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Conserved domains on  [gi|1484219890|gb|RJV93567|]
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PTS lactose/cellobiose transporter subunit IIA [Erysipelotrichaceae bacterium AF19-24AC]

Protein Classification

PTS lactose/cellobiose transporter subunit IIA( domain architecture ID 10491527)

PTS lactose/cellobiose transporter subunit IIA helps catalyze the phosphorylation of incoming sugar substrates leading to their translocation across the cell membrane; similar to Bacillus subtilis Lichenan-specific phosphotransferase enzyme IIA component

CATH:  1.20.58.280
Gene Ontology:  GO:0009401|GO:0016740
TCDB:  4.A.3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTS_IIA pfam02255
PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar ...
 10-103 6.81e-24

PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


:

Pssm-ID: 460510  Cd Length: 94  Bit Score: 87.10  E-value: 6.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484219890  10 NLSMNMILLAGNAREKIMKALTACEARNFITADSCLQAALSEIEEAHILQTETVQKEAMEQEYYYSMLFTHAQDTLMTIQ 89
Cdd:pfam02255   1 EIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKAQTELIQKEAGGEKVEVSLLLVHAQDHLMTAM 80

                          90
                  ....*....|....
gi 1484219890  90 SEYNIALHLVAILK 103
Cdd:pfam02255  81 TEKDLAKELIELYK 94
 
Name Accession Description Interval E-value
PTS_IIA pfam02255
PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar ...
 10-103 6.81e-24

PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 460510  Cd Length: 94  Bit Score: 87.10  E-value: 6.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484219890  10 NLSMNMILLAGNAREKIMKALTACEARNFITADSCLQAALSEIEEAHILQTETVQKEAMEQEYYYSMLFTHAQDTLMTIQ 89
Cdd:pfam02255   1 EIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKAQTELIQKEAGGEKVEVSLLLVHAQDHLMTAM 80

                          90
                  ....*....|....
gi 1484219890  90 SEYNIALHLVAILK 103
Cdd:pfam02255  81 TEKDLAKELIELYK 94
CelC COG1447
Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and ...
 9-103 2.65e-23

Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 441056  Cd Length: 100  Bit Score: 85.57  E-value: 2.65e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484219890   9 NNLSMNMILLAGNAREKIMKALTACEARNFITADSCLQAALSEIEEAHILQTETVQKEAMEQEYYYSMLFTHAQDTLMTI 88
Cdd:COG1447     1 EEIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKVQTELIQKEAGGEKVEVSLLLVHAQDHLMTA 80

                          90
                  ....*....|....*
gi 1484219890  89 QSEYNIALHLVAILK 103
Cdd:COG1447    81 MTEKDLAKELIELYK 95
PTS_IIA_lac cd00215
PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial ...
 8-103 9.73e-22

PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 238133  Cd Length: 97  Bit Score: 81.87  E-value: 9.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484219890   8 LNNLSMNMILLAGNAREKIMKALTACEARNFITADSCLQAALSEIEEAHILQTETVQKEAMEQEYYYSMLFTHAQDTLMT 87
Cdd:cd00215     1 LELISFQIILHAGNARSKALEALKAAKEGDFAEAEELLEEANDSLNEAHHAQTKLLQQEASGEKVEVSLLLVHAQDHLMT 80

                          90
                  ....*....|....*.
gi 1484219890  88 IQSEYNIALHLVAILK 103
Cdd:cd00215    81 TITLKDLAKEMIELYK 96
EIIA-LAC TIGR00823
phosphotransferase system enzyme II, lactose-specific, factor III; The PTS Lactose-N,N? ...
 11-103 1.99e-16

phosphotransferase system enzyme II, lactose-specific, factor III; The PTS Lactose-N,N?-Diacetylchitobiose-b-glucoside (Lac) Family (TC 4.A.3)Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Lac family includes several sequenced lactose (b-galactoside) permeases of Gram-positive bacteria as well as the E. coli N,N?-diacetylchitobiose (Chb)permease which can transport aromatic b-glucosides and cellobiose as well as the chitin disaccharide, Chb, but only Chb induces expression of the chboperon. While the Lac permeases consist of two polypeptide chains (IIA and IICB), the Chb permease of E. coli consists of three (IIA, IIB and IIC). In B. subtilis, a PTS permease similar to the Chb permease of E. coli is believed to transport lichenan (a b-1,3;1,4 glucan) degradation products, oligosaccharides of 2-4 glucose units. This model is specific for the IIA subunit of the Lac PTS family. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129903  Cd Length: 99  Bit Score: 68.23  E-value: 1.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484219890  11 LSMNMILLAGNAREKIMKALTACEARNFITADSCLQAALSEIEEAHILQTETVQKEAMEQEYYYSMLFTHAQDTLMTIQS 90
Cdd:TIGR00823   6 LGFEIVAYAGDARSKALEALKAAKAGDFAKARALVEQAGMCINEAHLAQTSLLAQEAGGGKMEVSLTMVHGQDHLMTTIL 85

                          90
                  ....*....|...
gi 1484219890  91 EYNIALHLVAILK 103
Cdd:TIGR00823  86 LKDLAAELIELYK 98
celC PRK09591
PTS cellobiose transporter subunit IIA;
6-103 5.64e-08

PTS cellobiose transporter subunit IIA;


Pssm-ID: 181975  Cd Length: 104  Bit Score: 46.72  E-value: 5.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484219890   6 DQLNNLSMNMILLAGNAREKIMKALTACEARNFITADSCLQAALSEIEEAHILQTETVQKEAMEQEYYYSMLFTHAQDTL 85
Cdd:PRK09591    4 EELQVAAFEIILHSGNARTEVHEAFAAMREGNFDLAEQKLNQSNEELLEAHHAQTKLLQEYASGTEIKIEIIMVHAQDHL 83

                          90
                  ....*....|....*...
gi 1484219890  86 MTIQSEYNIALHLVAILK 103
Cdd:PRK09591   84 MTTMTLREVAKEMLALYK 101
 
Name Accession Description Interval E-value
PTS_IIA pfam02255
PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar ...
 10-103 6.81e-24

PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 460510  Cd Length: 94  Bit Score: 87.10  E-value: 6.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484219890  10 NLSMNMILLAGNAREKIMKALTACEARNFITADSCLQAALSEIEEAHILQTETVQKEAMEQEYYYSMLFTHAQDTLMTIQ 89
Cdd:pfam02255   1 EIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKAQTELIQKEAGGEKVEVSLLLVHAQDHLMTAM 80

                          90
                  ....*....|....
gi 1484219890  90 SEYNIALHLVAILK 103
Cdd:pfam02255  81 TEKDLAKELIELYK 94
CelC COG1447
Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and ...
 9-103 2.65e-23

Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 441056  Cd Length: 100  Bit Score: 85.57  E-value: 2.65e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484219890   9 NNLSMNMILLAGNAREKIMKALTACEARNFITADSCLQAALSEIEEAHILQTETVQKEAMEQEYYYSMLFTHAQDTLMTI 88
Cdd:COG1447     1 EEIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKVQTELIQKEAGGEKVEVSLLLVHAQDHLMTA 80

                          90
                  ....*....|....*
gi 1484219890  89 QSEYNIALHLVAILK 103
Cdd:COG1447    81 MTEKDLAKELIELYK 95
PTS_IIA_lac cd00215
PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial ...
 8-103 9.73e-22

PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 238133  Cd Length: 97  Bit Score: 81.87  E-value: 9.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484219890   8 LNNLSMNMILLAGNAREKIMKALTACEARNFITADSCLQAALSEIEEAHILQTETVQKEAMEQEYYYSMLFTHAQDTLMT 87
Cdd:cd00215     1 LELISFQIILHAGNARSKALEALKAAKEGDFAEAEELLEEANDSLNEAHHAQTKLLQQEASGEKVEVSLLLVHAQDHLMT 80

                          90
                  ....*....|....*.
gi 1484219890  88 IQSEYNIALHLVAILK 103
Cdd:cd00215    81 TITLKDLAKEMIELYK 96
EIIA-LAC TIGR00823
phosphotransferase system enzyme II, lactose-specific, factor III; The PTS Lactose-N,N? ...
 11-103 1.99e-16

phosphotransferase system enzyme II, lactose-specific, factor III; The PTS Lactose-N,N?-Diacetylchitobiose-b-glucoside (Lac) Family (TC 4.A.3)Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Lac family includes several sequenced lactose (b-galactoside) permeases of Gram-positive bacteria as well as the E. coli N,N?-diacetylchitobiose (Chb)permease which can transport aromatic b-glucosides and cellobiose as well as the chitin disaccharide, Chb, but only Chb induces expression of the chboperon. While the Lac permeases consist of two polypeptide chains (IIA and IICB), the Chb permease of E. coli consists of three (IIA, IIB and IIC). In B. subtilis, a PTS permease similar to the Chb permease of E. coli is believed to transport lichenan (a b-1,3;1,4 glucan) degradation products, oligosaccharides of 2-4 glucose units. This model is specific for the IIA subunit of the Lac PTS family. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129903  Cd Length: 99  Bit Score: 68.23  E-value: 1.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484219890  11 LSMNMILLAGNAREKIMKALTACEARNFITADSCLQAALSEIEEAHILQTETVQKEAMEQEYYYSMLFTHAQDTLMTIQS 90
Cdd:TIGR00823   6 LGFEIVAYAGDARSKALEALKAAKAGDFAKARALVEQAGMCINEAHLAQTSLLAQEAGGGKMEVSLTMVHGQDHLMTTIL 85

                          90
                  ....*....|...
gi 1484219890  91 EYNIALHLVAILK 103
Cdd:TIGR00823  86 LKDLAAELIELYK 98
celC PRK09591
PTS cellobiose transporter subunit IIA;
6-103 5.64e-08

PTS cellobiose transporter subunit IIA;


Pssm-ID: 181975  Cd Length: 104  Bit Score: 46.72  E-value: 5.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484219890   6 DQLNNLSMNMILLAGNAREKIMKALTACEARNFITADSCLQAALSEIEEAHILQTETVQKEAMEQEYYYSMLFTHAQDTL 85
Cdd:PRK09591    4 EELQVAAFEIILHSGNARTEVHEAFAAMREGNFDLAEQKLNQSNEELLEAHHAQTKLLQEYASGTEIKIEIIMVHAQDHL 83

                          90
                  ....*....|....*...
gi 1484219890  86 MTIQSEYNIALHLVAILK 103
Cdd:PRK09591   84 MTTMTLREVAKEMLALYK 101
PRK10454 PRK10454
PTS N,N'-diacetylchitobiose transporter subunit IIA;
2-87 5.09e-07

PTS N,N'-diacetylchitobiose transporter subunit IIA;


Pssm-ID: 182472  Cd Length: 115  Bit Score: 44.49  E-value: 5.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484219890   2 QKDKDQLNNLSMNMILLAGNAREKIMKALTACEARNFITADSCLQAALSEIEEAHILQTETVQKEAMEQEYYYSMLFTHA 81
Cdd:PRK10454   11 QTEAEELEEVVMGLIINSGQARSLAYAALKQAKQGDFAAAKAMMDQSRMALNEAHLVQTKLIEGDQGEGKMKVSLVLVHA 90


                  ....*.
gi 1484219890  82 QDTLMT 87
Cdd:PRK10454   91 QDHLMT 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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