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Conserved domains on  [gi|1730112|sp|P98156|]
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RecName: Full=Very low-density lipoprotein receptor; Short=VLDL receptor; Short=VLDL-R; Flags: Precursor

Protein Classification

LDLa and Ldl_recept_b domain-containing protein( domain architecture ID 10819527)

protein containing domains LDLa, FXa_inhibition, LY, and Ldl_recept_b

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 568-608 2.60e-16

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 73.35  E-value: 2.60e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1730112    568 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLD 608
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
237-273 5.52e-12

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 60.73  E-value: 5.52e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1730112    237 TKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 273
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 33-67 2.66e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.66e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730112   33 CDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNC 67
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
276-312 5.70e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 5.70e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1730112    276 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 527-565 6.94e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.94  E-value: 6.94e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1730112    527 IYWTDAASK-TISVATLDGAKRKFLFNSDLREPASIAVDP 565
Cdd:pfam00058   3 LYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
153-188 1.49e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.49e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730112    153 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 188
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 71-103 4.64e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 4.64e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112      71 TCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 592-634 3.58e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 3.58e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1730112     592 RPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDR 634
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
192-224 3.94e-09

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 3.94e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1730112    192 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 224
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
111-149 4.26e-09

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 4.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1730112    111 RTCRINEISCGarSTQCIPVSWRCDGENDCDNGEDEENC 149
Cdd:pfam00057   1 STCSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 481-522 1.23e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.23e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1730112    481 QKLFWADLSQKA-IFSASIDDKVgRHFKMIDNVYNPAAIAVDW 522
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 655-695 7.73e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 7.73e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1730112    655 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 695
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
320-350 1.12e-07

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 1.12e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1730112    320 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 350
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 360-394 2.82e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 2.82e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730112    360 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 394
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
396-426 7.47e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 7.47e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112     396 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 426
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 706-749 5.01e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.07  E-value: 5.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1730112    706 CEDDmeNGGCEYLCLPAPQindhspKYTCSCPNGYNLEENGREC 749
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 568-608 2.60e-16

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 73.35  E-value: 2.60e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1730112    568 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLD 608
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
237-273 5.52e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 60.73  E-value: 5.52e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1730112    237 TKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 273
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 33-67 2.66e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.66e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730112   33 CDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNC 67
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 239-273 4.88e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 4.88e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730112  239 CPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 273
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
276-312 5.70e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 5.70e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1730112    276 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 527-565 6.94e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.94  E-value: 6.94e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1730112    527 IYWTDAASK-TISVATLDGAKRKFLFNSDLREPASIAVDP 565
Cdd:pfam00058   3 LYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
153-188 1.49e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.49e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730112    153 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 188
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 154-188 3.80e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 3.80e-10
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730112  154 CSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 188
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 71-103 4.64e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 4.64e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112      71 TCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 508-547 5.47e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 5.47e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1730112     508 MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGAKR 547
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
32-67 1.01e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 1.01e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730112     32 KCDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNC 67
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 72-103 1.24e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.24e-09
                        10        20        30
                ....*....|....*....|....*....|..
gi 1730112   72 CAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 32-64 1.36e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 1.36e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112      32 KCDSSQFQCTNGRCITLLWKCDGDEDCADGSDE 64
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 238-270 1.70e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 1.70e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112     238 KCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDE 270
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-103 1.76e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 1.76e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1730112     70 KTCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 550-591 2.28e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 2.28e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1730112     550 LFNSDLREPASIAVDPLSGFVYWSDWGEPaKIEKAGMNGFDR 591
Cdd:smart00135   3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 592-634 3.58e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 3.58e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1730112     592 RPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDR 634
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 278-312 3.64e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 3.64e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730112  278 CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
192-224 3.94e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 3.94e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1730112    192 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 224
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 192-224 3.95e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.95e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112     192 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 224
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
111-149 4.26e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 4.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1730112    111 RTCRINEISCGarSTQCIPVSWRCDGENDCDNGEDEENC 149
Cdd:pfam00057   1 STCSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 153-185 4.75e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 4.75e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112     153 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDE 185
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 481-522 1.23e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.23e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1730112    481 QKLFWADLSQKA-IFSASIDDKVgRHFKMIDNVYNPAAIAVDW 522
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 193-224 5.01e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 5.01e-08
                        10        20        30
                ....*....|....*....|....*....|..
gi 1730112  193 CGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 224
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 277-309 7.58e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.78  E-value: 7.58e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112     277 TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 309
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 655-695 7.73e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 7.73e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1730112    655 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 695
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
320-350 1.12e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 1.12e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1730112    320 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 350
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 613-654 1.21e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 1.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1730112    613 RLYWLDSKLH-MLSSVDLNGQDRRIVLKSLefLAHPLALTIFE 654
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 360-394 2.82e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 2.82e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730112    360 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 394
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 113-149 3.01e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.20  E-value: 3.01e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 1730112  113 CRINEISCGarSTQCIPVSWRCDGENDCDNGEDEENC 149
Cdd:cd00112   1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 320-350 7.00e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 7.00e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1730112     320 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 350
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 320-350 1.11e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 1.11e-06
                        10        20        30
                ....*....|....*....|....*....|.
gi 1730112  320 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 350
Cdd:cd00112   2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
396-426 7.47e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 7.47e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112     396 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 426
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 112-146 1.45e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.62  E-value: 1.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1730112     112 TCRINEISCGarSTQCIPVSWRCDGENDCDNGEDE 146
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
525-672 1.85e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.00  E-value: 1.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730112  525 KTIYWTDAASKTISVatLDGAKRKFLFNSDL-REPASIAVDPLSGFVYWSDWGEPA--KIEKAGMNgfdrrplVTEDIQ- 600
Cdd:COG3391  80 RRLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNGRvsVIDTATGK-------VVATIPv 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730112  601 --WPNGITLDLVKSRLYWLDSKLHMLS---SVdLNGQDRRiVLKSLEFLAHPLALTIFED--RVYWID-GENEAVYGANK 672
Cdd:COG3391 151 gaGPHGIAVDPDGKRLYVANSGSNTVSvivSV-IDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANrGSNTSNGGSNT 228
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 396-426 3.24e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 3.24e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 1730112  396 DIDECQNPGICS--QICINLKGGYKCECSRGYQ 426
Cdd:cd00054   1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 706-749 5.01e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.07  E-value: 5.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1730112    706 CEDDmeNGGCEYLCLPAPQindhspKYTCSCPNGYNLEENGREC 749
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 515-681 1.81e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 1.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730112  515 PAAIAVDWVYKtIYWTDAASKTISVATLDGAKRKFLFNSDLRE----PASIAVDplSGFVYWSDWG---------EPAKI 581
Cdd:cd14963  58 PYGIAVDSDGN-IYVADLYNGRIQVFDPDGKFLKYFPEKKDRVklisPAGLAID--DGKLYVSDVKkhkvivfdlEGKLL 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730112  582 EKAGMNGFDRrplvtEDIQWPNGITLDlVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKS---LEFLAHPLALTIFED-RV 657
Cdd:cd14963 135 LEFGKPGSEP-----GELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELNGSpdgKSGFVNPRGIAVDPDgNL 208

                       170       180
                ....*....|....*....|....
gi 1730112  658 YWIDGENEAVYGANKfTGSELATL 681
Cdd:cd14963 209 YVVDNLSHRVYVFDE-QGKELFTF 231
EGF_CA pfam07645
Calcium-binding EGF domain;
396-424 5.42e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 5.42e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1730112    396 DIDECQNPG-ICSQ--ICINLKGGYKCECSRG 424
Cdd:pfam07645   1 DVDECATGThNCPAntVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 568-608 2.60e-16

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 73.35  E-value: 2.60e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1730112    568 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLD 608
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
237-273 5.52e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 60.73  E-value: 5.52e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1730112    237 TKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 273
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 33-67 2.66e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.66e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730112   33 CDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNC 67
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 239-273 4.88e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 4.88e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730112  239 CPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 273
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
276-312 5.70e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 5.70e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1730112    276 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 527-565 6.94e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.94  E-value: 6.94e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1730112    527 IYWTDAASK-TISVATLDGAKRKFLFNSDLREPASIAVDP 565
Cdd:pfam00058   3 LYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
153-188 1.49e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.49e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730112    153 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 188
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 154-188 3.80e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 3.80e-10
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730112  154 CSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDC 188
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 71-103 4.64e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 4.64e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112      71 TCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 508-547 5.47e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 5.47e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1730112     508 MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGAKR 547
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
32-67 1.01e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 1.01e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730112     32 KCDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNC 67
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 72-103 1.24e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.24e-09
                        10        20        30
                ....*....|....*....|....*....|..
gi 1730112   72 CAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 32-64 1.36e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 1.36e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112      32 KCDSSQFQCTNGRCITLLWKCDGDEDCADGSDE 64
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 238-270 1.70e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 1.70e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112     238 KCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDE 270
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-103 1.76e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 1.76e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1730112     70 KTCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDE 103
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 550-591 2.28e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 2.28e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1730112     550 LFNSDLREPASIAVDPLSGFVYWSDWGEPaKIEKAGMNGFDR 591
Cdd:smart00135   3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 592-634 3.58e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 3.58e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1730112     592 RPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDR 634
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 278-312 3.64e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 3.64e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730112  278 CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
192-224 3.94e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 3.94e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1730112    192 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 224
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 192-224 3.95e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.95e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112     192 TCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 224
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
111-149 4.26e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 4.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1730112    111 RTCRINEISCGarSTQCIPVSWRCDGENDCDNGEDEENC 149
Cdd:pfam00057   1 STCSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 153-185 4.75e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 4.75e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112     153 TCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDE 185
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 481-522 1.23e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.23e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1730112    481 QKLFWADLSQKA-IFSASIDDKVgRHFKMIDNVYNPAAIAVDW 522
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 193-224 5.01e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 5.01e-08
                        10        20        30
                ....*....|....*....|....*....|..
gi 1730112  193 CGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 224
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 277-309 7.58e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.78  E-value: 7.58e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112     277 TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 309
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 655-695 7.73e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 7.73e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1730112    655 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 695
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
320-350 1.12e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 1.12e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1730112    320 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 350
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 613-654 1.21e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 1.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1730112    613 RLYWLDSKLH-MLSSVDLNGQDRRIVLKSLefLAHPLALTIFE 654
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 360-394 2.82e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 2.82e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730112    360 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 394
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 113-149 3.01e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.20  E-value: 3.01e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 1730112  113 CRINEISCGarSTQCIPVSWRCDGENDCDNGEDEENC 149
Cdd:cd00112   1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 320-350 7.00e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 7.00e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1730112     320 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 350
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 320-350 1.11e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 1.11e-06
                        10        20        30
                ....*....|....*....|....*....|.
gi 1730112  320 GPGKFKCRSGECIDMSKVCDQEQDCRDWSDE 350
Cdd:cd00112   2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
396-426 7.47e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 7.47e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730112     396 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 426
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 112-146 1.45e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.62  E-value: 1.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1730112     112 TCRINEISCGarSTQCIPVSWRCDGENDCDNGEDE 146
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
525-672 1.85e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.00  E-value: 1.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730112  525 KTIYWTDAASKTISVatLDGAKRKFLFNSDL-REPASIAVDPLSGFVYWSDWGEPA--KIEKAGMNgfdrrplVTEDIQ- 600
Cdd:COG3391  80 RRLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNGRvsVIDTATGK-------VVATIPv 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730112  601 --WPNGITLDLVKSRLYWLDSKLHMLS---SVdLNGQDRRiVLKSLEFLAHPLALTIFED--RVYWID-GENEAVYGANK 672
Cdd:COG3391 151 gaGPHGIAVDPDGKRLYVANSGSNTVSvivSV-IDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANrGSNTSNGGSNT 228
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 396-426 3.24e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 3.24e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 1730112  396 DIDECQNPGICS--QICINLKGGYKCECSRGYQ 426
Cdd:cd00054   1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 706-749 5.01e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.07  E-value: 5.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1730112    706 CEDDmeNGGCEYLCLPAPQindhspKYTCSCPNGYNLEENGREC 749
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
475-615 6.11e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.46  E-value: 6.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730112  475 DADIAAQKLFWADLSQKAIfsASIDDKVGRHFKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVatLDGAKRKFLFNSD 554
Cdd:COG3391  74 DAGADGRRLYVANSGSGRV--SVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIP 149

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1730112  555 L-REPASIAVDPLSGFVYWSDWGEP------AKIEKAGMNgfdrrplVTEDI---QWPNGITLDLVKSRLY 615
Cdd:COG3391 150 VgAGPHGIAVDPDGKRLYVANSGSNtvsvivSVIDTATGK-------VVATIpvgGGPVGVAVSPDGRRLY 213
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 479-637 6.86e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.57  E-value: 6.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730112  479 AAQKLFWADLSQKAIFSASIDDKVGRHFKMIDNvyNPAAIAVD-----WV---YKTIYWTDAASKTISVATLDGAKRKFL 550
Cdd:COG3386  17 PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSG--RPNGLAFDpdgrlLVadhGRGLVRFDPADGEVTVLADEYGKPLNR 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730112  551 FNsDLRepasiaVDPlSGFVYWSDwgepakiekagMNGFDRRP------------LVTEDIQWPNGITLDLVKSRLYWLD 618
Cdd:COG3386  95 PN-DGV------VDP-DGRLYFTD-----------MGEYLPTGalyrvdpdgslrVLADGLTFPNGIAFSPDGRTLYVAD 155

                       170       180
                ....*....|....*....|...
gi 1730112  619 SKLHMLSSVDLNGQ----DRRIV 637
Cdd:COG3386 156 TGAGRIYRFDLDADgtlgNRRVF 178
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
443-576 1.52e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 1.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730112  443 LIFTNRRD--IRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSasIDDKVGRHFKMIDNVYNPAAIAV 520
Cdd:COG3391  82 LYVANSGSgrVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVGAGPHGIAV 159

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 1730112  521 DWVYKTIYWTDAASKTIS--VATLDGAKRKFLFNSDLRE-PASIAVDPLSGFVYWSDWG 576
Cdd:COG3391 160 DPDGKRLYVANSGSNTVSviVSVIDTATGKVVATIPVGGgPVGVAVSPDGRRLYVANRG 218
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 515-681 1.81e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 1.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730112  515 PAAIAVDWVYKtIYWTDAASKTISVATLDGAKRKFLFNSDLRE----PASIAVDplSGFVYWSDWG---------EPAKI 581
Cdd:cd14963  58 PYGIAVDSDGN-IYVADLYNGRIQVFDPDGKFLKYFPEKKDRVklisPAGLAID--DGKLYVSDVKkhkvivfdlEGKLL 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730112  582 EKAGMNGFDRrplvtEDIQWPNGITLDlVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKS---LEFLAHPLALTIFED-RV 657
Cdd:cd14963 135 LEFGKPGSEP-----GELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELNGSpdgKSGFVNPRGIAVDPDgNL 208

                       170       180
                ....*....|....*....|....
gi 1730112  658 YWIDGENEAVYGANKfTGSELATL 681
Cdd:cd14963 209 YVVDNLSHRVYVFDE-QGKELFTF 231
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 471-574 2.89e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.65  E-value: 2.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730112  471 TVALDADiaaQKLFWADLSQKAIFsasIDDKVGRHFKMIDN-----VYNPAAIAVDwVYKTIYWTDAASKTISVATLDGA 545
Cdd:cd14962  16 GVAADGR---GRIYVADTGRGAVF---VFDLPNGKVFVIGNagpnrFVSPIGVAID-ANGNLYVSDAELGKVFVFDRDGK 88

                        90       100       110
                ....*....|....*....|....*....|
gi 1730112  546 KRKFLFNSDLRE-PASIAVDPLSGFVYWSD 574
Cdd:cd14962  89 FLRAIGAGALFKrPTGIAVDPAGKRLYVVD 118
EGF_CA pfam07645
Calcium-binding EGF domain;
396-424 5.42e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 5.42e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1730112    396 DIDECQNPG-ICSQ--ICINLKGGYKCECSRG 424
Cdd:pfam07645   1 DVDECATGThNCPAntVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 401-428 8.51e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 34.91  E-value: 8.51e-03
                          10        20
                  ....*....|....*....|....*...
gi 1730112    401 QNPGICSQICINLKGGYKCECSRGYQMD 428
Cdd:pfam14670   3 VNNGGCSHLCLNTPGGYTCSCPEGYELQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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