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Conserved domains on  [gi|11387136|sp|P95871|]
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RecName: Full=Tricorn protease homolog

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 63-1068 0e+00

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


:

Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 670.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136   63 AYYMYPDIRGDLISFTSDDDVWLLSLKDMKPLRITSGLGVSTRPKISPSGRKVAFSviwlkSGKQG-GDIYV--VEDGQA 139
Cdd:COG4946   23 GYLRYPAISGDTIVFVYAGDLWTVPADGGRARRLTSHPGYESFPRFSPDGKWIAFT-----SDYDGnTDVYVmpAEGGEP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  140 RRVTYFGSRNsRVAGWISEDE-IIVITDFHTPFIQWTEAYKVNVNNGKTEKLPFGMLSNIVIKDDIIVIA--RGYQDLPN 216
Cdd:COG4946   98 KRLTYHPAND-RVVGWTPDGKsVLFASNRGSPPSRSNQLYTVPVDGGLPERLPLPPAGDGSFSPDGKKLAytRIGREFRT 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  217 WKGYKGGTKGELWISSDGGKTFEKFVSLDGNVSWPMIVRERVYFLSDHEGVGNLYSVDLKGKDLRRHTNFTDYYCRNASS 296
Cdd:COG4946  177 WKRYRGGTAGDIWIYDLGTGEFTRLTDFGGNDRNPMWIGDRIYFLSDRDGTFNLYSYDPDGKDLRQLTHFKDFDVRFPST 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  297 DGKRIVFQNAGDIYLYDPEKDSLTKLDINLPTDRKKKQPKFVNVMEYMNEAVV--NGNYIALVSRGKVFLMRPWDGPSVQ 374
Cdd:COG4946  257 DGGRIVYEQGGDLYLLDLASGEPRKLNITLAGDFPQRRPRWVDVSGYLTSFALspDGKRVAFEARGEVFTVPAEKGPTRN 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  375 LGKKQGVKYRQIQVLPNGD-VIGVND---EDKLVILGKDGS---EKVINKDFSRIERVKVSPDGKKVLLSNNKLELWVYE 447
Cdd:COG4946  337 LTNTPGVRERLPAWSPDGKsIAYFSDasgEYELYIAPADGSgepKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVD 416

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  448 IDNDNARLIDKSEY-DLILEFDWHPNAEWFAYAFPEGYYTQSIKLAHID-GKVVRITTPYGYDFSPSFDPDGRYLYFLAA 525
Cdd:COG4946  417 LASGKVRKVDTDGYgDGISDLAWSPDSKWLAYSKPGPNQLSQIFLYDVEtGKTVQLTDGRYDDGSPAFSPDGKYLYFLSS 496

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  526 RHLDPTNDKVIFNLSFQRVVKPYLVVLGNY-YSPFNQPLDE------------------ANSNDKNVII--EGIEDRVVP 584
Cdd:COG4946  497 RDFNPTYGDLDFDLAFPRTTRIYAVPLRKDaPSPFAPESDEeaakkeedekkkkkkkddKKKKPKPVKIdfDGIEDRIVA 576

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  585 FPIEEENYVQIAGAKNNKIFLfSYPIRGLRSQTgdvfgrLEVYDLENKAKELYADNVSSFSLSSDKSKILLILKDSLRLF 664
Cdd:COG4946  577 LPVPAGNYSDLAAGKGGVLYL-LEPVEGAPGGT------LYRYDLEKRKTETLADGVSSYELSADGKKLLVRSGGRLRVV 649

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  665 DVNVKPDfnstgRKGGVIDLSRVKVYVEPEKEWRQMLRETWKLMKQNYWNEERLkNWDSILPKYERLLDRISTRFELSDV 744
Cdd:COG4946  650 DADAKPK-----DGSGKVDDKRRVVVPPEEEEQQFEEEWRRRRRRFYYDNDHGG-DDDWAGVYYYYLLLLARRRRDLLDL 723

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  745 IQEMQGETRTSHSYETAYDYDTPEPLSVGGLGAEFEYDESNKCYKITKIYVGDSTNENERSPLRDPGVQLNVGDCIKNID 824
Cdd:COG4946  724 LLDLLGELLLGHLGVLGGGGGGGDRPPGGGLGLGAALLGDGGGVRKIIIIGEIEDPPAPPPLPPPGVVVGGGGIIIVIVG 803

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  825 GEDANGNIYSHLIN----KDQVILDVITADGKNKRVTVKVLKDERFLIYRYWVEKNREYVHEKSKGRLGYIHIPDMMYQG 900
Cdd:COG4946  804 VGVGDDNDALLLLLllagKVTLLVLVLLTEGRGKVVVVVVVVVEELLRLLRWVRRRRRRVRRRSGGGGGGVGVYGMGGGG 883

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  901 FAEFYRLFMSEFHREGLVVDVRFNRGGFVSGLLLEKLLLKRVGY-DYPRNGKPIPMPYFSSPKVLVGITNEHAGSDGDIF 979
Cdd:COG4946  884 GGGFRRRFFFYYDYKGVIVDDIRGGGGGGGGLIIDLLLLLLLLRlRRRRGRRPPPPPPPPGPGPPPVLVLVASGGGGGSD 963

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  980 SFLFKKYKLGVLIGRRTWGGVVGIRPRYRLVDKTYISQPEFAVNFEDVGFGIENYGVDPDIVVEIKPDDYVNNRDTQLDT 1059
Cdd:COG4946  964 GFFFFKGGLGGGLGTGGGGGGGGGGGGGLDGGGGGGGGGPTGVFGGGGGGGGEEVGVPVPDDVVDVEEDVVDDDDDQQDE 1043


                 ....*....
gi 11387136 1060 AIELALKQL 1068
Cdd:COG4946 1044 AAAAALLLL 1052
 
Name Accession Description Interval E-value
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 63-1068 0e+00

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 670.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136   63 AYYMYPDIRGDLISFTSDDDVWLLSLKDMKPLRITSGLGVSTRPKISPSGRKVAFSviwlkSGKQG-GDIYV--VEDGQA 139
Cdd:COG4946   23 GYLRYPAISGDTIVFVYAGDLWTVPADGGRARRLTSHPGYESFPRFSPDGKWIAFT-----SDYDGnTDVYVmpAEGGEP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  140 RRVTYFGSRNsRVAGWISEDE-IIVITDFHTPFIQWTEAYKVNVNNGKTEKLPFGMLSNIVIKDDIIVIA--RGYQDLPN 216
Cdd:COG4946   98 KRLTYHPAND-RVVGWTPDGKsVLFASNRGSPPSRSNQLYTVPVDGGLPERLPLPPAGDGSFSPDGKKLAytRIGREFRT 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  217 WKGYKGGTKGELWISSDGGKTFEKFVSLDGNVSWPMIVRERVYFLSDHEGVGNLYSVDLKGKDLRRHTNFTDYYCRNASS 296
Cdd:COG4946  177 WKRYRGGTAGDIWIYDLGTGEFTRLTDFGGNDRNPMWIGDRIYFLSDRDGTFNLYSYDPDGKDLRQLTHFKDFDVRFPST 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  297 DGKRIVFQNAGDIYLYDPEKDSLTKLDINLPTDRKKKQPKFVNVMEYMNEAVV--NGNYIALVSRGKVFLMRPWDGPSVQ 374
Cdd:COG4946  257 DGGRIVYEQGGDLYLLDLASGEPRKLNITLAGDFPQRRPRWVDVSGYLTSFALspDGKRVAFEARGEVFTVPAEKGPTRN 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  375 LGKKQGVKYRQIQVLPNGD-VIGVND---EDKLVILGKDGS---EKVINKDFSRIERVKVSPDGKKVLLSNNKLELWVYE 447
Cdd:COG4946  337 LTNTPGVRERLPAWSPDGKsIAYFSDasgEYELYIAPADGSgepKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVD 416

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  448 IDNDNARLIDKSEY-DLILEFDWHPNAEWFAYAFPEGYYTQSIKLAHID-GKVVRITTPYGYDFSPSFDPDGRYLYFLAA 525
Cdd:COG4946  417 LASGKVRKVDTDGYgDGISDLAWSPDSKWLAYSKPGPNQLSQIFLYDVEtGKTVQLTDGRYDDGSPAFSPDGKYLYFLSS 496

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  526 RHLDPTNDKVIFNLSFQRVVKPYLVVLGNY-YSPFNQPLDE------------------ANSNDKNVII--EGIEDRVVP 584
Cdd:COG4946  497 RDFNPTYGDLDFDLAFPRTTRIYAVPLRKDaPSPFAPESDEeaakkeedekkkkkkkddKKKKPKPVKIdfDGIEDRIVA 576

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  585 FPIEEENYVQIAGAKNNKIFLfSYPIRGLRSQTgdvfgrLEVYDLENKAKELYADNVSSFSLSSDKSKILLILKDSLRLF 664
Cdd:COG4946  577 LPVPAGNYSDLAAGKGGVLYL-LEPVEGAPGGT------LYRYDLEKRKTETLADGVSSYELSADGKKLLVRSGGRLRVV 649

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  665 DVNVKPDfnstgRKGGVIDLSRVKVYVEPEKEWRQMLRETWKLMKQNYWNEERLkNWDSILPKYERLLDRISTRFELSDV 744
Cdd:COG4946  650 DADAKPK-----DGSGKVDDKRRVVVPPEEEEQQFEEEWRRRRRRFYYDNDHGG-DDDWAGVYYYYLLLLARRRRDLLDL 723

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  745 IQEMQGETRTSHSYETAYDYDTPEPLSVGGLGAEFEYDESNKCYKITKIYVGDSTNENERSPLRDPGVQLNVGDCIKNID 824
Cdd:COG4946  724 LLDLLGELLLGHLGVLGGGGGGGDRPPGGGLGLGAALLGDGGGVRKIIIIGEIEDPPAPPPLPPPGVVVGGGGIIIVIVG 803

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  825 GEDANGNIYSHLIN----KDQVILDVITADGKNKRVTVKVLKDERFLIYRYWVEKNREYVHEKSKGRLGYIHIPDMMYQG 900
Cdd:COG4946  804 VGVGDDNDALLLLLllagKVTLLVLVLLTEGRGKVVVVVVVVVEELLRLLRWVRRRRRRVRRRSGGGGGGVGVYGMGGGG 883

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  901 FAEFYRLFMSEFHREGLVVDVRFNRGGFVSGLLLEKLLLKRVGY-DYPRNGKPIPMPYFSSPKVLVGITNEHAGSDGDIF 979
Cdd:COG4946  884 GGGFRRRFFFYYDYKGVIVDDIRGGGGGGGGLIIDLLLLLLLLRlRRRRGRRPPPPPPPPGPGPPPVLVLVASGGGGGSD 963

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  980 SFLFKKYKLGVLIGRRTWGGVVGIRPRYRLVDKTYISQPEFAVNFEDVGFGIENYGVDPDIVVEIKPDDYVNNRDTQLDT 1059
Cdd:COG4946  964 GFFFFKGGLGGGLGTGGGGGGGGGGGGGLDGGGGGGGGGPTGVFGGGGGGGGEEVGVPVPDDVVDVEEDVVDDDDDQQDE 1043


                 ....*....
gi 11387136 1060 AIELALKQL 1068
Cdd:COG4946 1044 AAAAALLLL 1052
Peptidase_S41_TRI cd07562
Tricorn protease; serine protease family S41; The tricorn protease (TRI), a member of the S41 ...
 696-1066 1.21e-92

Tricorn protease; serine protease family S41; The tricorn protease (TRI), a member of the S41 peptidase family and named for its tricorn-like shape, exists only in some archaea and eubacteria. It has been shown to act as a carboxypeptidase, involved in the degradation of proteasomal products to preferentially yield di- and tripeptides, with subsequent and final degradations to free amino acid residues by tricorn interacting factors, F1, F2 and F3. Tricorn is a hexameric D3-symmetric protease of 720kD, and can self-associate further into a giant icosahedral capsid structure containing twenty copies of the complex. Each tricorn peptidase monomer consists of five structural domains: a six-bladed beta-propeller and a seven-bladed beta-propeller that limit access to the active site, the two domains (C1 and C2) that carry the active site residues, and a PDZ-like domain (proposed to be important for substrate recognition) between the C1 and C2 domains. The active site tetrad residues are distributed between the C1 and C2 domains, with serine and histidine on C1 and serine and glutamate on C2.


Pssm-ID: 143478 [Multi-domain]  Cd Length: 266  Bit Score: 296.42  E-value: 1.21e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  696 EWRQMLRETWKLMKQNYWNEE-RLKNWDSILPKYERLLDRISTRFELSDVIQEMQGETRTSHSYEtaydydtpeplsvgg 774
Cdd:cd07562    1 EWLQMFDEAWRLVRDNFYDPDmHGVDWDAVRAEYRPLLPRAATRAELADVLNEMLGELNDSHTGV--------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  775 lgaefeydesnkcykitkiyvgdstnenersplrdpgvqlnvgdciknidgedangniyshlinkdqvildvitadgknk 854
Cdd:cd07562      --------------------------------------------------------------------------------

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  855 rvtvkvlkdeRFLIYRYWVEKNREYVHEKSKGRLGYIHIPDMMYQGFAEFYRLFMSEFHREGLVVDVRFNRGGFVSGLLL 934
Cdd:cd07562   66 ----------SGLRYRDWVESNREYVEELSDGRIGYVHIPDMGDDGFAEFLRDLLAEVDKDGLIIDVRFNGGGNVADLLL 135

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  935 EKLLLKRVGYDYPRN-GKPIPMPYFSSPKVLVGITNEHAGSDGDIFSFLFKKYKLGVLIGRRTWGGVVgIRPRYRLVDKT 1013
Cdd:cd07562  136 DFLSRRRYGYDIPRGgGKPVTYPSGRWRGPVVVLVNEGSASDAEIFAYGFRALGLGPVVGTRTAGGVI-ISGRYRLPDGG 214

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 11387136 1014 YISQPEFAVNFEDvGFGIENYGVDPDIVVEIKPDDYVNNRDTQLDTAIELALK 1066
Cdd:cd07562  215 SLTVPEFGVYLPD-GGPLENRGVAPDIEVENTPEDVAAGRDPQLEAAIEELLK 266
TSPc smart00245
tail specific protease; tail specific protease
 853-1043 6.46e-40

tail specific protease; tail specific protease


Pssm-ID: 214582  Cd Length: 192  Bit Score: 146.25  E-value: 6.46e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136     853 NKRVTVKVLKDERFLIYRYWVEKNREyvheksKGRLGYIHIPDMMYQ--GFAEFYRLFMSEFHREGLVVDVRFNRGGFVS 930
Cdd:smart00245    1 SKERTIALIRDKIKIETLEGNVGYLR------FGFIGYIRIPEFSEHtsNLVEKAWKKLEKTNVEGLILDLRNNPGGLLS 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136     931 GLLLEK---LLLKRVGYDYPRN-GKPIPMPYFSSPKV---LVGITNEHAGSDGDIFSFLFKKYKLGVLIGRRTWG-GVVG 1002
Cdd:smart00245   75 AAIDVSslfLDKGVIVYTVYRRtGELWTYPANLGRKYskpLVVLVNKGTASASEIFAGALKDLGRATIVGERTFGkGLVQ 154

                           170       180       190       200
                    ....*....|....*....|....*....|....*....|.
gi 11387136    1003 IRPRYRLVDKTYISQPEFAVNfedVGFGIENYGVDPDIVVE 1043
Cdd:smart00245  155 QTVPLGDGSGLKLTVAKYYTP---SGKSIEKKGVEPDIQVP 192
Tricorn_PDZ pfam14685
Tricorn protease PDZ domain; This domain is the PDZ domain of tricorn protease.
 773-858 1.69e-32

Tricorn protease PDZ domain; This domain is the PDZ domain of tricorn protease.


Pssm-ID: 405386 [Multi-domain]  Cd Length: 88  Bit Score: 121.15  E-value: 1.69e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136    773 GGLGAEFEYDesNKCYKITKIYVGDSTNENERSPLRDPGVQLNVGDCIKNIDGE--DANGNIYSHLINKDQ--VILDVIT 848
Cdd:pfam14685    1 GLLGADLSRD--GGRYRIAKIYPGDSWDPEARSPLAEPGVDVRVGDCILAVDGRpvGPVTGPYSLLVGKAGqeVELTVRR 78

                           90
                   ....*....|
gi 11387136    849 ADGKNKRVTV 858
Cdd:pfam14685   79 KDGDARRVTV 88
 
Name Accession Description Interval E-value
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 63-1068 0e+00

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 670.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136   63 AYYMYPDIRGDLISFTSDDDVWLLSLKDMKPLRITSGLGVSTRPKISPSGRKVAFSviwlkSGKQG-GDIYV--VEDGQA 139
Cdd:COG4946   23 GYLRYPAISGDTIVFVYAGDLWTVPADGGRARRLTSHPGYESFPRFSPDGKWIAFT-----SDYDGnTDVYVmpAEGGEP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  140 RRVTYFGSRNsRVAGWISEDE-IIVITDFHTPFIQWTEAYKVNVNNGKTEKLPFGMLSNIVIKDDIIVIA--RGYQDLPN 216
Cdd:COG4946   98 KRLTYHPAND-RVVGWTPDGKsVLFASNRGSPPSRSNQLYTVPVDGGLPERLPLPPAGDGSFSPDGKKLAytRIGREFRT 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  217 WKGYKGGTKGELWISSDGGKTFEKFVSLDGNVSWPMIVRERVYFLSDHEGVGNLYSVDLKGKDLRRHTNFTDYYCRNASS 296
Cdd:COG4946  177 WKRYRGGTAGDIWIYDLGTGEFTRLTDFGGNDRNPMWIGDRIYFLSDRDGTFNLYSYDPDGKDLRQLTHFKDFDVRFPST 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  297 DGKRIVFQNAGDIYLYDPEKDSLTKLDINLPTDRKKKQPKFVNVMEYMNEAVV--NGNYIALVSRGKVFLMRPWDGPSVQ 374
Cdd:COG4946  257 DGGRIVYEQGGDLYLLDLASGEPRKLNITLAGDFPQRRPRWVDVSGYLTSFALspDGKRVAFEARGEVFTVPAEKGPTRN 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  375 LGKKQGVKYRQIQVLPNGD-VIGVND---EDKLVILGKDGS---EKVINKDFSRIERVKVSPDGKKVLLSNNKLELWVYE 447
Cdd:COG4946  337 LTNTPGVRERLPAWSPDGKsIAYFSDasgEYELYIAPADGSgepKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVD 416

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  448 IDNDNARLIDKSEY-DLILEFDWHPNAEWFAYAFPEGYYTQSIKLAHID-GKVVRITTPYGYDFSPSFDPDGRYLYFLAA 525
Cdd:COG4946  417 LASGKVRKVDTDGYgDGISDLAWSPDSKWLAYSKPGPNQLSQIFLYDVEtGKTVQLTDGRYDDGSPAFSPDGKYLYFLSS 496

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  526 RHLDPTNDKVIFNLSFQRVVKPYLVVLGNY-YSPFNQPLDE------------------ANSNDKNVII--EGIEDRVVP 584
Cdd:COG4946  497 RDFNPTYGDLDFDLAFPRTTRIYAVPLRKDaPSPFAPESDEeaakkeedekkkkkkkddKKKKPKPVKIdfDGIEDRIVA 576

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  585 FPIEEENYVQIAGAKNNKIFLfSYPIRGLRSQTgdvfgrLEVYDLENKAKELYADNVSSFSLSSDKSKILLILKDSLRLF 664
Cdd:COG4946  577 LPVPAGNYSDLAAGKGGVLYL-LEPVEGAPGGT------LYRYDLEKRKTETLADGVSSYELSADGKKLLVRSGGRLRVV 649

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  665 DVNVKPDfnstgRKGGVIDLSRVKVYVEPEKEWRQMLRETWKLMKQNYWNEERLkNWDSILPKYERLLDRISTRFELSDV 744
Cdd:COG4946  650 DADAKPK-----DGSGKVDDKRRVVVPPEEEEQQFEEEWRRRRRRFYYDNDHGG-DDDWAGVYYYYLLLLARRRRDLLDL 723

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  745 IQEMQGETRTSHSYETAYDYDTPEPLSVGGLGAEFEYDESNKCYKITKIYVGDSTNENERSPLRDPGVQLNVGDCIKNID 824
Cdd:COG4946  724 LLDLLGELLLGHLGVLGGGGGGGDRPPGGGLGLGAALLGDGGGVRKIIIIGEIEDPPAPPPLPPPGVVVGGGGIIIVIVG 803

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  825 GEDANGNIYSHLIN----KDQVILDVITADGKNKRVTVKVLKDERFLIYRYWVEKNREYVHEKSKGRLGYIHIPDMMYQG 900
Cdd:COG4946  804 VGVGDDNDALLLLLllagKVTLLVLVLLTEGRGKVVVVVVVVVEELLRLLRWVRRRRRRVRRRSGGGGGGVGVYGMGGGG 883

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  901 FAEFYRLFMSEFHREGLVVDVRFNRGGFVSGLLLEKLLLKRVGY-DYPRNGKPIPMPYFSSPKVLVGITNEHAGSDGDIF 979
Cdd:COG4946  884 GGGFRRRFFFYYDYKGVIVDDIRGGGGGGGGLIIDLLLLLLLLRlRRRRGRRPPPPPPPPGPGPPPVLVLVASGGGGGSD 963

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  980 SFLFKKYKLGVLIGRRTWGGVVGIRPRYRLVDKTYISQPEFAVNFEDVGFGIENYGVDPDIVVEIKPDDYVNNRDTQLDT 1059
Cdd:COG4946  964 GFFFFKGGLGGGLGTGGGGGGGGGGGGGLDGGGGGGGGGPTGVFGGGGGGGGEEVGVPVPDDVVDVEEDVVDDDDDQQDE 1043


                 ....*....
gi 11387136 1060 AIELALKQL 1068
Cdd:COG4946 1044 AAAAALLLL 1052
Peptidase_S41_TRI cd07562
Tricorn protease; serine protease family S41; The tricorn protease (TRI), a member of the S41 ...
 696-1066 1.21e-92

Tricorn protease; serine protease family S41; The tricorn protease (TRI), a member of the S41 peptidase family and named for its tricorn-like shape, exists only in some archaea and eubacteria. It has been shown to act as a carboxypeptidase, involved in the degradation of proteasomal products to preferentially yield di- and tripeptides, with subsequent and final degradations to free amino acid residues by tricorn interacting factors, F1, F2 and F3. Tricorn is a hexameric D3-symmetric protease of 720kD, and can self-associate further into a giant icosahedral capsid structure containing twenty copies of the complex. Each tricorn peptidase monomer consists of five structural domains: a six-bladed beta-propeller and a seven-bladed beta-propeller that limit access to the active site, the two domains (C1 and C2) that carry the active site residues, and a PDZ-like domain (proposed to be important for substrate recognition) between the C1 and C2 domains. The active site tetrad residues are distributed between the C1 and C2 domains, with serine and histidine on C1 and serine and glutamate on C2.


Pssm-ID: 143478 [Multi-domain]  Cd Length: 266  Bit Score: 296.42  E-value: 1.21e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  696 EWRQMLRETWKLMKQNYWNEE-RLKNWDSILPKYERLLDRISTRFELSDVIQEMQGETRTSHSYEtaydydtpeplsvgg 774
Cdd:cd07562    1 EWLQMFDEAWRLVRDNFYDPDmHGVDWDAVRAEYRPLLPRAATRAELADVLNEMLGELNDSHTGV--------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  775 lgaefeydesnkcykitkiyvgdstnenersplrdpgvqlnvgdciknidgedangniyshlinkdqvildvitadgknk 854
Cdd:cd07562      --------------------------------------------------------------------------------

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  855 rvtvkvlkdeRFLIYRYWVEKNREYVHEKSKGRLGYIHIPDMMYQGFAEFYRLFMSEFHREGLVVDVRFNRGGFVSGLLL 934
Cdd:cd07562   66 ----------SGLRYRDWVESNREYVEELSDGRIGYVHIPDMGDDGFAEFLRDLLAEVDKDGLIIDVRFNGGGNVADLLL 135

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  935 EKLLLKRVGYDYPRN-GKPIPMPYFSSPKVLVGITNEHAGSDGDIFSFLFKKYKLGVLIGRRTWGGVVgIRPRYRLVDKT 1013
Cdd:cd07562  136 DFLSRRRYGYDIPRGgGKPVTYPSGRWRGPVVVLVNEGSASDAEIFAYGFRALGLGPVVGTRTAGGVI-ISGRYRLPDGG 214

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 11387136 1014 YISQPEFAVNFEDvGFGIENYGVDPDIVVEIKPDDYVNNRDTQLDTAIELALK 1066
Cdd:cd07562  215 SLTVPEFGVYLPD-GGPLENRGVAPDIEVENTPEDVAAGRDPQLEAAIEELLK 266
CtpA COG0793
C-terminal processing protease CtpA/Prc, contains a PDZ domain [Posttranslational modification, ...
 699-1063 5.98e-55

C-terminal processing protease CtpA/Prc, contains a PDZ domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440556 [Multi-domain]  Cd Length: 341  Bit Score: 194.70  E-value: 5.98e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  699 QMLRETWKLMKQNYWneerlknwdsilpkyerllDRISTRFELSDVIQEMQGETRTSHSY----ETAYDYDTPEPLSVGG 774
Cdd:COG0793    1 QLFDEVWRLIRDNYV-------------------DEYDDRDLAEGALNGMLGELGDPHSYyldpEEYEDFQESTSGEFGG 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  775 LGAEFEYDesNKCYKITKIYvgdstnenERSPLRDPGVQlnVGDCIKNIDGEDANG----NIYSHLINKdqvildvitad 850
Cdd:COG0793   62 LGAELGEE--DGKVVVVSVI--------PGSPAEKAGIK--PGDIILAIDGKSVAGltldDAVKLLRGK----------- 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  851 gKNKRVTVKVLKDERFLIYRywVEKNREYVHEKS------KGRLGYIHIPDMMYQGFAEFYRLFMS--EFHREGLVVDVR 922
Cdd:COG0793  119 -AGTKVTLTIKRPGEGEPIT--VTLTRAEIKLPSveakllEGKIGYIRIPSFGENTAEEFKRALKElkKQGAKGLILDLR 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  923 FNRGGFVSGLLL---EKLLLKRVGYDYPRNGKPIPmpYFSSPKV------LVGITNEHAGSDGDIFSFLFKKYKLGVLIG 993
Cdd:COG0793  196 NNPGGLLDEAVEladLFLPKGPIVYTRGRNGKVET--YKATPGGalydgpLVVLVNEGSASASEIFAGALQDYGRGVIVG 273

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  994 RRTWGGVVgIRPRYRLVDKTYISQPEFAVnFEDVGFGIENYGVDPDIVVEIKPDDYVNNRDTQLDTAIEL 1063
Cdd:COG0793  274 TRTFGKGS-VQTVFPLPDGGALKLTTARY-YTPSGRSIQGKGVEPDIEVPLTPEDLLKGRDPQLEKALEL 341
TSPc smart00245
tail specific protease; tail specific protease
 853-1043 6.46e-40

tail specific protease; tail specific protease


Pssm-ID: 214582  Cd Length: 192  Bit Score: 146.25  E-value: 6.46e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136     853 NKRVTVKVLKDERFLIYRYWVEKNREyvheksKGRLGYIHIPDMMYQ--GFAEFYRLFMSEFHREGLVVDVRFNRGGFVS 930
Cdd:smart00245    1 SKERTIALIRDKIKIETLEGNVGYLR------FGFIGYIRIPEFSEHtsNLVEKAWKKLEKTNVEGLILDLRNNPGGLLS 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136     931 GLLLEK---LLLKRVGYDYPRN-GKPIPMPYFSSPKV---LVGITNEHAGSDGDIFSFLFKKYKLGVLIGRRTWG-GVVG 1002
Cdd:smart00245   75 AAIDVSslfLDKGVIVYTVYRRtGELWTYPANLGRKYskpLVVLVNKGTASASEIFAGALKDLGRATIVGERTFGkGLVQ 154

                           170       180       190       200
                    ....*....|....*....|....*....|....*....|.
gi 11387136    1003 IRPRYRLVDKTYISQPEFAVNfedVGFGIENYGVDPDIVVE 1043
Cdd:smart00245  155 QTVPLGDGSGLKLTVAKYYTP---SGKSIEKKGVEPDIQVP 192
Tricorn_PDZ pfam14685
Tricorn protease PDZ domain; This domain is the PDZ domain of tricorn protease.
 773-858 1.69e-32

Tricorn protease PDZ domain; This domain is the PDZ domain of tricorn protease.


Pssm-ID: 405386 [Multi-domain]  Cd Length: 88  Bit Score: 121.15  E-value: 1.69e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136    773 GGLGAEFEYDesNKCYKITKIYVGDSTNENERSPLRDPGVQLNVGDCIKNIDGE--DANGNIYSHLINKDQ--VILDVIT 848
Cdd:pfam14685    1 GLLGADLSRD--GGRYRIAKIYPGDSWDPEARSPLAEPGVDVRVGDCILAVDGRpvGPVTGPYSLLVGKAGqeVELTVRR 78

                           90
                   ....*....|
gi 11387136    849 ADGKNKRVTV 858
Cdd:pfam14685   79 KDGDARRVTV 88
cpPDZ_Tricorn-protease cd10828
circularly permuted PDZ domain of Tricorn protease, and related proteins; permuted PDZ (PSD-95 ...
 772-860 4.75e-32

circularly permuted PDZ domain of Tricorn protease, and related proteins; permuted PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of Tricorn protease, and related domains. The tricorn protease can degrade oligopeptides (which may have been generated by the proteasome) and channel the products to F1, F2 and F3 proteases which, in turn, catalyze the terminal degradation step yielding free amino acids. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains and as well as those with circular permutations and domain swapping of beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2); arranged as A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F. The tricorn family PDZ domain is a circularly permuted PDZ domain which places beta-strand A on the C-terminus. Another permutation exists in the PDZ superfamily which places both beta-strands A and B on the C-terminus.


Pssm-ID: 467628 [Multi-domain]  Cd Length: 93  Bit Score: 120.12  E-value: 4.75e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  772 VGGLGAEFEYDESnKCYKITKIYVGDSTNENERSPLRDPGVQLNVGDCIKNIDGE--DANGNIYSHLINK--DQVILDVI 847
Cdd:cd10828    1 IGLLGADFKYDES-GCYRIARIYKGDSWNENERSPLAAPGVDVRVGDLIVAIDGEpvGAVKNPYSLLVGKagTQVVLTVS 79

                         90
                 ....*....|....
gi 11387136  848 TAD-GKNKRVTVKV 860
Cdd:cd10828   80 PKGgGDVRRVTVVP 93
Peptidase_S41 pfam03572
Peptidase family S41;
887-1042 3.24e-30

Peptidase family S41;


Pssm-ID: 460977  Cd Length: 165  Bit Score: 117.32  E-value: 3.24e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136    887 RLGYIHIPDM---MYQGFAEFYRLFMSEfHREGLVVDVRFNRGGFVSGLLLEKLLLKRVGYDYPRNGKPIPMP------- 956
Cdd:pfam03572    1 KIGYIRIPSFsekTAKELAEALKELKKQ-GVKGLILDLRGNPGGLLSAAVEIASLFLPDGTIVSTRGRDGSKEvyfaagk 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136    957 --YFSSPKVLVGITNEHAGSDGDIFSFLFKKYKLGVLIGRRTwGGVVGIRPRYRLVDKTYISQPEFAVNFEDVGFgIENY 1034
Cdd:pfam03572   80 adEVLWKGPLVVLVNEGSASASEIFAGALQDNGRATLVGERT-FGKGTVQTVYPLPDGSALKLTIAKYYTPDGRS-IEGK 157


                   ....*...
gi 11387136   1035 GVDPDIVV 1042
Cdd:pfam03572  158 GIEPDIEV 165
Peptidase_S41 cd06567
C-terminal processing peptidase family S41; Peptidase family S41 (C-terminal processing ...
 888-1043 6.89e-27

C-terminal processing peptidase family S41; Peptidase family S41 (C-terminal processing peptidase or CTPase family) contains very different subfamilies; it includes photosystem II D1 C-terminal processing protease (CTPase), interphotoreceptor retinoid-binding protein IRBP and tricorn protease (TRI). CTPase and TRI both contain the PDZ domain while IRBP, although being very similar to the tail-specific protease domain, lacks the PDZ insertion domain and hydrolytic activity. These serine proteases have distinctly different active sites: in CTPase, the active site consists of a serine/lysine catalytic dyad while in tricorn core protease, it is a tetrad (serine, histidine, serine, glutamate). CPases with different substrate specificities in different species include processing of D1 protein of the photosystem II reaction center in higher plants and cleavage of a peptide of 11 residues from the precursor form of penicillin-binding protein; and others such as tricorn protease (TRI) act as a carboxypeptidase, involved in the degradation of proteasomal products. CTPase homolog IRBP, secreted by photoreceptors into the interphotoreceptor matrix, having arisen in the early evolution of the vertebrate eye, promotes the release of all-trans retinol from photoreceptors and facilitates its delivery to the retinal pigment epithelium.


Pssm-ID: 143475 [Multi-domain]  Cd Length: 224  Bit Score: 109.69  E-value: 6.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  888 LGYIHIPDMMYQGFAEFYRLFMSEFHR--EGLVVDVRFNRGGFVSGLLL--------EKLLLKRVGYDYPRNGKPIPMPY 957
Cdd:cd06567   61 IGYIRIPSFSAESTAEELREALAELKKgvKGLILDLRNNPGGLLSAAVElaslflpkGKIVVTTRRRGGNETEYVAPGGG 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  958 FSSPKVLVGITNEHAGSDGDIFSFLFKKYKLGVLIGRRTWGGVVGIRPRYRLvDKTYISQPEFAVnFEDVGFGIENYGVD 1037
Cdd:cd06567  141 SLYDGPLVVLVNEGSASASEIFAGALQDLGRATLVGERTFGKGSVQTVFPLL-DGSALKLTTAKY-YTPSGRSIEGKGVE 218


                 ....*.
gi 11387136 1038 PDIVVE 1043
Cdd:cd06567  219 PDIEVP 224
Tricorn_C1 pfam14684
Tricorn protease C1 domain; This domain is the C1 core domain of tricorn protease. This is a ...
 694-762 1.29e-25

Tricorn protease C1 domain; This domain is the C1 core domain of tricorn protease. This is a mixed alpha-beta domain.


Pssm-ID: 434126 [Multi-domain]  Cd Length: 70  Bit Score: 100.72  E-value: 1.29e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136    694 EKEWRQMLRETWKLMKQNYWNEE-RLKNWDSILPKYERLLDRISTRFELSDVIQEMQGETRTSHSYETAY 762
Cdd:pfam14684    1 EAEWRQMFDEAWRLLRDNFYDPDmHGVDWEAVRERYRPLLPRIATRDDLSDLLSEMLGELNTSHSYVRGG 70
Peptidase_S41_IRBP cd07563
Interphotoreceptor retinoid-binding protein; serine protease family S41; Interphotoreceptor ...
 820-1064 1.64e-11

Interphotoreceptor retinoid-binding protein; serine protease family S41; Interphotoreceptor retinoid-binding protein (IRBP) is a homolog of the S41 protease, C-terminal processing peptidase (CTPase) family. It is thought to facilitate the compartmentalization of the visual cycle that requires poorly soluble and potentially toxic retinoids to cross the aqueous subretinal space between the photoreceptors and the retinal pigment epithelium (RPE). IRBP is secreted by photoreceptors into the interphotoreceptor matrix (IPM) where it is rapidly turned over by a combination of RPE and photoreceptor endocytosis. It is the most abundant soluble protein component of the IPM, consisting of homologous modules, each repeat structure arising through the duplication (as in teleost IRBP) or quadruplication (in tetrapods) of an ancient gene, arisen in the early evolution of the vertebrate eye. IRBP has been shown to promote the release of all-trans retinol from photoreceptors and facilitates its delivery to the RPE. Conversely, IRBP can promote the release of 11-cis-retinal from the RPE, prevent its isomerization in the subretinal space, and transfer it to photoreceptors. In vivo evidence implicates IRBP as a retinoid transporter in the visual cycle, suggesting a critical role for IRBP in cone function essential for human vision. IRBP is a dominant autoimmune antigen in the eye; IRBP proteolysis analysis has proven a useful biomarker for autoimmune uveitis (AU) disorders, a major cause of blindness. This family also includes a chlamydia-secreted protein, designated chlamydia protease-like activity factor (CPAF), known to degrade host proteins, enabling Chlamydia to evade host defenses and replicate.


Pssm-ID: 143479 [Multi-domain]  Cd Length: 250  Bit Score: 65.78  E-value: 1.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  820 IKNIDGEDangnIYSHLinKDQVILDVITADGKNKRVT--VKVLKDERFLIYrywveknreYVhekskgrlGYIHIPDMM 897
Cdd:cd07563   18 AKGIDWDA----LAARL--RAQVYLDITSPEELAAVLTadLQELGDGHLNVS---------YI--------GYLRIDSFG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  898 YQGFA---EFYRLFMSEFHR-EGLVVDVRFNRGGFVSGLLLE----KLLLKRVGYD--YPRNG----------KPIPMPY 957
Cdd:cd07563   75 GFEIAaaeALLDEALDKLADtDALIIDLRYNGGGSDSLVAYLasyfTDEDKPVHLYtiYKRPGntttelwtlpVVPGGRY 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  958 FSSPKVLVgITNEHAGSDGDIFSFLFKKYKLGVLIGRRTWGGVVGIRPrYRLVDKTYISQPEFAVNFEDVGFGIENYGVD 1037
Cdd:cd07563  155 GYTKPVYV-LTSPVTFSAAEEFAYALKQLKRATVVGETTAGGASPVLP-FPLPNGLYLTVPTSRSVDPITGTNWEGVGVP 232

                        250       260
                 ....*....|....*....|....*..
gi 11387136 1038 PDIVVEIKPDdyvnnrdtqLDTAIELA 1064
Cdd:cd07563  233 PDIEVPATPG---------YDDALERA 250
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 82-287 2.15e-09

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 57.37  E-value: 2.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136   82 DVWLLSLKDMKPLRITSGLGVSTRPKISPSGRKVAFSviwlkSGKQGG-DIYVV--EDGQARRVTYFGSRNSrvAGWISE 158
Cdd:COG0823   12 DIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFT-----SDRGGGpQIYVVdaDGGEPRRLTFGGGYNA--SPSWSP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  159 D-EIIVITDFHTPFIQwteAYKVNVNNGKTEKLPFGMLSnivikddiiviargyqdlPNWkgykggtkgelwiSSDGgkt 237
Cdd:COG0823   85 DgKRLAFVSRSDGRFD---IYVLDLDGGAPRRLTDGPGS------------------PSW-------------SPDG--- 127

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 11387136  238 fekfvsldgnvswpmivrERVYFLSDHEGVGNLYSVDLKGKdLRRHTNFT 287
Cdd:COG0823  128 ------------------RRIVFSSDRGGRPDLYVVDLDGR-KRRLTPAS 158
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 409-527 1.07e-08

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 55.45  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  409 DGSEKVINKDFSRIERVKVSPDGKKVLLSNN---KLELWVYEIDNDNARLIDKSEYDLIlEFDWHPNAEWFAYA-FPEGY 484
Cdd:COG0823   20 GGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDrggGPQIYVVDADGGEPRRLTFGGGYNA-SPSWSPDGKRLAFVsRSDGR 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 11387136  485 YtqSIKLAHIDGK-VVRITTPYGydfSPSFDPDGRYLYFLAARH 527
Cdd:COG0823   99 F--DIYVLDLDGGaPRRLTDGPG---SPSWSPDGRRIVFSSDRG 137
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 68-143 3.17e-07

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 51.21  E-value: 3.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136   68 PDirGDLISFTSDD----DVWLLSLKDMKPLRITSGLGVSTRPKISPSGRKVAFSviwlKSGKQGGDIYVV--EDGQARR 141
Cdd:COG0823   40 PD--GRRIAFTSDRgggpQIYVVDADGGEPRRLTFGGGYNASPSWSPDGKRLAFV----SRSDGRFDIYVLdlDGGAPRR 113


                 ..
gi 11387136  142 VT 143
Cdd:COG0823  114 LT 115
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 230-322 9.79e-07

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 49.67  E-value: 9.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  230 ISSDGGKTFEKFVSLDGNvswpmivreRVYFLSDHEGVGNLYSVDLKGKDLRRHTnFTDYYCRNA--SSDGKRIVFQNAG 307
Cdd:COG0823   26 LTNSPGIDTSPAWSPDGR---------RIAFTSDRGGGPQIYVVDADGGEPRRLT-FGGGYNASPswSPDGKRLAFVSRS 95

                         90
                 ....*....|....*....
gi 11387136  308 ----DIYLYDPEKDSLTKL 322
Cdd:COG0823   96 dgrfDIYVLDLDGGAPRRL 114
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 434-526 2.29e-06

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 48.51  E-value: 2.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  434 VLLSNNKLELWVYEIDNDNARLIDKSEYDlILEFDWHPNAEWFAYAFPEGYYTQsIKLAHIDG-KVVRITTPYGYDFSPS 512
Cdd:COG0823    4 TLSRDGNSDIYVVDLDGGEPRRLTNSPGI-DTSPAWSPDGRRIAFTSDRGGGPQ-IYVVDADGgEPRRLTFGGGYNASPS 81

                         90
                 ....*....|....
gi 11387136  513 FDPDGRYLYFLAAR 526
Cdd:COG0823   82 WSPDGKRLAFVSRS 95
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 63-145 5.09e-06

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 47.74  E-value: 5.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136   63 AYYMYPDI--RGDLISFTSDD----DVWLLSLKDMKPLRITSGLGVstrPKISPSGRKVAFSviwlkSGKQG-GDIYVVE 135
Cdd:COG0823   75 GYNASPSWspDGKRLAFVSRSdgrfDIYVLDLDGGAPRRLTDGPGS---PSWSPDGRRIVFS-----SDRGGrPDLYVVD 146

                         90
                 ....*....|.
gi 11387136  136 -DGQARRVTYF 145
Cdd:COG0823  147 lDGRKRRLTPA 157
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 258-395 1.99e-05

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 45.82  E-value: 1.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387136  258 VYFLSDHEGVGNLYSVDLKGKDLRRHTNFTDYYCRNA-SSDGKRIVF----QNAGDIYLYDPEKDSLTKLDinlPTDRKK 332
Cdd:COG0823    1 LAFTLSRDGNSDIYVVDLDGGEPRRLTNSPGIDTSPAwSPDGRRIAFtsdrGGGPQIYVVDADGGEPRRLT---FGGGYN 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 11387136  333 KQPKFVNvmeymneavvNGNYIALVSRGK----VFLMRPWDGPSVQLGKKQGvkyrQIQVLPNGDVI 395
Cdd:COG0823   78 ASPSWSP----------DGKRLAFVSRSDgrfdIYVLDLDGGAPRRLTDGPG----SPSWSPDGRRI 130
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 495-530 3.59e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 42.35  E-value: 3.59e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 11387136  495 DGKVVRITTPYGYDFSPSFDPDGRYLYFLAARHLDP 530
Cdd:COG0823   20 GGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGP 55
PD40 pfam07676
WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. ...
 498-522 1.28e-03

WD40-like Beta Propeller Repeat; This family appears to be related to the pfam00400 repeat. This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].


Pssm-ID: 429587 [Multi-domain]  Cd Length: 37  Bit Score: 37.50  E-value: 1.28e-03
                           10        20
                   ....*....|....*....|....*
gi 11387136    498 VVRITTPYGYDFSPSFDPDGRYLYF 522
Cdd:pfam07676    1 LGRLTNTPGNETAPSWSPDGKRLAF 25
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 226-278 4.17e-03

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 41.03  E-value: 4.17e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 11387136    226 GELWISSDGGKTFEKFVSLDGNVSWPMIV-----RERVYFLSDHEGVgnLYSVDlKGK 278
Cdd:pfam15902    1 SEVYRSHDYGKTWKKVKDVPDGEAILAIYphpydNDRAYLLTDGKKH--YYTTD-RGK 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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