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Conserved domains on  [gi|3183237|sp|P87177|]
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RecName: Full=Uncharacterized WD repeat-containing protein C3D6.12

Protein Classification

WD40 and Utp12 domain-containing protein( domain architecture ID 11455513)

protein containing domains WD40, and Utp12

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 391-686 1.64e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 216.05  E-value: 1.64e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  391 EIPGHRADVRTLALSANHDVILSG-ANGSLKLWNKKTTSCIRTIeCGY---VLAASFINNDKCIVSAYKSGELEVYDIAS 466
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGsGDGTIKVWDLETGELLRTL-KGHtgpVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  467 SSLIERIQAHDGAIWDLAVGHDGTYFATASADHTVKLWSLKssfdfvpgTTRKVTTLKleqtrqiDFTDDVLAVKISPDG 546
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--------TGKCLTTLR-------GHTDWVNSVAFSPDG 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  547 RFVAASLLDNTVKVYYLDSLKFFLNLYGHKLPVLSMDISYDSKLLVTCSADKNVKIWGLDFGDCHKSIFAHQDSIMEVTF 626
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3183237  627 QPDTYNFFTCSKDREVRYWDGKSFDLILKLRGHHSEVWALAVGPT--FVVSGSHDHSIRLWE 686
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
84-606 2.10e-46

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.63  E-value: 2.10e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237   84 ADGSIRLWKDGELLITLNGHKSAVTTMDFDKMGTRLASGSMDTDIIVWDIVAETGLFRLRGHKDQITKLLFItppsknta 163
Cdd:COG2319  16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-------- 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  164 eetvvdtdidsgdmdvdskSSDSFLLSVGKDSFMKLWDLSIQHCVETHVDHQGEIWAMCVSPDAKRCLTAGTGSDVKVWE 243
Cdd:COG2319  88 -------------------PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  244 IsfpddnnftpttKAFQQLGTFTRQsrdrpitlaydvsnryvvfqahdrllevfrlrssaelekilnrrrrrkksedvsi 323
Cdd:COG2319 149 L------------ATGKLLRTLTGH------------------------------------------------------- 161

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  324 tlkdeyepfalirtTARASSVAWIPGNRTptLVTSLQNNSIEVYalDVKSEGSAAPLTerasrisaieipGHRADVRTLA 403
Cdd:COG2319 162 --------------SGAVTSVAFSPDGKL--LASGSDDGTVRLW--DLATGKLLRTLT------------GHTGAVRSVA 211

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  404 LSANHDVILSG-ANGSLKLWNKKTTSCIRTIE--CGYVLAASFINNDKCIVSAYKSGELEVYDIASSSLIERIQAHDGAI 480
Cdd:COG2319 212 FSPDGKLLASGsADGTVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  481 WDLAVGHDGTYFATASADHTVKLWSLKssfdfvpgTTRKVTTLKleqtrqiDFTDDVLAVKISPDGRFVAASLLDNTVKV 560
Cdd:COG2319 292 NSVAFSPDGKLLASGSDDGTVRLWDLA--------TGKLLRTLT-------GHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*.
gi 3183237  561 YYLDSLKFFLNLYGHKLPVLSMDISYDSKLLVTCSADKNVKIWGLD 606
Cdd:COG2319 357 WDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 788-890 4.85e-27

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


:

Pssm-ID: 461125  Cd Length: 106  Bit Score: 106.09  E-value: 4.85e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237    788 AEEYVLNT-FKKIRSSHLDDALLVLPFEHVLSLFRFIDIWASRK-WSIPLVSRIIFFLLRTYHRQLTTTVKMRPLLNNIR 865
Cdd:pfam04003   1 NDEYLLESvLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERsPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*
gi 3183237    866 SSLRGSLQEERSLIGYNAAGLSYLR 890
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLL 105
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 391-686 1.64e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 216.05  E-value: 1.64e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  391 EIPGHRADVRTLALSANHDVILSG-ANGSLKLWNKKTTSCIRTIeCGY---VLAASFINNDKCIVSAYKSGELEVYDIAS 466
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGsGDGTIKVWDLETGELLRTL-KGHtgpVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  467 SSLIERIQAHDGAIWDLAVGHDGTYFATASADHTVKLWSLKssfdfvpgTTRKVTTLKleqtrqiDFTDDVLAVKISPDG 546
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--------TGKCLTTLR-------GHTDWVNSVAFSPDG 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  547 RFVAASLLDNTVKVYYLDSLKFFLNLYGHKLPVLSMDISYDSKLLVTCSADKNVKIWGLDFGDCHKSIFAHQDSIMEVTF 626
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3183237  627 QPDTYNFFTCSKDREVRYWDGKSFDLILKLRGHHSEVWALAVGPT--FVVSGSHDHSIRLWE 686
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
330-685 1.56e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 203.22  E-value: 1.56e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  330 EPFALIRTTARASSVAWIPGNRTptLVTSLQNNSIEVYalDVKSEGSAAPLTerasrisaieipGHRADVRTLALSANHD 409
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPDGRL--LASASADGTVRLW--DLATGLLLRTLT------------GHTGAVRSVAFSPDGK 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  410 VILSG-ANGSLKLWNKKTTSCIRTIEC--GYVLAASFINNDKCIVSAYKSGELEVYDIASSSLIERIQAHDGAIWDLAVG 486
Cdd:COG2319 134 TLASGsADGTVRLWDLATGKLLRTLTGhsGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  487 HDGTYFATASADHTVKLWSLKssfdfvpgTTRKVTTLKleqtrqiDFTDDVLAVKISPDGRFVAASLLDNTVKVYYLDSL 566
Cdd:COG2319 214 PDGKLLASGSADGTVRLWDLA--------TGKLLRTLT-------GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  567 KFFLNLYGHKLPVLSMDISYDSKLLVTCSADKNVKIWGLDFGDCHKSIFAHQDSIMEVTFQPDTYNFFTCSKDREVRYWD 646
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 3183237  647 GKSFDLILKLRGHHSEVWALAVGP--TFVVSGSHDHSIRLW 685
Cdd:COG2319 359 LATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
84-606 2.10e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.63  E-value: 2.10e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237   84 ADGSIRLWKDGELLITLNGHKSAVTTMDFDKMGTRLASGSMDTDIIVWDIVAETGLFRLRGHKDQITKLLFItppsknta 163
Cdd:COG2319  16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-------- 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  164 eetvvdtdidsgdmdvdskSSDSFLLSVGKDSFMKLWDLSIQHCVETHVDHQGEIWAMCVSPDAKRCLTAGTGSDVKVWE 243
Cdd:COG2319  88 -------------------PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  244 IsfpddnnftpttKAFQQLGTFTRQsrdrpitlaydvsnryvvfqahdrllevfrlrssaelekilnrrrrrkksedvsi 323
Cdd:COG2319 149 L------------ATGKLLRTLTGH------------------------------------------------------- 161

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  324 tlkdeyepfalirtTARASSVAWIPGNRTptLVTSLQNNSIEVYalDVKSEGSAAPLTerasrisaieipGHRADVRTLA 403
Cdd:COG2319 162 --------------SGAVTSVAFSPDGKL--LASGSDDGTVRLW--DLATGKLLRTLT------------GHTGAVRSVA 211

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  404 LSANHDVILSG-ANGSLKLWNKKTTSCIRTIE--CGYVLAASFINNDKCIVSAYKSGELEVYDIASSSLIERIQAHDGAI 480
Cdd:COG2319 212 FSPDGKLLASGsADGTVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  481 WDLAVGHDGTYFATASADHTVKLWSLKssfdfvpgTTRKVTTLKleqtrqiDFTDDVLAVKISPDGRFVAASLLDNTVKV 560
Cdd:COG2319 292 NSVAFSPDGKLLASGSDDGTVRLWDLA--------TGKLLRTLT-------GHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*.
gi 3183237  561 YYLDSLKFFLNLYGHKLPVLSMDISYDSKLLVTCSADKNVKIWGLD 606
Cdd:COG2319 357 WDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-368 4.13e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.32  E-value: 4.13e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237   45 SVLEWDLKTGQLLSKWKD-SDCSAKVTCIANFDEMYAVGYaDGSIRLW--KDGELLITLNGHKSAVTTMDFDKMGTRLAS 121
Cdd:cd00200  32 TIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSS-DKTIRLWdlETGECVRTLTGHTSYVSSVAFSPDGRILSS 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  122 GSMDTDIIVWDIVAETGLFRLRGHKDQITKLLFItppskntaeetvvdtdidsgdmdvdskSSDSFLLSVGKDSFMKLWD 201
Cdd:cd00200 111 SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS---------------------------PDGTFVASSSQDGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  202 LSIQHCVETHVDHQGEIWAMCVSPDAKRCLTAGTGSDVKVWEISfpddnnftpttkAFQQLGTFTRqSRDRPITLAYDVS 281
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS------------TGKCLGTLRG-HENGVNSVAFSPD 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  282 NRYVVFQAHDRLLEVFRLRssaelekilnrrrrrkkSEDVSITLKdeyepfaliRTTARASSVAWIPGnrTPTLVTSLQN 361
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLR-----------------TGECVQTLS---------GHTNSVTSLAWSPD--GKRLASGSAD 282


                ....*..
gi 3183237  362 NSIEVYA 368
Cdd:cd00200 283 GTIRIWD 289
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 788-890 4.85e-27

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 106.09  E-value: 4.85e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237    788 AEEYVLNT-FKKIRSSHLDDALLVLPFEHVLSLFRFIDIWASRK-WSIPLVSRIIFFLLRTYHRQLTTTVKMRPLLNNIR 865
Cdd:pfam04003   1 NDEYLLESvLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERsPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*
gi 3183237    866 SSLRGSLQEERSLIGYNAAGLSYLR 890
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLL 105
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 450-605 9.97e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.33  E-value: 9.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237   450 IVSAYKSGELEVYDIASSSLIERIQAHDGAIWDLAVGH-DGTYFATASADHTVKLWSLKSSFdfvpgttrKVTTLKLEQt 528
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGV--------SIGTIKTKA- 618

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237   529 rqidftdDVLAVKISPD-GRFVAASLLDNtvKVYYLDslkfflnLYGHKLPVLSM-----DISY----DSKLLVTCSADK 598
Cdd:PLN00181 619 -------NICCVQFPSEsGRSLAFGSADH--KVYYYD-------LRNPKLPLCTMighskTVSYvrfvDSSTLVSSSTDN 682


                 ....*..
gi 3183237   599 NVKIWGL 605
Cdd:PLN00181 683 TLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 93-132 4.06e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 4.06e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 3183237      93 DGELLITLNGHKSAVTTMDFDKMGTRLASGSMDTDIIVWD 132
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 466-505 6.96e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 6.96e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 3183237     466 SSSLIERIQAHDGAIWDLAVGHDGTYFATASADHTVKLWS 505
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
94-132 9.20e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 9.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3183237     94 GELLITLNGHKSAVTTMDFDKMGTRLASGSMDTDIIVWD 132
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
467-505 5.88e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 5.88e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3183237    467 SSLIERIQAHDGAIWDLAVGHDGTYFATASADHTVKLWS 505
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 391-686 1.64e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 216.05  E-value: 1.64e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  391 EIPGHRADVRTLALSANHDVILSG-ANGSLKLWNKKTTSCIRTIeCGY---VLAASFINNDKCIVSAYKSGELEVYDIAS 466
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGsGDGTIKVWDLETGELLRTL-KGHtgpVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  467 SSLIERIQAHDGAIWDLAVGHDGTYFATASADHTVKLWSLKssfdfvpgTTRKVTTLKleqtrqiDFTDDVLAVKISPDG 546
Cdd:cd00200  83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--------TGKCLTTLR-------GHTDWVNSVAFSPDG 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  547 RFVAASLLDNTVKVYYLDSLKFFLNLYGHKLPVLSMDISYDSKLLVTCSADKNVKIWGLDFGDCHKSIFAHQDSIMEVTF 626
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3183237  627 QPDTYNFFTCSKDREVRYWDGKSFDLILKLRGHHSEVWALAVGPT--FVVSGSHDHSIRLWE 686
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
330-685 1.56e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 203.22  E-value: 1.56e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  330 EPFALIRTTARASSVAWIPGNRTptLVTSLQNNSIEVYalDVKSEGSAAPLTerasrisaieipGHRADVRTLALSANHD 409
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPDGRL--LASASADGTVRLW--DLATGLLLRTLT------------GHTGAVRSVAFSPDGK 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  410 VILSG-ANGSLKLWNKKTTSCIRTIEC--GYVLAASFINNDKCIVSAYKSGELEVYDIASSSLIERIQAHDGAIWDLAVG 486
Cdd:COG2319 134 TLASGsADGTVRLWDLATGKLLRTLTGhsGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  487 HDGTYFATASADHTVKLWSLKssfdfvpgTTRKVTTLKleqtrqiDFTDDVLAVKISPDGRFVAASLLDNTVKVYYLDSL 566
Cdd:COG2319 214 PDGKLLASGSADGTVRLWDLA--------TGKLLRTLT-------GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  567 KFFLNLYGHKLPVLSMDISYDSKLLVTCSADKNVKIWGLDFGDCHKSIFAHQDSIMEVTFQPDTYNFFTCSKDREVRYWD 646
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 3183237  647 GKSFDLILKLRGHHSEVWALAVGP--TFVVSGSHDHSIRLW 685
Cdd:COG2319 359 LATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
368-686 2.95e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.97  E-value: 2.95e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  368 ALDVKSEGSAAPLTERASRISAIEIPGHRADVRTLALSANHDVILSGAN-GSLKLWNKKTTSCIRTIEC--GYVLAASFI 444
Cdd:COG2319  50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAdGTVRLWDLATGLLLRTLTGhtGAVRSVAFS 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  445 NNDKCIVSAYKSGELEVYDIASSSLIERIQAHDGAIWDLAVGHDGTYFATASADHTVKLWSLKssfdfvpgTTRKVTTLK 524
Cdd:COG2319 130 PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--------TGKLLRTLT 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  525 leqtrqiDFTDDVLAVKISPDGRFVAASLLDNTVKVYYLDSLKFFLNLYGHKLPVLSMDISYDSKLLVTCSADKNVKIWG 604
Cdd:COG2319 202 -------GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  605 LDFGDCHKSIFAHQDSIMEVTFQPDTYNFFTCSKDREVRYWDGKSFDLILKLRGHHSEVWALAVGP--TFVVSGSHDHSI 682
Cdd:COG2319 275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKTLASGSDDGTV 354


                ....
gi 3183237  683 RLWE 686
Cdd:COG2319 355 RLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
368-686 8.95e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.57  E-value: 8.95e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  368 ALDVKSEGSAAPLTERASRISAIEIPGHRADVRTLALSANHDVILSGA-NGSLKLWNKKTTSCIRTIEC--GYVLAASFI 444
Cdd:COG2319   8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAgDLTLLLLDAAAGALLATLLGhtAAVLSVAFS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  445 NNDKCIVSAYKSGELEVYDIASSSLIERIQAHDGAIWDLAVGHDGTYFATASADHTVKLWSLKssfdfvpgTTRKVTTLK 524
Cdd:COG2319  88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--------TGKLLRTLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  525 leqtrqiDFTDDVLAVKISPDGRFVAASLLDNTVKVYYLDSLKFFLNLYGHKLPVLSMDISYDSKLLVTCSADKNVKIWG 604
Cdd:COG2319 160 -------GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  605 LDFGDCHKSIFAHQDSIMEVTFQPDTYNFFTCSKDREVRYWDGKSFDLILKLRGHHSEVWALAVGP--TFVVSGSHDHSI 682
Cdd:COG2319 233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTV 312


                ....
gi 3183237  683 RLWE 686
Cdd:COG2319 313 RLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
183-646 1.76e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.71  E-value: 1.76e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  183 SSDSFLLSVGKDSFMKLWDLSIQHCVETHVDHQGEIWAMCVSPDAKRCLTAGTGSDVKVWEIsfpddnnftpttkAFQQL 262
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA-------------AAGAL 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  263 GTFTRQSRDRPITLAYDVSNRYVVFQAHDRLLEVFRLRSSAELekilnrrrrrkksedvsitlkdeyepFALIRTTARAS 342
Cdd:COG2319  71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL--------------------------RTLTGHTGAVR 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  343 SVAWIPGNRTptLVTSLQNNSIEVYalDVKSEGSAAPLTerasrisaieipGHRADVRTLALSANHDVILSG-ANGSLKL 421
Cdd:COG2319 125 SVAFSPDGKT--LASGSADGTVRLW--DLATGKLLRTLT------------GHSGAVTSVAFSPDGKLLASGsDDGTVRL 188

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  422 WNKKTTSCIRTIEC--GYVLAASFINNDKCIVSAYKSGELEVYDIASSSLIERIQAHDGAIWDLAVGHDGTYFATASADH 499
Cdd:COG2319 189 WDLATGKLLRTLTGhtGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADG 268

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  500 TVKLWSLKssfdfvpgTTRKVTTLKleqtrqiDFTDDVLAVKISPDGRFVAASLLDNTVKVYYLDSLKFFLNLYGHKLPV 579
Cdd:COG2319 269 TVRLWDLA--------TGELLRTLT-------GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3183237  580 LSMDISYDSKLLVTCSADKNVKIWGLDFGDCHKSIFAHQDSIMEVTFQPDTYNFFTCSKDREVRYWD 646
Cdd:COG2319 334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
84-606 2.10e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.63  E-value: 2.10e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237   84 ADGSIRLWKDGELLITLNGHKSAVTTMDFDKMGTRLASGSMDTDIIVWDIVAETGLFRLRGHKDQITKLLFItppsknta 163
Cdd:COG2319  16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-------- 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  164 eetvvdtdidsgdmdvdskSSDSFLLSVGKDSFMKLWDLSIQHCVETHVDHQGEIWAMCVSPDAKRCLTAGTGSDVKVWE 243
Cdd:COG2319  88 -------------------PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  244 IsfpddnnftpttKAFQQLGTFTRQsrdrpitlaydvsnryvvfqahdrllevfrlrssaelekilnrrrrrkksedvsi 323
Cdd:COG2319 149 L------------ATGKLLRTLTGH------------------------------------------------------- 161

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  324 tlkdeyepfalirtTARASSVAWIPGNRTptLVTSLQNNSIEVYalDVKSEGSAAPLTerasrisaieipGHRADVRTLA 403
Cdd:COG2319 162 --------------SGAVTSVAFSPDGKL--LASGSDDGTVRLW--DLATGKLLRTLT------------GHTGAVRSVA 211

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  404 LSANHDVILSG-ANGSLKLWNKKTTSCIRTIE--CGYVLAASFINNDKCIVSAYKSGELEVYDIASSSLIERIQAHDGAI 480
Cdd:COG2319 212 FSPDGKLLASGsADGTVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  481 WDLAVGHDGTYFATASADHTVKLWSLKssfdfvpgTTRKVTTLKleqtrqiDFTDDVLAVKISPDGRFVAASLLDNTVKV 560
Cdd:COG2319 292 NSVAFSPDGKLLASGSDDGTVRLWDLA--------TGKLLRTLT-------GHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*.
gi 3183237  561 YYLDSLKFFLNLYGHKLPVLSMDISYDSKLLVTCSADKNVKIWGLD 606
Cdd:COG2319 357 WDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
403-685 1.62e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.60  E-value: 1.62e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  403 ALSANHDVILSGANGSLKLWNKKTTSCIRTIECGYVLAASFINNDKCIVSAYKSGELEVYDIASSSLIERIQAHDGAIWD 482
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  483 LAVGHDGTYFATASADHTVKLWSLKSSfdfvpgttrkvttlkLEQTRQIDFTDDVLAVKISPDGRFVAASLLDNTVKVYY 562
Cdd:COG2319  84 VAFSPDGRLLASASADGTVRLWDLATG---------------LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  563 LDSLKFFLNLYGHKLPVLSMDISYDSKLLVTCSADKNVKIWGLDFGDCHKSIFAHQDSIMEVTFQPDTYNFFTCSKDREV 642
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 3183237  643 RYWDGKSFDLILKLRGHHSEVWALAVGP--TFVVSGSHDHSIRLW 685
Cdd:COG2319 229 RLWDLATGKLLRTLTGHSGSVRSVAFSPdgRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
29-508 2.59e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.05  E-value: 2.59e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237   29 SSSAKSVGRAIVGGLESVLEWDLKTGQLLSKWKDSDCSAKVTCIANFDEMYAVGYADGSIRLW--KDGELLITLNGHKSA 106
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLdaAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  107 VTTMDFDKMGTRLASGSMDTDIIVWDIVAETGLFRLRGHKDQITKLLFitppskntaeetvvdtdidsgdmdvdskSSD- 185
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF----------------------------SPDg 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  186 SFLLSVGKDSFMKLWDLSIQHCVETHVDHQGEIWAMCVSPDAKRCLTAGTGSDVKVWEIsfpddnnftpttKAFQQLGTF 265
Cdd:COG2319 133 KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL------------ATGKLLRTL 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  266 TRQSrDRPITLAYDVSNRYVVFQAHDRLLEVFRLRSSAELEkilnrrrrrkksedvsiTLKDEyepfalirtTARASSVA 345
Cdd:COG2319 201 TGHT-GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR-----------------TLTGH---------SGSVRSVA 253

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  346 WIPGNRTptLVTSLQNNSIEVYALDvksegsaaplTERASRIsaieIPGHRADVRTLALSANHDVILSG-ANGSLKLWNK 424
Cdd:COG2319 254 FSPDGRL--LASGSADGTVRLWDLA----------TGELLRT----LTGHSGGVNSVAFSPDGKLLASGsDDGTVRLWDL 317

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  425 KTTSCIRTIE--CGYVLAASFINNDKCIVSAYKSGELEVYDIASSSLIERIQAHDGAIWDLAVGHDGTYFATASADHTVK 502
Cdd:COG2319 318 ATGKLLRTLTghTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397


                ....*.
gi 3183237  503 LWSLKS 508
Cdd:COG2319 398 LWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-368 4.13e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.32  E-value: 4.13e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237   45 SVLEWDLKTGQLLSKWKD-SDCSAKVTCIANFDEMYAVGYaDGSIRLW--KDGELLITLNGHKSAVTTMDFDKMGTRLAS 121
Cdd:cd00200  32 TIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSS-DKTIRLWdlETGECVRTLTGHTSYVSSVAFSPDGRILSS 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  122 GSMDTDIIVWDIVAETGLFRLRGHKDQITKLLFItppskntaeetvvdtdidsgdmdvdskSSDSFLLSVGKDSFMKLWD 201
Cdd:cd00200 111 SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS---------------------------PDGTFVASSSQDGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  202 LSIQHCVETHVDHQGEIWAMCVSPDAKRCLTAGTGSDVKVWEISfpddnnftpttkAFQQLGTFTRqSRDRPITLAYDVS 281
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS------------TGKCLGTLRG-HENGVNSVAFSPD 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  282 NRYVVFQAHDRLLEVFRLRssaelekilnrrrrrkkSEDVSITLKdeyepfaliRTTARASSVAWIPGnrTPTLVTSLQN 361
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLR-----------------TGECVQTLS---------GHTNSVTSLAWSPD--GKRLASGSAD 282


                ....*..
gi 3183237  362 NSIEVYA 368
Cdd:cd00200 283 GTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-505 6.06e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.93  E-value: 6.06e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237   96 LLITLNGHKSAVTTMDFDKMGTRLASGSMDTDIIVWDIVAETGLFRLRGHKDQITKLLFItppskntaeetvvdtdidsg 175
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-------------------- 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  176 dmdvdskSSDSFLLSVGKDSFMKLWDLSIQHCVETHVDHQGEIWAMCVSPDAKRCLTAGTGSDVKVWEIsfpddNNFTPT 255
Cdd:cd00200  61 -------ADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-----ETGKCL 128

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  256 TkafqqlgtftrqsrdrpitlaydvsnryvVFQAHdrllevfrlrssaelekilnrrrrrkksedvsitlkdeyepfali 335
Cdd:cd00200 129 T-----------------------------TLRGH--------------------------------------------- 134

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  336 rtTARASSVAWIPGNRtpTLVTSLQNNSIEVYalDVKSEGSAAplterasrisaiEIPGHRADVRTLALSAN-HDVILSG 414
Cdd:cd00200 135 --TDWVNSVAFSPDGT--FVASSSQDGTIKLW--DLRTGKCVA------------TLTGHTGEVNSVAFSPDgEKLLSSS 196

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  415 ANGSLKLWNKKTTSCIRTIE--CGYVLAASFINNDKCIVSAYKSGELEVYDIASSSLIERIQAHDGAIWDLAVGHDGTYF 492
Cdd:cd00200 197 SDGTIKLWDLSTGKCLGTLRghENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276

                       410
                ....*....|...
gi 3183237  493 ATASADHTVKLWS 505
Cdd:cd00200 277 ASGSADGTIRIWD 289
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 788-890 4.85e-27

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 106.09  E-value: 4.85e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237    788 AEEYVLNT-FKKIRSSHLDDALLVLPFEHVLSLFRFIDIWASRK-WSIPLVSRIIFFLLRTYHRQLTTTVKMRPLLNNIR 865
Cdd:pfam04003   1 NDEYLLESvLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERsPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*
gi 3183237    866 SSLRGSLQEERSLIGYNAAGLSYLR 890
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLL 105
WD40 COG2319
WD40 repeat [General function prediction only];
543-686 3.86e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 3.86e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  543 SPDGRFVAASLLDNTVKVYYLDSLKFFLNLYGHKLPVLSMDISYDSKLLVTCSADKNVKIWGLDFGDCHKSIFAHQDSIM 622
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3183237  623 EVTFQPDTYNFFTCSKDREVRYWDGKSFDLILKLRGHHSEVWALAVGP--TFVVSGSHDHSIRLWE 686
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWD 148
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 450-605 9.97e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.33  E-value: 9.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237   450 IVSAYKSGELEVYDIASSSLIERIQAHDGAIWDLAVGH-DGTYFATASADHTVKLWSLKSSFdfvpgttrKVTTLKLEQt 528
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGV--------SIGTIKTKA- 618

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237   529 rqidftdDVLAVKISPD-GRFVAASLLDNtvKVYYLDslkfflnLYGHKLPVLSM-----DISY----DSKLLVTCSADK 598
Cdd:PLN00181 619 -------NICCVQFPSEsGRSLAFGSADH--KVYYYD-------LRNPKLPLCTMighskTVSYvrfvDSSTLVSSSTDN 682


                 ....*..
gi 3183237   599 NVKIWGL 605
Cdd:PLN00181 683 TLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 93-132 4.06e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 4.06e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 3183237      93 DGELLITLNGHKSAVTTMDFDKMGTRLASGSMDTDIIVWD 132
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 466-505 6.96e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 6.96e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 3183237     466 SSSLIERIQAHDGAIWDLAVGHDGTYFATASADHTVKLWS 505
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
94-132 9.20e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 9.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3183237     94 GELLITLNGHKSAVTTMDFDKMGTRLASGSMDTDIIVWD 132
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
467-505 5.88e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 5.88e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3183237    467 SSLIERIQAHDGAIWDLAVGHDGTYFATASADHTVKLWS 505
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
572-603 8.70e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 8.70e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 3183237    572 LYGHKLPVLSMDISYDSKLLVTCSADKNVKIW 603
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
348-566 9.69e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.77  E-value: 9.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  348 PGNRTPTLVTSLQNNSIEVYALDVKSEGSAAPLTERASRISAIEIPGHRADVRTLALSANHDVILSGANGSLKLWNKKTT 427
Cdd:COG3391  21 LAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3183237  428 SCIRTIECG---YVLAASfINNDKCIVSAYKSGELEVYDIASSSLIERIQAHDGAiWDLAVGHDGTY-FATASADHTVKL 503
Cdd:COG3391 101 KVVATIPVGggpRGLAVD-PDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP-HGIAVDPDGKRlYVANSGSNTVSV 178

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3183237  504 wslkssfdFVpgttRKVTTLKLEQTRQIDFTDDVLAVKISPDGRFV--------AASLLDNTVKVYYLDSL 566
Cdd:COG3391 179 --------IV----SVIDTATGKVVATIPVGGGPVGVAVSPDGRRLyvanrgsnTSNGGSNTVSVIDLATL 237
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 572-603 1.30e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.30e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 3183237     572 LYGHKLPVLSMDISYDSKLLVTCSADKNVKIW 603
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
650-686 1.66e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.66e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3183237    650 FDLILKLRGHHSEVWALAVGP--TFVVSGSHDHSIRLWE 686
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPdgKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 649-686 2.05e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 2.05e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 3183237     649 SFDLILKLRGHHSEVWALAVGP--TFVVSGSHDHSIRLWE 686
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPdgKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 608-646 3.66e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.66e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 3183237     608 GDCHKSIFAHQDSIMEVTFQPDTYNFFTCSKDREVRYWD 646
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
608-646 7.25e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 7.25e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3183237    608 GDCHKSIFAHQDSIMEVTFQPDTYNFFTCSKDREVRYWD 646
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 206-243 1.53e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.53e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 3183237     206 HCVETHVDHQGEIWAMCVSPDAKRCLTAGTGSDVKVWE 243
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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