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Conserved domains on  [gi|215274120|sp|Q61169|]
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RecName: Full=Transcription factor GATA-6; AltName: Full=GATA-binding factor 6

Protein Classification

GATA-type transcription factor( domain architecture ID 13711593)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0006355|GO:0008270|GO:0043565
PubMed:  31574210

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 147-371 3.31e-48

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


:

Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 165.68  E-value: 3.31e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274120  147 MYQTLAALSSQGPAAYDGAPGGFVHSAAAAaaaaaaassPVYVPTTRVGSMLSGLPYLQGAGSGPSNHAGgaGAHPGWSQ 226
Cdd:pfam05349   1 MYQSLALAANHGQAAYDHDSGGFLHSAASS---------PVYVPTTRVPSMLPTLPYLQGCGSSQQSHPV--SSHSGWAQ 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274120  227 ASADSPPYggggaagggaagpggaGSATAHASARFPYSPSPPMANGAARDpGGYVAAggtgagsvsggggSLAAMGGREh 306
Cdd:pfam05349  70 AGAESSSY----------------NPGSPHPSPRFSYSHSPPGSNGTSRD-AAYQSP-------------LLISAGGRE- 118

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215274120  307 QYSSLsaARPLNGTYHHhhhhhpTYSPYMAAPLTPAWPAGPFETPVLHSLQGRaGAPLPVpRGPS 371
Cdd:pfam05349 119 QYGAL--GRPLGGSYPS------PYPAYVSPEMAPSWTAGPFDSSVLHSLQGR-GAPLPG-RRPN 173
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 437-488 6.96e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 85.89  E-value: 6.96e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215274120 437 SCANCHTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMKKEG-IQTRKRK 488
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 383-428 1.44e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.64  E-value: 1.44e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 215274120 383 ECVNCGSIQTPLWRRDG-TGHYLCNACGLYSKMNGLSRPLIKPQKRV 428
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQ 47
GAT1 super family cl35034
GATA Zn-finger-containing transcription factor [Transcription];
437-584 8.79e-10

GATA Zn-finger-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5641:

Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 61.43  E-value: 8.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274120 437 SCANCHTTTTTLWRR-----NAEGEPVCNACGLYMKLHGVPR-PLAMKKEGIQTR-KRKPKNINKSKACSGNSSgSVPMT 509
Cdd:COG5641  160 VCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRsSRSSHNNNDSNGENANTE-SIGNS 238

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215274120 510 PTSSSSNSDDCTKntspstQATTSGVGASVMSAVGENANPEnsdlKYSGQDGLYIGVSLSSPAEVTSSVRQDSWC 584
Cdd:COG5641  239 SASKLTKSWEERP------QGRQLLSDAGSLSPRSNNPKSP----LLEGLMGSTSLQPVSTPKLVLPSDKKRSTL 303
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 147-371 3.31e-48

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 165.68  E-value: 3.31e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274120  147 MYQTLAALSSQGPAAYDGAPGGFVHSAAAAaaaaaaassPVYVPTTRVGSMLSGLPYLQGAGSGPSNHAGgaGAHPGWSQ 226
Cdd:pfam05349   1 MYQSLALAANHGQAAYDHDSGGFLHSAASS---------PVYVPTTRVPSMLPTLPYLQGCGSSQQSHPV--SSHSGWAQ 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274120  227 ASADSPPYggggaagggaagpggaGSATAHASARFPYSPSPPMANGAARDpGGYVAAggtgagsvsggggSLAAMGGREh 306
Cdd:pfam05349  70 AGAESSSY----------------NPGSPHPSPRFSYSHSPPGSNGTSRD-AAYQSP-------------LLISAGGRE- 118

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215274120  307 QYSSLsaARPLNGTYHHhhhhhpTYSPYMAAPLTPAWPAGPFETPVLHSLQGRaGAPLPVpRGPS 371
Cdd:pfam05349 119 QYGAL--GRPLGGSYPS------PYPAYVSPEMAPSWTAGPFDSSVLHSLQGR-GAPLPG-RRPN 173
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 437-488 6.96e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 85.89  E-value: 6.96e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215274120 437 SCANCHTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMKKEG-IQTRKRK 488
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
435-482 1.08e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 77.07  E-value: 1.08e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 215274120   435 GLSCANCHTTTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMKKEGI 482
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 383-428 1.44e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.64  E-value: 1.44e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 215274120 383 ECVNCGSIQTPLWRRDG-TGHYLCNACGLYSKMNGLSRPLIKPQKRV 428
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQ 47
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 438-472 6.09e-14

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 65.80  E-value: 6.09e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 215274120  438 CANCHTTTTTLWRRNAEGEP-VCNACGLYMKLHGVP 472
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
382-429 3.73e-13

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 63.98  E-value: 3.73e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 215274120   382 RECVNCGSIQTPLWRRDGTGH-YLCNACGLYSKMNGLSRPLIKPQKRVP 429
Cdd:smart00401   4 RSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLKRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 384-417 6.05e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 60.02  E-value: 6.05e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 215274120  384 CVNCGSIQTPLWRRDGTGHY-LCNACGLYSKMNGL 417
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGL 35
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
437-584 8.79e-10

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 61.43  E-value: 8.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274120 437 SCANCHTTTTTLWRR-----NAEGEPVCNACGLYMKLHGVPR-PLAMKKEGIQTR-KRKPKNINKSKACSGNSSgSVPMT 509
Cdd:COG5641  160 VCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRsSRSSHNNNDSNGENANTE-SIGNS 238

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215274120 510 PTSSSSNSDDCTKntspstQATTSGVGASVMSAVGENANPEnsdlKYSGQDGLYIGVSLSSPAEVTSSVRQDSWC 584
Cdd:COG5641  239 SASKLTKSWEERP------QGRQLLSDAGSLSPRSNNPKSP----LLEGLMGSTSLQPVSTPKLVLPSDKKRSTL 303
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 147-371 3.31e-48

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 165.68  E-value: 3.31e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274120  147 MYQTLAALSSQGPAAYDGAPGGFVHSAAAAaaaaaaassPVYVPTTRVGSMLSGLPYLQGAGSGPSNHAGgaGAHPGWSQ 226
Cdd:pfam05349   1 MYQSLALAANHGQAAYDHDSGGFLHSAASS---------PVYVPTTRVPSMLPTLPYLQGCGSSQQSHPV--SSHSGWAQ 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274120  227 ASADSPPYggggaagggaagpggaGSATAHASARFPYSPSPPMANGAARDpGGYVAAggtgagsvsggggSLAAMGGREh 306
Cdd:pfam05349  70 AGAESSSY----------------NPGSPHPSPRFSYSHSPPGSNGTSRD-AAYQSP-------------LLISAGGRE- 118

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215274120  307 QYSSLsaARPLNGTYHHhhhhhpTYSPYMAAPLTPAWPAGPFETPVLHSLQGRaGAPLPVpRGPS 371
Cdd:pfam05349 119 QYGAL--GRPLGGSYPS------PYPAYVSPEMAPSWTAGPFDSSVLHSLQGR-GAPLPG-RRPN 173
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 437-488 6.96e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 85.89  E-value: 6.96e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 215274120 437 SCANCHTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMKKEG-IQTRKRK 488
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
435-482 1.08e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 77.07  E-value: 1.08e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 215274120   435 GLSCANCHTTTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMKKEGI 482
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 383-428 1.44e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.64  E-value: 1.44e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 215274120 383 ECVNCGSIQTPLWRRDG-TGHYLCNACGLYSKMNGLSRPLIKPQKRV 428
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQ 47
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 438-472 6.09e-14

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 65.80  E-value: 6.09e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 215274120  438 CANCHTTTTTLWRRNAEGEP-VCNACGLYMKLHGVP 472
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
382-429 3.73e-13

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 63.98  E-value: 3.73e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 215274120   382 RECVNCGSIQTPLWRRDGTGH-YLCNACGLYSKMNGLSRPLIKPQKRVP 429
Cdd:smart00401   4 RSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLKRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 384-417 6.05e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 60.02  E-value: 6.05e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 215274120  384 CVNCGSIQTPLWRRDGTGHY-LCNACGLYSKMNGL 417
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGL 35
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
437-584 8.79e-10

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 61.43  E-value: 8.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274120 437 SCANCHTTTTTLWRR-----NAEGEPVCNACGLYMKLHGVPR-PLAMKKEGIQTR-KRKPKNINKSKACSGNSSgSVPMT 509
Cdd:COG5641  160 VCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRsSRSSHNNNDSNGENANTE-SIGNS 238

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215274120 510 PTSSSSNSDDCTKntspstQATTSGVGASVMSAVGENANPEnsdlKYSGQDGLYIGVSLSSPAEVTSSVRQDSWC 584
Cdd:COG5641  239 SASKLTKSWEERP------QGRQLLSDAGSLSPRSNNPKSP----LLEGLMGSTSLQPVSTPKLVLPSDKKRSTL 303
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
386-527 1.55e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 60.66  E-value: 1.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274120 386 NCGSIQTPLWRR-DGTGHYLCNACGLYSKMNGLSRPLikPQKRVPSSRRLGLSCANCHTTTTTLWRrnaEGEPVCNACGL 464
Cdd:COG5641  303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKIL---SPPTTSNSPGA 377

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 215274120 465 YMKLHGVPRPLAMKKEGIQTRKRKPKNINKSkacsgnSSGSVPMTPTSSSSNSDDCTKNTSPS 527
Cdd:COG5641  378 QVKLPNQTRSTGATKKKITRRRMNSGKIPAL------SSSMKNPVPKEFSPLIPQSTESETPS 434
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
367-585 3.27e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 52.95  E-value: 3.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274120 367 PRGPSTDLLEDLSESRECVNCGSIQTPLWRRD-----GTGHYLCNACGLYSKMNGLSRPLIKPQKRVPSSRRLGLSCANC 441
Cdd:COG5641  144 SLNPNNNQSDNSNQPHVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274120 442 -HTTTTTLWRRNAEGEPVCNACGLYMKLHGvpRPLAMKKEGIQTRKRKPKNINKSKACSGNSSGSVPMTP--TSSSSNSD 518
Cdd:COG5641  224 dSNGENANTESIGNSSASKLTKSWEERPQG--RQLLSDAGSLSPRSNNPKSPLLEGLMGSTSLQPVSTPKlvLPSDKKRS 301

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215274120 519 DCTKNTspstqATTSGVGASVMSAVGENANPeNSDLKYSGQDGLyigvslsSPAEVTSSVRQDSWCA 585
Cdd:COG5641  302 TLTTST-----ATPLWRRTSDKSSFSCNASG-SALKPPGSKRPL-------LPKPDPNSKRSNATCM 355
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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