NCBI Conserved Domain Search

NCBI

3D Macromolecular Structures

Conserved Domains

Conserved domains on [gi|313104083|sp|Q86VB7|]

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RecName: Full=Scavenger receptor cysteine-rich type 1 protein M130; AltName: Full=Hemoglobin scavenger receptor; AltName: CD_antigen=CD163; Contains: RecName: Full=Soluble CD163; Short=sCD163; Flags: Precursor

Protein Classification

scavenger receptor cysteine-rich domain-containing protein( domain architecture ID 10640959)

scavenger receptor cysteine-rich (SRCR) domain-containing protein os a member of the group B scavenger receptor cysteine-rich family (SRCR-SF), composed of tandem-repeats of the SRCR domain

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

719-819

5.76e-47

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

:

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 162.90 E-value: 5.76e-47

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    719 LRLVNGGGRCAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQC 798
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    799 HSHGWGQQNCRHKEDAGVICS 819
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

159-259

1.02e-43

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

:

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 153.65 E-value: 1.02e-43

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    159 MRLTRGGNMCSGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNC 238
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    239 KHQGWGKHNCDHAEDAGVICS 259
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

266-366

8.62e-43

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

:

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 150.96 E-value: 8.62e-43

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    266 LRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQC 345
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    346 KHHEWGKHYCNHNEDAGVTCS 366
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

51-152

4.62e-42

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

:

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 149.03 E-value: 4.62e-42

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083     51 LRLVDGENKCSGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSCRGNESALWDC 130
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|..
gi 313104083    131 KHDGWGKHsNCTHQQDAGVTCS 152
Cdd:smart00202   81 PHSGWGSH-NCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

929-1029

8.51e-42

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

:

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 148.26 E-value: 8.51e-42

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    929 IRLQEGPTSCSGRVEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDC 1008
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083   1009 PARRWGHSECGHKEDAAVNCT 1029
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

479-578

2.83e-36

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

:

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 132.47 E-value: 2.83e-36

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    479 RLVGGDIPCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEFQCEGHESHLSLCP 558
Cdd:smart00202    2 RLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDCP 81

                            90       100
                    ....*....|....*....|
gi 313104083    559 VAPRPEGTCSHSRDVGVVCS 578
Cdd:smart00202   82 HSGWGSHNCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

583-683

2.30e-34

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

:

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 127.07 E-value: 2.30e-34

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    583 IRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDC 662
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    663 PVTALGASLCPSEQVASVICS 683
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

373-473

1.21e-32

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

:

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 122.07 E-value: 1.21e-32

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    373 LRLRGGGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQATNTWLFLSSCNGNETSLWDC 452
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    453 KNWQWGGLTCDHYEEAKITCS 473
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

Name

Accession

Description

Interval

E-value

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

719-819

5.76e-47

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 162.90 E-value: 5.76e-47

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    719 LRLVNGGGRCAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQC 798
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    799 HSHGWGQQNCRHKEDAGVICS 819
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

159-259

1.02e-43

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 153.65 E-value: 1.02e-43

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    159 MRLTRGGNMCSGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNC 238
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    239 KHQGWGKHNCDHAEDAGVICS 259
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

266-366

8.62e-43

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 150.96 E-value: 8.62e-43

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    266 LRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQC 345
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    346 KHHEWGKHYCNHNEDAGVTCS 366
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

51-152

4.62e-42

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 149.03 E-value: 4.62e-42

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083     51 LRLVDGENKCSGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSCRGNESALWDC 130
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|..
gi 313104083    131 KHDGWGKHsNCTHQQDAGVTCS 152
Cdd:smart00202   81 PHSGWGSH-NCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

929-1029

8.51e-42

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 148.26 E-value: 8.51e-42

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    929 IRLQEGPTSCSGRVEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDC 1008
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083   1009 PARRWGHSECGHKEDAAVNCT 1029
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

724-819

7.18e-40

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 142.52 E-value: 7.18e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   724 GGGRCAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGS-AHFGEG-TGPIWLDEMKCNGKESRIWQCHSH 801
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGcSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083   802 GWGQQNCRHKEDAGVICS 819
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

164-259

9.35e-37

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 133.66 E-value: 9.35e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   164 GGNMCSGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGS-SNFGEG-SGPIWFDDLICNGNESALWNCKHQ 241
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGcSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083   242 GWGKHNCDHAEDAGVICS 259
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

934-1029

1.16e-36

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 133.27 E-value: 1.16e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   934 GPTSCSGRVEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALKAFKEAE-FGQG-TGPIWLNEVKCKGNESSLWDCPAR 1011
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGCSyFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083  1012 RWGHSECGHKEDAAVNCT 1029
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

479-578

2.83e-36

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 132.47 E-value: 2.83e-36

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    479 RLVGGDIPCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEFQCEGHESHLSLCP 558
Cdd:smart00202    2 RLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDCP 81

                            90       100
                    ....*....|....*....|
gi 313104083    559 VAPRPEGTCSHSRDVGVVCS 578
Cdd:smart00202   82 HSGWGSHNCSHGEDAGVVCS 101

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

271-366

1.59e-34

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 127.49 E-value: 1.59e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   271 GVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTA-IGRVNASKGF-GHIWLDSVSCQGHEPAIWQCKHH 348
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSApSGCSYFGPGStGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083   349 EWGKHYCNHNEDAGVTCS 366
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

583-683

2.30e-34

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 127.07 E-value: 2.30e-34

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    583 IRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDC 662
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    663 PVTALGASLCPSEQVASVICS 683
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

56-152

2.55e-33

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 124.03 E-value: 2.55e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    56 GENKCSGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPG--WANSSAGSGRIWMDHVSCRGNESALWDCKHD 133
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSgcSYFGPGSTGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*....
gi 313104083   134 GWGKHsNCTHQQDAGVTCS 152
Cdd:pfam00530   81 PWGNH-NCSHSEDAGVICS 98

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

373-473

1.21e-32

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 122.07 E-value: 1.21e-32

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    373 LRLRGGGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQATNTWLFLSSCNGNETSLWDC 452
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    453 KNWQWGGLTCDHYEEAKITCS 473
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

483-578

2.57e-30

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 115.17 E-value: 2.57e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   483 GDIPCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGG-AHFGEG-NGQIWAEEFQCEGHESHLSLCPVA 560
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGcSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083   561 PRPEGTCSHSRDVGVVCS 578
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

588-683

2.05e-28

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 109.77 E-value: 2.05e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   588 GKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGG-ARFGKG-NGQIWRHMFHCTGTEQHMGDCPVT 665
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGcSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083   666 ALGASLCPSEQVASVICS 683
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

378-473

9.09e-28

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 108.23 E-value: 9.09e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   378 GGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQATNTWLFLS--SCNGNETSLWDCKNW 455
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGCSYFGPGSTGPIWLDdvRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083   456 QWGGLTCDHYEEAKITCS 473
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

Name

Accession

Description

Interval

E-value

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

719-819

5.76e-47

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 162.90 E-value: 5.76e-47

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    719 LRLVNGGGRCAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQC 798
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    799 HSHGWGQQNCRHKEDAGVICS 819
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

159-259

1.02e-43

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 153.65 E-value: 1.02e-43

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    159 MRLTRGGNMCSGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNC 238
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    239 KHQGWGKHNCDHAEDAGVICS 259
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

266-366

8.62e-43

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 150.96 E-value: 8.62e-43

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    266 LRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQC 345
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    346 KHHEWGKHYCNHNEDAGVTCS 366
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

51-152

4.62e-42

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 149.03 E-value: 4.62e-42

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083     51 LRLVDGENKCSGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSCRGNESALWDC 130
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|..
gi 313104083    131 KHDGWGKHsNCTHQQDAGVTCS 152
Cdd:smart00202   81 PHSGWGSH-NCSHGEDAGVVCS 101

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

929-1029

8.51e-42

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 148.26 E-value: 8.51e-42

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    929 IRLQEGPTSCSGRVEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDC 1008
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083   1009 PARRWGHSECGHKEDAAVNCT 1029
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

724-819

7.18e-40

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 142.52 E-value: 7.18e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   724 GGGRCAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGS-AHFGEG-TGPIWLDEMKCNGKESRIWQCHSH 801
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGcSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083   802 GWGQQNCRHKEDAGVICS 819
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

164-259

9.35e-37

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 133.66 E-value: 9.35e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   164 GGNMCSGRIEIKFQGRWGTVCDDNFNIDHASVICRQLECGSAVSFSGS-SNFGEG-SGPIWFDDLICNGNESALWNCKHQ 241
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGcSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083   242 GWGKHNCDHAEDAGVICS 259
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

934-1029

1.16e-36

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 133.27 E-value: 1.16e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   934 GPTSCSGRVEIWHGGSWGTVCDDSWDLDDAQVVCQQLGCGPALKAFKEAE-FGQG-TGPIWLNEVKCKGNESSLWDCPAR 1011
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGCSyFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083  1012 RWGHSECGHKEDAAVNCT 1029
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

479-578

2.83e-36

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 132.47 E-value: 2.83e-36

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    479 RLVGGDIPCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEFQCEGHESHLSLCP 558
Cdd:smart00202    2 RLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDCP 81

                            90       100
                    ....*....|....*....|
gi 313104083    559 VAPRPEGTCSHSRDVGVVCS 578
Cdd:smart00202   82 HSGWGSHNCSHGEDAGVVCS 101

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

271-366

1.59e-34

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 127.49 E-value: 1.59e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   271 GVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTA-IGRVNASKGF-GHIWLDSVSCQGHEPAIWQCKHH 348
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSApSGCSYFGPGStGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083   349 EWGKHYCNHNEDAGVTCS 366
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

583-683

2.30e-34

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 127.07 E-value: 2.30e-34

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    583 IRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDC 662
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    663 PVTALGASLCPSEQVASVICS 683
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

56-152

2.55e-33

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 124.03 E-value: 2.55e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    56 GENKCSGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPG--WANSSAGSGRIWMDHVSCRGNESALWDCKHD 133
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSgcSYFGPGSTGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*....
gi 313104083   134 GWGKHsNCTHQQDAGVTCS 152
Cdd:pfam00530   81 PWGNH-NCSHSEDAGVICS 98

SR

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...

373-473

1.21e-32

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.

Pssm-ID: 214555 [Multi-domain] Cd Length: 101 Bit Score: 122.07 E-value: 1.21e-32

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083    373 LRLRGGGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQATNTWLFLSSCNGNETSLWDC 452
Cdd:smart00202    1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                            90       100
                    ....*....|....*....|.
gi 313104083    453 KNWQWGGLTCDHYEEAKITCS 473
Cdd:smart00202   81 PHSGWGSHNCSHGEDAGVVCS 101

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

483-578

2.57e-30

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 115.17 E-value: 2.57e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   483 GDIPCSGRVEVKHGDTWGSICDSDFSLEAASVLCRELQCGTVVSILGG-AHFGEG-NGQIWAEEFQCEGHESHLSLCPVA 560
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGcSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083   561 PRPEGTCSHSRDVGVVCS 578
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

588-683

2.05e-28

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 109.77 E-value: 2.05e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   588 GKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGVALSTPGG-ARFGKG-NGQIWRHMFHCTGTEQHMGDCPVT 665
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGcSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083   666 ALGASLCPSEQVASVICS 683
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

SRCR

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...

378-473

9.09e-28

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.

Pssm-ID: 459844 Cd Length: 98 Bit Score: 108.23 E-value: 9.09e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313104083   378 GGSRCAGTVEVEIQRLLGKVCDRGWGLKEADVVCRQLGCGSALKTSYQVYSKIQATNTWLFLS--SCNGNETSLWDCKNW 455
Cdd:pfam00530    1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGCSYFGPGSTGPIWLDdvRCSGNETSLWQCPHR 80

                           90
                   ....*....|....*...
gi 313104083   456 QWGGLTCDHYEEAKITCS 473
Cdd:pfam00530   81 PWGNHNCSHSEDAGVICS 98

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01

References:

Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

Functional characterization of the conserved domain architecture found on the query. Click here to see more details.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

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