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Conserved domains on  [gi|47116746|sp|Q9CPU4|]
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RecName: Full=Glutathione S-transferase 3, mitochondrial; AltName: Full=Glutathione peroxidase MGST3; AltName: Full=LTC4 synthase MGST3

Protein Classification

MAPEG family protein( domain architecture ID 10471516)

MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family protein is a membrane associated protein; similar to mammalian prostaglandin E synthase, leukotriene C4 synthase, arachidonate 5-lipoxygenase-activating protein, microsomal glutathione S-transferases, and mitochondrial glutathione S-transferase 3

CATH:  1.20.120.550
Gene Ontology:  GO:0016020
PubMed:  10091672|10673221

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 11-130 1.99e-24

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


:

Pssm-ID: 460074  Cd Length: 127  Bit Score: 91.21  E-value: 1.99e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47116746    11 VLLTGAASFVMVLHLAINVGKARKKYKV---EYPVMYSTDPENGHMFNCIQRAHQNTLEVYPPFLFFLTVGGV--YHPRI 85
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVgdgGANPERALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLtgGSPGL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 47116746    86 ASGLGLAWIIGRVLYAYGYYTGDPSKRYRG-AVGSLALFALMGTTV 130
Cdd:pfam01124  81 AALLAWAYVVARVLHALGYATGNPPLRSLGfLLGFLALLALAVLAL 126
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 11-130 1.99e-24

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 91.21  E-value: 1.99e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47116746    11 VLLTGAASFVMVLHLAINVGKARKKYKV---EYPVMYSTDPENGHMFNCIQRAHQNTLEVYPPFLFFLTVGGV--YHPRI 85
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVgdgGANPERALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLtgGSPGL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 47116746    86 ASGLGLAWIIGRVLYAYGYYTGDPSKRYRG-AVGSLALFALMGTTV 130
Cdd:pfam01124  81 AALLAWAYVVARVLHALGYATGNPPLRSLGfLLGFLALLALAVLAL 126
YecN COG3788
Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];
12-127 2.66e-10

Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];


Pssm-ID: 443002  Cd Length: 131  Bit Score: 54.86  E-value: 2.66e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47116746  12 LLTGAASFVMVLHLAINVGKARKKYKVEYPvmystDPENGHMFNCIqRAHQNTLEVYPPFLFFLTVGGVYHPRIA--SGL 89
Cdd:COG3788   7 ALYAALLALLLLVLSLRVVRLRRKYRVALG-----DGGDPELQRAI-RAHGNFVEYVPLALILLLLLELNGAPAWwlHLL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 47116746  90 GLAWIIGRVLYAYGYYTGDPSKRYR--GAVGS-LALFALMG 127
Cdd:COG3788  81 GIALLLGRLLHAYGLSRSKGPSPGRaiGMLLTfLVLLALAV 121
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 11-130 1.99e-24

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 91.21  E-value: 1.99e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47116746    11 VLLTGAASFVMVLHLAINVGKARKKYKV---EYPVMYSTDPENGHMFNCIQRAHQNTLEVYPPFLFFLTVGGV--YHPRI 85
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVgdgGANPERALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLtgGSPGL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 47116746    86 ASGLGLAWIIGRVLYAYGYYTGDPSKRYRG-AVGSLALFALMGTTV 130
Cdd:pfam01124  81 AALLAWAYVVARVLHALGYATGNPPLRSLGfLLGFLALLALAVLAL 126
YecN COG3788
Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];
12-127 2.66e-10

Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];


Pssm-ID: 443002  Cd Length: 131  Bit Score: 54.86  E-value: 2.66e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47116746  12 LLTGAASFVMVLHLAINVGKARKKYKVEYPvmystDPENGHMFNCIqRAHQNTLEVYPPFLFFLTVGGVYHPRIA--SGL 89
Cdd:COG3788   7 ALYAALLALLLLVLSLRVVRLRRKYRVALG-----DGGDPELQRAI-RAHGNFVEYVPLALILLLLLELNGAPAWwlHLL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 47116746  90 GLAWIIGRVLYAYGYYTGDPSKRYR--GAVGS-LALFALMG 127
Cdd:COG3788  81 GIALLLGRLLHAYGLSRSKGPSPGRaiGMLLTfLVLLALAV 121
COG3686 COG3686
Uncharacterized conserved protein, MAPEG superfamily [Function unknown];
58-126 2.65e-04

Uncharacterized conserved protein, MAPEG superfamily [Function unknown];


Pssm-ID: 442902  Cd Length: 130  Bit Score: 38.64  E-value: 2.65e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47116746  58 QRAHQNTLEVYPPF---LFFLTVGGVYHPRIAsGLGLAWIIGRVLYAYGYYTGDPSKR---YrgAVGSLALFALM 126
Cdd:COG3686  54 NRAQQNAFEALPLFaaaVLVAHLTGASSATTA-LLAIAFLAARVLYVPAYLAGLPPLRslvW--AVGFLCTVALF 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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