGNIYVADLYNGRIQVFDPDGKFLkyfPEKKDRVKLISPAgLAIDDGKLYVSDVKKHKVIVF 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  159 TRQGQEIASVLKSGTARNLAYHPQGLLIAS-----VSDSGSLHL--INPNGKIEREIS-----------------TGQGR 214
Cdd:cd14963 128 DLEGKLLLEFGKPGSEPGELSYPNGIAVDEdgniyVADSGNGRIqvFDKNGKFIKELNgspdgksgfvnprgiavDPDGN 207

                       170       180
                ....*....|....*....|....*...
gi 3025122  215 I-------NNVN-FSPNGEQLLTSGING 234
Cdd:cd14963 208 LyvvdnlsHRVYvFDEQGKELFTFGGRG 235
WD40 pfam00400
WD domain, G-beta repeat;
202-240 2.05e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3025122    202 GKIEREISTGQGRINNVNFSPNGEQLLTSGINGSAKLWN 240
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 229-325 2.20e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.11  E-value: 2.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  229 TSGINGSAKLW--NLAGeliHEYKVVPT--GWVNSAQFYPKGEWLATASD-DGTIRFWQK--DGQLIYELPLVNARLTSL 301
Cdd:COG0823   4 TLSRDGNSDIYvvDLDG---GEPRRLTNspGIDTSPAWSPDGRRIAFTSDrGGGPQIYVVdaDGGEPRRLTFGGGYNASP 80

                        90       100
                ....*....|....*....|....*..
gi 3025122  302 SFSPDGKQLAATSSQG---QVWVFNLS 325
Cdd:COG0823  81 SWSPDGKRLAFVSRSDgrfDIYVLDLD 107
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 178-325 3.09e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 38.72  E-value: 3.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  178 AYHPQGLLIASVSDSGSLHLINPNGKIEREISTGQGRINNVNFSPNGEQLLTSGINGSAKLWNLAGE---LIHEY----- 249
Cdd:COG3386  14 VWDPDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDPADGEvtvLADEYgkpln 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122  250 -----KVVPTG--WVNSAQFYPKGEWLATASDDGTIRfwqkdgQLIYELPLVNarltSLSFSPDGKQL-AATSSQGQVWV 321
Cdd:COG3386  94 rpndgVVDPDGrlYFTDMGEYLPTGALYRVDPDGSLR------VLADGLTFPN----GIAFSPDGRTLyVADTGAGRIYR 163


                ....
gi 3025122  322 FNLS 325
Cdd:COG3386 164 FDLD 167
WD40 pfam00400
WD domain, G-beta repeat;
40-76 3.39e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 3.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 3025122     40 NLERQFTGSDVAINRIHFSPDGQFLLTAAADGVGTLW 76
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 54-193 6.38e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 37.65  E-value: 6.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3025122   54 RI-HFSPDGQFLLTaaadgvgtlWTKEGEMLGQLQGQkppmFNARLSPDRQILITTGYDGTIRLWNLQGELL-----EEQ 127
Cdd:cd14956 129 RIqKFDPDGSFLRQ---------WGGTGIEPGSFNYP----RGVAVDPDGTLYVADTYNDRIQVFDNDGAFLrkwggRGT 195

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3025122  128 QPHR-AAVADAIFSPDSQIIVTCSDDGQTKIFTRQGQEIASVLKSGTARNLAYHPQGLLIAS-----VSDSG 193
Cdd:cd14956 196 GPGQfNYPYGIAIDPDGNVFVADFGNNRIQKFTADGTFLTSWGSPGTGPGQFKNPWGVVVDAdgtvyVADSN 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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