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Conserved domains on  [gi|1802592431|gb|QHR22154|]
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peptide chain release factor 1 [Mycoplasmoides pneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 3-359 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


:

Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 585.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431   3 FDKQFFSSVEKIVELAEQLEKDLNKPDLTFEQIKAINKELKHKQPLVV--KFKEFKRLIDQALEAEAILENNeLKELHDE 80
Cdd:TIGR00019   1 MKPSLLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIvdCYREYQQAQEDIKEAKEILEES-DPEMREM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  81 AKKELERVRSVVPEYEEALKLLLLPIDENNQKNVIVELRPAAGGDESCIFLADLFNMYRNFCTNKGWKLQINEM-IPSSV 159
Cdd:TIGR00019  80 AKEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSAnETELG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 160 GLNFVSFEVNGVDVFAKLKFESGVHRVQRVPATESKGRVHTSTVTVAVLPQLEAVEVHINPADLRVDTYRASGAGGQHVN 239
Cdd:TIGR00019 160 GYKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 240 RTESAVRITHLPTGIVVSCQEGKSQFTNRDTAMKMLRAKLWEKAQNEQLSTQAGLRKSQVGSGDRAEKIRTYNYPQNRVT 319
Cdd:TIGR00019 240 TTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVT 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1802592431 320 DHRIKLTVNKLNTIILGDLDEIIEALQADEKKQQLENFFS 359
Cdd:TIGR00019 320 DHRINLTLYKLDEVLEGDLDELIEALIAEDQAQQLAALSE 359
 
Name Accession Description Interval E-value
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 3-359 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 585.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431   3 FDKQFFSSVEKIVELAEQLEKDLNKPDLTFEQIKAINKELKHKQPLVV--KFKEFKRLIDQALEAEAILENNeLKELHDE 80
Cdd:TIGR00019   1 MKPSLLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIvdCYREYQQAQEDIKEAKEILEES-DPEMREM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  81 AKKELERVRSVVPEYEEALKLLLLPIDENNQKNVIVELRPAAGGDESCIFLADLFNMYRNFCTNKGWKLQINEM-IPSSV 159
Cdd:TIGR00019  80 AKEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSAnETELG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 160 GLNFVSFEVNGVDVFAKLKFESGVHRVQRVPATESKGRVHTSTVTVAVLPQLEAVEVHINPADLRVDTYRASGAGGQHVN 239
Cdd:TIGR00019 160 GYKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 240 RTESAVRITHLPTGIVVSCQEGKSQFTNRDTAMKMLRAKLWEKAQNEQLSTQAGLRKSQVGSGDRAEKIRTYNYPQNRVT 319
Cdd:TIGR00019 240 TTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVT 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1802592431 320 DHRIKLTVNKLNTIILGDLDEIIEALQADEKKQQLENFFS 359
Cdd:TIGR00019 320 DHRINLTLYKLDEVLEGDLDELIEALIAEDQAQQLAALSE 359
prfA PRK00591
peptide chain release factor 1; Validated
 5-356 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 541.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431   5 KQFFSSVEKIVELAEQLEKDLNKPDLT--FEQIKAINKELKHKQPLVVKFKEFKRLIDQALEAEAILENNELKELHDEAK 82
Cdd:PRK00591    2 PSMLDKLEALEERYEELEALLSDPEVIsdQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  83 KELERVRSVVPEYEEALKLLLLPIDENNQKNVIVELRPAAGGDESCIFLADLFNMYRNFCTNKGWKLQINEMIPSSV-GL 161
Cdd:PRK00591   82 EELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELgGY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 162 NFVSFEVNGVDVFAKLKFESGVHRVQRVPATESKGRVHTSTVTVAVLPQLEAVEVHINPADLRVDTYRASGAGGQHVNRT 241
Cdd:PRK00591  162 KEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 242 ESAVRITHLPTGIVVSCQEGKSQFTNRDTAMKMLRAKLWEKAQNEQLSTQAGLRKSQVGSGDRAEKIRTYNYPQNRVTDH 321
Cdd:PRK00591  242 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDH 321

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1802592431 322 RIKLTVNKLNTIILGDLDEIIEALQADEKKQQLEN 356
Cdd:PRK00591  322 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAA 356
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 7-356 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 540.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431   7 FFSSVEKIVELAEQLEKDLNKPDLT--FEQIKAINKELKHKQPLVVKFKEFKRLIDQALEAEAILENNELKELHDEAKKE 84
Cdd:COG0216     2 MLDKLEALEERYEELEALLSDPEVIsdQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  85 LERVRSVVPEYEEALKLLLLPIDENNQKNVIVELRPAAGGDESCIFLADLFNMYRNFCTNKGWKLQINEMIPSSV-GLNF 163
Cdd:COG0216    82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELgGYKE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 164 VSFEVNGVDVFAKLKFESGVHRVQRVPATESKGRVHTSTVTVAVLPQLEAVEVHINPADLRVDTYRASGAGGQHVNRTES 243
Cdd:COG0216   162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 244 AVRITHLPTGIVVSCQEGKSQFTNRDTAMKMLRAKLWEKAQNEQLSTQAGLRKSQVGSGDRAEKIRTYNYPQNRVTDHRI 323
Cdd:COG0216   242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1802592431 324 KLTVNKLNTIILGDLDEIIEALQADEKKQQLEN 356
Cdd:COG0216   322 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAA 354
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 19-205 3.66e-76

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 233.04  E-value: 3.66e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  19 EQLEKDLNKPDLTF--EQIKAINKELKHKQPLVVKFKEFKRLIDQALEAEAILENNELKELhdeAKKELERVRSVVPEYE 96
Cdd:pfam03462   6 EELEALLSDPDVWDdqKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLEDPELAEL---AEEELEELEKRLEELE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  97 EALKLLLLPIDENNQKNVIVELRPAAGGDESCIFLADLFNMYRNFCTNKGWKLQINEMIPSSV-GLNFVSFEVNGVDVFA 175
Cdd:pfam03462  83 EELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAgGIKEATFEISGEGAYG 162

                         170       180       190
                  ....*....|....*....|....*....|
gi 1802592431 176 KLKFESGVHRVQRVPATESKGRVHTSTVTV 205
Cdd:pfam03462 163 RLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
68-180 1.50e-34

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 122.96  E-value: 1.50e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431   68 ILENNELKELHDEAKKELERVRSVV-PEYEEALKLLLLPIDENNQKNVIVELRPAAGGDESCIFLADLFNMYRNFCTNKG 146
Cdd:smart00937   2 LLEEEEDDEMRELAEEELEELEAELeEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKG 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1802592431  147 WKLQINEMIPSSV-GLNFVSFEVNGVDVFAKLKFE 180
Cdd:smart00937  82 WKVEVLDESEGELgGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 3-359 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 585.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431   3 FDKQFFSSVEKIVELAEQLEKDLNKPDLTFEQIKAINKELKHKQPLVV--KFKEFKRLIDQALEAEAILENNeLKELHDE 80
Cdd:TIGR00019   1 MKPSLLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIvdCYREYQQAQEDIKEAKEILEES-DPEMREM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  81 AKKELERVRSVVPEYEEALKLLLLPIDENNQKNVIVELRPAAGGDESCIFLADLFNMYRNFCTNKGWKLQINEM-IPSSV 159
Cdd:TIGR00019  80 AKEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSAnETELG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 160 GLNFVSFEVNGVDVFAKLKFESGVHRVQRVPATESKGRVHTSTVTVAVLPQLEAVEVHINPADLRVDTYRASGAGGQHVN 239
Cdd:TIGR00019 160 GYKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 240 RTESAVRITHLPTGIVVSCQEGKSQFTNRDTAMKMLRAKLWEKAQNEQLSTQAGLRKSQVGSGDRAEKIRTYNYPQNRVT 319
Cdd:TIGR00019 240 TTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVT 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1802592431 320 DHRIKLTVNKLNTIILGDLDEIIEALQADEKKQQLENFFS 359
Cdd:TIGR00019 320 DHRINLTLYKLDEVLEGDLDELIEALIAEDQAQQLAALSE 359
prfA PRK00591
peptide chain release factor 1; Validated
 5-356 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 541.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431   5 KQFFSSVEKIVELAEQLEKDLNKPDLT--FEQIKAINKELKHKQPLVVKFKEFKRLIDQALEAEAILENNELKELHDEAK 82
Cdd:PRK00591    2 PSMLDKLEALEERYEELEALLSDPEVIsdQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  83 KELERVRSVVPEYEEALKLLLLPIDENNQKNVIVELRPAAGGDESCIFLADLFNMYRNFCTNKGWKLQINEMIPSSV-GL 161
Cdd:PRK00591   82 EELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELgGY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 162 NFVSFEVNGVDVFAKLKFESGVHRVQRVPATESKGRVHTSTVTVAVLPQLEAVEVHINPADLRVDTYRASGAGGQHVNRT 241
Cdd:PRK00591  162 KEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 242 ESAVRITHLPTGIVVSCQEGKSQFTNRDTAMKMLRAKLWEKAQNEQLSTQAGLRKSQVGSGDRAEKIRTYNYPQNRVTDH 321
Cdd:PRK00591  242 DSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDH 321

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1802592431 322 RIKLTVNKLNTIILGDLDEIIEALQADEKKQQLEN 356
Cdd:PRK00591  322 RINLTLYKLDEVMEGDLDELIDALIAEDQAEKLAA 356
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 7-356 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 540.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431   7 FFSSVEKIVELAEQLEKDLNKPDLT--FEQIKAINKELKHKQPLVVKFKEFKRLIDQALEAEAILENNELKELHDEAKKE 84
Cdd:COG0216     2 MLDKLEALEERYEELEALLSDPEVIsdQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  85 LERVRSVVPEYEEALKLLLLPIDENNQKNVIVELRPAAGGDESCIFLADLFNMYRNFCTNKGWKLQINEMIPSSV-GLNF 163
Cdd:COG0216    82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELgGYKE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 164 VSFEVNGVDVFAKLKFESGVHRVQRVPATESKGRVHTSTVTVAVLPQLEAVEVHINPADLRVDTYRASGAGGQHVNRTES 243
Cdd:COG0216   162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 244 AVRITHLPTGIVVSCQEGKSQFTNRDTAMKMLRAKLWEKAQNEQLSTQAGLRKSQVGSGDRAEKIRTYNYPQNRVTDHRI 323
Cdd:COG0216   242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1802592431 324 KLTVNKLNTIILGDLDEIIEALQADEKKQQLEN 356
Cdd:COG0216   322 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAA 354
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 10-344 4.88e-81

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 251.62  E-value: 4.88e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  10 SVEKIVELAEQLEKDLNKPDLTFEQIKA--INKELKHKQPLVVKFKEFKRLIDQALEAEAILENNELKELHDEAKKELER 87
Cdd:TIGR00020  24 DPEKKKARLEELEKEMEDPNFWNDQERAqaVIKERSSLEAVLDTLEELKNSLEDLSELLELAVEEDDEETFNELDAELKA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  88 VRSVVPEYEeaLKLLLlpIDENNQKNVIVELRPAAGGDESCIFLADLFNMYRNFCTNKGWKLQINEMIPSSV-GLNFVSF 166
Cdd:TIGR00020 104 LEKKLAELE--LRTML--SGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEaGIKSVTI 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 167 EVNGVDVFAKLKFESGVHRVQRVPATESKGRVHTSTVTVAVLPQL-EAVEVHINPADLRVDTYRASGAGGQHVNRTESAV 245
Cdd:TIGR00020 180 LIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVdDDIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAV 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 246 RITHLPTGIVVSCQEGKSQFTNRDTAMKMLRAKLWEKAQNEQLSTQAGLR--KSQVGSGDraeKIRTYNY-PQNRVTDHR 322
Cdd:TIGR00020 260 RITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEgeKSEIGWGS---QIRSYVLhPYSMVKDLR 336

                         330       340
                  ....*....|....*....|..
gi 1802592431 323 IKLTVNKLNTIILGDLDEIIEA 344
Cdd:TIGR00020 337 TGYETGNVQAVLDGDIDQFIEA 358
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 19-205 3.66e-76

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 233.04  E-value: 3.66e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  19 EQLEKDLNKPDLTF--EQIKAINKELKHKQPLVVKFKEFKRLIDQALEAEAILENNELKELhdeAKKELERVRSVVPEYE 96
Cdd:pfam03462   6 EELEALLSDPDVWDdqKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLEDPELAEL---AEEELEELEKRLEELE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  97 EALKLLLLPIDENNQKNVIVELRPAAGGDESCIFLADLFNMYRNFCTNKGWKLQINEMIPSSV-GLNFVSFEVNGVDVFA 175
Cdd:pfam03462  83 EELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAgGIKEATFEISGEGAYG 162

                         170       180       190
                  ....*....|....*....|....*....|
gi 1802592431 176 KLKFESGVHRVQRVPATESKGRVHTSTVTV 205
Cdd:pfam03462 163 RLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 66-344 3.23e-65

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 209.13  E-value: 3.23e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  66 EAILENNELKELHdEAKKELERVRSVVPEYE------EALKLLLLPIDENNQKNVIVELRPAAGGDESCIFLADLFNMYR 139
Cdd:PRK08787   14 SGLADAGELLDLA-ESEQDEDTALAVIADLDkyqahvEKLEFQRMFSGQMDGANAFVDIQAGAGGTEAQDWAEILLRMYL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 140 NFCTNKGWKLQINEMIPSSV-GLNFVSFEVNGVDVFAKLKFESGVHRVQRVPATESKGRVHTSTVTVAVLPQLE-AVEVH 217
Cdd:PRK08787   93 RWAESRGWKTELMEVSGGEVaGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEVDdNIEID 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 218 INPADLRVDTYRASGAGGQHVNRTESAVRITHLPTGIVVSCQEGKSQFTNRDTAMKMLRAKLWE----KAQNEQLSTQAg 293
Cdd:PRK08787  173 INPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYElevqKRNAEKDALEA- 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1802592431 294 lRKSQVGSGdraEKIRTYNYPQNRVTDHRIKLTVNKLNTIILGDLDEIIEA 344
Cdd:PRK08787  252 -TKSDIGWG---SQIRNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVEA 298
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 38-344 5.65e-62

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 201.19  E-value: 5.65e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  38 INKELKHKQPLVVKFKEFKRLIDQALEAEAILENNElKELHDEAKKELERVRSVVpeyeEALKLLLLPIDENNQKNVIVE 117
Cdd:PRK05589   16 ITSEEKYLKDKLDKYNHLRNRIEDIEVLCEMMSEED-DEMKKEIISEVKNIKEEI----DRFKIETLLSGEYDRNNAILT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 118 LRPAAGGDESCIFLADLFNMYRNFCTNKGWKLQINEMIPS-SVGLNFVSFEVNGVDVFAKLKFESGVHRVQRVPATESKG 196
Cdd:PRK05589   91 LHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGdEAGIKSVTLKITGEFAYGYLKAEKGIHRLVRISPFNANG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 197 RVHTSTVTVAVLPQL-EAVEVHINPADLRVDTYRASGAGGQHVNRTESAVRITHLPTGIVVSCQEGKSQFTNRDTAMKML 275
Cdd:PRK05589  171 KRQTSFASVEVLPELtDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAMKML 250

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1802592431 276 RAKLW---EKAQNEQLSTQAGLRKsQVGSGDraeKIRTYNY-PQNRVTDHRIKLTVNKLNTIILGDLDEIIEA 344
Cdd:PRK05589  251 KSKLVelkERAHKEKIEDLTGELK-DMGWGS---QIRSYVFhPYNLVKDHRTGVETSNVDSVMDGDIDNFITQ 319
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 212-322 6.74e-59

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 185.70  E-value: 6.74e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 212 EAVEVHINPADLRVDTYRASGAGGQHVNRTESAVRITHLPTGIVVSCQEGKSQFTNRDTAMKMLRAKLweKAQNEQLSTQ 291
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARL--YELEEEKEEE 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1802592431 292 AGLR-KSQVGSGDRAEKIRTYNY-PQNRVTDHR 322
Cdd:pfam00472  79 KKRRiKSQVGSGDRSEQIRTYNFkPQSRVKDHR 111
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 36-344 1.30e-58

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 192.64  E-value: 1.30e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  36 KAINKELKHKQPLVVKFKEFKRLIDQALEAEAILENNELKELHDEAKKELERVRSVVPEYEEALkLLLLPIDENNqknVI 115
Cdd:PRK06746   14 QAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMNEYELQL-LLSDPYDKNN---AI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 116 VELRPAAGGDESCIFLADLFNMYRNFCTNKGWKLQINEMIP-SSVGLNFVSFEVNGVDVFAKLKFESGVHRVQRVPATES 194
Cdd:PRK06746   90 LELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPgDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 195 KGRVHTSTVTVAVLPQL-EAVEVHINPADLRVDTYRASGAGGQHVNRTESAVRITHLPTGIVVSCQEGKSQFTNRDTAMK 273
Cdd:PRK06746  170 SGRRHTSFVSCEVVPEFnDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMK 249

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1802592431 274 MLRAKLWEKAQNEQLSTQAGLRKSQ--VGSGdraEKIRTYNY-PQNRVTDHRIKLTVNKLNTIILGDLDEIIEA 344
Cdd:PRK06746  250 MLKAKLYQKKLEEQQAELDEIRGEQkeIGWG---SQIRSYVFhPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDA 320
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 57-344 1.33e-54

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 182.39  E-value: 1.33e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431  57 RLIDQALEaeailENNELKELHDEakkelERVRSVVPEYEEALKLLLLPID----------ENNQKNVIVELRPAAGGDE 126
Cdd:PRK07342   33 NHLEQTLN-----DNIELIAMGEE-----EGDKSIVEDAEKTIRDLKDEIDrrqidallsgEADANDTYLEVHAGAGGTE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 127 SCIFLADLFNMYRNFCTNKGWKLQINEMIP-SSVGLNFVSFEVNGVDVFAKLKFESGVHRVQRVPATESKGRVHTSTVTV 205
Cdd:PRK07342  103 SQDWASMLLRMYTRWAERQGRKVEVLEVHDgEEAGIKSATILVKGHNAYGWLKTESGVHRLVRISPYDSNARRHTSFASI 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 206 AVLPQLE-AVEVHINPADLRVDTYRASGAGGQHVNRTESAVRITHLPTGIVVSCQEGKSQFTNRDTAMKMLRAKLWEK-- 282
Cdd:PRK07342  183 WVYPVIDdNIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAKAWSMLRARLYEEel 262

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1802592431 283 AQNEQLSTQAGLRKSQVGSGdraEKIRTYNY-PQNRVTDHRIKLTVNKLNTIILGDLDEIIEA 344
Cdd:PRK07342  263 KKREEATNAAAASKTDIGWG---HQIRSYVLqPYQLVKDLRTGVESTNPQDVLDGDLNEFMEA 322
PCRF smart00937
This domain is found in peptide chain release factors;
68-180 1.50e-34

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 122.96  E-value: 1.50e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431   68 ILENNELKELHDEAKKELERVRSVV-PEYEEALKLLLLPIDENNQKNVIVELRPAAGGDESCIFLADLFNMYRNFCTNKG 146
Cdd:smart00937   2 LLEEEEDDEMRELAEEELEELEAELeEELEELLKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKG 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1802592431  147 WKLQINEMIPSSV-GLNFVSFEVNGVDVFAKLKFE 180
Cdd:smart00937  82 WKVEVLDESEGELgGIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 215-322 4.94e-33

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 119.85  E-value: 4.94e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 215 EVHINPADLRVDTYRASGAGGQHVNRTESAVRITH------------LPTGIVVSCQEGKSQFTNRDTAMKMLRAKLWE- 281
Cdd:COG1186    20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEa 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1802592431 282 -KAQNEQLSTQAgLRKSQVgsgDRAE--KIRtynypqNRVTDHR 322
Cdd:COG1186   100 eLEPKERRATKP-TRGSKK---RRLWgkQIR------SMVKDLR 133
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 114-314 4.26e-23

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 95.22  E-value: 4.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 114 VIVELRPAAGGDESCIFLADLFNMYRNFCTNKGWKLQINEMIPS-------SVglnFVSFEVNGVDVFAKlKFESGVHRV 186
Cdd:TIGR03072   1 ILLQLSSAQGPAECCLAVAKALERLTREAAARGVRVEVLEQEPGevpgtlrSA---LVSLDGEAAAALAD-RWEGTLLWI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 187 QRVPATESKGRvHTSTVTVAVLPQLEavevHINPADLRVDTYRASGAGGQHVNRTESAVRITHLPTGIVVSCQEGKSQFT 266
Cdd:TIGR03072  77 CPSPYRPHHRR-KNWFIGVQRFSASE----EATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHA 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1802592431 267 NRDTAMKMLRAKLwEKAQNEQLSTQAGLRKSQVGSGDRAEKIRTYNYP 314
Cdd:TIGR03072 152 NKRLATLLLAVRL-ADLQQEQAAALRAERRTAHHQIERGNPVRVFKGE 198
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
216-277 1.52e-07

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 49.77  E-value: 1.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802592431 216 VHINPADLRVDTYRASGAGGQHVNRTESAV------RITHLP---------------TG---IVVSCQEGKSQFTNRDTA 271
Cdd:PRK09256    8 LVIPENELEWRFIRASGPGGQNVNKVSTAVelrfdiAASSLPefykerllalaghriTKdgvIVIKAQEFRSQERNREDA 87


                  ....*.
gi 1802592431 272 MKMLRA 277
Cdd:PRK09256   88 LERLVA 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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