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Conserved domains on  [gi|1723905638|gb|QEE14913|]
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carbonic anhydrase [Candidatus Prometheoarchaeum syntrophicum]

Protein Classification

carbonic anhydrase( domain architecture ID 10658772)

carbonic anhydrase (CA) catalyzes the zinc-dependent reversible hydration of carbon dioxide into bicarbonate and a proton

CATH:  3.40.1050.10
EC:  4.2.1.1
Gene Ontology:  GO:0004089|GO:0008270
PubMed:  11696553|9336012

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 43-193 5.95e-35

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


:

Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 120.30  E-value: 5.95e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638   43 RAVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNII---TLDVLRSILVAIYELDAKFIVIMGHTECGM---AILDNENKI 116
Cdd:smart00947   7 KALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIVppyDDGVLASLEYAVEVLGVKEIVVCGHTDCGAvkaALDDEPGLI 86

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1723905638  117 DHLKEKLGDKLLETLEKIGNKDPLDWfgffnqgkwnENAKEQAKSIQKFLD-ENIPKENQPEIITMLYNLESGEVEFI 193
Cdd:smart00947  87 DNWLERIRPARERALEELGDVDALEE----------LNVRDQVENLRTSPAiREAVAKGKLKVHGWVYDIETGKLEVL 154
 
Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 43-193 5.95e-35

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 120.30  E-value: 5.95e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638   43 RAVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNII---TLDVLRSILVAIYELDAKFIVIMGHTECGM---AILDNENKI 116
Cdd:smart00947   7 KALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIVppyDDGVLASLEYAVEVLGVKEIVVCGHTDCGAvkaALDDEPGLI 86

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1723905638  117 DHLKEKLGDKLLETLEKIGNKDPLDWfgffnqgkwnENAKEQAKSIQKFLD-ENIPKENQPEIITMLYNLESGEVEFI 193
Cdd:smart00947  87 DNWLERIRPARERALEELGDVDALEE----------LNVRDQVENLRTSPAiREAVAKGKLKVHGWVYDIETGKLEVL 154
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 44-190 3.66e-30

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 108.37  E-value: 3.66e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  44 AVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNIIT---LDVLRSILVAIYELDAKFIVIMGHTECGM---AILDNENK-- 115
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFDTGPGDLFVVRNAGNLVPpydLNVLASIEYAVEVLKVKHIVVCGHSGCGAvkaALDAAGPAel 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638 116 ---IDHLKEKLGD---KLLETLEKIGNKDPLDWFgffnQGKwnENAKEQAKSIQKF--LDENIpKENQPEIITMLYNLES 187
Cdd:pfam00484  81 pgfIDNWLRHIRPaveRVAEELESLDDPEERDDA----LEE--LNVREQVENLRTFpiVREAV-AKGKLKIHGWVYDLET 153


                  ...
gi 1723905638 188 GEV 190
Cdd:pfam00484 154 GEV 156
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 43-193 1.89e-28

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 102.58  E-value: 1.89e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  43 RAVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNIIT---LDVLRSILVAIYELDAKFIVIMGHTECGMAILDNEnkidhl 119
Cdd:cd00382     4 KALIIGCSDSRVPPELIFGLGPGDLFVVRNAGNLVPpydLDVLASLEYAVEVLGVKHIIVCGHTDCGAVKALVE------ 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1723905638 120 keklgdklletlekignkdpldwfgffnqgkwnENAKEQAKSIQK--FLDENIpKENQPEIITMLYNLESGEVEFI 193
Cdd:cd00382    78 ---------------------------------ENVREQVENLRShpLIQEAV-APGELKVHGWVYDIETGKLEVL 119
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
43-193 1.11e-24

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 95.23  E-value: 1.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  43 RAVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNII---TLDVLRSILVAIYELDAKFIVIMGHTECGM--AILDNENK-- 115
Cdd:COG0288    36 FALVIGCSDSRVPPELIFDQGPGDLFVVRNAGNVVppyDPGVLASIEYAVEVLGVKLIVVLGHSGCGAvkAALDGLELee 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638 116 ---IDHLKEKLGDKLLETLEKIGNKDPLDWFGFFNQgkwnENAKEQAKSIQKF--LDENIpKENQPEIITMLYNLESGEV 190
Cdd:COG0288   116 lglIGNWLRHIRPAVERVRAELPAADGEERLDRLVE----LNVREQVENLRTSpiVREAV-AAGKLKVHGWVYDLATGRV 190


                  ...
gi 1723905638 191 EFI 193
Cdd:COG0288   191 EFL 193
PRK15219 PRK15219
carbonic anhydrase; Provisional
 44-193 3.92e-14

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 68.32  E-value: 3.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  44 AVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNIITLDVLRSILVAIYELDAKFIVIMGHTECGM---AILDNE-----NK 115
Cdd:PRK15219   92 AVILSCIDSRAPAEIILDTGIGETFNSRVAGNISNDDLLGSMEFACAVAGAKVVLVMGHTACGAvkgAIDNVElgnltGL 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638 116 IDHLKEKLGDKLLETLEKIGNKDPLDWFGffnqgkwNENAKEQAKSIQKF--LDENIPKENQPEIITMLYNLESGEVEFI 193
Cdd:PRK15219  172 LDRIKPAIEVTEFDGERSSKNYKFVDAVA-------RKNVELTIENIRKNspILRKLEQEGKIKIVGSMYNLNGGKVEFF 244
 
Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 43-193 5.95e-35

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 120.30  E-value: 5.95e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638   43 RAVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNII---TLDVLRSILVAIYELDAKFIVIMGHTECGM---AILDNENKI 116
Cdd:smart00947   7 KALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIVppyDDGVLASLEYAVEVLGVKEIVVCGHTDCGAvkaALDDEPGLI 86

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1723905638  117 DHLKEKLGDKLLETLEKIGNKDPLDWfgffnqgkwnENAKEQAKSIQKFLD-ENIPKENQPEIITMLYNLESGEVEFI 193
Cdd:smart00947  87 DNWLERIRPARERALEELGDVDALEE----------LNVRDQVENLRTSPAiREAVAKGKLKVHGWVYDIETGKLEVL 154
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 44-190 3.66e-30

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 108.37  E-value: 3.66e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  44 AVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNIIT---LDVLRSILVAIYELDAKFIVIMGHTECGM---AILDNENK-- 115
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFDTGPGDLFVVRNAGNLVPpydLNVLASIEYAVEVLKVKHIVVCGHSGCGAvkaALDAAGPAel 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638 116 ---IDHLKEKLGD---KLLETLEKIGNKDPLDWFgffnQGKwnENAKEQAKSIQKF--LDENIpKENQPEIITMLYNLES 187
Cdd:pfam00484  81 pgfIDNWLRHIRPaveRVAEELESLDDPEERDDA----LEE--LNVREQVENLRTFpiVREAV-AKGKLKIHGWVYDLET 153


                  ...
gi 1723905638 188 GEV 190
Cdd:pfam00484 154 GEV 156
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 43-193 1.89e-28

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 102.58  E-value: 1.89e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  43 RAVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNIIT---LDVLRSILVAIYELDAKFIVIMGHTECGMAILDNEnkidhl 119
Cdd:cd00382     4 KALIIGCSDSRVPPELIFGLGPGDLFVVRNAGNLVPpydLDVLASLEYAVEVLGVKHIIVCGHTDCGAVKALVE------ 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1723905638 120 keklgdklletlekignkdpldwfgffnqgkwnENAKEQAKSIQK--FLDENIpKENQPEIITMLYNLESGEVEFI 193
Cdd:cd00382    78 ---------------------------------ENVREQVENLRShpLIQEAV-APGELKVHGWVYDIETGKLEVL 119
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
43-193 1.11e-24

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 95.23  E-value: 1.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  43 RAVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNII---TLDVLRSILVAIYELDAKFIVIMGHTECGM--AILDNENK-- 115
Cdd:COG0288    36 FALVIGCSDSRVPPELIFDQGPGDLFVVRNAGNVVppyDPGVLASIEYAVEVLGVKLIVVLGHSGCGAvkAALDGLELee 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638 116 ---IDHLKEKLGDKLLETLEKIGNKDPLDWFGFFNQgkwnENAKEQAKSIQKF--LDENIpKENQPEIITMLYNLESGEV 190
Cdd:COG0288   116 lglIGNWLRHIRPAVERVRAELPAADGEERLDRLVE----LNVREQVENLRTSpiVREAV-AAGKLKVHGWVYDLATGRV 190


                  ...
gi 1723905638 191 EFI 193
Cdd:COG0288   191 EFL 193
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 43-171 4.08e-24

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 92.31  E-value: 4.08e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  43 RAVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNIITLDVLRSILVAIYELDAKFIVIMGHTECGMAILDNENkidhLKEK 122
Cdd:cd03379     4 KLAIVTCMDARLDPEKALGLKLGDAKVIRNAGGRVTDDAIRSLVVSVYLLGTREIIVIHHTDCGMLTFTDEE----LKEK 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1723905638 123 LGDKLLeTLEKIGNKDPLDWFGFFNQgkwNENAKEQAKSIQK--FLDENIP 171
Cdd:cd03379    80 MKERGI-AEAYGGIDKEFWFLGFDDL---EESVREDVERIRNhpLIPDDVP 126
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 44-193 1.77e-22

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 88.35  E-value: 1.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  44 AVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNIITLDVLRSILVAIYELDAKFIVIMGHTECG-----MAILDNENKIDH 118
Cdd:cd03378    41 AVILSCSDSRVPPEIIFDQGLGDLFVVRVAGNIVDDDVLGSLEYAVEVLGVPLVVVLGHESCGavaaaAVRANVKATVAK 120

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1723905638 119 LKEKlgDKLLETLEkignkdpldwfgffnqgkwnenakeqaksiqkfldenipKENQPEIITMLYNLESGEVEFI 193
Cdd:cd03378   121 LRSR--SPIIAELV---------------------------------------AAGKLKIVGAYYDLDTGKVEFL 154
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 16-141 1.62e-15

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 71.03  E-value: 1.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  16 QFKEFLLKRNKEWIKK-KDGSSIingslRAVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNII--------TLDVLRSIL 86
Cdd:cd00884     4 RFRKEYFPEERELFEKlAKGQSP-----KALFIACSDSRVVPALITQTQPGELFVVRNVGNLVppyepdggFHGTSAAIE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1723905638  87 VAIYELDAKFIVIMGHTECG-----MAILDNENKIDHLKE--KLGDKLLETLEKIGNKDPLD 141
Cdd:cd00884    79 YAVAVLKVEHIVVCGHSDCGgiralLSPEDLLDKLPFIGKwlRIAEPAKEVVLAELSHADFD 140
PRK15219 PRK15219
carbonic anhydrase; Provisional
 44-193 3.92e-14

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 68.32  E-value: 3.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  44 AVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNIITLDVLRSILVAIYELDAKFIVIMGHTECGM---AILDNE-----NK 115
Cdd:PRK15219   92 AVILSCIDSRAPAEIILDTGIGETFNSRVAGNISNDDLLGSMEFACAVAGAKVVLVMGHTACGAvkgAIDNVElgnltGL 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638 116 IDHLKEKLGDKLLETLEKIGNKDPLDWFGffnqgkwNENAKEQAKSIQKF--LDENIPKENQPEIITMLYNLESGEVEFI 193
Cdd:PRK15219  172 LDRIKPAIEVTEFDGERSSKNYKFVDAVA-------RKNVELTIENIRKNspILRKLEQEGKIKIVGSMYNLNGGKVEFF 244
beta_CA_cladeA cd00883
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 48-190 1.48e-13

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238448  Cd Length: 182  Bit Score: 65.66  E-value: 1.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  48 GCIDSRVPIEKIFQAKPGELLVLKNAGNIITLDVLRSILV---AIYELDAKFIVIMGHTECG--MAILDN------ENKI 116
Cdd:cd00883    31 GCSDSRVPENTILGLLPGEVFVHRNIANLVSPTDLNCLSVlqyAVDVLKVKHIIVCGHYGCGgvKAALTGkrlgllDNWL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638 117 DHLKEkLGDKLLETLEKIGNKDPldwfgffnqgKWN----ENAKEQAKSIQKF--LDENIPKENQPEIITMLYNLESGEV 190
Cdd:cd00883   111 RPIRD-VYRLHAAELDALEDEEE----------RVDrlveLNVVEQVKNLCKTpiVQDAWKRGQELEVHGWVYDLGDGLL 179
PRK10437 PRK10437
carbonic anhydrase; Provisional
 19-112 2.82e-09

carbonic anhydrase; Provisional


Pssm-ID: 182460  Cd Length: 220  Bit Score: 54.55  E-value: 2.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  19 EFLLKRNKEW---IKKKDGSSIINGSL----RAVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNIIT---LDVLRSILVA 88
Cdd:PRK10437    5 DTLISNNALWskmLVEEDPGFFEKLAQaqkpRFLWIGCSDSRVPAERLTGLEPGELFVHRNVANLVIhtdLNCLSVVQYA 84

                          90       100
                  ....*....|....*....|....*.
gi 1723905638  89 IYELDAKFIVIMGHTECG--MAILDN 112
Cdd:PRK10437   85 VDVLEVEHIIICGHYGCGgvQAAVEN 110
PLN02154 PLN02154
carbonic anhydrase
 2-114 1.29e-07

carbonic anhydrase


Pssm-ID: 215111  Cd Length: 290  Bit Score: 50.52  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638   2 DNSIDILDKQisKSQFKEFLLKRNKEWIKKKDGSSIINgSLRAVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNIIT--- 78
Cdd:PLN02154   70 ETSYDFLDEM--RHRFLKFKRQKYLPEIEKFKALAIAQ-SPKVMVIGCADSRVCPSYVLGFQPGEAFTIRNVANLVTpvq 146

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1723905638  79 ---LDVLRSILVAIYELDAKFIVIMGHTECG--MAILDNEN 114
Cdd:PLN02154  147 ngpTETNSALEFAVTTLQVENIIVMGHSNCGgiAALMSHQN 187
PLN00416 PLN00416
carbonate dehydratase
 45-112 4.22e-05

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 42.71  E-value: 4.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  45 VVLGCIDSRVPIEKIFQAKPGELLVLKNAGNIIT-------LDVLRSILVAIYELDAKFIVIMGHTECG-----MAILDN 112
Cdd:PLN00416   83 LVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPpfdqkrhSGVGAAVEYAVVHLKVENILVIGHSCCGgikglMSIEDD 162
PLN03014 PLN03014
carbonic anhydrase
 41-121 6.45e-05

carbonic anhydrase


Pssm-ID: 178588 [Multi-domain]  Cd Length: 347  Bit Score: 42.41  E-value: 6.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  41 SLRAVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNII-TLDVLR------SILVAIYELDAKFIVIMGHTECG-----MA 108
Cdd:PLN03014  159 SPKYMVFACSDSRVCPSHVLDFQPGDAFVVRNIANMVpPFDKVKyggvgaAIEYAVLHLKVENIVVIGHSACGgikglMS 238

                          90
                  ....*....|....
gi 1723905638 109 I-LDNENKIDHLKE 121
Cdd:PLN03014  239 FpLDGNNSTDFIED 252
PLN03019 PLN03019
carbonic anhydrase
 41-121 6.10e-04

carbonic anhydrase


Pssm-ID: 166660  Cd Length: 330  Bit Score: 39.74  E-value: 6.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  41 SLRAVVLGCIDSRVPIEKIFQAKPGELLVLKNAGNII-TLDVLR------SILVAIYELDAKFIVIMGHTECG-----MA 108
Cdd:PLN03019  154 SPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVpPFDKVKyagvgaAIEYAVLHLKVENIVVIGHSACGgikglMS 233

                          90
                  ....*....|....
gi 1723905638 109 I-LDNENKIDHLKE 121
Cdd:PLN03019  234 FpLDGNNSTDFIED 247
PLN03006 PLN03006
carbonate dehydratase
 45-117 3.85e-03

carbonate dehydratase


Pssm-ID: 178583  Cd Length: 301  Bit Score: 37.03  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723905638  45 VVLGCIDSRVPIEKIFQAKPGELLVLKNAGNII------TLDVLRSILVAIYELDAKFIVIMGHTECG--MAILDNENKI 116
Cdd:PLN03006  116 LVIACADSRVCPSAVLGFQPGDAFTVRNIANLVppyesgPTETKAALEFSVNTLNVENILVIGHSRCGgiQALMKMEDEG 195


                  .
gi 1723905638 117 D 117
Cdd:PLN03006  196 D 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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