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Conserved domains on  [gi|21759471|sp|Q9CQU5|]
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RecName: Full=ZW10 interactor; AltName: Full=ZW10-interacting protein 1; Short=Zwint-1

Protein Classification

ZW10 interactor( domain architecture ID 710300)

ZW10 interactor (ZWINT) is involved in kinetochore formation and spindle checkpoint activity. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochore.

Gene Ontology:  GO:0007093|GO:0000776
PubMed:  21775627|15824131

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zwint super family cl25779
ZW10 interactor; This family of proteins is found in eukaryotes. Proteins in this family are ...
 35-236 4.82e-72

ZW10 interactor; This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 281 amino acids in length.


The actual alignment was detected with superfamily member pfam15556:

Pssm-ID: 464766 [Multi-domain]  Cd Length: 252  Bit Score: 220.62  E-value: 4.82e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471    35 QEEAELPAKIMEEFMRNSRKKDKLLCSQLQVVNFLQTFLAQEDTEQSPDALASEDASRQKATETKEQWKDMKATYMDHVD 114
Cdd:pfam15556   1 QEEAELPAQILAEFVMDSRKKDKLLCSQLQVVDFLQNFLAQEDTAQGLDPLASEDTSRQKAIAAKEQWKELKATYQEHVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471   115 VIKCALSEALPQVKEAHRKYTELQKAFEQLEAKKRVLEEKLQLAQKQWVLQQ-KRLQNLTKISAEVKRRRKRALEKLDGS 193
Cdd:pfam15556  81 AITSALTQALPKMEEAQRKRAQLQEALEQLQAKKQMAMEKLRTAQKQWQLQQeKHLQHLAEVSAEVRERQTGTQQELERL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 21759471   194 HQELETLKQQAGQEQEKLQRNQSYLQLLCSLQNKLVISEGKAE 236
Cdd:pfam15556 161 YQELGTLKQQAGQERDKLQRHQTFLQLLYTLQGKLLFPEAEAE 203
 
Name Accession Description Interval E-value
Zwint pfam15556
ZW10 interactor; This family of proteins is found in eukaryotes. Proteins in this family are ...
 35-236 4.82e-72

ZW10 interactor; This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 281 amino acids in length.


Pssm-ID: 464766 [Multi-domain]  Cd Length: 252  Bit Score: 220.62  E-value: 4.82e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471    35 QEEAELPAKIMEEFMRNSRKKDKLLCSQLQVVNFLQTFLAQEDTEQSPDALASEDASRQKATETKEQWKDMKATYMDHVD 114
Cdd:pfam15556   1 QEEAELPAQILAEFVMDSRKKDKLLCSQLQVVDFLQNFLAQEDTAQGLDPLASEDTSRQKAIAAKEQWKELKATYQEHVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471   115 VIKCALSEALPQVKEAHRKYTELQKAFEQLEAKKRVLEEKLQLAQKQWVLQQ-KRLQNLTKISAEVKRRRKRALEKLDGS 193
Cdd:pfam15556  81 AITSALTQALPKMEEAQRKRAQLQEALEQLQAKKQMAMEKLRTAQKQWQLQQeKHLQHLAEVSAEVRERQTGTQQELERL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 21759471   194 HQELETLKQQAGQEQEKLQRNQSYLQLLCSLQNKLVISEGKAE 236
Cdd:pfam15556 161 YQELGTLKQQAGQERDKLQRHQTFLQLLYTLQGKLLFPEAEAE 203
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 126-215 5.75e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 5.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471 126 QVKEAHRKYTELQKAFEQLEAKKRVLEEKLQLAQKQWVLQQKRLQNLTKISAEVKRRRKRALEKLDGSHQELETLKQQAG 205
Cdd:COG1196 254 ELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELE 333

                        90
                ....*....|
gi 21759471 206 QEQEKLQRNQ 215
Cdd:COG1196 334 ELEEELEELE 343
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 75-238 1.76e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 1.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471     75 QEDTEQSPDALASEDASRQKATETKEQWKDMKAT---YMDHVDVIKCALSEALPQVKEAHRKYTELQKAFEQLEAKKRVL 151
Cdd:TIGR02168  708 EELEEELEQLRKELEELSRQISALRKDLARLEAEveqLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEEL 787

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471    152 EEKLQLAQKQWVLQQKRLQNLTKISAEVKRRRKRALEKLDGSHQELETLKQQAGQEQEKLQRNQSYLQLLCSLQNKLVIS 231
Cdd:TIGR02168  788 EAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEEL 867


                   ....*..
gi 21759471    232 EGKAEDK 238
Cdd:TIGR02168  868 IEELESE 874
COG6 smart01087
Conserved oligomeric complex COG6; COG6 is a component of the conserved oligomeric golgi ...
 126-215 6.58e-03

Conserved oligomeric complex COG6; COG6 is a component of the conserved oligomeric golgi complex, which is composed of eight different subunits and is required for normal golgi morphology and localisation.


Pssm-ID: 215018  Cd Length: 598  Bit Score: 37.69  E-value: 6.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471    126 QVKEAHRKYTELQKAFEQLEAKKRVLEEKLQLAQ---KQWVLQQKRLQNLTKISAEVKRRRKRALEKLDGSHQELETL-- 200
Cdd:smart01087  54 QLNTAKNQTQDLISEASELQEELALLELKKKLLDaflSKFTLSQDELDVLTSREGPIDDEFFQVLDKVQEIHEDCSVLlq 133

                           90
                   ....*....|....*...
gi 21759471    201 --KQQAGQE-QEKLQRNQ 215
Cdd:smart01087 134 neYQTAGLEiMEKMNQLL 151
 
Name Accession Description Interval E-value
Zwint pfam15556
ZW10 interactor; This family of proteins is found in eukaryotes. Proteins in this family are ...
 35-236 4.82e-72

ZW10 interactor; This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 281 amino acids in length.


Pssm-ID: 464766 [Multi-domain]  Cd Length: 252  Bit Score: 220.62  E-value: 4.82e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471    35 QEEAELPAKIMEEFMRNSRKKDKLLCSQLQVVNFLQTFLAQEDTEQSPDALASEDASRQKATETKEQWKDMKATYMDHVD 114
Cdd:pfam15556   1 QEEAELPAQILAEFVMDSRKKDKLLCSQLQVVDFLQNFLAQEDTAQGLDPLASEDTSRQKAIAAKEQWKELKATYQEHVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471   115 VIKCALSEALPQVKEAHRKYTELQKAFEQLEAKKRVLEEKLQLAQKQWVLQQ-KRLQNLTKISAEVKRRRKRALEKLDGS 193
Cdd:pfam15556  81 AITSALTQALPKMEEAQRKRAQLQEALEQLQAKKQMAMEKLRTAQKQWQLQQeKHLQHLAEVSAEVRERQTGTQQELERL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 21759471   194 HQELETLKQQAGQEQEKLQRNQSYLQLLCSLQNKLVISEGKAE 236
Cdd:pfam15556 161 YQELGTLKQQAGQERDKLQRHQTFLQLLYTLQGKLLFPEAEAE 203
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 126-215 5.75e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 5.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471 126 QVKEAHRKYTELQKAFEQLEAKKRVLEEKLQLAQKQWVLQQKRLQNLTKISAEVKRRRKRALEKLDGSHQELETLKQQAG 205
Cdd:COG1196 254 ELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELE 333

                        90
                ....*....|
gi 21759471 206 QEQEKLQRNQ 215
Cdd:COG1196 334 ELEEELEELE 343
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 75-238 1.76e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 1.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471     75 QEDTEQSPDALASEDASRQKATETKEQWKDMKAT---YMDHVDVIKCALSEALPQVKEAHRKYTELQKAFEQLEAKKRVL 151
Cdd:TIGR02168  708 EELEEELEQLRKELEELSRQISALRKDLARLEAEveqLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEEL 787

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471    152 EEKLQLAQKQWVLQQKRLQNLTKISAEVKRRRKRALEKLDGSHQELETLKQQAGQEQEKLQRNQSYLQLLCSLQNKLVIS 231
Cdd:TIGR02168  788 EAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEEL 867


                   ....*..
gi 21759471    232 EGKAEDK 238
Cdd:TIGR02168  868 IEELESE 874
COG6 smart01087
Conserved oligomeric complex COG6; COG6 is a component of the conserved oligomeric golgi ...
 126-215 6.58e-03

Conserved oligomeric complex COG6; COG6 is a component of the conserved oligomeric golgi complex, which is composed of eight different subunits and is required for normal golgi morphology and localisation.


Pssm-ID: 215018  Cd Length: 598  Bit Score: 37.69  E-value: 6.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471    126 QVKEAHRKYTELQKAFEQLEAKKRVLEEKLQLAQ---KQWVLQQKRLQNLTKISAEVKRRRKRALEKLDGSHQELETL-- 200
Cdd:smart01087  54 QLNTAKNQTQDLISEASELQEELALLELKKKLLDaflSKFTLSQDELDVLTSREGPIDDEFFQVLDKVQEIHEDCSVLlq 133

                           90
                   ....*....|....*...
gi 21759471    201 --KQQAGQE-QEKLQRNQ 215
Cdd:smart01087 134 neYQTAGLEiMEKMNQLL 151
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 86-238 6.64e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 37.74  E-value: 6.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471     86 ASEDASRQKATETKEQWKDMKATYMDHVDVIKCALSEALPQVKEAHRKYTELQKAFEQLEAKKRVLEEKL-QLAQKQWVL 164
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLeELEEDLSSL 749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471    165 QQKRLQN---LTKISAEVKRRR------KRALEKL--DGSHQELETLKQQAGQEQEKLQRNQSYLQLLCSLQNKLVISEG 233
Cdd:TIGR02169  750 EQEIENVkseLKELEARIEELEedlhklEEALNDLeaRLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKE 829


                   ....*
gi 21759471    234 KAEDK 238
Cdd:TIGR02169  830 YLEKE 834
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 119-221 8.91e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 37.34  E-value: 8.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759471    119 ALSEALPQVKEAHRKYTELQKAFEQLEAKKRVLEEKLQLAQKQWVLQQKRLQNLTKISAEVKRRRKRALEKLDGSHQELE 198
Cdd:TIGR02168  247 ELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLE 326

                           90       100
                   ....*....|....*....|...
gi 21759471    199 TLKQQAGQEQEKLQRNQSYLQLL 221
Cdd:TIGR02168  327 ELESKLDELAEELAELEEKLEEL 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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