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Conserved domains on  [gi|317373434|sp|Q8NB78|]
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RecName: Full=Lysine-specific histone demethylase 2; AltName: Full=Flavin-containing amine oxidase domain-containing protein 1; AltName: Full=Lysine-specific histone demethylase 1B

Protein Classification

lysine-specific histone demethylase 1B( domain architecture ID 13726372)

lysine-specific histone demethylase 1B (KDM1B) demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor

EC:  1.14.99.66
Gene Symbol:  KDM1B
Gene Ontology:  GO:0008270|GO:0050660|GO:0032452|GO:0042393|GO:0034720
PubMed:  23266887|23260659

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02328 super family cl33466
lysine-specific histone demethylase 1 homolog
 302-819 3.07e-97

lysine-specific histone demethylase 1 homolog


The actual alignment was detected with superfamily member PLN02328:

Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 321.17  E-value: 3.07e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 302 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LSVGADQYLLPKDY 380
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 381 HNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVwDDKSFKGVTV----GRGAQIVNGCINNPVALMCEQLGI 456
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV-KTMKMKGDGVvaaaDLGGSVLTGINGNPLGVLARQLGL 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 457 SMHKFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRK---DKTQLQDVPLGEKIEeiykAFIKESGIQFSELEG 533
Cdd:PLN02328 316 PLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQER 391

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 534 QVLQFHLSNLEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTT 613
Cdd:PLN02328 392 MLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG 470

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 614 dGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGL 693
Cdd:PLN02328 471 -GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGE 546

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 694 FAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELF--KEQEVPDPTKYFVTRWSTDPWIQMAYSFVK 771
Cdd:PLN02328 547 FFLFYSYSSVSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFhpKGIVVPDPVQAVCTRWGKDCFTYGSYSYVA 626

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 317373434 772 TGGSGEAYDIIAEDI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:PLN02328 627 VGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-191 4.42e-09

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 52.70  E-value: 4.42e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 317373434  138 YWVQCTKpeCRKWRQLTKEIQlTPQIAKTYRCGMKPNTAIKpetsdHCSLPEDL 191
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPDPKYN-----SCDAPEEI 46
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 302-819 3.07e-97

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 321.17  E-value: 3.07e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 302 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LSVGADQYLLPKDY 380
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 381 HNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVwDDKSFKGVTV----GRGAQIVNGCINNPVALMCEQLGI 456
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV-KTMKMKGDGVvaaaDLGGSVLTGINGNPLGVLARQLGL 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 457 SMHKFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRK---DKTQLQDVPLGEKIEeiykAFIKESGIQFSELEG 533
Cdd:PLN02328 316 PLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQER 391

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 534 QVLQFHLSNLEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTT 613
Cdd:PLN02328 392 MLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG 470

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 614 dGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGL 693
Cdd:PLN02328 471 -GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGE 546

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 694 FAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELF--KEQEVPDPTKYFVTRWSTDPWIQMAYSFVK 771
Cdd:PLN02328 547 FFLFYSYSSVSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFhpKGIVVPDPVQAVCTRWGKDCFTYGSYSYVA 626

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 317373434 772 TGGSGEAYDIIAEDI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:PLN02328 627 VGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 399-819 2.59e-76

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 254.72  E-value: 2.59e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  399 RQLHNFGIKVTVLEAKDRIGGRVWDDKsFKGVTVGRGAQIVNGCiNNPVALMCEQLGI----SMHKFGERCDLIQEGGRI 474
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLedrlVLPDPAPFYTVLFAGGRR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  475 tDPTIDKRMDFHFNALLDVVSEWR-KDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQ-----------VLQFHLSN 542
Cdd:pfam01593  86 -YPGDFRRVPAGWEGLLEFGRLLSiPEKLRLGLAALASDALDEFDLDDFSLAESLLFLGRRgpgdvevwdrlIDPELFAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  543 LEYACGSNLHQVSARS----WDHNEFFAQFAGDHTLLTPGYSVIIEKLAE---GLDIQLKSPVQCIDYSGDEVQVTTTDG 615
Cdd:pfam01593 165 LPFASGAFAGDPSELSaglaLPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTDG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  616 TGYSAQKVLVTVPLALLQkgAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDsKVQGADFFGHVPPSASKRGLFA 695
Cdd:pfam01593 245 EVIEADAVIVTVPLGVLK--RILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWP-DLGLLGLLSELLTGLGTAFSWL 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  696 VFYDMDPQKKHSVLMS-VIAGEAVASVRTLDDKQVLQQCMATLRELFKEqEVPDPTKYFVTRWSTDPWIQMAYSFVKTGG 774
Cdd:pfam01593 322 TFPNRAPPGKGLLLLVyVGPGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLPQYGP 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 317373434  775 SGEAYDIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:pfam01593 401 GHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
399-821 8.16e-75

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 250.61  E-value: 8.16e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 399 RQLHNFGIKVTVLEAKDRIGGRVW-DDKSFKGVTVGRGAQIVNGcinNPVALM--CEQLGISMHKFGERCD---LIQEGG 472
Cdd:COG1231   24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMRIPP---SHTNLLalARELGLPLEPFPNENGnalLYLGGK 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 473 RITDPTIDKRMDFHF-------NALLDVVSEWRKDKTQLQDVPLGEkieeiykaFIKESGIQFSelegqVLQFHLSNLEY 545
Cdd:COG1231  101 RVRAGEIAADLRGVAellakllRALAAALDPWAHPAAELDRESLAE--------WLRRNGASPS-----ARRLLGLLGAG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 546 ACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGL--DIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKV 623
Cdd:COG1231  168 EYGADPDELSLLDLLRYAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAV 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 624 LVTVPLALLQKgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSKRGLFAVFYDMD 701
Cdd:COG1231  248 IVTVPPSVLRR--IEFDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYPSN 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 702 PQ-KKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEqEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD 780
Cdd:COG1231  318 GPdGGAGVLLGYVGGDDARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGP 396

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 317373434 781 IIAEdIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAA 821
Cdd:COG1231  397 ALAE-PDGRIHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-191 4.42e-09

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 52.70  E-value: 4.42e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 317373434  138 YWVQCTKpeCRKWRQLTKEIQlTPQIAKTYRCGMKPNTAIKpetsdHCSLPEDL 191
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPDPKYN-----SCDAPEEI 46
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 405-776 3.06e-04

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 44.06  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  405 GIKVTVLEAKDRIGGRVWDDKSfKGVTVGRGAQIVNGcINNPVALMCEQLGIS----MHKFGERCDLIQEGGRITDPT-I 479
Cdd:TIGR00562  29 PVELTLVEASDRVGGKIQTVKE-DGYLIERGPDSFLE-RKKSAPDLVKDLGLEhvlvSDATGQRYVLVNRGKLMPVPTkI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  480 DKRMDFHFNAL---LDVVSEWRKDKTQLQDVPLG---------EKIEEIYKAFIkeSGIQFSELEGQVL-----QFHLSN 542
Cdd:TIGR00562 107 APFVKTGLFSLggkLRAGMDFIRPASPGKDESVEefvrrrfgdEVVENLIEPLL--SGIYAGDPSKLSLkstfpKFYQTE 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  543 LEYacGS---------NLHQvSARSWDHNEFFAQFAGdhtlltpGYSVIIEKLAEGLDIQLK-------SPVQCIDYSGD 606
Cdd:TIGR00562 185 QKH--GSlilgmkktrNLPQ-GSGLQLTAKKQGQDFQ-------TLATGLETLPEEIEKRLKltkvykgTKVTKLSHRGS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  607 EVQVTTTDGTGYSAQKVLVTVPlallQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGadfFGHVPP 686
Cdd:TIGR00562 255 NYTLELDNGVTVETDSVVVTAP----HKAAAGLLSELSNSASSHLDKIHSPPVANVNLGFPEGSVDGELEG---FGFLIS 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  687 SASKRGLFAVFYD------MDPQKKhSVLMSVIAGEAVASVRTLDDKQVLQqcmATLRELFKEQEVP-DPTKYFVTRWST 759
Cdd:TIGR00562 328 RSSKFAILGCIFTsklfpnRAPPGK-TLLTAYIGGATDESIVDLSENEIIN---IVLRDLKKVLNINnEPEMLCVTRWHR 403

                         410       420
                  ....*....|....*....|....*.
gi 317373434  760 ---------DPWIQMAYSFVKTGGSG 776
Cdd:TIGR00562 404 aipqyhvghDQRLKEARELLESAYPG 429
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 302-819 3.07e-97

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 321.17  E-value: 3.07e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 302 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LSVGADQYLLPKDY 380
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 381 HNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVwDDKSFKGVTV----GRGAQIVNGCINNPVALMCEQLGI 456
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV-KTMKMKGDGVvaaaDLGGSVLTGINGNPLGVLARQLGL 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 457 SMHKFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRK---DKTQLQDVPLGEKIEeiykAFIKESGIQFSELEG 533
Cdd:PLN02328 316 PLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQER 391

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 534 QVLQFHLSNLEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTT 613
Cdd:PLN02328 392 MLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG 470

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 614 dGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGL 693
Cdd:PLN02328 471 -GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGE 546

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 694 FAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELF--KEQEVPDPTKYFVTRWSTDPWIQMAYSFVK 771
Cdd:PLN02328 547 FFLFYSYSSVSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFhpKGIVVPDPVQAVCTRWGKDCFTYGSYSYVA 626

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 317373434 772 TGGSGEAYDIIAEDI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:PLN02328 627 VGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
PLN03000 PLN03000
amine oxidase
 307-820 1.89e-96

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 320.81  E-value: 1.89e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 307 YLALRNLILALWYTNCKEALTPQKCIphiivrGLVRIRCVQEVERILYFMTRKGLINTGVLSVGADQYllPKDYHNKSVI 386
Cdd:PLN03000 117 YILIRNHIISKWRENISSWVTKEMFL------GSIPKHCSSLLDSAYNYLVTHGYINFGIAQAIKDKF--PAQSSKSSVV 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 387 IIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDK---SFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGE 463
Cdd:PLN03000 189 IVGAGLSGLAAARQLMRFGFKVTVLEGRKRPGGRVYTKKmeaNRVGAAADLGGSVLTGTLGNPLGIIARQLGSSLYKVRD 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 464 RCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDKTQLQ-DVPLGEKIEeiykAFIKESGIQFSELEGQVLQFHLSN 542
Cdd:PLN03000 269 KCPLYRVDGKPVDPDVDLKVEVAFNQLLDKASKLRQLMGDVSmDVSLGAALE----TFRQVSGNDVATEEMGLFNWHLAN 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 543 LEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTTDGTgYSAQK 622
Cdd:PLN03000 345 LEYANAGLVSKLSLAFWDQDDPY-DMGGDHCFLPGGNGRLVQALAENVPILYEKTVQTIRYGSNGVKVIAGNQV-YEGDM 422

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 623 VLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGLFAVFYDMDP 702
Cdd:PLN03000 423 VLCTVPLGVLKNGSIKFVPELPQRKLDCIKRLGFGLLNKVAMLFPYVFWSTDL---DTFGHLTEDPNYRGEFFLFYSYAP 499

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 703 QKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEQ--EVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD 780
Cdd:PLN03000 500 VAGGPLLIALVAGEAAHKFETMPPTDAVTRVLHILRGIYEPQgiNVPDPLQTVCTRWGGDPFSLGSYSNVAVGASGDDYD 579

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|.
gi 317373434 781 IIAEDI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKIA 820
Cdd:PLN03000 580 ILAESVgDGRLFFAGEATTRRYPATMHGAFVTGLREAANMA 620
PLN02529 PLN02529
lysine-specific histone demethylase 1
 307-819 8.97e-96

lysine-specific histone demethylase 1


Pssm-ID: 178144 [Multi-domain]  Cd Length: 738  Bit Score: 315.29  E-value: 8.97e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 307 YLALRNLILALWYTNCKEALTpqkciphiivRGLVRIRCVQEVERILY----FMTRKGLINTGVLSVGADQylLPKDYHN 382
Cdd:PLN02529  93 YIVVRNHILARWRSNVGIWLS----------KGQIKETVSSEYEHLISaaydFLLYNGYINFGVSPSFASP--IPEEGTE 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 383 KSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDK-SFKG--VTVGRGAQIVNGCINNPVALMCEQLGISMH 459
Cdd:PLN02529 161 GSVIIVGAGLAGLAAARQLLSFGFKVVVLEGRNRPGGRVYTQKmGRKGqfAAVDLGGSVITGIHANPLGVLARQLSIPLH 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 460 KFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDKTQL-QDVPLGEKIEEIYKAFikesGIQFSELEGQVLQF 538
Cdd:PLN02529 241 KVRDNCPLYKPDGALVDKEIDSNIEFIFNKLLDKVTELRQIMGGFaNDISLGSVLERLRQLY----GVARSTEERQLLDW 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 539 HLSNLEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTTDGTgY 618
Cdd:PLN02529 317 HLANLEYANAGCLSDLSAAYWDQDDPY-EMGGDHCFLAGGNWRLINALCEGVPIFYGKTVDTIKYGNDGVEVIAGSQV-F 394

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 619 SAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGLFAVFY 698
Cdd:PLN02529 395 QADMVLCTVPLGVLKKRTIRFEPELPRRKLAAIDRLGFGLLNKVAMVFPSVFWGEEL---DTFGCLNESSNKRGEFFLFY 471

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 699 DMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELF--KEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSG 776
Cdd:PLN02529 472 GYHTVSGGPALVALVAGEAAQRFENTDPSTLLHRVLSVLRGIYnpKGINVPDPIQTICTRWGSDPLSYGSYSHVRVQSSG 551

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 317373434 777 EAYDIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:PLN02529 552 SDYDILAESVSGRLFFAGEATTRQYPATMHGAFLSGLREASRI 594
PLN02976 PLN02976
amine oxidase
 383-819 5.96e-83

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 291.00  E-value: 5.96e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  383 KSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDKSFKGVTVGRGAQIVNGC--------INNPVALMCEQL 454
Cdd:PLN02976  694 KKIIVVGAGPAGLTAARHLQRQGFSVTVLEARSRIGGRVYTDRSSLSVPVDLGASIITGVeadvaterRPDPSSLICAQL 773

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  455 GISMHKFGERCDL--IQEGGRITDpTIDKRMDFHFNALLD----VVSE-----------------------------WRK 499
Cdd:PLN02976  774 GLELTVLNSDCPLydVVTGEKVPA-DLDEALEAEYNSLLDdmvlLVAQkgehamkmsledgleyalkrrrmprpgvdIDE 852

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  500 DKTQLQDVPL--GEKIEEIYKAFIKESGIQF-SELEGQVLQFHLSNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLT 576
Cdd:PLN02976  853 TELGNAADDLydSASTGVDGGHCEKESKEDVlSPLERRVMNWHFAHLEYGCAALLKEVSLPYWNQDDVYGGFGGAHCMIK 932

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  577 PGYSVIIEKLAEGLDIQLKSPVQCIDYSGDE----------VQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEK 646
Cdd:PLN02976  933 GGYSNVVESLAEGLDIHLNHVVTDVSYGSKDagasgssrkkVKVSTSNGSEFLGDAVLITVPLGCLKAETIKFSPPLPDW 1012

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  647 KMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDD 726
Cdd:PLN02976 1013 KYSSIQRLGFGVLNKVVLEFPEVFWDDSV---DYFGATAEETDLRGQCFMFWNVKKTVGAPVLIALVVGKAAIDGQSMSS 1089

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  727 KQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIQGTVFFAGEATNRHFPQTVT 806
Cdd:PLN02976 1090 SDHVNHALMVLRKLFGEALVPDPVASVVTDWGRDPFSYGAYSYVAIGASGEDYDILGRPVENCLFFAGEATCKEHPDTVG 1169

                         490
                  ....*....|...
gi 317373434  807 GAYLSGVREASKI 819
Cdd:PLN02976 1170 GAMMSGLREAVRI 1182
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 399-819 2.59e-76

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 254.72  E-value: 2.59e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  399 RQLHNFGIKVTVLEAKDRIGGRVWDDKsFKGVTVGRGAQIVNGCiNNPVALMCEQLGI----SMHKFGERCDLIQEGGRI 474
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLedrlVLPDPAPFYTVLFAGGRR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  475 tDPTIDKRMDFHFNALLDVVSEWR-KDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQ-----------VLQFHLSN 542
Cdd:pfam01593  86 -YPGDFRRVPAGWEGLLEFGRLLSiPEKLRLGLAALASDALDEFDLDDFSLAESLLFLGRRgpgdvevwdrlIDPELFAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  543 LEYACGSNLHQVSARS----WDHNEFFAQFAGDHTLLTPGYSVIIEKLAE---GLDIQLKSPVQCIDYSGDEVQVTTTDG 615
Cdd:pfam01593 165 LPFASGAFAGDPSELSaglaLPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTDG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  616 TGYSAQKVLVTVPLALLQkgAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDsKVQGADFFGHVPPSASKRGLFA 695
Cdd:pfam01593 245 EVIEADAVIVTVPLGVLK--RILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWP-DLGLLGLLSELLTGLGTAFSWL 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  696 VFYDMDPQKKHSVLMS-VIAGEAVASVRTLDDKQVLQQCMATLRELFKEqEVPDPTKYFVTRWSTDPWIQMAYSFVKTGG 774
Cdd:pfam01593 322 TFPNRAPPGKGLLLLVyVGPGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLPQYGP 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 317373434  775 SGEAYDIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:pfam01593 401 GHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
399-821 8.16e-75

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 250.61  E-value: 8.16e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 399 RQLHNFGIKVTVLEAKDRIGGRVW-DDKSFKGVTVGRGAQIVNGcinNPVALM--CEQLGISMHKFGERCD---LIQEGG 472
Cdd:COG1231   24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMRIPP---SHTNLLalARELGLPLEPFPNENGnalLYLGGK 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 473 RITDPTIDKRMDFHF-------NALLDVVSEWRKDKTQLQDVPLGEkieeiykaFIKESGIQFSelegqVLQFHLSNLEY 545
Cdd:COG1231  101 RVRAGEIAADLRGVAellakllRALAAALDPWAHPAAELDRESLAE--------WLRRNGASPS-----ARRLLGLLGAG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 546 ACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGL--DIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKV 623
Cdd:COG1231  168 EYGADPDELSLLDLLRYAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAV 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 624 LVTVPLALLQKgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSKRGLFAVFYDMD 701
Cdd:COG1231  248 IVTVPPSVLRR--IEFDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYPSN 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 702 PQ-KKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEqEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD 780
Cdd:COG1231  318 GPdGGAGVLLGYVGGDDARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGP 396

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 317373434 781 IIAEdIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAA 821
Cdd:COG1231  397 ALAE-PDGRIHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
PLN02268 PLN02268
probable polyamine oxidase
 384-819 3.55e-70

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 237.66  E-value: 3.55e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 384 SVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDKSFkGVTVGRGAQIVNG-CINNPVALMCEQLGISMHKFG 462
Cdd:PLN02268   2 SVIVIGGGIAGIAAARALHDASFKVTLLESRDRIGGRVHTDYSF-GFPVDMGASWLHGvCNENPLAPLIGRLGLPLYRTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 463 -----------ERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDktQLQDVPLGEKIEEIYK--AFIKESGIQFs 529
Cdd:PLN02268  81 gdnsvlydhdlESYALFDMDGNQVPQELVTKVGETFERILEETEKVRDE--HEEDMSLLQAISIVLErhPELRLEGLAH- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 530 elegQVLQFHLSNLEYACGSNLHQVSARSWDHNEFFAqfaGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQ 609
Cdd:PLN02268 158 ----EVLQWYLCRMEGWFAADADTISLKSWDQEELLE---GGHGLMVRGYDPVINTLAKGLDIRLNHRVTKIVRRYNGVK 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 610 VTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSkvqgADFFGHVPPSAS 689
Cdd:PLN02268 231 VTVEDGTTFVADAAIIAVPLGVLKANIIKFEPELPEWKEEAISDLGVGIENKIALHFDSVFWPN----VEFLGVVAPTSY 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 690 KRGLfavFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKeqEVPDPTKYFVTRWSTDPWIQMAYSF 769
Cdd:PLN02268 307 GCSY---FLNLHKATGHPVLVYMPAGRLARDIEKLSDEAAANFAMSQLKKMLP--DATEPVQYLVSRWGSDPNSLGCYSY 381

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 317373434 770 VKTGGSGEAYDIIAEDIqGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:PLN02268 382 DLVGKPHDLYERLRAPV-DNLFFAGEATSSDFPGSVHGAYSTGVMAAEEC 430
PLN02676 PLN02676
polyamine oxidase
 384-819 7.49e-42

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 159.88  E-value: 7.49e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 384 SVIIIGAGPAGLAAARQLHNFGIK-VTVLEAKDRIGGRVwDDKSFKGVTVGRGA---QIVNGCINNPVALMCEQLGISMh 459
Cdd:PLN02676  28 SVIIVGAGMSGISAAKTLSEAGIEdILILEATDRIGGRM-RKANFAGVSVELGAnwvEGVGGPESNPIWELANKLKLRT- 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 460 kFGERCDLI------QEGGRITDPTIDKRMDfhfnaLLDVVSEW------RKDKTQLQDVPLgEKIEEIYKAFIKesgiq 527
Cdd:PLN02676 106 -FYSDFDNLssniykQDGGLYPKKVVQKSMK-----VADASDEFgenlsiSLSAKKAVDISI-LTAQRLFGQVPK----- 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 528 fSELEgQVLQFHLSNLEYAcgSNLHQVSARSWDHNEFFAQFAGDHTLLTP--GYSVIIEKLAEG---------LD--IQL 594
Cdd:PLN02676 174 -TPLE-MVIDYYNYDYEFA--EPPRVTSLKNTEPNPTFVDFGEDEYFVADprGYESLVYYLAEQflstksgkiTDprLKL 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 595 KSPVQCIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSK 674
Cdd:PLN02676 250 NKVVREISYSKNGVTVKTEDGSVYRAKYVIVSVSLGVLQSDLIKFKPPLPDWKIEAIYQFDMAVYTKIFLKFPYKFWPSG 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 675 vQGADFFGHvppSASKRGLFAVFYDMDPQKKHS--VLMSVIAGEAvASVRTLDDKQVLQQCMATLRELFKEQeVPDPTKY 752
Cdd:PLN02676 330 -PGTEFFLY---AHERRGYYPFWQHLENEYPGSnvLFVTVTDEES-RRIEQQPDSETKAEIMEVLRKMFGPN-IPEATDI 403

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 317373434 753 FVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIqGTVFFAGEATNRHFPQTVTGAYLSGVrEASKI 819
Cdd:PLN02676 404 LVPRWWSNRFFKGSYSNWPIGVSRYEFDQIRAPV-GRVYFTGEHTSEKYNGYVHGAYLAGI-DTAND 468
PLN02568 PLN02568
polyamine oxidase
 407-819 9.93e-39

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 151.91  E-value: 9.93e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 407 KVTVLEAKDRIGGRVwDDKSFKGVTVGRGAQIVNGCINNPV--------ALMCEQLGISMHKFGERCDLIQEGGRITDPT 478
Cdd:PLN02568  35 ELTVVEGGDRIGGRI-NTSEFGGERIEMGATWIHGIGGSPVykiaqeagSLESDEPWECMDGFPDRPKTVAEGGFEVDPS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 479 IDKRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIE----------------------EIYKAFIKE-------SGIQFS 529
Cdd:PLN02568 114 IVESISTLFRGLMDDAQGKLIEPSEVDEVDFVKLAAkaarvcesggggsvgsflrrglDAYWDSVSAdeqikgyGGWSRK 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 530 ELEGQVLQFHlSNLE--YACGSNLHQVSarsWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLD---IQLKSPVQCIDYS 604
Cdd:PLN02568 194 LLEEAIFTMH-ENTQrtYTSADDLSTLD---LAAESEYRMFPGEEITIAKGYLSVIEALASVLPpgtIQLGRKVTRIEWQ 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 605 GDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQ----FNPPLSEKKMKAINSLGAGIIEKIALQFPYRFwDSKVQGAD- 679
Cdd:PLN02568 270 DEPVKLHFADGSTMTADHVIVTVSLGVLKAGIGEdsglFSPPLPDFKTDAISRLGFGVVNKLFVELSPRP-DGSPEDVAk 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 680 -------FFGHVPPSASK------RGLFAVFydmdP-QKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEQE 745
Cdd:PLN02568 349 fpflqmaFHRSDSEARHDkipwwmRRTASIC----PiHKNSSVLLSWFAGKEALELEKLSDEEIIRGVQTTLSSFLKRRV 424

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 746 VPDP---------------------TKYFVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIQGT------------VFF 792
Cdd:PLN02568 425 AGLGsqshplcnggassndgsrwkfVKVLKSKWGTDPLFLGSYSYVAVGSSGDDLDRMAEPLPRIsdhdqaggpplqLLF 504

                        490       500
                 ....*....|....*....|....*..
gi 317373434 793 AGEATNRHFPQTVTGAYLSGVREASKI 819
Cdd:PLN02568 505 AGEATHRTHYSTTHGAYFSGLREANRL 531
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-191 4.42e-09

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 52.70  E-value: 4.42e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 317373434  138 YWVQCTKpeCRKWRQLTKEIQlTPQIAKTYRCGMKPNTAIKpetsdHCSLPEDL 191
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPDPKYN-----SCDAPEEI 46
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 394-757 4.79e-08

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 56.38  E-value: 4.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 394 GLAAARQLHNFGIKVTVLEAKDRIGGRVwddKSF--KGVTVGRGAQIVngCINNPVAL-MCEQLGIS--MHKFGERCDLI 468
Cdd:COG1232   13 GLTAAYRLAKAGHEVTVLEASDRVGGLI---RTVevDGFRIDRGPHSF--LTRDPEVLeLLRELGLGdeLVWPNTRKSYI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 469 QEGGRITD-PTidKRMDFHFNALLDVVSEWR-------KDKTQLQDVPLGEKI-----EEIYKAFIKE--SGIqFS---- 529
Cdd:COG1232   88 YYGGKLHPlPQ--GPLALLRSPLLSLAGKLRallellaPRRPPGEDESLAEFVrrrfgREVYERLVEPllEGV-YAgdpd 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 530 ELEGQ-VLQFhLSNLEYACGSNLHQVSA--RSWDHNEFFAQFAGdhtlltpGYSVIIEKLAEGL---DIQLKSPVQCIDY 603
Cdd:COG1232  165 ELSADwAFPR-LKRLELEHGSLIKGALAlrKGAKAGEVFGYLRG-------GLGTLVEALAEALeagEIRLGTRVTAIER 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 604 SGDEVQVTTTDGTGYSAQKVLVTVPLALLQKgAIQFNPPLSEKKMKAINSLGAGIiekIALQFPyrfwDSKVQGADFFGH 683
Cdd:COG1232  237 EGGGWRVTTSDGETIEADAVVSATPAPALAR-LLAPLPPEVAAALAGIPYASVAV---VALGFD----RPDLPPPDGFGW 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 684 VPPSASKRGLFAVFY------DMDPQKKHSVLMSvIAGEAVASVRTLDDKQVLQQCMATLRELFKEQevPDPTKYFVTRW 757
Cdd:COG1232  309 LVPRDEGVPILAVTFssnkwpHRAPDGKVLLRLE-VGGAGDPELWQLSDEELVALALADLRKLLGID--AEPVDTRVVRW 385
PRK07233 PRK07233
hypothetical protein; Provisional
 578-656 2.81e-07

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 53.74  E-value: 2.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434 578 GYSVIIEKLAE-----GLDIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKgaiqFNPPLSEK---KMK 649
Cdd:PRK07233 196 GFATLIDALAEaiearGGEIRLGTPVTSVVIDGGGVTGVEVDGEEEDFDAVISTAPPPILAR----LVPDLPADvlaRLR 271


                 ....*..
gi 317373434 650 AINSLGA 656
Cdd:PRK07233 272 RIDYQGV 278
SWIRM pfam04433
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ...
 292-363 5.35e-05

SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.


Pssm-ID: 461307 [Multi-domain]  Cd Length: 78  Bit Score: 42.16  E-value: 5.35e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 317373434  292 DELYEFPEY----SRDPTMYLALRNLILALWYTNCKEALTPQKCiphiivRGLVRIrCVQEVERILYFMTRKGLIN 363
Cdd:pfam04433   9 IEKRLLPEFfngkSKTPEVYLEIRNFILNLWRENPKEYLTKTDA------RRALKG-DVNLISRIHEFLERWGLIN 77
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 405-776 3.06e-04

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 44.06  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  405 GIKVTVLEAKDRIGGRVWDDKSfKGVTVGRGAQIVNGcINNPVALMCEQLGIS----MHKFGERCDLIQEGGRITDPT-I 479
Cdd:TIGR00562  29 PVELTLVEASDRVGGKIQTVKE-DGYLIERGPDSFLE-RKKSAPDLVKDLGLEhvlvSDATGQRYVLVNRGKLMPVPTkI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  480 DKRMDFHFNAL---LDVVSEWRKDKTQLQDVPLG---------EKIEEIYKAFIkeSGIQFSELEGQVL-----QFHLSN 542
Cdd:TIGR00562 107 APFVKTGLFSLggkLRAGMDFIRPASPGKDESVEefvrrrfgdEVVENLIEPLL--SGIYAGDPSKLSLkstfpKFYQTE 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  543 LEYacGS---------NLHQvSARSWDHNEFFAQFAGdhtlltpGYSVIIEKLAEGLDIQLK-------SPVQCIDYSGD 606
Cdd:TIGR00562 185 QKH--GSlilgmkktrNLPQ-GSGLQLTAKKQGQDFQ-------TLATGLETLPEEIEKRLKltkvykgTKVTKLSHRGS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  607 EVQVTTTDGTGYSAQKVLVTVPlallQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGadfFGHVPP 686
Cdd:TIGR00562 255 NYTLELDNGVTVETDSVVVTAP----HKAAAGLLSELSNSASSHLDKIHSPPVANVNLGFPEGSVDGELEG---FGFLIS 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373434  687 SASKRGLFAVFYD------MDPQKKhSVLMSVIAGEAVASVRTLDDKQVLQqcmATLRELFKEQEVP-DPTKYFVTRWST 759
Cdd:TIGR00562 328 RSSKFAILGCIFTsklfpnRAPPGK-TLLTAYIGGATDESIVDLSENEIIN---IVLRDLKKVLNINnEPEMLCVTRWHR 403

                         410       420
                  ....*....|....*....|....*.
gi 317373434  760 ---------DPWIQMAYSFVKTGGSG 776
Cdd:TIGR00562 404 aipqyhvghDQRLKEARELLESAYPG 429
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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